Diketahui: Acyclovir 2,5% dalam 10 mL, pH = 7,4 ⦋ H 3 O ⦌ = 10-7,4

pKa = pH ± 1
β = 0,01
Ditanyakan : Tentukan dapar dan konsentrasi dapar
Jawab:
Dapar phosfat KH2PO4/Na2HPO4 (6,2 – 8)
pKa = 7,21
Ka = 6,3 x 10-8
BM KH2PO4 = 141,96
BM Na2HPO4 = 139,09
Ka⦋ H 3 O ⦌
β=2,303 C
( Ka+ ⦋ H 3 O ⦌ )2

6,3 x 10−8 10−7,4

0,01=2,303C 2
( 6,3 x 10−8 +10−7,4 )
0,000000063× 0,0000000398
0,01=2,303C
( 0,000000063 ×0,0000000398 )2

2,7064 × 10−15
0,01=2,303C 2
( 1,028 ×10−7 )
2,7064 × 10−15
0,01=2,303C
1,0568 ×10−14
0,2706
0,01=2,303C
1,0568
0,01=2,303C 0,2561
0,01 0,01
C= = =0,01695 ≈ 0,017
2,303× 0,2561 0,5898
[ garam ]
pH= pKa+log
[ asam ]
[ garam ]
7,4=7,21+log
[ asam ]
[ garam ]
0,19=log
[ asam ]
[ garam ]
1,5488=
[ asam ]
1,5488 [ asam ] =[ garam ]
[ asam ] + [ garam ] =0,017
[ asam ] + 1,5488 [ asam ]=0,017
2 ,5488 [ asam ] =0,017

[ asam ] = 0,017
2,5488
mol
[ KH 2 PO 4 ]=0,0066 L

[ garam ]=1,5488 [ asam ]

[ garam ]=1,5488× 0,0066 mol =0,0102 mol

L L
mol
[ Na2 H PO 4 ]=0,0102 L

g 1000
[ KH 2 PO 4 ]= BM × v (mL)
g 1000
0,0066= ×
141,96 10
0,0066 ×141,96 × 10
g= =0,009369 ≈ 0,0094 gram=9,4 mg
1000
g 1000
[ Na2 H PO 4 ]= BM × v (mL)
g 1000
0,0102= ×
139,09 10
0,0102 ×139,09 ×10
g= =0,014187 ≈ 0,0142 gram=14,2 mg
1000