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Kerbs Cycle 2015 - MSC - CH - 14 (Naeem Ullah)
Kerbs Cycle 2015 - MSC - CH - 14 (Naeem Ullah)
It is also referred to as Tricarboxylic Acid (TCA) cycle. In prokaryotic cells, the acid cycle
occurs within the cytoplasm; in eukaryotic cells, the acid cycle takes place within the matrix
of the mitochondria. The cycle was first presented by scientist “Sir Hans Adolf Krebs” (1900
to 1981). He was awarded by Nobel Prize for physiology and Medicine in 1953 with Fritz
Albert.
The process oxidizes glucose derivatives, fatty acids and amino acids to carbon dioxide (CO2)
through a series of enzyme controlled steps. The purpose of the Krebs cycle is to
gather (eight) high-energy electrons from these fuels by oxidizing them, which are transported
by activated carriers NADH and FADH2 to the electron transport chain. The Krebs cycle is
also the source for the precursors of many other molecules, and is therefore an amphibole
pathway (meaning it is both anabolic and catabolic).