Sone eS] Bo 98 go baat ape cain SS Sal $F al Nye J yesh el PS 2 SS laps SSL At ae ‘095 tab lt Jobe LAS ssp or ote (Stem Cells) sah la Spe aS ob jhe 8 pepe ala Upbe jose le Uple Al sts ple place ea gli sla Je Sd Glee 2S le aaa pale lye a abl ge Sy9 gorate IS dd le Joke) be oto Es ot S09 a Saks Jnl gh nar OS ga SAS ay ge ah 9 Oh es la Jal Shy ok le See SR A Sloe Hd Se Ut ee 2» Bal yr SASS Co IATL) set S opt ole cH LSS ob OK sof hp ba gl ay tea sl la ty sets le per lo Wy p> ja ln Jol sag tebe ln Jp SE ly WT Sle te a Jake 9 te ee G8 me EGS an lk le pt oeSe che Upbeat pla Ad Jose Se 18 88 ge Gah Gls Jobe he oS sa go SLE 25 SHE SAL Seb ag stn sake Jol Se pe arb se Jol Sy el a bs 5 le Ese Hd et ae Mt Ea stg Sa ple 4 at ats Cee pt ail Jal Se eh ke pt Sea le Jrlf A SM ed oll MN St re Al ot E ple sagt dle Iyer Gath at cam 52 sated sale Jobe Se Sp ets B le ple Jad Jape te lt Ulf els sta eh Eps JAS ph a sl ul Using gl dl Goh Lalas ig Aas la Jol ee Sl aT ga ogee eel Sit BDI Soo BS A Se ot Sat ae ee 5 Oe Ce Ub Sl te ot St Syke 2) Spt ge nt lane 8 ole go hse Ol ont etd se Ie Ste Jake ee ble phe el ile tee eb tee lt pl ob he ai ne aS ed SO SBE SI op Se 9 ree ee ae ole 2 at ecb le Sg DE nS) ols Sole ete cla Ips Atay plato al ool Fg ol) ge geen GO Og ed Sle Jal gee nt 5 ge sled DES ggEB Se ee I Sade Sat a SoS Ul 5 Tape Cee Sone Si Say ot Hath ee Cay Cpe Vg AS) Ca Sle (a5 ge waty Sind & Voss SS) Sl je OF eb i se Jel IS hI SI it eS cle Ua ashe SS Une et Sade Slee Se oye ole gay, aca Ala gL gan Lad jo Ll Sa las pall, Ne eS a A I i Sd ase cI LS A ae NS cop ale la Ls Ia go uli ag 19 aS gl Joe Las aS of law 4 oyKF a cay ey pS pe SAS a 9 al a Vy a Ls se jy, Sige by gad oat NE ge aly a ans pel, gece Sas sle pl lly IS: Bm Aly god Sl sl pb te pa 235 ge maby te ts gan oe aS aly go Sul es te aS ola Jgle PDE ee eS 0p 58 on ee Hine it ke Jol ek ALN oe ontt Se t eS eD AS ee Ne stil hn Joe oS apt fap stl la Spe 0 sign la Js ce ee stalin she ale ol 2 aS gest op ge etal Se gia Lag! ee ee Kea” "ite sain Sg" inf scl lt Sy es ee G8, al as Vyas 9 8D ety le Upbeat (CLL ) ape Stag a =) EA W248 coe JL DD ML cal att ole Ga MT 9 oan Go gall dB tie eaSp$ I 9Ls bp Sy (Hairy cell leukemia) aga Jobe aS) ge al Meow aS oul aT AL yo Voss 9 BF | stig sl Jol shee el CML ) gape soci ad 1 2S ge Mean Ly ail on Fate 8 aS) lca aS ey ep yen ee | stg le Jae lee Gol CALL ) ale (52 gl) Scag gay oT SS ge Me fei) tl 5 A ee She g coe FES 18 ood Eo! Ge lt ALL aid oe a)Ee aS Ay ty 8 8 Minas la Joe len col (CAML ) abe stan eat Spo taalnn Gaile 9 ple A 8 ot SY Nj phd Solge wei Shag Ag Fag CEES SS Sl gee ca bya a NaS Og Ge AE Lae) Gy eee SN gat ha SI ge ts IS a a oS) So Cle AS et ath oat le CHILLI) SHEN lene lj A dae a sane ge GL SUS ate tpt po Sie a soot ses ge GUlsil Ly wala SDL Sele Sih Alike el ly a See dy hs le tte Jee AE ple Sat SJB antl GM JL pile ae pa lA tay Sis che Seianptl SU oeie stan Sy abe tegen oS) 4! ablbn (alo By cal) 59 age les Sie glee 9 sl Le) gash ay sl ei atl Cae oll PAS LSS 52 epeaty lll jo saSal a Hel pas GS a pre og ce lel asl GY ey Fg lyn ge 99 4 la he gall ag gl Se a 9 AEE A Ses ee Gla Sp) oll gy cles ses ll ea) 4 Hal a a gl ai bles ae le Sk a eS cl oy Spl gn abe 9 le gJs fsb Se 9 eased oS gl gy. = AEs A) AS clos an ph al IB Ban EM WS foe le ine 9 NSA SE Se LiL aS acca salle Je 2 eine at off bho gah ty EL ail NOS A Be ToS pileup Je ys ccgne olin Cane GIT aS Yd jh IP ge AS le 3g Shs SL wake oS Ae be IRIEL Ue gl bl JU LSS oye pI 285 ge AN ae ig gS a jh AS J ga RaeSaline eigen ape ale tn SY ee a ga WF knoe 9 GS Mop ame poet 2208 Spb alent gl 9 taf he ots opt lo Sl oS Gale Man oS one ap Sal pe Gaye p Bee aps 0 JAHRE I Gls cas lla ab slays) cane el SS lls cle J es ol legs yee Le aheye lee alge el at Se Se aS I abe in ea Mine ie Na Soe te (topoisomerase ) jey3! 5355 gle aS esl (alkylating ) suis alll alge glee Coe aS leg, ls sigh eal Sle gS 4 Mee Snead ge 1 Se aS) a Ea es 8) ola sce Lo 9 Gal py etal le lan I 89 oa 9 900 ation aan ge ll Sed EE eR OE En EE LE OYA I 0 ty 9 Kae Ments ghee apr Se ge Sui Se an ESI pbs egg Cgc Gul a Mee halo CHTLVAD) Ss gy pile! Toeell ag) gpg es Co Sane HTPLVAT yyy cpl gry ble go tly agate T-cell pasgh pli a aS jl est ka sper le GAS alate g cpille Tocell aS Q Ll og yal gjlees ul ag Me AS aj atl Mase cea ay aslgld Se 9 5 Sj) ae Cl Gan Sate geil ay Mal goMpile able AEH a aS sha ie oy SA pe eet Sd ST at ee SE Sy oe! setae gag cul Mean ah Ly lp ly yale yas GUL nye Kaayi el ely oF ool it) cee oy sald poy) oe GLI! pane Ge Eo |) phe ale ee LD sole pt ee ashen Spl ty eas ay as ble Sine aS ln Lad lg a Lele 5 SES ge > 8s pa 99 i> lt Jobe aw ale aS) lt ge ayo gu ob gl eed Une Sy ls Jub sae se Donte pe Sale SS pled ob Say y att AIS] aol Le WL Cal Se ae a a Mee Sree Glew cal oars1 ABL SS ye dary 998 Sg 4 | CULS LN SU yl pane can a abe ad 4 Fl Spl ip SL be JAS Gols eo J ah EI ite Jo Sal Se atl a JE phe al BS gay Ag lB AIS AF hs dj te le Gy lea inn Sa pj Se ald cal Sane Lae ga yl gle als (ie pk Gah AoE Ga oad og 9) a aa Yee SG ok yg whe gl gel ys 2a slo agi es da Le! Ps Sip Ee ny LIB cay 2S Ss! cla Sa ah sin s8) O88 Con bse es Slee on CSL Sine 58 ete Ll A) oS el Lal ht gat ately cabal bs a iy cls cas olin bo glpaealo,o Sap one Sel Sanja IS le Sipe Sop tthe ole Sle AE ALE Gul ye Ata IL cal 81 LBs Gal eS yh gS Labi ly go 5 Kellan ui Us Lol OS Gyles Sy UL 29S SOL OTe Lobo S Gye gob GRAY Joy ae a ONE ol LS Ty eg Sa eye oe lynne SalI Ss SE cb sy sith cael ode DR jp Ay pre |p VT UO S salys Bb Leb Say aS Cee el |) cere) aM Lat SIE y eat AL RE gh ol sph pla Let slp Sol See 2 le Gays yee a 2S coe ert VAS Jone Al 8 ppg La Sg Sed leerl ee bie Le Jal slat ag aly |p CBO lS Glad Sy lClesl 9s eel S88 gt tah Sk pl ha a J SAN aS ta go poste OG 5 oS Sle Se sh Ha cle Jol 2 ope cmalhgan a gl SN ae pall Cal ly ge at SL ts AT ee Ls ty ges ope ole Sol 9g gay late ad Se ate Le apy cla jhe 2 aS la Joe AS Sal cl ol =e tele a SE lel ate oo slag tp We Joe 0 898 Bale eso oe ILE see ate ye 8 Sa Ia LAS pale AI pal I] lyst 5 east BS gt Teena tae lt te dale Satya pa eng en J SLE gel aly lel ole Se 0 ia 9 a ll in 2 ont Si le oli pe Joe Ws leo SoS pa Ly Le ad Igy Cai ge Se stad y Sip pel pa gga (AS AS ge Cottey, PRN) SS SE MEG BE AS op Se job b Say Syed jhe) teed sop 5 - 8 ge hs obese ieUe falest ple PH Lat eS Fg ashe oe AL a RS Ge uy bt lp Sg Sole als! cently ead oa Ly oly phe ge le igs Teel Sera Gla ple le epigeg falls) ip Ee ae Se SL a 0 ge a) Galante ab Gale lo pyinan SS psig Al a cele t gigas, Se Vio CML ) gaye sarighe GaSe oil Je ule oy ao ane "Ls" Eby phe Sib g Jae Saba SF gale) ali pe ele) gabe Sal ae Sty ELI by es pS Sa I) le fl ete GL y jhe ip Ke jf MIL I ai tla | (cul 0a |) ee PH LA ae ee leh ABS TS apne 9 955 pent asin art ay Oe ls ge BIE Lad oe spe phan a |y gale aKtaasT atngts apap jlo © aS jh gle cae copy sol slum Cele asp Oey SS cot Silat (Ela aS lo phe 2 ayLne pie pL Lg pte hl Sat ay ge ey Se Gel ae a Neal ge © as he Led Aisole cba tahia ghee gehen eat si pH a a jays oe ll ala a3 al Me SB ay Se ig a va Fy LLG leo sole ale Use iy pel ay glee eee ip oot di gleyo Cal ere y8 Call Sn alge cediny ana alse Jae cb | lab sys pp algey Gha gle Ey IB! Ygal Grbsed Ses * lage a ch Lat Os se ele un le ple Wl # glans cle SL Sty Gotan ae ls hi gS cla Jae jeans la Seg at ol Sinn ann lo aalyS NP ied ype Ls rape SOL SAU onret 9 O88 SD Me os oat Taalye a igs lye delay a wo fa ole aS a te Spins (lage cel Soa Sy ore jlo agyy jane gd ge aaa MS yb lng” S coal glen gle WL See alan te pt age aaa lays” Let oles” AF dh ype lan 96 on Ste hig Aaan sls oo Se eSLes Gan gig AS Oy lle eh la 4 jhe Cal San atl LS opay gabe Sy ae La epee LET pace a EVLA ly | las aglaw le Le gpd kia wes Des Awe ea 9 ge etal Gage BS Cos" oT ads Ln et By gT cle SLs g syne A ge oles de! 39 gags yl ash 2s ope glay9 a J cae aS! 9 agulie Shee ssh Site ISS rbe 9 Soph ey? 9 ob Bie A SoS lhe ol hae Sl a Jah ly Sohet Spe ole Signy ater yt opt dalee pleys yao LIE ge Spt aj gl Li Baa 8b 9 oa Jog BS aye Cal! cal ely gail Spa ad oy Mae Nal SS ge SRE gla aes et Lt te oT ete bse A ype ays ola OL a go St eth I6 Gad Sis8 Yaa go Sales Lae Se 9 oath GIS ls ob S slo cle Bue Se ay Copa 0 od eal yy Ga Legh 9 OFS y4 oy 9 alge Sa Kea Let BS Se gh Sy, cl gles eS YS gman SiS) Calg Lad Col ae bg ano fey gin Ss | Lad cS Bn ol las men 9 Si, ets lp man ld gh Geena VAT LE SS ga lay? Se aly SOE oS JAI ool Sot 5 JU ult lhe Gematol LE col SI te lye ss aS gles 2 one abt ey oS te Se Se 9 ab abs gl ype? Le Syn iF ep peat Su UL lye ally ge 9 Cal ne by wid ogy GLa Sled Sal Sine eye | Sy ate ol LS ihe oppo BOs AD ee 98 jIgleys Gay NLS steslyy Gedy a8 soot Lad sole AN LS lle age gy ley ge cee lle te Cay le Gla ge lil Glens Gaya Ae ols LS pa tay Male ay gles ale 7) Sel Se Gath antl GLE Sl Sal hae Galle Gayleoy Boe + SEL Slap 6 ob Spry Kal goat gee es ULES Sag ape Gay a bie ans go oS jg gla Gla GLE Solin ls le Sige aglys GOEL! SE a Ul ge lc ag pla sli tal se AT) lite ln lee CaS SNA a ge ph wl GEIB J con Gly gla reel sae St ALS aS opt ot obey 9 HB JEG cH at ale 28 tb cll oles woe casks jar Oty J as ft ABS 208 pty Se I IST eS JAS pL Sel Sine HE Syl 9,8 eam a ST, pl bee SE Sep oie pl es i cana a ae a Fa ota Glas aS SL ale ce SI eS ge lb |, lo Gypl gla lds coe Ra LL oe oe eg aap ote Al Gee ly SAS SURE oop I Coe al el apts JUS Aga yy 8 Sle hy Sy ledwip et + ag fell aS) ela Jobe a AS lla? ga lg ee Gla? lla? ted Lge ye WE sj Se Sey yl se 8 a pW Sie 8 Se Cl Sie Lat aS Ee al 8 ela le cla My ll? eet Sets S28 Lb Tog oS oan oe ype lag gS eioles a ¢ opt ebay 9 008 IIE IS AIL ys Ss Seb) b-IV) ary LS He BS Sy Boy ool cle) Wy Sly KOBE S Sb setae cal Ay le BB J ota yy HI ls leo AS aw le oe SI sy pee day le Wales Ge ey a aage a, NL Pala AS ae lsh cul oe Pa me IS ae SS oan Se Sey all ty a GS Susy IE 999 4 |) oT ote BD S38 or op ous soon Sole PAB AS be L921 aS a Jah eat eal Gate ME he len & LE Legs cot NS ad Snr Si tl a A Go AE lth 9 Fe SIE y Je hays pe OS iat ALS sie Gl Gy,9 w Le Lag b Say tae |) gel la Sette y) aob pe et alee AS ae Sts aAlS ple (3979 ty Ny Wag sts Sebi SoA ale OS ered Ommaya ge S oy BE Se Bb I) Alas eat ule Gath Sys ES i os tt nS oe GF A on BaD oe IE ee coe i) BE Se Sa at a oe Lael aes aale 949 4 Ue BaF et oy9 Gta eSlee ie ae lens ae Sell SIS clogs | ott JOO sF clon Neskee bal ap ge Jp elke oye intrathecal hyo cant oop ee CH Gel leg phe 2 FU caine I Sl Soe ps Se AF ay Sls 399 Se al pa tae ele phe Cpe Vane ly? et SL clays Gly asl Se Sal gp 94 pled AS 9 S254 a lays 9 Cal Saw ad ls oS ge stl 80 Gen 9 sh ier Ig lays et 8 Sot Spey jad Ja Ay yb AS ASO ool ts Sins ale ule Wye! eB ge S gee ole fale a IS ge ata ng b Gul sig Ge AS aS 5 ig ST ps ly el sip a5 wine Sb5 Slat a san > le la Jae sl a Sj) ns lye gard 9 ae slo le # nls alae opt SabsT Les a als alge eat SS ne hl cee yo eer koe Se Sole sha SAS als IF Halil ony Ld gk et le ale GAS le oer tite GALS Ly fb Ee Le ga Ls es ea ite yp al Sine dad SL Gla Sade gf oa aay a gt Ase SLA Uples te cay Lol A a i HID ge lg iad sn sh ee p> JS, Hy Lo Saal Sine tra Gl Eay sale Goes i clelage LaF ag kage Sy Sel Sod Saw las yard ge Atay ga ge Aly clin ag iy gis i gto © el ohne Li cat ales 88 5g Se SLA aed le IS ge Bh Ga aI Hs ay le le le Je SIR Soy Ged Gb Cae 58 By peg lngb kyo ag edhe lle aS jag Sy gd Sah U apa Al ge Sley® ened ela gop Saddle Jole U prea @ A eb sinh Be ce bob ge OE ey a et ole le S HOT ATS - th yA bo Rin 9 al Sn bo Lape tp sla pot ell ln glasba aoe Sal pine pygall 2 Cpa AF lad says asl ppl gl ole 4p Cal Se lly> eae all GIy — cet tp 2098 arly 9S ppl sglas 5 Le QUE Gee 20, Gigs ile pypel oF ays Jezel tl yatle Cept Spas BBL glia pe wale Sule soo Col See oly tty ool le bbe cool San flay eet Gh obi cole elt ag ams Sage GEES 9 Al EEE Fale EL ls Les Cl yee Gata tig hale SleMAS bad Jeb Seas Mado gle yoga 098 cadhes CaSlya oy Si tal ge jog este 59 ately yo aS she Ie aubus glays SES HLT ilo cl hn le Keyl aS te Mae pl ae 2 One She ey ble AS Soy seed oles cleats jl eps cede! (Gleevec) Imatinib cts (3 sigs ge mut wads gli 2p eee agg aba ola leg ple Geant SI Su ae Gee ottghe Sd oles ly his go 8 aaliaal 9,y0 Steves, =e Sada gS Se Je Ie wy gd see ga) Gla Jpeg og se lta lags deakan ls 9 SS Stn eal gay lh gle ty Spee Sat ote Se ee iJ GR without, with Gleevec® Gleevec ¥ % x cena % tevin SEE Sine SY i tt sin Glas th ee ARS ip Hla apa Le tle le IS aba Sypely CB jppe SL te at i sla caBle on Spt tee Slab eel Elia slo asaoly o ela Sed 9 as bas Says tan ob SS ge | ole aS OBE ache Se ge I Slee lke 301) at tee els SF Saal Ale col pe 8 stay SEIS Se Sash JAS "lags Ss Gaal" HE ty Sac tle a cles OS ste Ili le aS 0S go Jo pb Ly gee Se Se age SE Sj) Gest AF ge ae aS le Sole AS ge SS SY he be 8p NN OM nl ee wk 8 Eg Se al ES SY LE Le i BS Sel Sa AT HO an aie ata a 4 Ut Jen cle ess Sle’ ao AIS L ga la Jobe ty Se OF geoph ue Ge ade ype ES See eps Gay a pln gal Sty cle ee ep Sal oe Lat gly 9 Ba le Bile ls Sit ly bias ise 5 fe a a Se nn aloe lags ep ee os las ote he A Se Cea ta oe aes Jee 8 pasty ee let Ja Sel Oe ob aes cle eS ole cise be Lyla pe Sal Sa ad dhe Saye oF aah a os dle he 99 0 ans Jb Gulesl oye Oe phy itwbsnbolss + ore to2 IS ASP le phe OS lly ie a le etl oy! ge oh 3 le Sn) opin bald 20S Gp SAL, glee ol Ela U Ske lae 9 ea sat pad Ley jn ln oss i linn Fa ee cals Ft ST hg cle at we plead in ate yp en 9 5p 8 Sa bas gel coals 8 am ope | aS la Sale gant oe py SI LS Uyaee aF el gt ge Sun te IF SE A EL Li a San i lr apt ge ad py Se Soe yey Seca He le see pe wy opt oe ed SGA te 508d oon lag le Bang oa yh & ll Bl les tle ibe GLep abo Ls ag gil ple Spt lead» EAN eet aye ae a ge La WS St Sle ly Slaps ce 2 MSN La ajay olaye All 32 cael Sian lad lage ei apd ular y KAS aja cal Sa yp Spann 33g Lcd nye So a gg Fay slays hn a Gust Lope cll si ssi Orgs la ie ge aly aS pla aS ae a aagt Deh SATU alge wily ee oD Spats ly th sal eal ly a ob in Ube alle ele ae ells AF a EAS ge SS ig eS gr gb KY a ge Lad Ee aly al ol yg gle cate ye yye oy Sy sey Sl Sea lS ase a ul le GZ oe eS Si abthes Jobe aise, CLS Cae ERS ee SNE A eal Joe i Se SB Sah Ie pe HD ae po 9 coSh ele per we ce Si Sel oleye (oe ale eae IF go ag A Sat ag b GoW pola 98 ne Le a iv le Ale ed MG le CBlye ne 20 Ge OMe 2 opt te le (dcp JEN Se lel ale ae a ee 8 Sai Seay Sa i ls le pb Lat dn Ae Sake nite mete cl Spb Gol 20,5 ee abet ee alg salen slo Sob jf arae Gist cle ole idea ay gee plan jo aS gt She oS sh abe NL ph Je Sue sche sla ple op gr plat lela 9 soles Jobe lasing wal cody con 49,8 La La a Ly og gol le ASN I Bg de ood LAS og salen lt JaLe jase soles abe sige 9 Autologous j) * Le ake ceil aig go lo yp Lat soley le Jpbe te Ly Wg U ole Ug las act a pol ree Lat se lk Jal ah Bote SLI! oe pepe aS le Jp at pte 4 Sal San Bene wi Le obese Li hays gan aM ol CBS ne 088 Aarde le Jobe oe i ge end 9 spd ps vale Fb Lad ag ol olen Le Soha 5055 sad soles Joke sige Se 9 (Allogeneic) So on: all oop ye Se 5! Sale gllge Bp 2 tL Le pola U pay aly aly, Sel Sane 0assS lanl og ge soit ese lal Se lleagit cle Subesl ost Sp OOF Ge eal OS LS Yip AF eas Taal gobs a pe AMT Ls ln Jy Loa Taal gle ple gL De Joie asst Jp is ly ot als one ga 6 Let 1 Gymgenic) Ls clans xs so ge sit a lls glean sis gals la 51 be 9 oan ssl sla Jae ie) 8 Iya sik sl rs a ga jal ola Jobe Sy JBL pS Sa MAU sey og" gales ele Jy Spo gets eel Cay (lyst pe ge) Gp je ap ge a ga Sls BE ase 9b ely ag ga eS yeh a ok a Fal Lis to alg set gested cee GML yale Jy tag dg ties ag 9 ale ay Eatin aa sly schiy Jae siggy jf aay Cal Sine he ae ol pap als seit gb Sie At Se pa ob So aby oly SS gel gh la Jae dS Ea 08d iy alee 1, eltel goby gla Jobe aS gobi yo Cast Saw oF 980 ge" (GVHD) gjee ale ying laa" So Ie PEL opty pt sakes la Sale Ga) S lial Gps ke a Jyh csslan Ge 9 ot Sy He Ge Shy? edi gt gp pS Seo gS Ris My cay aS sae gi y9 Rd coo Ty law eagle gla al ae U beast ans gg das bb JUG Ge alge I ony gles 2 g Ab nad Las bas aly go GVHD ola BEE SEL Joe Sal Se ag oe CLL a 2 BT aT ae ols oll Staging SU Jose inet classification Kai classification Definition |%% of patients] Risk group | Definition eof patients <3 Typhoid Lymphoeytosis only Lymphadenopathy Intermediate Hepato- or splenomegaly lymphadenopathy Hemoglobin < 100 g/L or Platelets < 100 Hemoglobin < 100 g/L. 0% Platelets < 100% 10%,ssl on Aap cb 9 she mA bys Ro Sty Se sta pe alps Lt eal Se ole Ba IS Se gana 098 Sole gi Sy ais LOWE Ly Gaul FAS Wy |) LS cal obo je tech SS pel aS Cats IR ULE SIE ge JEU ean Ky 2ST Sl ge lg! af salph ol | gael JS a Ole hw lt eye ABE ye Jy Stings aie 9 ae b cel ang SB hn ih a a Sige 6 po SN) US LS ee ee Je Gebel yao gets SUL Jie ae oF hee |e ciety BL al AF AS Saeed Syn 9s Ate Gla! old Sly ge tl a cas 39s gla sles Rete 8 LR gles Gh Sad ae 80 Spb GOF SABe 9 39 St ean Gab ly 2 pile Sly Glace enp2 2 SE Vyas ays] aalySd tee IR gel BS GT Gly ody alla ace Ge ho I ed Me Lh tcl eae gt Si eb ool al LS oben cae ce uals 35,)9 5338 Si a eK Va oat 5 Syty sa ES ly Soe Se CaS be ay aby tal sel at ete eal Bly 8 ly Syed SN Fas re Seng inlay aeons antl ose Sas cual Sa gag ay auaddle gelato sola pe le og Ftile alae ole bays aes 9 am 8 IB AG ge LA ag EOL Me gL ja a aE NE Gl ole 9 Sd et ast lle Sale hays olla Bilne HIF ALAS ple 90,9 JS le eigieo5 be ie sp Aalto NIE Ge ian lps cad Sea Lad cd gs saad Ibn yan puliol y gall i a ks eS Beetle Salar Se sols Job 8 Sas) BS y Ate LT ly Eee Ay Sag el Cl San LAS slg ge Sige fi Fale as gaS te bie oS Ua il ciple PL Se oy le ge Bly! |p Seer IG TABT Se atl ole Naty te Silo | lags ase cL sl ley Soipblaps Hy Mine ey Eyl lh ne JAS SS og Lat ty Sd Se ely tk SY asl Shae oh gles Cope ay aby tL eae ally ge Gl ad slau isle STS Lo9 sips 5 fan Shion 9 Gh LS ifs ele Sole lel eS te EE alae I SRS TE Schl ele IE ALS ye eS Shs opt SSI IF Ug SSI Ly a le JplS Jl ay J Sal San BS ge SS 88 Snot gi fla Saye as Flas gab plan aly shy ge dls gend'y Sian OM pg A atta N, Le sa al ila aS ES ge aig lng Ay lll IRE ag og sane phe (js a JF Ua gs Gly jh Suge Sly Sd ls eet dl NUS Bly 8 ge LEI ays Ge |) OS HIN eg Seid gb called 9 as GG PLS igen Mag Lah tS Sally ag sl calad Bg Gag nas U Gly a> AS cad ga Lad sly Re pt A AO BE catia HJ pags Od Bie ye Lays I ee ig ole Gab le AS SS tee sips te eb! gat ply Let caleS gy I 098 ay GUL Cal Saw Lad glee ey ALL Jp 39 oye & alle ed ee sal al IS AL AS gk np gh SS Ll a Sas en SL att ihe JS iat ik le aly ce (ole le oj L EL Cae abel oe Ld) oles te Ee IL aN LS Slay ole oy go lad NL Sof ge Oo La Sih Goa b Sy so let A Sp SL Lao aly gol OS le 9 Ls Wy 335 i Seg ete poland Salad al gle cee sat ae oe Gal gles af gS gag Ty 8 9£9G Elle tig aad AIS LL ely cls PS ce gk Kay Lgl ge aa RS ip ld a lS Gd lg I Aaal ayy 8 ae se gl shye aS ae Boge Lay ale og? ge CdSe ple Los Sa Las Salad hg cyan ily srk D2 4S Se 9h pe AS col clic ly Sen CAs alg ae Sian ty LS ga ley ia cee alg 9 Aig SSS a ge lle AL LF mE ao ye al ogy Lb OL say le oy Say a tna daly dhe CO aS pa | ee eS cle cal ey ge gb a Sly OS als oy lhe Sib leh as Sy Bee Settle BL Les Le os) obs ob Jad he i the oe SS ge Sa cy Maps eyo an Ip ge tle COIS ES oy lala gaint 08 ue 9 Saw tS asl soy SE labs S28 iy gh le tle ay Sead Bld alee Se al Cl Kae Sle th AB ae oy San eg Spal he opelsatilace giles SO Te a a ln ts ed SEO 9 Lt E55 OI oe AS A NF GS ig DE! AE LS STL, ol a2 Qf g of LaLa aS od ac Lad lig g LA walle y Led col cal ll adh ea ae Lh le hae Spey Steet 9 Salar aly fg 2 oles yo a SS tl Se2L LS gy gle Cab ally ags a Ley yb alge jeaBl oye Gel Saw lad EOL Sate gf lie ploy ie Se AS Sp Salem OS aly A geld SC ple el ans, le Un lab peg Flys aya Ls Mga ge aye La SS ce peg bly late oJS2ae ati Saree 395 gb GIS Stel popes 9 sal las ite cain add p eagles Demis 8 ata gute pel IP weoldladtaylilad a Ui La Pestp Le glial oan dn aif gal 9 sh SS al get salam ala ag Fina slg ay ye eS] A,$ ok as Spl y gles y gual GW gs gail ABLE Stata ly ls alg bob ole Gileo oy Se oS Ue hye salad el) CiaIL GALL, pat Salam Cl Sia Bag Pa age lie SS igri Sly ag Fig Si ly tgalgy cal gan a U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Cancer Institute (NCT) www.cancer.gov