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 TRAUMA

A randomized controlled trial of cemented


versus cementless arthroplasty in patients
with a displaced femoral neck fracture
A FOUR-YEAR FOLLOW-UP
B. Barenius, Aims
C. Inngul, The aim of this study was to compare the functional and radiological outcomes in patients
Z. Alagic, with a displaced fracture of the hip who were treated with a cemented or a cementless
A. Enocson femoral stem.

From Stockholm South Patients and Methods


General Hospital, A four-year follow-up of a randomized controlled study included 141 patients who
Stockholm, Sweden underwent surgery for a displaced femoral neck fracture. Patients were randomized to
receive either a cemented (n = 67) or a cementless (n = 74) stem at hemiarthroplasty (HA;
n = 83) or total hip arthroplasty (THA; n = 58).

Results
Early differences in functional outcome, assessed using the Harris Hip Score, the Short
Musculoskeletal Functional Assessment score and EuroQol-5D, with better results in
cemented group, deteriorated over time and there were no statistically significant
 B. Barenius, MD, PhD, differences at 48 months. Two (3%) patients in the cemented group and five (6.8%) in the
Consultant Orthopaedic cementless group underwent further surgery for a periprosthetic fracture. This difference
Surgeon
 C. Inngul, MD, PhD, was statistically significant (p = 0.4). No patient underwent further surgery for instability or
Consultant Orthopaedic infection between one and four years postoperatively. The mortality and the radiological
Surgeon
Department of Clinical Science outcomes were similar in both groups.
and Education,
Södersjukhuset, Karolinska
Institute, Unit of Orthopaedics, Conclusion
Stockholm South General Patients with a displaced femoral neck fracture treated with an arthroplasty using a
Hospital, Stockholm, Sweden.
cemented or cementless stem had good function and few complications up to four years
 Z. Alagic, MD, Radiologist
Department of Molecular
postoperatively. However, due to the poor short-term functional outcomes in the
Medicine and Surgery, Unit of cementless group, the findings do not support their routine use in the treatment of these
Diagnostic Radiology,
Karolinska University Hospital,
elderly patients.
Karolinska Institute,
Stockholm, Sweden.
Cite this article: Bone Joint J 2018;100-B:1087–93.
 A. Enocson, MD, PhD,
Consultant Orthopaedic
A displaced femoral neck fracture in an elderly complications in the short term.9,11,13,14,16-18
Surgeon patient is a life-threatening injury. Primary However, there is a higher incidence of
Department of Clinical Science
and Education,
operative treatment with an arthroplasty as soon as periprosthetic fractures when using cementless
Södersjukhuset, Karolinska possible after the injury has proven satisfactory stems.9,19,20 Although most studies support the use
Institute, Unit of Orthopaedics,
Stockholm South General
outcomes in several studies. Most patients regain of a cemented stem, few have compared cemented
Hospital, Stockholm, Sweden good or acceptable function and pain relief, whether and cementless stems beyond two years.
and Department of Molecular
Medicine and Surgery, Unit of
a hemiarthroplasty (HA) or a total hip arthroplasty The aim of this study was to investigate the
Orthopaedics, Karolinska (THA) is used.1-3 The risk of complications and mid-term outcomes, including the need for further
University Hospital, Karolinska
Institute, Stockholm, Sweden.
mortality is, however, high.4,5 One risk factor for surgery, function, health-related quality of life
cardiopulmonary events is fat embolism from the (HRQoL), and radiological appearance in elderly
Correspondence should be sent
to B. Barenius; email: femoral canal when using a cemented stem.6,7 This patients with a femoral neck fracture treated with
bjorn.barenius@ki.se risk is reduced by using a cementless stem. A arthroplasty, comparing a cemented with a
©2018 The British Editorial number of authors have compared cemented and cementless stem.
Society of Bone & Joint Surgery cementless stems in these patients.8-15 In some, the
do:10.1302/0301-620X.100B8.
BJJ-2017-1593.R1 $2.00 stems performed similarly,8,10,12,15 whereas in Patients and Methods
others, cemented stems performed better in Between October 2009 and April 2013, 964
Bone Joint J
2018;100-B:1087–93. restoring function and pain relief with fewer patients with a displaced femoral neck fracture

VOL. 100-B, No. 8, AUGUST 2018 1087


1088 B. BARENIUS, C. INNGUL, Z. ALAGIC, A. ENOCSON

Table I. Baseline data for all patients (n = 141) in relation to the type of stem used

Cemented stem (n = 67) Cementless stem (n = 74)


Mean age, yrs (range) 81.2 (65 to 96) 81.3 (66 to 93)
Mean cognitive function, SPMSQ score (range) 9.3 (5 to 10) 9.0 (6 to 10)
Female gender, n (%) 46 (69) 53 (72)
ASA33 class 1 or 2, n (%) 35 (52) 32 (43)
Mobility: no walking aid or just one stick, n (%) 56 (84) 57 (77)
ADL n in Katz group A, n (%)* 63 (94) 66 (89)
Hemiarthroplasty, n (%) 39 (58) 44 (60)
Total hip arthroplasty, n (%) 28 (42) 30 (41)
At 24-mth follow-up (n = 53) (n = 53)
Age, mean (range) 82.3 (68 to 99) 82.8 (68 to 95)
Gender, female n (%) 37 (49) 38 (51)
At 48-mth follow-up (n = 43) (n = 43)
Age, mean (range) 84.4 (69 to 99) 83.6 (71 to 94)
Gender, female n (%) 31 (49) 32 (51)
*Katz group A, totally independent in all activities of daily living
SPMSQ, Short Portable Mental Status Questionnaire; ASA, American Society of Anesthesiologists; ADL, activities
of daily living

(Garden grade 3 or 4)21 were treated at the unit of Orthopaedics, possible, and all patients received thromboembolic prophylaxis
Stockholm South General Hospital. Inclusion criteria for the with low molecular heparin (4500 IU Tinzaparin) for 30 days
study were: age ≥ 65 years old, living and moving with the first dose being given on the evening after the surgery.
independently (with or without walking aids) and without drug Primary assessment. Preoperatively, self-administered ques-
or alcohol abuse. The trauma also had to be low-energy and the tionnaires regarding living conditions, activities of daily living
patients had to be without severe cognitive dysfunction, thus (ADL),24 health-related quality of life (EuroQol(EQ)-5D),25 and
able to give > three correct answers on the Short Portable the Short Musculoskeletal Function Assessment questionnaire
Mental Status Questionnaire.22 Patients with symptomatic (SMFA)26 were completed with the help of a research nurse, to
osteoarthritis, rheumatoid arthritis or trauma > 48 hours before include information that the patients could recall for the week
admission were excluded. A total of 141 patients fulfilling these before the fracture. Patients were reviewed four, 12, 24 and 48
criteria gave written consent and were included. Randomization months postoperatively. The results from the four- and 12-month
was performed using sealed envelopes. This was originally reviews have been published in this journal.11 At each review, a
designed as two studies with a cutoff between the studies at the research nurse collected the EQ-5D and SMFA scores. An ortho-
age of 80 years. Due to slow recruitment, the decision was made paedic surgeon recorded the Harris Hip Score (HHS).27 Compli-
in November 2012 to pool all patients into one study. Patients cations were recorded as described by the patients and from the
aged between 65 and 79 years were allocated to a cemented or medical records if a complication was treated at another hospital.
reversed hybrid THA, while patients aged > 80 years were Radiographic outcome. An anteroposterior (AP) view of the
allocated to a cemented or cementless unipolar HA. pelvis and AP and lateral views of the hip were obtained before
All operations were performed by a group of 14 orthopaedic and after surgery, and at the time of the routine reviews. A
surgeons who were experienced in both techniques. A routine radiologist (ZA) reviewed all the radiographs. The proximal
direct lateral approach was used with the patient in a lateral femoral bone stock was classified according to Dorr (type A, B, or
decubitus position.23 The components used in the cemented C).28 Heterotopic ossification (HO) was graded as described by
group were an Exeter stem (Stryker, Kalamazoo, Michigan) Brooker et al,29 and acetabular erosion in the HA group was
with a unipolar head in patients undergoing HA and a 32 mm assessed as described by Baker et al.30 Significant radiological
head and a cross-linked polyethylene (XLPE) Marathon cup loosening of either the acetabular or femoral component was
(DePuy Synthes, Warsaw, Indiana) in those undergoing THA. defined as a radiolucent zone of > 2 mm around the whole
For the cementless group, a hydroxyapatite-coated Bimetric component.31 Significant subsidence of the stem was defined as
stem (Zimmer Biomet, Warsaw, Indiana) was used with a > 5 mm.32
unipolar head for those undergoing HA and a 32 mm head and Statistical analysis. A power analysis was performed after
the same type of acetabular component as in the cemented group pooling the two original studies. This indicated that 140 patients
for those undergoing THA. Gentamicin-loaded Optipac were needed at the 12-month review, assuming 10% mortality,
(Zimmer. Biomet, Warsaw, Indiana) cement was used for all to detect a five-point difference in HHS, with 80% power and a
cemented components. Antibiotic prophylaxis involved three 5% level of significance. The intention-to-treat principle was
doses of intravenous Cloxacillin 2 g given between 30 and 60 used in the analysis. Analysis was performed using the IBM
minutes before surgery, and three and six hours after the first SPSS 22.0 software package for Macintosh (IBM Corp.,
dose. Surgery was performed under spinal anaesthesia, if Armonk, New York). Nominal variables were tested by chi-

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A RANDOMIZED CONTROLLED TRIAL OF CEMENTED VERSUS CEMENTLESS ARTHROPLASTY 1089

964 patients eligible for inclusion

Excluded
Cognitive dysfunction, mental illness, or language barrier (n = 279)
No available study surgeon (n = 185)
Not fit enough for arthroplasty surgery (n = 81)
Fracture older than 48 hours (n = 53)
Not independent walking or living (n = 51)
Missed study cases (n = 40)
Pathological fractures (n = 37)
Declined to participate (n = 36)
Other reasons (n = 61)

Included (n = 141)

Cemented (n = 67) Cementless (n = 74)

Randomized Randomized Randomized Randomized


THA (n = 28) HA (n = 39) THA (n = 30) HA (n = 44)

Treatment Treatment
Treatment Treatment
HA (n = 38) Cementless HA (n = 41)
THA (n = 28) THA (n = 30)
ORIF (n = 1) Cemented HA (n = 3)

Deceased (n = 2) Deceased (n = 7) Deceased (n = 3) Deceased (n = 7)


Lost to follow-up (n = 0) Lost to follow-up (n = 5) Lost to follow-up (n = 2) Lost to follow-up (n = 9)

Available at 24-mth Available at 24-mth Available at 24-mth Available at 24-mth


follow-up (n = 26) follow-up (n = 27) follow-up (n = 25) follow-up (n = 28)

Deceased (n = 6) Deceased (n = 10) Deceased (n = 6) Deceased (n = 14)


Lost to follow-up (n = 1) Lost to follow-up (n = 7) Lost to follow-up (n = 2) Lost to follow-up (n = 9)

Available at 48-mth Available at 48-mth


Available at 48-mth Available at 48-mth
follow-up (n = 21) follow-up (n = 22)
follow-up (n = 22) follow-up (n = 21)

1 phone interview only 1 phone interview only


3 questionnaires only
1 questionnaire only

Fig. 1

Flowchart of all the patients. THA, total hip arthroplasty; HA, hemiarthroplasty; ORIF, open reduction and internal fixation.

squared test or Fisher’s exact test. Ordinal variables and non- Mortality and adverse events. Since the review, 12 months
normality distributed interval and ratio scale variables were postoperatively, 25 patients had died at 48 months. The
evaluated by the Mann–Whitney U test. The tests were two- mortality 24-months postoperatively was 13% (9/67) in the
sided and the results were considered significant at p < 0.05. cemented group and 14% (10/74) in the cementless group
Ethical approval. The study was approved by the local ethics (p = 1.0). The mortality 48 months postoperatively was 24%
committee (2009/1188-3/1 and 2013/412-32) and was (16/67) in the cemented group and 28% (20/74) in the
registered at www.clinicaltrials.gov (NCT 01798472). cementless group (p = 0.8). Seven patients, (two of 67 (3%)
in the cemented group and five of 74 (6.8%) in the
Results cementless group) underwent further surgery due to a
A total of 141 patients were included, and 67 patients were periprosthetic fracture, between 12 and 48 months
randomized to a cemented, and 74 to a cementless stem. postoperatively (p = 0.4). One patient with a cemented HA
At the final follow-up after four years, 86 patients were underwent conversion to a THA after 12 months due to
alive and willing to participate. The baseline data of the acetabular erosion. No patient required further surgery due to
patients are shown in Table I and a flowchart of the study in dislocation or infection after 12 months. Details on adverse
Figure 1. events are shown in Table II.

VOL. 100-B, No. 8, AUGUST 2018


1090 B. BARENIUS, C. INNGUL, Z. ALAGIC, A. ENOCSON

Table II. Adverse events between 12 and 24 months follow-up.

Adverse event Cemented stem Cementless stem


Reoperation due to periprosthetic fracture, n (%) 2 (3.0) 5 (6.8)
Revision to total hip arthroplasty, n (%) 1/26 (3.8)* 0 (0)
Trendelenburg limp, n (%) 1 (1.5) 3 (4.1)
Trochanteric pain, n (%) 2 (3.0) 0 (0)
*Proportion calculated according to the 26 patients with cemented HA that were assessed at the
12-month follow-up

Cemented Cementless Cemented Cementless


1.2
1.2

1
1

0.8
0.8

0.6 0.6

0.4 0.4

0.2 0.2

0 0
Pre-injury 4 mths 12 mths 24 mths 48 mths Pre-injury 4 mths 12 mths 24 mths 48 mths
(N/S) (p = 0.001) (p < 0.001) (p = 0.02) (N/S) (N/S) (p = 0.09) (p = 0.01) (N/S) (N/S)
Fig. 2a Fig. 2b

Cemented Cementless

1.2

0.8

0.6

0.4

0.2

0
Pre-injury 4 mths 12 mths 24 mths 48 mths
(N/S) (p = 0.09) (p = 0.01) (N/S) (N/S)
Fig. 2c

a) Graph showing the mean EuroQol-5D (EQ-5D)scores for all patients (a) those undergoing a hemiarthoplasty (b) and total hip arthroplasty (c).
N/S, not significant.

Functional outcome. Apart from a higher mean total HHS in outcome scores are shown in Table III. HRQoL assessed by EQ-
the cemented group after four months and a higher mean HHS 5D is shown in Figure 2. The results were statistically better in
pain subscore at 24 months for the cemented group, the groups the cemented group for the first 24 months, but were similar in
had similar HHS at all follow-ups. The mean SMFA scores in both groups thereafter (Fig. 2a). Additional results in the
the cemented group were better for dysfunction and/or bother subgroups of patients who underwent a HA and THA are shown
scores at the early follow-ups compared with the cementless in Figs. 2b and 2c, respectively, and although there remained a
group, but the scores deteriorated for the cemented group and at visible difference between groups in the THA subgroup at 48
the final follow-up the scores were similar. The functional months, this difference was not statistically significant.

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A RANDOMIZED CONTROLLED TRIAL OF CEMENTED VERSUS CEMENTLESS ARTHROPLASTY 1091

Table III. Functional outcome by Harris Hip Score (HHS) and Short Musculoskeletal Function Assessment (SMFA) score

Functional outcome n Cemented stem Cementless stem p-value*


Mean HHS score, total (SD)
4 mths 127 78 (14) 70.7 (14.6) 0.004†
12 mths 123 82.3 (13.1) 78.6 (17.1) 0.09
24 mths 104 76.7 (15.1) 70.7 (19.1) 0.06
48 mths 84 76.8 (13.1) 72.1 (19.8) 0.49
Mean HHS score, pain (SD)
4 mths 127 39.6 (8.2) 37.2 (9.1) 0.07
12 mths 123 40.7 (8.8) 38.9 (9.0) 0.10
24 mths 106 39.4 (8.8) 36.8 (9.4) 0.04†
48 mths 86 40.8 (6.6) 37.2 (10.1) 0.07
Mean SMFA score, dysfunction (SD)
Preoperative 138 17.9 (13.8) 21.2 (14.3) 0.14
4 mths 125 29.8 (17.5) 39.2 (19.6) 0.007†
12 mths 118 22.3 (16.3) 34.9 (22.2) 0.001†
24 mths 102 26.4 (19.4) 33.2 (21.8) 0.12
48 mths 82 32.4 (25.0) 34.3 (24.3) 0.63
Mean SMFA score, bother (SD)
Preoperative 133 12.7 (14) 12.5 (11.3) 0.55
4 mths 117 26.9 (19.4) 32,2 (19.9) 0.11
12 mths 116 18.6 (16.8) 29 (21.1) 0.007†
24 mths 102 18.7(16.0) 28.3 (21.3) 0.027†
48 mths 81 25.2 (22.6) 28.1(22.0) 0.57
*Student’s t-test
†Statistically significant

Table IV. Radiological assessment; the data are presented as the numbers according
to available radiographs at the different follow-ups

Assessment Cemented stem Cementless stem


Brooker, 24 mths*
None 9/48 8/46
Islands 19/48 21/46
Spurrs > 1 cm apart 15/48 13/46
Spurrs < 1 cm apart 4/48 3/46
Ankylosis 1/48 1/46
Brooker, 48 mths*
None 6/37 8/37
Islands 15/37 16/37
Spurrs > 1 cm apart 13/37 12/37
Spurrs < 1 cm apart 3/37 1/37
Baker, 24 mths†
None 15/24 15/23
Joint space narrowing 9/24 8/23
Joint space disappeared 1/24 0/23
Baker, 48 mths†
None 10/17 10/17
Joint space narrowing 6/17 6/17
Joint space disappeared 0/17 1/17
Protrusio 1/17 0/17
*For all arthroplasty types
†For hemiarthroplasty patients only

Radiological assessment. Subsidence of the stem by > 5 mm Discussion


was seen in 8.5% (4/47) of the cemented group and in 6.4% The main finding in this study was that the differences in
(3/47) of the cementless group at the 24-month follow-up function one year postoperatively in patients with a fracture of
(p = 0.7); and in 14% (5/37) of the cemented group and 8.3% the hip treated with a cemented or cementless stem disappeared
(3/36) of the cementless group at 48 months (p = 0.5). No with the passage of time. Good functional outcomes followed
component showed signs of loosening at any time. The the use of both forms of fixation, two years postoperatively,
frequency of HO formation and acetabular erosion were with few adverse events and similar mortality. The function,
similar in the two groups (Table IV). assessed by the HHS, peaked 12 months postoperatively and

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1092 B. BARENIUS, C. INNGUL, Z. ALAGIC, A. ENOCSON

subsequently decreased although the pain subscore remained indications. The mortality in this study was similar to other
similar in both groups. This finding differs from that of Langslet studies.9,17,18,36 The size of the study makes further analyses of
et al,18 who reported better HHSs after five years for patients mortality uncertain, but there seemed to be no differences
with a cementless stem. The mean HHS in our patients was between the groups. There are reports from large cohorts that a
similar to theirs at one and four years postoperatively for the higher mortality one day postoperatively follows the use of a
cemented group, but there was a large difference for the cemented stem. Costain et al37 found a statistically significant
cementless group. However, in their series, less than 50% of the difference, with a mortality one day postoperatively of 0.5% in
patients who were available one year postoperatively were a cementless group and 0.8% in a cemented group (p < 0.001).
available five years postoperatively. Only 34% of the patients The risk of death was, however, reversed after one week and
remained in the cementless group, compared with 58% in our remained higher in the cementless group, with mortality of 21%
series. We noted a trend of decreasing HRQoL, EQ-5D and an after one year in the cemented group and 30% in the cementless
increasingly impaired SMFA in the cemented group over time. group (p < 0.001). Our interpretation of these findings is that the
We interpret this as reflecting older age and decreasing general risk of cement syndrome leading to an increased risk of death is
health rather than an effect of the different methods of fixation not a valid argument for choosing a cementless stem, the 0.3%
of the stem. It could also be an effect of the mixed population of lower risk the first day is not comparable with the higher
patients undergoing THA and HA, as the decrease in the EQ-5D mortality from one week adding up to 9% higher mortality after
seemed to be more pronounced in the cemented HA subgroup. 1 year in the cementless stem group.
We noted five postoperative periprosthetic fractures, two in The main strengths of the study are the relatively long follow-
the cemented group (3%) and five in the cementless group up and the well-structured study protocol. The study, however,
(6.8%) between one and four years postoperatively. This has limitations. The power analysis was performed to compare
difference was not statistically significant (p = 0.4). In a the one-year results and the conclusions are weakened by the
randomized trial comparing 112 cemented bipolar arthroplasties subsequent loss to follow-up and selection bias in relation to the
with 108 cementless bipolar arthroplasties, Langslet et al18 patients that were available at the final follow-up. Some of the
found 7.4% periprosthetic fractures in the cementless group, patients who were alive and declined to take part did so because
compared with 1% in the cemented group after five years. of comorbidities which were not related to the fracture, such as
However, only three out of the eight fractures in the cementless dementia or general health issues due to age. The study was
group occurred after the one-year follow-up. Sköldenberg et al34 originally designed as two separate studies and the mixed cohort
reported six (12%) fractures, all after two years, in a series of of patients undergoing THA and HA could be a confounding
patients with a fracture of the femoral neck treated with a factor, especially regarding function and HRQoL. However, the
cementless THA. stems used were the same, and the same method of
In summary, few patients in these studies have follow-up of randomization was used for the THA and HA groups. The
up to five years and the differences in frequency of proportion of patients treated with THA and HA in the groups
periprosthetic fractures between the types of fixation after 4 remained similar over time. We deem the effect from the mixed
years could be explained by chance. It seems reasonable to groups to have a very minor impact on the results of the stems
assume that the long-term risk of a periprosthetic fracture in because there were similar amounts of drop outs in all groups.
these patients will be more affected by the risk of falling again In conclusion, we confirmed that patients with a displaced
rather than by the type of fixation of the stem. The long-term femoral neck fracture treated with an arthroplasty using a
risk of developing a complication with a cementless stem might cemented or a cementless stem had good function and few
be acceptable but combined with the risk of an early complications up to four years postoperatively. However, due to
complication the picture is different. There was a higher the poor short-term functional results in the cementless group,
frequency of intraoperative complications in the cementless the findings do not support their routine use in the treatment of
group in the initial report of this study,11 leading to a higher total these elderly patients.
risk of a complication for patients treated in this way. This
reasoning is in line with the current literature. In a recent meta- Take home message:
analysis, Veldman et al35 reported that the risk of a complication -This randomized controlled trial reports similar results four
years after a displaced femoral neck fracture treated with a
was a factor favouring the use of a cemented stem. Chammut et
cemented or cementless arthroplasty, but due to the earlier
al9 stopped their randomized controlled trial due to a high rate of published one year results with higher complication frequencies in the
early complications in the cementless group, and Rogmark et cementless stem group, the cemented stem solution is deemed a safer
al14 found a hazard ratio for reoperation of 3.6 due to choice for this patient group.

periprosthetic fracture after the use of a cementless compared - The clinical relevance of the study is that orthopaedic surgeons treating
patients with displaced femoral neck fractures should be aware of the
with a cemented stem in their register study. early complications in their treatment choice because the long-term
Few patients with either form of fixation require further results for the survivors are good regardless of fixation.
surgery up to four years postoperatively. In the early report of
this study, one patient underwent surgery due to instability and References
one due to infection, during the first postoperative year.11 No 1. Hedbeck CJ, Blomfeldt R, Lapidus G, et al. Unipolar hemiarthroplasty versus
bipolar hemiarthroplasty in the most elderly patients with displaced femoral neck
patient has subsequently required further surgery for these fractures: a randomised, controlled trial. Int Orthop 2011;35:1703–1711.

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2. Inngul C, Hedbeck CJ, Blomfeldt R, et al. Unipolar hemiarthroplasty versus 24. Katz S, Ford AB, Moskowitz RW, Jackson BA, Jaffe MW. Studies of illness in
bipolar hemiarthroplasty in patients with displaced femoral neck fractures: a four- the aged. The index of ADL: a standardized measure of biological and psychosocial
year follow-up of a randomised controlled trial. Int Orthop 2013;37:2457–2464. function. JAMA 1963;185:914–919.
3. Johansson T. Internal fixation compared with total hip replacement for displaced 25. Brooks R. EuroQol: the current state of play. Health Policy 1996;37:53–72.
femoral neck fractures: a minimum fifteen-year follow-up study of a previously 26. Swiontkowski MF, Engelberg R, Martin DP, Agel J. Short musculoskeletal
reported randomized trial. J Bone Joint Surg [Am] 2014;96-A:46. function assessment questionnaire: validity, reliability, and responsiveness. J Bone
4. Haentjens P, Magaziner J, Colón-Emeric CS, et al. Meta-analysis: excess Joint Surg [Am] 1999;81-A:1245–1260.
mortality after hip fracture among older women and men. Ann Intern Med 27. Harris WH. Traumatic arthritis of the hip after dislocation and acetabular fractures:
2010;152:380–390. treatment by mold arthroplasty. An end-result study using a new method of result
5. Lund CA, Møller AM, Wetterslev J, Lundstrøm LH. Organizational factors and evaluation. J Bone Joint Surg [Am] 1969;51-A:737–755.
long-term mortality after hip fracture surgery. A cohort study of 6143 consecutive 28. Dorr LD, Faugere MC, Mackel AM, et al. Structural and cellular assessment of
patients undergoing hip fracture surgery. PLoS One 2014;9:99308. bone quality of proximal femur. Bone 1993;14:231–242.
6. Pitto RP, Blunk J, Kössler M. Transesophageal echocardiography and clinical 29. Brooker AF, Bowerman JW, Robinson RA, Riley LH Jr. Ectopic ossification
features of fat embolism during cemented total hip arthroplasty. A randomized study following total hip replacement. Incidence and a method of classification. J Bone
in patients with a femoral neck fracture. Arch Orthop Trauma Surg 2000;120:53–58. Joint Surg [Am] 1973;55-A:1629–1632.
7. Olsen F, Kotyra M, Houltz E, Ricksten SE. Bone cement implantation syndrome in 30. Baker RP, Squires B, Gargan MF, Bannister GC. Total hip arthroplasty and
cemented hemiarthroplasty for femoral neck fracture: incidence, risk factors, and hemiarthroplasty in mobile, independent patients with a displaced intracapsular
effect on outcome. Br J Anaesth 2014;113:800–806. fracture of the femoral neck. A randomized, controlled trial. J Bone Joint Surg [Am]
8. Parker MI, Pryor G, Gurusamy K. Cemented versus uncemented hemiarthroplasty 2006;88-A:2583–2589.
for intracapsular hip fractures: A randomised controlled trial in 400 patients. J Bone 31. Keogh CF, Munk PL, Gee R, Chan LP, Marchinkow LO. Imaging of the painful hip
Joint Surg [Br] 2010;92-B:116–122. arthroplasty. AJR Am J Roentgenol 2003;180:115–120.
9. Chammout G, Muren O, Laurencikas E, et al. More complications with 32. Malchau H, Kärrholm J, Wang YX, Herberts P. Accuracy of migration analysis in
uncemented than cemented femoral stems in total hip replacement for displaced hip arthroplasty. Digitized and conventional radiography, compared to
femoral neck fractures in the elderly. Acta Orthop 2017;88:145–151. radiostereometry in 51 patients. Acta Orthop Scand 1995;66:418–424.
10. Deangelis JP, Ademi A, Staff I, Lewis CG. Cemented versus uncemented 33. Saklad M. Grading of patients for surgical procedures. Anesthesiol 1941;2:281–284.
hemiarthroplasty for displaced femoral neck fractures: a prospective randomized trial 34. Sköldenberg OG, Sjöö H, Kelly-Pettersson P, et al. Good stability but high
with early follow-up. J Orthop Trauma 2012;26:135–140. periprosthetic bone mineral loss and late-occurring periprosthetic fractures with use
11. Inngul C, Blomfeldt R, Ponzer S, Enocson A. Cemented versus uncemented of uncemented tapered femoral stems in patients with a femoral neck fracture. Acta
arthroplasty in patients with a displaced fracture of the femoral neck: a randomised Orthop 2014;85:396–402.
controlled trial. Bone Joint J 2015;97-B:1475–1480. 35. Veldman HD, Heyligers IC, Grimm B, Boymans TA. Cemented versus cementless
12. Figved W, Opland V, Frihagen F, et al. Cemented versus uncemented hemiarthroplasty for a displaced fracture of the femoral neck: a systematic review
hemiarthroplasty for displaced femoral neck fractures. Clin Orthop Relat Res and meta-analysis of current generation hip stems. Bone Joint J 2017;99-B:421–431.
2009;467:2426–2435. 36. Wang Z, Bhattacharyya T. Outcomes of hemiarthroplasty and total hip arthroplasty
13. Taylor F, Wright M, Zhu M. Hemiarthroplasty of the hip with and without cement: for femoral neck fracture: a medicare cohort study. J Orthop Trauma 2017;31:260–263.
a randomized clinical trial. J Bone Joint Surg [Am] 2012;94-A:577–583. 37. Costain DJ, Whitehouse SL, Pratt NL, et al. Perioperative mortality after
14. Rogmark C, Fenstad AM, Leonardsson O, et al. Posterior approach and hemiarthroplasty related to fixation method. Acta Orthop 2011;82:275–281.
uncemented stems increases the risk of reoperation after hemiarthroplasties in
elderly hip fracture patients. Acta Orthop 2014;85:18–25. Author contributions:
15. Ning GZ, Li YL, Wu Q, et al. Cemented versus uncemented hemiarthroplasty for B. Barenius: Designing and planning the study, Collecting and analyzing the
displaced femoral neck fractures: an updated meta-analysis. Eur J Orthop Surg data, Writing the manuscript.
Traumatol 2014;24:7–14. C. Inngul: Designing and planning the study, Collecting and analyzing the
16. Parker MJ, Gurusamy KS, Azegami S. Arthroplasties (with and without bone data, Writing the manuscript.
cement) for proximal femoral fractures in adults. Cochrane Database Syst Rev Z. Alagic: Designing and planning the study, Analyzing the radiographs. Writ-
2010;6:CD001706. ing the manuscript.
A. Enocson: Designing and planning the study, Collecting and analyzing the
17. Rogmark C, Leonardsson O. Hip arthroplasty for the treatment of displaced data, Writing the manuscript.
fractures of the femoral neck in elderly patients. Bone Joint J 2016;98-B:291–297.
Funding statement:
18. Veldman HD, Heyligers IC, Grimm B, Boymans TA. Cemented versus cementless No benefits in any form have been received or will be received from a com-
hemiarthroplasty for a displaced fracture of the femoral neck: a systematic review mercial party related directly or indirectly to the subject of this article.
and meta-analysis of current generation hip stems. Bone Joint J 2017;99-B:421–431.
Acknowledgements:
19. Leonardsson O, Kärrholm J, Åkesson K, Garellick G, Rogmark C. Higher risk of The authors wish to thank Sari Ponzer and Richard Blomfeldt, both at Depart-
reoperation for bipolar and uncemented hemiarthroplasty. Acta Orthop 2012;83:459– ment of Orthopaedics and Clinical Science and Education, Karolinska Insti-
466. tute, Stockholm South Hospital, Stockholm, Sweden, for their valuable
20. Langslet E, Frihagen F, Opland V, et al. Cemented versus uncemented contribution to the study.
hemiarthroplasty for displaced femoral neck fractures: 5-year followup of a
randomized trial. Clin Orthop Relat Res 2014;472:1291–1299. To make this study possible the authors also would like to acknowledge the
work by the research nurses Catharina Levander and Elisabeth Skogman, and
21. Garden RS. Low-angle fixation in fractures of the femoral neck. J Bone Joint Surg the study surgeons Buster Sandgren, Radford Ekholm, Carl-Johan Hedbeck,
[Br] 1961;43-B:647–663. Per Hamberg, Rickard Miedel, Ulla Lind, Karl Eriksson, Lasse Lapidus, Anders
22. Pfeiffer E. A short portable mental status questionnaire for the assessment of Norrman, Richard Blomfeldt, Uffe Hylin, Christian Inngul, Anders Enocson
organic brain deficit in elderly patients. J Am Geriatr Soc 1975;23:433–441. and Hasse Törnkvist.
23. Gammer W. A modified lateroanterior approach in operations for hip arthroplasty. This article was primary edited by J. Scott.
Clin Orthop Relat Res 1985;199:169–172.

VOL. 100-B, No. 8, AUGUST 2018

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