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5.0 Leukopoiesis PDF
5.0 Leukopoiesis PDF
Lesson Objectives
2. neutrophil maturation stage where it is part of both storage and maturation pool in
the bone marrow
a) Metamyelocyte b) band c) myelocyte d) segmented neutrophil
Neutrophils
Eosinophils
Basophils
Types of WBC’s
Agranulocytes—do not have
granules in their cytoplasm
Lymphocytes
Monocytes
Granuloctyes
Neutrophils
Stain light purple with neutral dyes
3-5 lobes in nucleus
65% of WBC count
Highly mobile/very active
Diapedesis—Can leave blood vessels and enter
tissue space
Phagocytosis (eater), contain several lysosomes
(janitor)
Neutrophils
•Very fine granules that respond to
both acid and basic stains
•The cytoplasm as a whole stains
pink
•Neutrophils are avid phagocytes at
sites of acute infection
Granulocytes
Eosinophils or Acidophils:
Large, numerous granules
Nuclei with 2-3 lobes
2-5% of WBC count
Found in lining of respiratory and digestive tracts
Important functions involve protections against
infections caused by parasitic worms and
involvement in allergic reactions
Secrete anti-inflammatory substances in allergic
reactions
Basophils
Least numerous--0.5-1%
Diapedesis—Can leave blood vessels and enter
tissue space
Contain histamine, serotonin,
heparin—inflammatory chemical
Histamine is an inflammatory chemical that
makes blood vessels leaky and attracts other
WBCs to the inflammatory site
Agranulocytes
• lack visible cytoplasmic granules
• Their nuclei are spherical oval or kidney-shaped
• The agranulocytes include lymphocytes and
monocytes
Agranulocytes
Lymphocytes
Smallest WBC
Large eccentric nuclei
small amount of cytoplasm (scanty)
Account for 25% of WBC count
Two types—T lymphocytes—attack an infect or
cancerous cell, B lymphocytes—produce
antibodies against specific antigens (foreign
body)
Agranulocytes
Monocytes
Largest of WBCs
Dark kidney bean shaped nuclei (indented
nucleus)
Highly phagocytic
Abundant cytoplasm
When they migrate into the tissues, they change
into macrophages
Macrophages are very important in fighting
chronic infections, such as tuberculosis
Lungs- Alveolar macrophages
Liver- Kupffer cells
Pleural cavity- Serosal macrophages
Lymphoid tissue- macrophages
Bone- Osetoclasts
• The granulocytes and the monocytes protect
the body against invading organisms by
ingesting them by the process of phagocytosis
• The lymphocytes function mainly in connection
with the immune system. However, a function
of certain lymphocytes is to attach themselves
to specific invading organisms and destroy
them, an action similar to those of the
granulocytes and monocytes
Leucocyte Numbers