SAFETY DATA SHEET Version 6.

3
Revision Date 26.02.2019
according to Regulation (EC) No. 1907/2006 Print Date 23.04.2020
GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers
Product name : tert-Butyl methyl ether
Product Number : 306975
Brand : Sigma-Aldrich
Index-No. : 603-181-00-X
REACH No. : 01-2119452786-27-XXXX
CAS-No. : 1634-04-4
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances
1.3 Details of the supplier of the safety data sheet
Company : Sigma-Aldrich Inc.
3050 Spruce Street
ST. LOUIS MO 63103
UNITED STATES
Telephone : +1 314 771-5765
Fax : +1 800 325-5052
1.4 Emergency telephone number
Emergency Phone # : +1-703-527-3887

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Flammable liquids (Category 2), H225
Skin irritation (Category 2), H315
For the full text of the H-Statements mentioned in this Section, see Section 16.
2.2 Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogram

Signal word Danger

Hazard statement(s)
H225 Highly flammable liquid and vapour.

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 H315 Causes skin irritation.
Precautionary statement(s)
P210 Keep away from heat, hot surfaces, sparks, open flames and
other ignition sources. No smoking.
Supplemental Hazard none
Statements
2.3 Other hazards
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.1 Substances
Synonyms : MTBE
Methyl tert-butyl ether

Formula : C5H12O
Molecular weight : 88,15 g/mol
CAS-No. : 1634-04-4
EC-No. : 216-653-1
Index-No. : 603-181-00-X
Component Classification Concentration
tert-Butyl methyl ether
Flam. Liq. 2; Skin Irrit. 2; <= 100 %
H225, H315
For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse
mouth with water. Consult a physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section
2.2) and/or in section 11

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4.3 Indication of any immediate medical attention and special treatment needed
No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture
Carbon oxides
5.3 Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
5.4 Further information
Use water spray to cool unopened containers.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure
adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas.
Beware of vapours accumulating to form explosive concentrations. Vapours can
accumulate in low areas.
For personal protection see section 8.
6.2 Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-
brushing and place in container for disposal according to local regulations (see section
13).
6.4 Reference to other sections
For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.
Keep away from sources of ignition - No smoking.Take measures to prevent the build up of
electrostatic charge.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent
leakage.
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

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SECTION 8: Exposure controls/personal protection
8.1 Control parameters
Components with workplace control parameters
8.2 Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands
before breaks and at the end of workday.
Personal protective equipment
Eye/face protection
Face shield and safety glasses Use equipment for eye protection tested and
approved under appropriate government standards such as NIOSH (US) or EN
166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact
with this product. Dispose of contaminated gloves after use in accordance with
applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of Regulation (EU)
2016/425 and the standard EN 374 derived from it.
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0,4 mm
Break through time: 230 min
Material tested:Camatril® (KCL 730 / Aldrich Z677442, Size M)
data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail
sales@kcl.de, test method: EN374
If used in solution, or mixed with other substances, and under conditions which
differ from EN 374, contact the supplier of the CE approved gloves. This
recommendation is advisory only and must be evaluated by an industrial hygienist
and safety officer familiar with the specific situation of anticipated use by our
customers. It should not be construed as offering an approval for any specific use
scenario.
Body Protection
Impervious clothing, Flame retardant antistatic protective clothing., The type of
protective equipment must be selected according to the concentration and amount
of the dangerous substance at the specific workplace.
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-
face respirator with multi-purpose combination (US) or type AXBEK (EN 14387)
respirator cartridges as a backup to engineering controls. If the respirator is the sole
means of protection, use a full-face supplied air respirator. Use respirators and
components tested and approved under appropriate government standards such as
NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

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SECTION 9: Physical and chemical properties
9.1 Information on basic physical and chemical properties
a) Appearance Form: liquid
b) Odour No data available
c) Odour Threshold No data available
d) pH No data available
e) Melting Melting point/range: -108,6 °C
point/freezing point
f) Initial boiling point 55 - 56 °C - lit.
and boiling range
g) Flash point -33,0 °C - closed cup
h) Evaporation rate No data available
i) Flammability (solid, No data available
gas)
j) Upper/lower Upper explosion limit: 15,1 %(V)
flammability or Lower explosion limit: 1,6 %(V)
explosive limits
k) Vapour pressure 1018,7 hPa at 55,0 °C
279,2 hPa at 20,0 °C
l) Vapour density No data available
m) Relative density 0,74 g/cm3 at 25 °C
n) Water solubility 42 g/l at 20 °C - OECD Test Guideline 105
o) Partition coefficient: log Pow: 1,06
n-octanol/water
p) Auto-ignition 374,0 °C
temperature
q) Decomposition No data available
temperature
r) Viscosity 0,464 mm2/s at 20 °C - 0,409 mm2/s at 40 °C -
s) Explosive properties No data available
t) Oxidizing properties No data available
9.2 Other safety information
No data available

SECTION 10: Stability and reactivity

10.1 Reactivity
No data available
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
No data available

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10.4 Conditions to avoid
Heat, flames and sparks.
10.5 Incompatible materials
Oxidizing agents, Strong acids
10.6 Hazardous decomposition products
Hazardous decomposition products formed under fire conditions. - Carbon oxides
Other decomposition products - No data available
In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects
Acute toxicity
LD50 Oral - Rat - male and female - > 2.000 mg/kg
(OECD Test Guideline 401)
LC50 Inhalation - Rat - male and female - 4 h - 85 mg/l
(OECD Test Guideline 403)
LD50 Dermal - Rabbit - male and female - > 2.000 mg/kg
(OECD Test Guideline 402)
Skin corrosion/irritation
Skin - Rabbit
Result: Skin irritation - 4 h
(OECD Test Guideline 404)
Drying-out effect resulting in rough and chapped skin.
Serious eye damage/eye irritation
Eyes - Rabbit
Result: No eye irritation
(OECD Test Guideline 405)
Respiratory or skin sensitisation
Sensitisation test (Magnusson and Kligman): - Guinea pig
Result: Does not cause skin sensitisation.
(OECD Test Guideline 406)
Germ cell mutagenicity
No data available
In vitro mammalian cell gene mutation test
Chinese hamster lung cells
Result: negative
OECD Test Guideline 486
Mouse - male and female - Liver cells
Result: negative
Carcinogenicity
Reproductive toxicity
No data available
Specific target organ toxicity - single exposure
No data available
Acute inhalation toxicity - Possible damages:, mucosal irritations
Specific target organ toxicity - repeated exposure
No data available

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 Aspiration hazard
No data available
Additional Information
Repeated dose toxicity - Rat - male and female - Oral - 90 d - No observed adverse effect
level - 3.000 mg/kg
Subchronic toxicity
RTECS: KN5250000

Nausea, Vomiting, Dizziness, Central nervous system depression, Aspiration or inhalation

may cause chemical pneumonitis., MTBE (methyl-tert-butyl ether) is reported to metabolize
to tert-butyl alcohol and formaldehyde by microsomal demethylation, MTBE (methyl-tert-
butyl ether) should be considered a "potential human carcinogen" due to an increase in
leydig interstitial cell tumors of testes in male rats and an increase in lymphomas,
leukemias, and uterine sarcomas in female rats., In another unpublished study MTBE was
shown to be carcinogenic due to "increased incidence of a rare type of kidney tumor" in
male rats and an "increase in the incidence of hepatocellular adenomas" in female mice., To
the best of our knowledge, the chemical, physical, and toxicological properties have not
been thoroughly investigated.
Central nervous system -

SECTION 12: Ecological information

12.1 Toxicity
Toxicity to fish semi-static test LC50 - Menidia beryllina - 574 mg/l - 96 h
(OECD Test Guideline 203)
Toxicity to daphnia flow-through test EC50 - Americamysis bahia (Mysid) - 187 mg/l -
and other aquatic 96 h
invertebrates (US-EPA OPPTS 850.1035)
Toxicity to algae static test IC50 - Pseudokirchneriella subcapitata (green algae) - 491
mg/l - 96 h
Toxicity to bacteria static test EC10 - Pseudomonas putida - 710 mg/l - 18 h
Remarks: (ECHA)
12.2 Persistence and degradability
Biodegradability aerobic - Exposure time 7 d
Result: 9,24 % - Not readily biodegradable.
(OECD Test Guideline 301D)
12.3 Bioaccumulative potential
Bioaccumulation Cyprinus carpio (Carp) - 28 d
at 25 °C(tert-Butyl methyl ether)

Bioconcentration factor (BCF): 1,5

12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.

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12.6 Other adverse effects
No data available

SECTION 13: Disposal considerations

13.1 Waste treatment methods
Product
Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra
care in igniting as this material is highly flammable. Offer surplus and non-recyclable
solutions to a licensed disposal company.
Contaminated packaging
Dispose of as unused product.

SECTION 14: Transport information

14.1 UN number
ADR/RID: 2398 IMDG: 2398 IATA: 2398
14.2 UN proper shipping name
ADR/RID: METHYL tert-BUTYL ETHER
IMDG: METHYL tert-BUTYL ETHER
IATA: Methyl tert-butyl ether
14.3 Transport hazard class(es)
ADR/RID: 3 IMDG: 3 IATA: 3
14.4 Packaging group
ADR/RID: II IMDG: II IATA: II
14.5 Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
14.6 Special precautions for user
No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the
substance or mixture
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.2 Chemical safety assessment

For this product a chemical safety assessment was not carried out

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.
H225 Highly flammable liquid and vapour.
H315 Causes skin irritation.

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 Further information
Copyright 2018 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies
for internal use only.
The above information is believed to be correct but does not purport to be all inclusive
and shall be used only as a guide. The information in this document is based on the
present state of our knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any guarantee of the properties of
the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any
damage resulting from handling or from contact with the above product. See
www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional
terms and conditions of sale.

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