Efest* I* locul de etimlnrm; eb,*mbf uffh firrfipuffcMff*te

Vlt*:a allmtnedl mtdlermtntrlor dln mgmlrm

Ve= Keif,303 = log C'l{ogrs2fif -ffi

Ks = constanta dE elimirmre: Ct C2 = mncentratlib pt la timFii t! si H'

Depindt ds: r) Ffinpff*hfiflr flgca"*frlmlcO rftr fu}ft*rtiIor, # salsE dQ

ednrinistrarc feesortgr*J; el g61l1ttul farmacoctne&; 6t parloadr dtil rffi!fitl
clrredian; oj vercte; 4Etrru* t11io1ggfrca # prto;ggrm*i glrsnpiea drE dfi*#nf,ruf

f,firrpuf fn can JunrelafeJ ; I{*rociuue m edfue raenf srsr

TtflA al unora dintc rmedicamentE (acHs) ists {h 3 ori m*i lung in fimput noptti #€t
in pr*portii
aiua. Acidose din timpul *omnuhi det*nnina dhtinuar*a ioaimrii. d*fuaiurwa
rnei meri in ta*rf,uri si, raabsorHia mai tntan*a l* nFlelul rini*hilsr'

pentru Eu,t*ertride seft!tu.ate Is *mr.rmE$.rt stg in gercml nui rrsra dss* ta adulti'
pentru meeasi fua de penfrc#lha conenffitta *tquina seete an varcta, fara m exiete
o inEuffidenta renala decelsb'ih.

Irfreractfuai Privins alirxl naree

lrl dr*inistr*rca e*corniknta s &ua san raa{ rnuk medic*r*nte pot apare
intenadiune piuind eliminama o*te pot iflftuetls uiteH
de etiminare

Elimina*ur medi*arnenblor pa eal* ffi'dil

lileusrhms fntFlttete;

a) filfet?gtromrrl*-a' Pasfr*n;
b) reaDsorsfle tuDrrlere'paslra sil ectlvc;
cI s*crsff* *r$utilfiE ' Pa#tn #rc{rrr;
dl toats cele truf mecaaiEttP
srnt fltraH h niusld gHrnrdului rensl. Din $orn*ruf urina trese in
Muk nedicamente
p*rte din suffitantpb Ii@, rual*dtdn e o
tubli rcneri. aici ge r€abgofi me mai m*re
F*,tt dimin# Prifi
rcecfiitibrar* a plmrmi cu urina tubulare. unele nrcdicslr*nh
eUnS X Ef$nlnrru nudhmrrrshrdtn orymLm

Er ts{tt s$ntft# dn
Ultturu Etrfa * hrrnecqc}rpffii pin mru Stfi ffitlt s ri msHhofffll
organisrn

Bqrport*nt* c*nar*ierli: *tat rlrt* fnderf,er @

Jfihi fiffnE
rffir*H du#or rl rmd*'Ifsr
efscsolor rdirult; rr{Glrryll rflrtff,|d .dsfif,Iffi3,{fi
eefor rd PtIuItc
€aits dG tltttlm*t al* IftdiEilft*llirlor

lffi$tk Ear! m&t

gunt e*[e ffir&gf,m, utn*sm p.rrru ir*frsru*s *s{k*r*br
rnetabolizate in oqnnism

- rEnht*i - *r$et*ateE hidrsestuffi

. tuhul {Igc*su - stffitenla &s|uiirkffitE
pc t& srd* # ns#orb*b*H
rmkfih
' Plmnenl - cde g$*sisssi
- ct*anat - Bb Yolfilih $i l@e
- tmrutll * hur*fii' mrmtiE l#ta' bila

shfisHf,n pe rmi mulu €fil' dfif a'dsa o * &

un nrsdic*lnBnt sa poeta erimin*

ehnina re Pred orni nanta

ru{lG|rltm$nor
fffiamit*ntb Enplicetr [n usmlnrts*
. cffi inttrttn in gc'etla ru**g fre r'mhhafii*m'
sunt Eeh ltztrologiles,
specifrce fieelei cai
Formlrubmrrrxdcaraartbla**dhul**ffiror1*t*lm
re nilurlrd'o#l & ol*fltiffira' Eludn*l*a in
- nctr*rsforrBrts, fti,d actlve f8ilna$odhilrsB
aG#*taformerypro&mo#adeto'Ml*tmddedlmimrg
mlrformrte' m lMbglffi' rHffi Pd fi afist i ffidn#ttb
firyft dar
- #It ftrma :

ffi 81r€s si #6ebtiE

 r*15r6tls es{tvq tubulgrr lntt$Il coniafi} proilmrNl, ln * prfircrh *ucc*iltmah Inthna ela
axsetloi r6n*la. otl maf rrFltl t#e rmrallr trbulrn

Fonnr dr rlfmlntrr, Li nlvtlul rlntrchllar rubrHntrlo ra elhnlnr ce elert

nemd&ltralr *eufd sr m*tr[s$fl
Vttrrr rllmlmrtt nnrlr.
Elimimraa rcnal* ra poata rrtlla ta rnl*utr, orr, lunl,
lnllrcntrk dr: $ructure chlffqHl .duraa* ttarua lbn+tonda a rinfehilor; *{-ul urinii,
esockrea cu alte rfiedicemEntet macardEmul lntlrn ds dlminaru; d*tribuirsa
iltadicamsntdsr in edo trsl tas[osrr hidrlcr ale organirrnului; legrarea & proteinele
$*matf,ca, varstr,stf, rila patofagnlca

- viteta slirninarii unei *ubstenH din orgmieffi scadE , iR eaeul unsi dlurere
scauute ai ln lngulidantr rsnsH
. la urr*tdci, date fiind *ederaa frtfrurli gbrnerulera el a fluxulrri plarmatic
r€ural. eele util30 3s mlsrhee &srancG-ul seatininei
- La pH acid, cand ion{rsree zuhmlantsl estc eprotBo mmpleta, reabsofutla
este rdure. M6dicarrenhh m,re modificr pH+d urinsl pot area nu runnai
efects localg {aaupra elilninarii tunals}, dar si grnarala {pd produe modiftceri
ehc{rotities ri nNe reserrrei elcatlrp].
- Elfrminarea eets ir*aerc rcpo,?tlo{reta cu v.durnul de tlictrihdis o rubstanta
cart $s di*tr*hrh in toate sectoareh hidrice, liltreaea la mivelul glomrrulilor
sl
eete reako&ita din tubil rematri in proportb egeH cu r *pei+$G
excrda lent
- medicamentele legate in proportii ridicste,
fcireula in sange in h*rna liber* in
cantitati rnf,eil. *e ellrrdna hnt prin rin{chi.
- eliminaFBa renala a s*betankbr psato fi grabitr prin crestErea dirrrezei. prin
modlficarea pH-ului udnei
Etscts la iloctrl *llmlnsrll.
aetiune terapeutica {antibiotioe, dluretkn},
BfEcts noclve (cristalurla h o cancsrtratb udnara apmpri,ata
de satureti* -
pentru unale sulfamik. iritarea rinictlilsr- produra
de fenoli si ulduri Gbrice!,
 Gloarstce * uI rwtaf = toltmurl de SEsaa dr crrg e*!e e&*ffi o rubstattt*
de mtxe (hfuhl. *n tmrfrtatea tlre ftrqr Cl r d mfnine* rub 1fi.3$ mffintrt u*et
de elfirrinm sc* *nur+tlcatiy

Ellmln*rsa msdlc*rrcrts.lor F crh dlgc#a

a) i{ecanirms
- rf,iminsFe lmEtr- erm#ldefe affieftafie gel, S*# rasofuHb dar
nea$sorfraArfe,, a'e nU lra$e{seaffi mrcffiS€h HbtJhIi tligesliV
- inkrmdiul seqet** sduam
- h muoami geaficr Eau irileclffuF memEfrnfi *enliFnngf,hHa prrt
nfu*ehrl
care se poate face trcceea suffintefur h anrbele s8nsl[i. fun€ib G
lipffiltstf,igtp. iuni:ilG si grad*d e Mffi re pffiin*, *48 EfHrik ?GGEfr
suhtsrtelor prin mw$ranala bi@iffi"
-esnfnare ph sffitie btlar*
bl lrit6p *limlmrr* m*dhmrsrsdor p* dr ggtrillur - Lfit@Btd ds tr8rttifi$
intff{irtal, Grabirm strrnir*r$i sa pmm r+efire pin secielee tlt trsg*i$e.

Efirminar*a medirar*errtelor Fa cale prlmoaart

al t1lamni*rrs: prin ffi,aiwn la *iffi$ iftftfsliuhli efudar pcrtrr* *ubffitt*

g$rcaEc si tiBlstils
prin eer,e{fih hrorsiilr {iodud. Eclrzdi" s*tltt dt xnaniu} si
pin sewctiits nazah tioeril
b) Form* dc ail*ralnarB' rretrirfla{arm#
& el lITteza elindnarii sr.estanffi la nftEhll dveohhtr €ste depedenta in mere
@
iJl.
;i: mastrre de tradul de trolefist#e
d) Sdstantele elinfnate prin mcretiile bronaice Pot inilusmh compoaltftr
f,G€toffi. Sarwib de amsidn sl kamnM dE rodfu "..+ *cdinir*te
secretiei* dnnhuarea vroozit#ii ffiie
$llnninaru* mrbnete

-H
-_-
S#irFBbffi # eitd dla*mmrtil{ilt
illesan*rm: FrIn tu{orirla

a&h cu cduhh Gonrrs*rl ffi firnr*tll*

ftiF [sEfu m *mi.rs artfind. fim5lh, Mnurk- gr$- ubtut udeffiil,
gr*enftdxia*

kn@fitr:kmpa#a
b$cdgs& *d#r[nm *rscilcnE in phh si dwa d6o6

EffinlamrpdnniM lffitt
Ce r*dcrtta dc eEssnar* a msdksm*slor
Ee*p*eta tqffi gcmr*h & tumm pafn mmrhrsr*ffi hel6gil6

Sr esnmt*a h W md eH mrilmnffi hdt{ * l# ff|s tffit # lffit

pl*ma

Hx*ffimrffoh ffi Uw in hSHa m&m -.* ffirrgstqmni*n*&l slgffiIds*, &H slm

ffinire# *a tmrm, frt mnt**affi tmd.

A nirmglftnzkfdG fd fi dminiEirstr b mEmE ( #ii sa dmfrm Wn lspilo} frrs ehcils

eflrpra sr,rgarului, &oanEce rut ss *fiofu dh Ubd frffiiu d stgryrdul