1.

Characteristics of carbachol
 ANSWER:

 it exerts both nicotinic and muscarinic effects

 it is resistant to acetylcholinesterase

 it decreases intraocular pressure

2. Characteristics of pilocarpine
ANSWER:
 It causes miosis and a decrease in intraocular pressure

 It is useful in the treatment of glaucoma

 It is a tertiary amine alkaloid

3. Chronic long – term therapy of myasthenia is usually

accomplished with what
ANSWER: neostigmine

4. Cholinesterase inhibitors do not produce what

5. Indicate a cholinesterase inhibitor, which has an additional direct
nicotinic agonist effect
ANSWER: neostigmine

6. Indicate a cholinomimetic agent , which is related to direct acting

drugs
ANSWER: carbachol
7. Indicate a reversible cholinesterase inhibitor
ANSWER: physostigmine
8. Indicate cholinesterase activator
ANSWER: pralidoxime
9. Indicate the organophosphate cholinesterase inhibitor w/c can
make up in an aqueous sol. For ophthalmic use
ANSWER: echothiophate

10. Indicate the reversible cholinesterase inhibitor , which penetrates

the BBB
ANSWER: physostigmine

11. IS ACETYL CHOLINE is not a specific neurotransmitter of what

ANSWER: sympathetic postganglionic nerve endings.
12. Muscarinic receptors are located where

ANSWER: autonomic effector cell

13. Parasympathomimetic drugs cause what

ANSWER: bradycardia

14. Properties of bethanechol has all of the following except

ANSWER: it exerts both nicotinic and muscarinic effects

15. The dominant initial sights of acute cholinesterase inhibitors

intoxication
 ANSWER:

 Bronchial constriction

 Salivation, sweating

 Vomiting and diarrhea

16. The excessive stimulation of muscarinic receptors by pilocarpine

and choline esters is blocked competitively with
ANSWER: atropine

17. The location of m2 cholinoreceptor type

 ANSWER: heart
18. The moa of indirect acting cholinomimetic agents

ANSWER: inhibition of the hydrolysis of endogenous

acetylcholine

19. The symptom of mushroom poisoning is/are

ANSWER: dryness of mouth , hyperpyrexia , hallucination
20. The symptoms of excessive stimulation of muscarinic receptors

 ANSWER:

 Miosis, bradycardia

 Abdominal cramps , diarrhea

 Increased salivation ,excessive bronchial secreation

21. The toxic effects of a large dose of nicotine

ANSWER: dramatic hypertension and tachycardia

22. What increases isofluorophate

ANSWER:
 Salivation

 Lacrimation

 Muscle twitching

23. What is m-cholinomimetic agent is

ANSWER: pilocarpine

24. Which of the ffg. Cholinomimetics is a drug of choice for reversing

effects of non-depolarizing neuromuscular relaxants
ANSWER: edrophonium

25. Which of the following cholinesterase inhibitors is irreversible

 ANSWER: isoflurophate
26. Which of the following cholinomimetics activates both muscarinic

and nicotinic receptors

ANSWER: bethanechol
27. Which of the following cholinomimetics is a plant derivative with

lower potency than nicotine but with a similar spectrum of action

ANSWER: lobeline

28. Which of the following cholinomimetics is commonly used in the

treatment of glaucoma
ANSWER: pilocarpine

29. Which of the following cholinomimetics is indirect acting

ANSWER: edrophonium

30. Which of the following cholinomimetics is most widely used for

paralytic ileus and atony of the urinary bladder
ANSWER: neostigmine

31. Which of the following cholinomimetics is used in the treatment

of atropine intoxication
ANSWER: physostigmine

32. Which of the following direct-acting cholinomimetics has the

shortest duration of action
ANSWER: acetylcholine

33. Which of the following direct-acting cholinomimetics is mainly

muscarinic in action
ANSWER: bethanechol
34. Which of the following drugs is used for acute toxic effects of
organophosphate cho0linesterase inhibitors
ANSWER: pralidoxime

35. Why is acetylcholine not used in clinical practice

ANSWER: because it is very rapidly hydrolyzed