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USMLE 1 FA Equations

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34 facts by linoner (/u/linoner)

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Pharm -Vol of distribution Vd= (amount of drug in body)/(plasma concentration)

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USMLE Step 1 Flashca…

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Pharm -T1/2 T1/2= (0.7*Vd)/(CL)
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CL= (rate of elimination/plasma concentration) =

Pharm-CL (clearance)
Vd*Ke(elimination constant)

Pharm-LD (loading dose) LD= (Cp*Vd)/F (bioavailability=1 if IV)

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USMLE Step 2 CK Flas…

Pharm- D (maintenance dose) D= (Cp*CL*dosage interval, if not continuous)/F (F=1 if IV)
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Stats- Sensitivity Sensitivity= TP/(TP+FN)

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Stats- Speci city Speci city= TN/ (TN+FP) CST Review
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Stats- PPV PPV= TP/ (TP+FP) (/premium/33/)

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Stats- NPV NPV= TN/ (TN+FN) FREE
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Stats- Odds Ratio OR (case control)= ad/bc

Stats- Relative risk RR= [a/(a+b)]/[c/(c+d)]

Stats- Attributable risk

AR (a/a+b) (c/c+d)
 AR= (a/a+b) - (c/c+d)

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Stats- Relative risk reduction RRR= 1-RR RR= [a/(a+b)]/[c/(c+d)]

Stats- Absolute risk reduction ARR= (c/c+d) - (a/a+b)

Stats- NNT NNT= 1/ARR ARR= (c/c+d) - (a/a+b)

Stats- NNH NNH= 1/AR AR= (a/a+b) - (c/c+d)

CO= SV*HR
Cardiac Output
CO= (rate of O2 consumption)/(arterial O2-venous O2)

MAP MAP= CO*TPR (MAP COPTR triangle)

Resistance (#1 factor) RADIUS! (8*viscocity*length)/(pi*r^4)

Ejection Fraction EF= SV/EDV = (EDV-ESV)/EDV

Cx= (Ux*Uv)/Px Inulin for GFR or Creat for eGFR; PAH for
Renal Clearances
eRPF

RPF (e w/PAH clearance) RBF= RPF/ (1-crit)

RBF
Usually 20-25% Cardiac Output

FF= GFR/RPF

Normal FF= 20%

PDA-> prostaglandins dilate AFFARENT (inhibited by

FF and factors a ecting it NSAIDS)- bc a erent no change in FF, both RPF and GFR
change in same direction

ACE-> Angiotensin 2 Constricts E erent (inhibited by

ACEI/ARBS- renal protective for diabetics)

Na- (Cl+HCO) 8-12 normal, over 12=^anion gap, associated

Anion Gap with MUDPILES organic acid poisonings, DKA, LATE ASA
poisoning (early shows alkalemia), lactic acidosis

Physiological dead space Vd= Vt * [(PaCO2-PECO2)/PaCO2) taco paco peco paco

pulmonary vascular resistance PVR= (Ppulm art - P lft atrium)/ CO

PAO2= PIO2 - (PaCO2/R)

R is normally 0.8 PIO2 is normally 150 mmHg

Alveolar gas equation
Normal A-a gradient should be (age/4)+4 ; ie for a 40yo
should be 14
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