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Anesthetic MAC (%) | Blood:Gas Coefficient @
37°C
.4
Oxide
ei
2.3
otioneFactors affect MAC
Decreasing MAC Uitee coy Ades
- Increasing age “
> Pregnancy
+ Hypothermia -
~ Hypothyroidism :
- Hyponatraemia -
- Hyporension -
~ Hypoxia
+. Metabolic acidosis
+ Acute alcohol
- Narcotics
- Ketamine
- Benzodiazepines
- a2 agonists
+ Lithium
Young age (infants and
children)
Hyperthermia
Hypernatraeia
Chronic alcohol use
Increased
sympathoadrena
stimulation (MAO
inhibitors, acute
amphetamines,
ephedrine, cocaine)
~~,
Duration of anaesthesia
Sex
Alkalosis
Hypertension
Anaemia
Magnesium and
potassium level