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High Riskneonate 141114084056 Conversion Gate02
High Riskneonate 141114084056 Conversion Gate02
&
neurodevlopmental outcome
By
Dr.Osama Arafa Abd EL Hameed
M. B.,B.CH - M.Sc Pediatrics - Ph. D.
Consultant
Pediatrician & Neonatologist
Head of Pediatrics Department - Port-
Fouad Hospital
GOALS
• Perinatal prevention
• Resuscitation and stabilization
• Evaluate and manage
• Monitoring and therapeutic
modalities
• Family centered care
Predisposing factors
• Pregnancy between the age of 15-19yrs
• Elderly women
• Wrong dates
• Multiple pregnancy
• Fetal anomalies
• Hereditary
Introduction:
Definition of High-risk Neonate:
Any baby exposed to any condition that
make the survival rate of the neonate at
danger.
Factors that contribute to have a High-
risk Neonate:
A) High-risk pregnancies: e.g.: Toxemias
• Thermoregulation
• Digestive
• Renal
Physiologic Challenges of the
premature infant
• Respiratory and Cardiac
– Lack of surfactant
– Pulmonary blood vessels
– Ductus arteriosus
HYPOTHERMIA
Definition:
It is a condition characterized by
lowering of body temperature than 36°C.
Types of Hypothermia:
2- Secondary Hypothermia:
This occurs due to factors other than
those immediately associated with
delivery.
Important contributory factors are:
e.g.: Acute infection especially
Septicemia.
II) According to Severity:
1- Evaporation:
Heat loss that resulted from
expenditure of internal thermal energy to
convert liquid on an exposed surface to
gases, e.g.: amniotic fluid, sweat.
Prevention:
Carefully dry the infant
after delivery or after bathing.
2- Conduction:
Heat loss occurred from
direct contact between body surface
and cooler solid object.
Prevention:
Warm all objects before
the infant comes into contact with
them.
3- Convection:
Heat loss is resulted from
exposure of an infant to direct source of
air draft.
Prevention:
· Keep infant out of drafts.
· Close one end of heat shield in
incubator to reduce velocity of air.
4- Radiation:
It occurred from body
surface to relatively distant objects that
are cooler than skin temperature.
ISOLETTE/ RADIANT or
INCUBATOR OPEN
WARMER
*) General management:
1- Infant should be warmed quickly by wrapping
in a warm towel.
2- Uses extra clothes or blankets to keep the
baby warm.
3- If the infant is in incubator, increase the
incubator’s temperature.
4- Use hot water bottle (its temperature 50 °C).
5- Food given or even intravenous solution
should be warm.
6- Avoid exposure to direct source of air drafts.
7- Check body temperature frequently.
8- Give antibiotic if infection is present.
HYPERTHERMIA
Definition:
It is a condition
characterized by an elevation in body
temperature more than 38°C.
Causes:
1- Disturbance in Heat Regulating Center
caused by intracranial hemorrhage, or
intracranial edema.
2- Incubator temperature is set too high.
3- Dehydrating fever
*) Management :
9- Irritability.
diabetes.
II) For an infant:
All IDMs should receive
continuous observation and intensive care.
Serum glucose levels should be checked at birth and
at half an hour, 1, 2, 4, 8, 12, 24, 36 and 48 hours of
age:
- If clinically well and normoglycemic; oral or
gavage feeding should be started and continued
within 2 hours intervals.
- If hypoglycemic; give 2 – 4 ml/kg of 10%
dextrose over 5 minutes, repeated as needed. A
continuous infusion of 10% glucose at a rate of 8-10
mg/kg/min. Start enteral feeding as soon as possible.
Give Corticosteroids in persistent hypoglycemia.
Treatment of other complications
should also start; oxygen therapy
for RDS, calcium gluconate 10%
for hypocalcemia, phototherapy
for hyperbilirubinemia……………..
etc.
Neonatal Sepsis
Introduction:
The newborn infant is
uniquely susceptible to acquire infection,
whether bacterial, viral or fungal. Bacterial
sepsis and meningitis continue to be major
causes of morbidity and mortality in the
newborn. The mortality rate due to sepsis
ranges from 20% to as high as 80% among
neonates. Surviving infants can have
significant neurologic squeal because of CNS
involvement.
Definition:
include:
(ESR)
- Cultures:
Management of Sepsis:
- Prevention: through proper application
to infection control practices.
- Early onset sepsis; give intrapartum
antimicrobial prophylaxis (IAP) to the
mother.
- Neonates with clinically suspected
sepsis:
*) Culture should be obtained first.
*) The recommended antibiotics are ampicilin and
gentamicin.
*) Third generation cephalosporins (Cefotaxime) may
replace gentamicin if meningitis is clinically suspected or if
gram-negative rods are dominant in the unit.
- Late onset neonatal sepsis:
Vancomycin in combination with either gentamicin or
cephalosporins should be considered in penicillin
resistant cases.
Note: Administer all medications IV.
Nursing consideration
• Prevention
• Curative
Prevention
1- Demonstrate the effect of hand washing upon
the prevention of the noscomical infections.
2 -Standard precautions should be applied in the
nursery for infection prevention.
3- Instillation of antibiotics into newborn’s eye 1-2
hours after birth is done to prevent the infection.
4- Skin car should be done using worm water and
may use mild soup for removal of blood or
meconium and avoid the removal of vernix
caseosa.
5- Cord care should be cared out regularly using
alcohol or an antimicrobial agent.
Curative
• Encourage breast feeding from the mother.
• Adequate fluid and caloric intake should be
administered by gavage feeding or intravenous
fluid as ordered.
• Extra-measure for hypothermia or hyperthermia
that may take place to the newborn.
• Administering medications as doctor order.
• Follow the isolation precautions.
• Monitoring intravenous infusion rate and
antibiotics are the nurse responsibility.
• Administer the medication in the prescribed
dose, route, and time within hour after it is
prepared to avoid the loss of drug stability.
• Care must be taken in suctioning secretions
from the newborn as it may be infected.
• . Isolation procedures are implemented
according to the isolation protocols of the
hospital.
• Observe for the complication e.g. meningitis
and septic shock.
• Encourage in-service programs and
continuing education of nurses regarding the
infection control precautions.
Hypoxic Ischemic
Encephalopathy (HIE)
Grade I HIE:
- Alternating periods of lethargy and
irritability, hyper-alertness and jitteriness.
- Poor feeding.
- Exaggerated and/or a spontaneous Moro
reflex.
- Increased heart rate and dilated pupil.
- No seizure activity.
- Symptoms resolved in 24 hours.
Grade II HIE:
- Lethargy.
- Poor feeding, depressed gag reflex.
- Hypotonia.
- Low heart rate and papillary constriction.
- 50-70% of infants display seizures,
usually in the first 24 hours after birth.
- Oliguria.
( HIE )
Grade III HIE:
- Coma.
- Flaccidity.
- Absent reflexes.
- Oliguria.
Unconjugated Bilirubin
+
Plasma protein
Liver
Which released from plasma protein inside the liver and
connected with Glucuronic acid and Glucuronyl Transferese
Enzyme (in the presence of normal Ph, O2, and normal body
temperature) to become Conjugated Bilirubin , that has 3
pathways:
Bile duct Kidney Gastrointestinal
tract
To digest fat. (Urobilin Urobilinogen) (Stercobilin
Stercobilinogen)
to obtain normal color of urine. to obtain normal
color of stool.
The following are possible causes of
hyperbilirubinemia in the newly born
infants:
1. Over production of bilirubin.
2. Under excretion of bilirubin .
3. Combined over production and
under excretion.
4. Physiological jaundice .
5. Breast milk associated jaundice .
Complication:
cause Kernicterus.
Clinical Presentation:
Kernicterus progresses through 4 stages:
Stage I: Poor Moro reflex, poor feeding, vomiting,
high-pitched cry, decreased tone and lethargy.
Stage II: Spasticity, seizures, fever. Neonatal
mortality is high at this stage (80%).
Stage III: A symptomatic (Spasticity decreases
and all remaining clinical signs and symptoms may
disappear).
Stage IV: Appears after the neonatal period.
Long-term sequelae can include: spasticity
quadriplegia, deafness and mental retardation (for
the 20%).
•Management of unconjugated
hyperbilirubinemia:
·
•Phototherapy:
Nursing care for those infants receiving
Phototherapy:
1 . Cover the infant’s eyes and genital
organs.
2. The infant must be turned frequently
to expose all body surface areas to the
light.
3. Serum bilirubin level /4 – 12 hours.
4. Each shift, eyes are checked for
evidence of discharge or excessive
pressure on the lids and eye care should
be done using warm water, then apply eye
drops or ointment.
5. Eye cover should be removed during
feeding, and this opportunity is taken to
provide visual and sensory stimuli.
6. Avoid oily lubricants or lotion on the
infant’s exposed skin, because this can act
as a barrier that prevent penetration of light
through the skin.
7. Increase feeds in volume and calories.
Add 20% additional fluid volume to
compensate for insensible and intestinal
water loss.
8. Intake and output chart.
• Blood exchange transfusion
Crash Cart.
Neonatal Respiratory
Disorders
Common Neonatal Respiratory
disorders:
Respiratory distress
surfactant system.
Risk factors (High risk group):
B) Specific:
Surfactant replacement therapy
through ET tube.
B) Transient Tachypnea of the
Newborn (TTN).
Definition:
TTN is a benign disease of near-
term or term infants who display respiratory
distress shortly after delivery. It occurs when
the infant fails to clear the airway of lung fluid
or mucus or has excess fluid in the lungs, this
limit the amount of alveolar surface available
for gas exchange, leading to respiratory rate
and depth to better use of the surface
available.
Risk factors:
· Secondary to hypothermia.
weeks of gestation.
(r= 0.88,
p <0.01)
rScO 2 -Right (%)
05
08
11
14
17
20
23
26
29
32
35
38
41
44
47
50
53
56
59
02
05
08
11
14
17
20
23
26
29
32
2:
2:
2:
2:
2:
2:
2:
2:
2:
2:
2:
2:
2:
2:
2:
2:
2:
2:
2:
2:
3:
3:
3:
3:
3:
3:
3:
3:
3:
3:
3:
1) Hou, Physiol Meas 2007; 2) Kurth, J Cereb Blood Flow Metab 2005;
3) Dent, J Thorac Cardiovasc Surg 2002
aEEG
• Filtered (2-15 Hz)
• Amplification
• Compressed (6 cm/hr)
• Semilogarithmic scale
• 1 channel (2 parietal leads)
• 1 channel for impedance
Background patterns
• Arterial saturation
(pulse oxymetry)
• Arterial blood
pressure
• Heart rate
• Cerebral oxygenation
by NIRS (rScO 2 )
• aEEG
Monitoring the neonatal brain
• Blood pressure
• Patent ductus arteriosus
• Autoregulatory ability
• (Mechanical) ventilation
• Surgery
Limits of normal blood pressure in neonates
*
$
• Blood pressure
• Patent ductus arteriosus
• Autoregulatory ability
• (Mechanical) ventilation
• Surgery
Hemodynamically important
PDA
• Ductal steal phenomenon in cerebral arteries
is a risk factor for cerebral damage in the
preterm infant (Perlman 1981)
PDA surgery after failure medication
GA 26.7 ±1.8 wks
PNA 7 days [4-39]
surger
y *
p<0.05 vs pre-clip
Suggestions
• Blood pressure
• Patent ductus arteriosus
• Autoregulatory ability
• (Mechanical) ventilation
• Surgery
Autoregulatory ability
(corr)
rScO2
Cerebral blood flow
(no corr)
(corr)
Brady, Stroke 2007/2010
pressure
MABP
Cerebral perfusion Wong, Pediatrics 2008
De Smet Adv Exp Med Biol. 2010
Aciado Ped Res 2011
21
40
60
80
100
120
140
160
180
200
:0
21 0
:1
21 8
:3
HR
(%)
(%)
21 6
Erythrocyt
:5
SaO 2
20 MABP
rScO 2
22 4
(b/min)
0 (mmHg)
:1
22 2
:3
22 0
:4
23 8
:0
Dopamine
23 6
:2
23 4
0: :42
00
0: :07
18
0: :07
36
0: :07
54
♂, sepsis, †
1: :07
12
Thrombo+FF
1: :07
30
1: :07
48
2: :07
06
2: :07
24
2: :07
42
3: :07
Dopamine
00
3: :07
18
3: :07
36
3: :07
54
4: :07
12
4: :07
30
4: :07
48
5: :07
06
Absence of cerebral autoregulation
5: :07
24
5: :07
Dobutamine and
42
:0
7
40
50
60
70
80
90
100
18:01
18:03
18:05
(%)
(%)
18:07 SaO 2
18:09
rScO 2
18:11
18:13
18:15
18:17
18:19
18:21
18:23
18:25
18:27
18:29
18:31
18:34
18:36
18:38
18:40
18:42
18:44
18:46
18:48
♂, 30 wk 945 g, day 1
18:50
18:52
18:54
18:56
18:58
19:00
19:02
19:04
19:06
19:08
19:10
19:12
MABP
19:14
(mmHg)
19:16
19:18
Presence cerebral autoregulation
19:20
10
20
30
40
50
Suggestions
• Blood pressure
• Patent ductus arteriosus
• Autoregulatory ability
• (Mechanical) ventilation
• Surgery
Suggestion
Hypotension
Patent ductus arteriosus
Autoregulatory ability
(Mechanical) ventilation
Surgery
Neonatal cardiac surgery
So
• Neurodevelopmental delay needs to be investigated
in relation to brain injury :
• brain monitoring
• (pre-existing) riskfactors
• brain injury by neuro-imaging
• longterm follow-up
• larger cohorts
• collaboration between disciplines in hospitals and
multi-center
Study design
Neonatal brain damage
• Leading to neuro
developmental
problems
• Cerebral palsy
• Behaviour/sch
Thank you