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Contraception: Heidery - Class DR. Hanaa Al 5 Gynaecology
Contraception: Heidery - Class DR. Hanaa Al 5 Gynaecology
Contraception: Heidery - Class DR. Hanaa Al 5 Gynaecology
Hanaa Al-Heidery
Contraception
Combined oral contraceptive pill:
Mode of action
• Ovulation inhibition (–ve feedback on hypothalamus + pituitary).
• Thickened cervical mucus preventing sperm penetration.
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Gynaecology 5th class DR. Hanaa Al-Heidery
Advantages
•Decrease menstrual blood loss and pain.
• Menstrual cycle can be regulated and controlled.
• Decrease risks of benign ovarian tumours.
• Decrease incidence of PID.
• Improvement in skin condition in acne vulgaris.
• Possible decrease symptoms:
- premenstrual syndrome.
- endometriosis.
• Decrease risks of colorectal cancer.
• Decrease ovarian cancer risk ≥ 50% during use and for >15yrs after.
Disadvantages
• Increase risks (although absolute risk is very low)
• VTE
• stroke
• Cardiovascular disease.
• Small increase risk of breast cancer: returns to the background risk
10yrs after stopping.
• Very small association with i risk of cervical cancer.
The pill and VTE
The absolute risk of VTE is:
• Background risk: 5:100 000 women/yr.
• 2 nd generation COCP: 10–15:100 000 women/yr.
• 3rd generation COCP: 25:100 000 women/yr.
• Pregnancy: 60:100 000 women/yr
.
Advice regarding the COCP and VTE
As long as women are well informed of the small increased risk of
thrombosis associated with 3rd generation pills, and do not have any
medical contraindications, it should be a matter of user preference and
clinical judgement on which COCP is to be prescribed. Combined
hormonal contraception is contraindicated where there is a personal
history of VTE or a known thrombogenic gene mutation.
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Gynaecology 5th class DR. Hanaa Al-Heidery
If 1 pill is missed
• Take the missed pill as soon as possible.
• Continue the rest of the pack as usual.
• No additional contraception is required.
If 2 or more pills are missed
• Take the most recent missed pill as soon as possible.
• Continue the rest of the pack as normal.
• A dditional contraceptive cover is required until 7 consecutive pills
have been taken.
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Gynaecology 5th class DR. Hanaa Al-Heidery
Progestagen-only pill
POPs currently marketed contain either levonorgestrel, norethisterone,
or etynodiol acetate. The failure rate ranges from 0.3 to 4.0% per 100
woman-years and decreases with age.
•Cerazette ® , a POP (75 micrograms desogestrel), reliably blocks
ovulation,increasing efficacy.
To be reliable, a POP must be taken at the same time every day.
Mode of action
• Thickened cervical mucus (4h after dose).
• Thin endometrium preventing implantation.
• Inhibition of ovulation (60% old POP, 97% desogestrel).
Indications
Useful in conditions where COCP is contraindicated:
• During lactation—has no effect on quality or quantity of milk.
• Sickle cell disease.
• SLE and other autoimmune diseases.
Side effects
• Menstrual disturbance—regular (40%), irregular (40%), or
amenorrhoea (20%).
• Headaches, nausea, mood swings, abdominal bloating, and breast
tenderness—usually subside after a few months.
Drug interactions
• Broad spectrum antibiotics do not affect the effi cacy of POP.
• Rifampicin and other enzyme-inducing drugs increase the metabolism
of POP, leading to a reduction in efficacy.
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Gynaecology 5th class DR. Hanaa Al-Heidery
Injectable progestagen
Depo-Provera ® (MDPA) (given 12-weekly)
• Useful for women who are unable or unwilling to take a pill.
• Contains 150mg of medroxyprogesterone.
• Very effective (failure rate <1 per 100 woman-years).
Side effects
• Menstrual disturbance (regular, irregular, or even amenorrhoea).
• Delayed conception (fertility may not return for 6–12mths).
• Weight gain (probably due to progestagen i appetite).
• Bone loss (small risk of d bone density with prolonged use).
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Gynaecology 5th class DR. Hanaa Al-Heidery
Side effects
Menstrual disturbance—20% amenorrhoea, 50% erratic bleeding.
Copper-bearing IUCD
• Provides long-term reversible contraception.
• Insertion is usually easy.
• May be retained beyond the menopause.
Very effective (failure rate of 0.6–0.8 per 100 woman-years).
Mode of action
• Foreign body reaction in the endometrium prevents implantation.
• Copper content may inhibit spermatozoa motility.
Complications
• Irregular PV bleeding, especially first 3–6mths.
• Risk of infection: screen for Chlamydia prior to insertion.
• IUCD expulsion: most common in the fi rst 3mths after insertion.
• Perforation: poor insertion technique or <4wks post-partum.
• Dysmenorrhoea.
• Missing threads. ‘Missing’ threads may indicate pregnancy,
expulsion or perforation. However, it is often the case that the threads are
merely sitting in the cervical canal or uterus. A pregnancy test should be
performed and emergency contraception/alternative contraception
provided until the IUD can be confirmed to be in situ, either by
visualization of the threads on speculum examination or an ultrasound
confirming presence of the IUD within the uterus.
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Gynaecology 5th class DR. Hanaa Al-Heidery
Mode of action
• It acts on the endometrium, leading to endometrial atrophy and
preventing implantation.
• Thickened cervical mucus inhibits sperm penetration.
• It is particularly useful when oestrogen is contraindicated.
• May be used in patients with a history of breast cancer: no disease for
5yrs and after consultation with breast surgeon.
• Breast-feeding: can be inserted 4 or more weeks post-partum.
Side effects
• Irregular PV bleeding is common in the fi rst 3–4mths: amenorrhoea in
up to 30% by 1yr.
• Hormonal symptoms: nausea, headache, breast tenderness, bloating.
Barrier contraception
Condoms
Male condoms are cheap and widely available. They protect against STIs
including HIV. They are the only reversible male method. Typical failure
rates are in the region of 24% since they rely on the user to put it on it
correctly, before penetration and before every act of sex. The female
condom is a lubricated polyurethane condom that is inserted into the
vagina. It also protects against STIs.
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Gynaecology 5th class DR. Hanaa Al-Heidery
Spermicides
Spermicide alone is not recommended for prevention of pregnancy as it is
of low effectiveness.
Nonoxynol 9 (N-9) is a spermicidal product sold as a gel, cream, foam,
sponge or pessary for use with diaphragms or caps. Some data have
suggested that frequent use of N-9 might increase the risk of HIV
transmission. It is therefore no longer recommended for women who are
at high risk of HIV infection.
Emergency contraception
Emergency contraception (EC) is licensed for use to protect women from
unwanted pregnancy following UPSI or contraceptive failure.
The two main forms are:
• Oral EC—LNG or ulipristal (ellaOne® ).
• Copper IUCD EC.
Levonogestrel (LNG EC)
• Consists of a single oral dose of 1.5mg of LNG.
• If taken within 72h of unprotected coitus it is estimated to prevent 85%
of expected pregnancies.
• It may be used up to 120h after, but effi cacy is uncertain and it is not
licensed for use after 72h.
• It may also be used more than once in a cycle if clinically indicated.
• It does not provide contraceptive cover for the remainder of the cycle,
another method of contraception must be used.
Side effects
• Nausea is common after ingestion.
• Vomiting only affects 1%.
• If a woman vomits within 2h of ingestion, she should take a further
dose as soon as possible.
• Erratic PV bleeding is common in the fi rst 7 days following treatment.
Ulipristal
• Progesterone receptor modulator.
• Licensed for use within 120h of UPSI.
• Can only be used once per cycle.
• Due to mode of action may impair the effectiveness of progestagen
containing contraceptives for the remainder of the cycle and so alternative
contraceptive methods are advised.
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Gynaecology 5th class DR. Hanaa Al-Heidery
Copper IUCD
• IUCD acts as an emergency contraceptive by inhibiting fertilization by
direct toxicity.
• Affects implantation by inducing an infl ammatory reaction in the
endometrium.
• The copper content may also inhibit sperm transport.
• IUCD EC can be inserted within 120h following UPSI.
• Failure rates are less than 1%.
The risks and complications for IUCD EC are similar to IUCD use in
general. It can be removed after the next menstruation provided that
no unprotected coitus has occurred since menstruation, or retained for
ongoing contraception.
Counselling
It is important to establish that the woman is taking the decision of her
own free will.
• Alternatives to procedure must be discussed, including long-acting
reversible contraceptives (LARCs) and vasectomy.
• Must use effective contraception until her fi rst period following
sterilization. The commonest reason for failure is already being
pregnant when the procedure is performed or in the same cycle!
• Reassure that there is no increased risk of heavier periods in
women >30yrs of age. There is a small association with increased
hysterectomy rates, but the reason is unclear.
• Laparoscopy and tubal occlusion with Filshie clips is usually the
method of choice and must be explained, including the operative risks.
• Counselling must be supported by printed information leafl ets.
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Gynaecology 5th class DR. Hanaa Al-Heidery
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