Primary herpetic whitlow on the finger of a dentist.

primary herpetic gingivostomatitis causing discrete vesicles and ulcers surrounded by

inflammation.
primary herpetic gingivostomatitis with extensive involvement of the keratinized tissues of the
tongue dorsum and non-keratinized tissues of the ventral tongue and labial mucosa.

Primary herpetic gingivostomatitis with mild presentation: erythematous maxillary anterior

gingiva with erythema and ulcer on upper labial mucosa, and crusted lesion on lower lip.

a b

Acute marginal gingivitis characteristic of primary herpes simplex virus infection. A, Mandibular
anterior gingiva; B, vesicles and inflammation around mandibular molars.
Primary herpes simplex of gingiva in an adult.

Crusted lesions of recurrent herpes labialis.

Typical lesions of recurrent intraoral herpes simplex virus infection in an immunocompetent

patient are clusters of small vesicles and ulcers on the heavily keratinized oral mucosa.
Herpes simplex of the tongue in a renal transplant patient.

Herpes simplex of the gingiva in a patient with leukemia receiving chemotherapy.

Cytology smear stained with Giemsa, demonstrating multinucleated giant cells.

Facial lesions of herpes zoster involving the second division of the trigeminal nerve.

Palatal lesions of herpes zoster of second division of the trigeminal nerve.

Herpes zoster of third division of trigeminal nerve.

Clustered vesicles of recrudescent herpes labialis on vermilion.

Recrudescent intraoral herpes simplex virus infection in an immunocompetent patient with

clusters of small coalescent ulcers on the keratinized palatal mucosa.
Recrudescent herpes simplex virus infection of the maxillary alveolar ridge mucosa in a patient
with lymphoma.

Recrudescent herpes simplex virus infection of the lateral tongue and oral commissure in a
patient with leukemia post-allogenic transplantation.

Biopsy of a herpes simplex virus ulcer demonstrating large epithelial cells with multiple ground-
glass nuclei.
Facial lesions of herpes zoster involving the third division of the trigeminal nerve.

Palatal lesions of herpes zoster involving the second division of the trigeminal nerve; note
unilateral distribution.

Cytomegalovirus ulcer on a background of hairy leukoplakia in a patient with AIDS.

A cluster of ulcers on the tongue of a patient with herpangina. The patient also had lesions of
the palate and posterior pharyngeal wall.

Necrotizing ulcerative gingivitis with typical punched out, necrotic and ulcerated interdental
papillae.

Fusospirochetal palatal lesions in a neutropenic patient.

Acute necrotizing ulcerative gingivitis in a patient without an underlying medical disorder.

Cancrum oris or noma. Courtesy of Dr. Gustavo Berger, Guatemala City, Guatemala.

Necrotizing ulcerative periodontitis with osteonecrosis in a patient with AIDS.

Early vesicular lesions in a patient who develops erythema multiforme after each episode of
recurrent herpes labialis.
Target lesions of the skin of the leg.

Erythema multiforme with target lesions of the skin of the hand.

Intraoral erythema multiforme with coalescent aphthous-like ulcers and erythema of the buccal
mucosa
Intraoral lesions of erythema multiforme

Erythema multiforme with target lesions on the skin of the fingers and intraoral ulcers.

Erythema multiforme with hemorrhagic crusts of the lips.

a b

Stevens–Johnson syndrome. Lips and labial mucosa (A), skin (B)

Plasma cell gingivitis presenting as desquamative gingivitis.

Contact allergy of the buccal mucosa due to cinnamon.

Aphthous-like ulcer associated with iron deficiency anemia; notice unusual location of ulcer on
the keratinized mucosa of the tongue dorsum; ulcers resolved when iron deficiency anemia was
treated.

Recurrent aphthous stomatitis of the tongue and floor of the mouth.

Recurrent aphthous stomatitis (minor) of the buccal mucosa.

Recurrent aphthous stomatitis (minor) of the lower labial mucosa presenting with several ulcers.

Recurrent aphthous stomatitis (major) of the buccal mucosa.

a b

Major aphthous ulcers of the labial mucosa (A) and alveolar mucosa (B)
Ulcer of the buccal mucosa secondary to Crohn’s disease.

Major aphthous ulcer in an HIV-infected patient.

a b

Aphthous ulcer (A) and skin lesion (B) in a patient with Behçets disease.

Herpetiform aphthous stomatitis with multiple <5 mm ulcers of palatal mucosa.

Early skin lesion of pemphigus vulgaris.

Extensive involvement of the skin in a patient with pemphigus vulgaris

Pemphigus vulgaris presenting as shallow, irregular red erosions of the ventral tongue with
ulcers and tissue tags.

a b

Shallow, irregular ulcers of the buccal mucosa (A) and tongue in a patient with pemphigus
vulgaris (B).
Pemphigus vulgaris of the buccal mucosa.

Pemphigus vulgaris presenting as erosions of the gingiva.

Photomicrograph of pemphigus vulgaris showing suprabasilar bulla with acantholysis.

Direct immunofluorescence study of pemphigus vulgaris showing intercellular deposition of IgG.

Paraneoplastic pemphigus in a patient with non-Hodgkin’s lymphoma.

Extensive lesions of the tongue in a patient with paraneoplastic pemphigus.

Chronic palatal lesions of pemphigus vegetans.

Extensive lesions of the buccal mucosa in a patient with paraneoplastic pemphigus.

Bullous pemphigoid lesion of the scalp.

Pemphigus vegetans with vegetative lesions of the skin.

Bullous pemphigoid resulting in tense skin blisters.

Mucous membrane pemphigoid of the conjunctiva with symblepharon formation.

Palatal lesions of mucous membrane pemphigoid.

Moderate desquamative gingivitis of mucous membrane pemphigoid.

Chronic desquamative gingival lesions of mucous membrane pemphigoid.

Intact vesicle of buccal mucosa in a patient with mucous membrane pemphigoid.

Mucous membrane pemphigoid causing lesions of the soft palate.

Photomicrograph of mucous membrane pemphigoid showing intact basal cells and subepithelial
bulla.
Direct immunofluorescence study of mucous membrane pemphigoid showing positive IgG
deposition in the basement membrane zone.

Soft splint used to hold topical steroids to treat desquamative gingivitis.

Soft medication splint used to treat desquamative gingivitis secondary to mucous membrane
pemphigoid.

Traumatic ulcer of the lateral tongue, healing.

Traumatic ulcer of the labial mucosa caused by a sharp tooth.

Ulcer from hot pizza burn on the palatal mucosa.

Traumatic ulcerative granuloma of the tongue, a typical site; note the surrounding keratosis.

Traumatic ulcerative granuloma of the buccal mucosa; not the depressed appearance of the
ulcer and surrounding keratosis.
Mucormycosis of the palate in a kidney transplant patient taking immunosuppressive drugs.