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GPAT-Handy Notes PDF
GPAT-Handy Notes PDF
GPAT-Handy Notes PDF
00 - 650 - 0.95
0 - 450 - 0.68
1 - 300 - 0.50
2 - 250 - 0.37
3 - 200 - 0.30
4 - 150 - 0.21
5 - 100 - 0.13
(oil:water:gum)
Oleoresins:- 1:2:1
L : Laurate - 20
P : Palmitate - 40
S : Stearate - 60
O : Oleate - 80
SOLUBILITY
Freely soluble - 1 - 10
Soluble - 10 - 30
STORAGE TEMPERATURE
Cold - 2 - 8 degree centi
Cool - 8 - 25
Warm - between 30 - 40
Compressibility index / carrs index = tapped density - bulk density / tapped density
25 - 30 - Excellent
31 - 35 - Good
36 - 40 - Fair
41 - 45 - Passable
46 - 55 - poor
56 - 65 - Very poor
Parenteral Use
Type I Glass:
Non-Parenteral Use
Type IV Glass:
You will find the details of the mechanism in text books or the following web sites:
http://www.organic-chemistry.org/frames.htm?http://www.organic-
chemistry.org/namedreactions/ or
http://www.chemlin.de/chemistry/name_reactions.htm or
http://www.tomchemie.de/Reaktionsmechanismen/reaktionsmechanismen.h...
See More
• Abbreviations
NAFDAC National Agency for Food and Drug Administration and Control,
Nigeria
OTC Over-The-Counter
QA Quality Assurance
QSM-WHO Quality Assurance and Safety of Medicines (WHO)
Rx Prescription
1)Plantago…seed,root,bark
8)morphine…analgesic,anticonvulsant,both,none
10)D-glyceraldehyde configuration…S,R,RS
21)witting reaction…phosprous
22)Cardinolide…butanone,batanedione,butanolides
25)BCE;FGI:…
30)BCCI memb
31)Fecl3+catechol colour….purple,red,green
37)Walden inversion….SN1,SN2,E1,E2
38)Blood pH..7.4
42)DLVO theory…
45)PCR sequence
50)AU..Bz..Cy….ans DX
52)Sania mirza….
54)book..fatima…
60)vch is permeable..polystrene…
61)bond energy…..
62)Tymoleptics??
67)Inhibitr f 50 s ….macrlide,tetracycline
68)synonym…Graphics
69)Pictorial
70)magnaminous
71)Rebate
77)SP angle…180
82)Anandamide….
88)Father f pharmacognosy..hippocrates
89)benzyme intermediate..
94)PEG liposome….
96)WOF is nt disacchrides….sucrose,maltose,lactose,glucopyranose
124)WOF is prodrug..sulindac,sulphasalazine,aspirin
129)glandular type,,,fracture….
134)GABA..increse cl level
137)Vulcanizin agent…..S,SO2
145)GC principle…adsorption,partition,both
151)subsidy definition..
162)Meyer’s reagent….
165)Topotecan…natural,synthetic,
167)clonidine….Antihypertensive,
172)Carbopol….PVA,PVP
179)Podophylotoxin…lignan dvt….
3.Heparin---- protamine
5.Antidepressants
b. SSRI’s-----cycloheptadine
6.Benzodiazepines---- flumazenil
9.Cocaine---- BZD’s for seizuries; labetalol for hypertension; Neuroleptics for psychosis.
11.Digoxin----- digibind
12.Electrolytes
17.Opiates-----naloxone; nalmefene
18.Organophosphates-------atro
pine; pralidoxamine
19.Salicylates------activated charcoal
• VACCINES
LIVE ATTENUATED:
measles
mumps
polio
rubella
typhoid
varicella
tuberculosis
yellowfever
INACTIVATED:
rabies
influenza
tetanus
hepatits A
RECOMBINANT:
hepatitis B
TOXOID:
diptheria
tetanus
MN2+ - ARGINASE
K+ - PYRUVATE KINASE
NI2+ - UREASE
MO - NITRATE REDUCTASE
SE - GLUTATHIONE PEROXIDASE
ALCOHOL
CHLORALHYDRATE
CORTISONE
NICOTINE
PREDNISOSLONE
PHENYTOIN
CHLORDIAZEPOXIDE
IMIPRAMINE
PHENOBARBITAL
TESTOSTERONE
ALLOPURINOL
ORAL ANTIDIABETICS
DISULFIRAM
METRONIDAZOLE
ORAL ANTICOAGULANTS
ANABOLIC AGENTS
CHLORAMPHENICOL
ISONIAZID
CEMETIDINE
Alkaptonuria - homogentisate1,2-dioxygenase
• DIAGNOSTIC TESTS
a)Syphilis-
B)Diptheria-
C) T.B-
Tuberculin,mantoux test
D) leprosy-
Lepromin tsest
Widal test
F)Rhumetoid arthritis-
G) Small pox-
Ouchterlony
E)Pneumonia-
F)brucellosis-
G)lymphogranuloma venerum-
Frei test
H)typhus fever-
I)hemophillius-
Ducrey test
G) scarlet fever-
Dick test
H)to detect human chornic gonadotrophin in serum of woman-
• BIOASSAYS OF DRUGS
BENZOPYRAN DERIVATIVES:
kromokalmn
bimakalim
erikalim
...See More
l.leichmanii - cyanocobalamin
l.viridans - thiamine
• Biological indicators
dry heast sterilisation (160 degre centi) : bacillus subtilis var niger
Alkylating agent
CML Indication
Dark skin(hyperpigmentation)
Endocrine insufficiency(adrenal)
Fibrosis
Amiodarone
Procainamide
Arsenium
Cisapride
Haloperidol
Erythromycin
Morphine side effects :MORPHINE
Myosis
Out of it(sedation)
Respiratory depression
Pneumonia(aspiration)
Hypotension
Infrequency(constipation,urina
ry retention)
Nausea
Emesis
Asthma
Salicylism
Reye's Syndrome
Idiosyncracy
Noise(tinnitus)
Stimulate CNS
Insomnia
Sevoflane
Halothane
Isoflurane
Nitrous oxide
Enflurane
Warfarin
Thalidomide
Epileptic drugs:Phenytoin,Valproate,Carb
amazepine
Retinoid
ACE inhibitor
Digoxin
Isoniazid
Spironolactone
Cimetidine
Oestrogens
Stilboestrol
Mental retardation
Electrolyte imbalance
Tolerance
Headache/ Hepatotoxicity
psYcological upset
Lactation in female
Dry mouth
Oedema
Parkinsonism
Cyclophosphamide
Methotrexate
Penicillamine
Phenytoin: adverse effects PHENYTOIN
P-450 interactions
Hirsutism
Enlarged gums
Nystagmus
Yellow-browning of skin
Teratogenicity
Osteomalacia
Vomiting
Alopecia
Liver toxicity
Pancreatitis/ Pancytopenia
Appetite increase
Tremor
Photosensitivity
Pigmentation of skin
Peripheral neuropathy
Selegiline
Amantadine
TI = LD / ED
Deoxy barbiturates
Barbiturates
Hydantoin
Aliphatic carb acids
Iminostilbenes
Succinimides
BZD's
Newer drugs
Phenyltriazines
Kidney toxicity
Antianabolic effect
Phototoxicity
Liver toxicity
Diabetes insipidus
Cough Angioedema
Agranulocystosis
Taste changes
Orthostatic hypotension
Leukopenia/Liver toxicity
Leukocytosis
Tremor/ Teratogenesis
Hypothyroidism
Upset stomach
Lightheadedness
Shortness of breath
Excessive sweating
Bed rest
Oxygen
Opiate
Monitor
Anticoagulate
ACE inhibitors
Beta-blockers
Diuretics
Methionine
Threonine
Leucine
Isoleucine
Tryptophan
Valine
Lysine
Phenyl alanine