Self-Assessment: 650 BOFs for MRCP(UK) and MRCP(I) Part I

About the Author: Self-Assessment:

Osama Shukir Muhammed Amin
MD, FRCP(Edin), FRCP(Glasg), FRCPI,
650 BOFs for MRCP(UK)
FRCP(Lond), FACP, FAHA, FCCP
and MRCP(I) Part I

Osama graduated from Baghdad University, College of Osama S. M. Amin

Medicine and was the valedictorian student in internal medicine. FRCP, FRCPI, FACP
He got membership diplomas of the Royal Colleges of Physicians
of Ireland and Glasgow and then became Board-certified in
neurology. Osama is a Fellow of the American College of
Physicians, Fellow of the Royal College of Physicians and
Surgeons of Glasgow, Fellow of the Royal College of Physicians
of Edinburgh, Fellow of the Royal College of Physicians of
Ireland, Fellow of the Royal College of Physicians of London,
and Fellow of the Stroke Council of the American Heart
Association/American Stroke Association. Currently, he is a
Clinical Associate Professor at the Clinical School of the
International Medical University, Malaysia. Osama published
more than 50 articles in international peer-reviewed neurology
journals and 5 self-assessment books for the membership
diploma of the Royal Colleges of Physicians of the United
Kingdom and Ireland. He is an associate editor, guest editor,
reviewer and former editor-in-chief in several international peer-
reviewed internal medicine and neurology journals. Osama is very
interested in Mesopotamian history and always tries to take
photos of archaeological sites and artifacts in museums, both in
Iraq and around the world. He is a contributor/team member of
"Medical MasterClass," the online educational arm of the Royal
College of Physicians of London, UK.
Osama S. M. Amin

ISBN 978-1-365-61609-9
90000

ID: 20220020
9 781365 616099 www.lulu.com
Self-Assessment: 650 BOFs for
MRCP(UK) and MRCP(I) Part I

Second Edition
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 Second Edition

Self-Assessment: 650 BOFs for

MRCP(UK) and MRCP(I) Part I

Osama S. M. Amin
MD, FRCP(Edin), FRCP(Glasg), FRCPI, FRCP(Lond), FACP, FAHA, FCCP

Clinical Associate Professor of Neurology

International Medical University,
Kuala Lumpur, Malaysia

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 Copyright © 2016. Osama S. M. Amin.

Copyright © 2016 by Osama S. M. Amin.

Copyright Notice:
All rights reserved. No part this publication may be reproduced or
transmitted in any form or by any means, electronic, mechanical,
photocopying, recording, or otherwise, without a prior permission of
the copyright owner in writing:

Osama S. M. Amin
Clinical School, International Medical University,
Jalan Rasah, 70300 Seremban, Negeri Sembilan,
Malaysia
Email: dr.osama.amin@gmail.com, osamashukir@imu.edu.my

First Edition: 2009.

Second Edition: 2016
ISBN: 978-1-365-61609-9

Disclaimer:
This book was written depending on reliable sources. However, while
every effort has been made to ensure its accuracy, no responsibility for
loss, damage, or injury occasioned on any person acting or refraining
from action as a result of information contained herein can be
accepted by the author or publisher.

Distributed by Lulu Press, Inc. Northern Carolina, USA.

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Dedication

To my lovely family:

Sarah, Awan, and Naz

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Acknowledgements

I woul like to thank my dear patients; their real clinical scenarios were used to
formualte and generate these questions.

A special gratitude goes to my other half, wife Sarah, for her endless support and
encouragement, and of course her extreme patience.

Osama

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Preface
“No human being is constituted to know the truth, the whole truth, and nothing but the
truth; and even the best of men must be content with fragments, with partial glimpses, never
the full fruition”, Sir William Osler (1849-1919).

F irst of all, this is the 2nd edition of my previous book, “Self-Assessment

for MRCP(UK) part 1”, which was published in 2009. The book has
undergone several changes and updates. Membership diplomas of the
Royal Colleges of Physicians of the United Kingdom, MRCP(UK), and Ireland,
MRCP(I), have several things in common. Their part I examination at a glance:
one-day examination; two-three hour papers (UK) or one-three hour paper
(Ireland); 200 (UK) or 100 (Ireland) best of five questions; no photographic
materials; and sat in an examination hall. The best initial step is to read
accredited textbooks. After then, self-assess yourself. Read this book, chapter
after chapter, try to find out your mistakes and gaps in knowledge, and then re-
read what you have missed.

In writing this book, I tried my best to include the commonest examination

themes. You may encounter negative or positive stems (i.e., one wrong stem or
one correct stem out of five stems). The questions’ objective is to teach, i.e., a
rapid review of every subject and theme. This book differs from my book “Get
Through MRCP part I; BOFs”, which was published in the year 2008 by the
Royal Society of Medicine Press in London. The latter concentrates mainly on
the diagnosis and management, i.e., what is the diagnosis, what is the next best
step, what feature is consistent with your preliminary diagnosis, and so on?

Undoubtedly, if you are well-prepared, you will pass the examination very
easily. No need to panic when you hear your colleagues’ past experiences. Lack
of preparation is the single most common reason for failure. Remember,
practice makes perfect. Read and self-assess, that’s it!

For a more comprehensive self-assessment, try my “Get Through MRCP part I”,
“Neurology: Self-Assessment for MRCP(UK) and MRCP(I)”, and “Mock Papers for
MRCPI part I, 2nd Edition” books.

Good luck with your career and exams!

Osama S. M. Amin
January 2017

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Recommended Reading
1. Walker B, Colledge NR, Ralston S, Penmen I. Davidson's Principles and
Practice of Medicine, 26th edition. London: Churchill Livingstone; 2014.

2. Kumar P, Clark ML. Kumar and Clark's Clinical Medicine, 8th edition.
Philadelphia: Saunders Ltd.; 2012.

3. Longo D, Fauci A, Kasper D, Hauser S, Jameson J, Loscalzo J.

Harrison’s principles of Internal Medicine, 18th edition. New York: McGraw-
Hill Professional, 2011.

4. Dale DC, Federman DD, ACP Medicine, 3rd edition. Philadelphia: BC

Decker Inc.; 2007.

5. Barrett KA, Barman SM, Boitano S, Brooks H. Ganong’s Review of

Medical Physiology, 24th edition. New York: McGraw-Hill Education /
Medical; 2012.

6. Lang TA, Secic M (eds.). How to Report Statistics in Medicine, Annotated

Guidelines for Authors, Editors, and Reviewers, 2nd edition. Philadelphia: The
American College of Physicians, 2006.

7. Rosene-Montella K, Keely EJ, Lee RV, Barbour LA (eds.). Medical Care

of the Pregnant Patient, 2nd edition. Philadelphia: The American College of
Physicians; 2007.

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Table of Contents:

Chapter 1: Cardiology ..............................................................................................11

QUESTIONS ................................................................................................................................... 12
Answers ..................................................................................................................................... 29
Chapter 2: Clinical Hematology and Oncology .......................................................... 51
QUESTIONS ................................................................................................................................... 52
Answer ...................................................................................................................................... 67
Chapter 3: Clinical Pharmacology, Therapeutics, and Toxicology ................................ 87
QUESTIONS ................................................................................................................................... 88
Answers ..................................................................................................................................... 97
Chapter 4: Clinical Sciences ....................................................................................107
QUESTIONS ................................................................................................................................. 108
Answers ................................................................................................................................... 121
Chapter 5: Dermatology .........................................................................................139
QUESTIONS ................................................................................................................................. 140
Answers ................................................................................................................................... 149
Chapter 6: Endocrinology, Diabetes, and Metabolic Diseases ....................................157
QUESTIONS ................................................................................................................................. 158
Answers ................................................................................................................................... 179
Chapter 7: Gastroenterology and Hepatology ...........................................................199
QUESTIONS ................................................................................................................................. 200
Answers ................................................................................................................................... 225
Chapter 8: Infectious Diseases and Genitourinary Medicine ..................................... 245
QUESTIONS ................................................................................................................................. 246
Answers ................................................................................................................................... 257
Chapter 9: Neurology, Psychiatry, and Ophthalmology ............................................ 269
QUESTIONS ................................................................................................................................. 270
Answers ................................................................................................................................... 287
Chapter 10: Nephrology ......................................................................................... 309
QUESTIONS ................................................................................................................................. 310
Answers ................................................................................................................................... 331
Chapter 11: Respiratory Medicine ........................................................................... 347
QUESTIONS ................................................................................................................................. 348
Answers ................................................................................................................................... 365
Chapter 12: Rheumatology ..................................................................................... 385
QUESTIONS ................................................................................................................................. 386
Answers ................................................................................................................................... 401

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You may also try other MRCP self-assessment books, which were
written by Osama S. M. Amin:

1. Get Through MRCP;BOFs:

This was published initially by the Royal Society of Medicine Press Ltd in 2008.
Now the book is published by CRC Press.

Get Through MRCP Part 1: BOFs provides over 600 questions and answers,
allowing the reader to test their knowledge in preparation for the MRCP Part 1
examination. Questions are presented in the style used in the real examination,
and answers are supplemented with useful additional explanatory material to
help the reader understand why their answer was right, or wrong. The book
offers a useful review of all elements of the syllabus, so the reader can feel fully
prepared when they enter the examination room.
2. Mock Papers for MRCPI, 2nd Edition:
This was published in December 2016 by Lulu Press Inc.

In this book, you will find 3 mock papers. Each one contains 100 questions in
a Best of Five (BOF) format. Self-assess, try to complete each paper within 3
hours, check out your answers, read the explanation, and re-read accredited
medicine textbooks to fill in the gap in your knowledge. Each question has an
“objective”; try to review what the objective is about. This is the only self-
assessment book specifically written to imitate the MRCPI part I examination.
3. Neurology: Self-Assessment for MRCP(UK) and MRCP(I):
This was published in September 2016 by Lulu Press Inc.

You will find 792 questions of different formats, distributed into 3 chapters.
The 215 multiple choice questions of chapter one will surf you onto a rapid
review of information to consolidate your background knowledge of neuro-
anatomy, neuro-physiology, neuro-pharmacology, neuro-pathology,…etc. In
addition, testing the clinical aspects of various diseases is also included.
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