PREDISPOSING FACTOR Precipitating Factor

Environmental condition (open spaces with water

Geographical area- tropical islands in pots, and plants
the Pacific (Philippines) Asia Immunocompromise
Mosquito carrying dengue virus
Soldier
Sweaty skin

Aedes aegypti (dengue virus carrier):8-12 days

viral replication on mosquitos’ salivary glands

Bite from mosquito (portal of entry in the

skin)

Allowing dengue virus to be inoculated

towards the circulation/blood

Incubation Period: 3-14 days

Virus disseminated rapidly into the blood

and stimulates WBs including B
lymphocytes that produces and secretes
immunoglobulins (antibodies), and
monocytes/macrophages, neutrophils
 Antibodies attach to the viral antigens, and then
monocytes/macrophages will perform
phagocytosis through Fe Receptors (FeR) within
the cells and dengue virus replicates in the cells

Recognition of dengue viral antigen

on infected monocyte

Entry to the Entry to the

spleen bone marrow
Release of cytokines which consist of
vasoactive agent such as interleukins,
tumor necrosis factor which
stimulates WBCs and pyrogen release
 DENGUE

Virus ultimately targets liver and spleen Cellular direct destruction and infection of
parenchymal cells where infection red bone marrow precursor cells as well as
produces apoptosis/cell death immunological shortened platelet

Hepatosplenomegaly Thrombocytopenia