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SNP 161121140004 PDF
SNP 161121140004 PDF
AT GC
GENETIC MARKER
SINGLE NUCLEOTIDE
POLYMORPHISM
(SNP)
by
Saloni Arora
SNP
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http://isaaa.org/siteimages/pocketkimages
/clip_image002_0018.jpg
SNP
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www. learn.genetics.com
SNP
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The nucleotide on SNP locus is called
> a major allele
> a minor allele
94% ---- A C T T A G C T G - G : major allele
6% ---- A C T T A G C T T - T: minor allele
http://projects.nfstc.org/pdi/Subject09/images/pdi_s09_m02_01_c.jpg
SNP
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Non-coding region
Coding region
NON-CODING REGION
A segment of DNA that does comprise a gene and thus does
not code for a protein .
CODING REGION SNP
Regions of DNA/RNA sequence that AT GC
code for proteins
SYNONYMOUS
A SNP in which both forms lead to the same polypeptide
sequence is called synonymous .
( sometimes called silent mutations )
NON-SYNONYMOUS
If a different polypeptide sequence is produced they are non
synonymous .
A non synonymous change may either be missense or
nonsense
• a missense change results in a different amino acid .
• a nonsense change results in a premature stop codon .
SNP
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http://learn.genetics.utah.edu/content/precision/snips/images/snp-types.jpg
SNP
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Personalized
Human genetic study medicines
Genetic marker
SNP
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http://www.ubooks.pub/Books/B0/E19R191
9/MAIN/images/image036.jpg
SNP
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AT GC
.http://www.ubooks.pub/Books/B0/E19R
1919/MAIN/images/image037.jpg
SNP
http://isaaa.org/siteimages/pocketkimages/clip002_0018.jpg
SNP
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SNP
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MAY BE HARMLESS
. Change in phenotype
. Pigmentation
. Livestock breeding programs
MAY BE HARMFUL
. Diabetes , cancer
. Parkinson’s disease
. Huntington’s disease
SNP
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“SNPs and snails and puppy dog tails, and
that’s what people are made of …”
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Single-nucleotide polymorphism / SNP | Learn
Science at Scitable .
Human Genome Project Information — SNP Fact
Sheet
http://www.ncbi.nlm.nih.gov/About/primer/snps.html
Carlson, Bruce (2008-06-15). "SNPs — A Shortcut
to Personalized Medicine". Genetic Engineering &
Biotechnology News. Mary Ann Liebert, Inc. 28 (12).
Retrieved 2008-07-06.
www.nature.com
www.pubmedcentral.gov.in