PHARMACOLOGY, TOXICOLOGY,

PHARMACOKINETICS
1. Two dose-response curve response plotted on the same
graph showed sigmoid curves having
the same slope and height. T curve is located to the right
of the A curve. Which of the following
statements is/are correct regarding curves A an:
I. A is more effective than B
II. A is more potent than B
III. A and B have the same ceiling dose
IV. B is the graph produced when A is given with its
competitive antagonist
V. B is the graph produced when A is given with its non-
competitive antagonist
a. Only I and III are correct
b. Only II, III and IV are correct
c. Only II and IV are correct
d. Only III and V are correct
e. Only V is correct
2. Two dose-response curve plotted on the same graph
showed sigmoid curves A and B, where A is
at the left of the graph with the height greater than B.
Which of the following statements is/are
correct regarding curves A and B?
I. A and B has equal efficacy
II. A and B have equal potency
III. B is a partial agonist of A
IV. B is the graph produced when A is given with its
competitive antagonist
V. B is the graph produced when A is given with its non-
competitive antagonist

a. Only I and III are correct

b. Only II, III and IV are correct
c. Only II and IV are correct
d. Only III and V are correct
e. Only V is correct
3. The cumulative number of subjects who display a
certain rersponse or effect to a drug is plotted
on a graph as shown below. The graph on the left
represents beneficial effect while the graph on
the right represents toxic effect, what is the therapeutic
index of the drug?
a.0.5 b. 1.5 c. 2.5 d.4.0
e. 5.0
4. An administration of one drug leads to a shift in the
log dose-response curve of another drug to
the left a range in the maximal efficacy, this is called
a. Agonism
b. Partial agonism
c. Non-competitive antagonism
d. Competitive antagonism
e. Potentiation
5. The action of this drug is dependent on a colligative
property
a. Mannitol
b. Cocaine
c. Reserpine
d. Furosemide
e. Losartan
6. Whiich of the following drug groups have mechanisms
of aaction that involve binding to enzymes
as target protiens
a. Benzodiazepines
b. Barbiturates
c. Calcium channel blockers
d. Non-steroidal anti-inflammatory agents
e. Phenothiazine antipsychotics
7. Voltage-gated ion channels serve as site of actions for
drugs such as
I. Diltiazem and Nifedipine
II. Lidocaine and Procaine
III. Captopril and Losartan
a. I only
b. I and II