Name: ANALIZA K.

LANTAYAN Date:JUNE 07, 2020

Note: To be passed until 12:00 PM, June 8, 2020, IN ANSWERING, JUST EDIT THIS WORKSHEET
THANK YOU!!!

Activity #3: Case Study (10pts)

1. Marlon, a 23 year old male with bipolar disorder went to the doctor for his monthly check-up.
He is currently taking drugs for his condition, but he is more concerned about one of his
medication causing him numbness. A laboratory result came out and a low sodium content
was found.
A. What drug causes him numbness?
 Drug that causes his numbness is Asenapine because the longer term (months or
years) because the longer you take the more likely you develop
Reference:
hhtps://:www.vopmhealth.org
https://www.namiorg

B. What drug causes him low sodium content?

 Drug that causes him low sodium content is Paroxetine. It contain serotonin that lower
effect of diphenylhydantoin that  leads to a reduction in posttetanic potentiation at
synapses, an inhibition of repetitive firing of action potentials and ultimately inhibits the
spread of seizure activity.
Reference:
https://europepmc.org/article/med/1158437
https://pubchem.ncbi.nlm.nih.gov/compound/5_5-Diphenylhydantoin-sodium-salt

C. What is the mechanism of action of this drug?

 The mechanism of action of this drug is most potent CYP2D6 inhibitors. It is a substrate
for and an inhibitor of this isoenzyme. Paroxetine has nonlinear pharmacokinetics, this
means that higher doses can produce disproportionately greater plasma drug
concentrations as the enzyme becomes saturated. By inhibiting CYP2D6, paroxetine
has the potential to increase concentrations of tricyclic antidepressants, phenothiazines
and type 1C antiarrythmics.
Reference:
https://psychopharmacologyinstitute.com/publication/the-psychopharmacology-of-
paroxetine-mechanism-of-action-indications-pharmacokinetics-and-dosing-2204
D. How is it to be managed?
 To managed it is to  starts with proper treatment, including medication and therapy. But there
is so much more you can do to help yourself on a day-to-day basis

TIPS HELP INFLUENCE TO TAKE GREATER CONTROL OVER YOUR SYMPTOMS, TO

STAY WELL LONGER AND QUICKLY REBOUND:
 Get involved in your treatment
 more informed you are, the better prepared you’ll be to deal with symptoms and make good
choices for yourself.
 Monitor your symptoms and moods
  time obvious symptoms of mania or depression appear, it is often too late to intercept the
mood swing, so keep a close watch for subtle changes in your mood, sleeping patterns,
energy level, and thoughts
 Reach out for face-to-face connection
 help in relieving bipolar depression and boosting your outlook and motivation.
 Develop an active daily routine
  lifestyle choices, including your sleeping, eating, and exercise patterns, have a significant
impact on your moods
 Keep stress to a minimum
 Don’t take on more than you can handle and take time to yourself if you’re feeling
overwhelmed.
 Learn how to relax.
deep breathing, meditation, yoga, and guided imagery can be very effective at reducing stress and
keeping you on an even keel.
improve your mood and keep depression at bay.
 Make leisure time a priority. 
Go to a funny movie, take a walk on the beach, listen to music, read a good book, or talk
to a friend because playing is an emotional and mental health necessity.
 Appeal to your senses.
Stay calm and energized by appealing to your senses: sight, sound, touch, smell, and
taste. Listen to music that lifts your mood, place flowers where you will see and smell them,
massage your hands and feet, or sip a warm drink.
 Watch what you put in your body
 Taking vitamins and drugs have an impact on symptoms to bipolar disorder
 Eat a healthy diet. 
 eat plenty of fresh fruits, vegetables, and whole grains and limit your fat and
sugar intake.
 Get your omega-3s.
 Omega-3 fatty acids 
decrease mood swings in bipolar disorder.
 increase your intake of omega-3 by eating cold-water fish such as salmon,
halibut, and sardines, soybeans, flaxseeds, canola oil, pumpkin seeds, and walnuts.
 Avoid alcohol and drugs. 
 interferes with sleep and may cause dangerous interactions with your
medications.
 Be cautious when taking any medication. 
 Certain prescription and over-the-counter medications can be problematic for
people with bipolar disorder.

Reference: https://www.helpguide.org/articles/bipolar-disorder/living-with-bipolar-disorder.htm
Quiz #3: Case Study (10pts)

1. Juliet, a 45 year old female, has sleep disorders and often got 1 hour sleep in one night, she often
drunk alcohol for her to get that sleep. She went to the doctor for check-up.
A. What specific drug should be prescribed?
 Specific drug should be prescribed is H1 receptor of antihistamine because it crossed blood-brain-
barrier so it block effect of Acetylcholine transmitter in Central Nervous System (CNS).
Reference:
https://www.youtube.com/watch?v=LU0ibynAdHc&feature=share&fbclid=IwAR1RfGVoOX2CK362Dw3dQJH-
BiUwTyENQGWQDQdHMvwSzmqIfAx-ulKIhL0

B. What are the advices to be given as her counseling on her drug prescribed?
 The advices to be given as her counseling on her drug prescribed are the following:
 It should be taken one a day
 It should be taken before bedtime to avoid engaging in an accident because it causes sleep.
Reference:
https://www.npra.gov.my/images/reg-and-noti/PI/scheduled-poison/cetirizine_cetirizine_cetirizine.pdf