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P16/Ki67 Dual Staining Improves The Detection Specificity of High Grade Cervical Lesions
P16/Ki67 Dual Staining Improves The Detection Specificity of High Grade Cervical Lesions
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BACKGROUND
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BACKGROUND
Negative
Positive
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METHODS
• A total of 223 patients with an average age of 39 years old were enrolled
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RESULTS p16INK4a/Ki67 dual staining had high specificity to detect CIN2 or greater lesions
100
83 Negative
80 Positive
Number of Cases
60 52
40 36
17
20 12
9 7
5 2 0
0
Inflammantion CIN 1 CIN 2 CIN 3 Cervical Cancer
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RESULTS p16INK4a/Ki67 dual staining had high specificity to detect CIN2 or greater lesions
• Detection for CIN2+ in P16/KI67 compared with cytology and high risk HPV test.
100% AUC cut off CIN2
90% 1
80%
0.8
70%
60%
Sensitivity
0.6
50%
40% 0.4
30%
20% 0.2
10%
0
0% 0 0.2 0.4 0.6 0.8 1
P16/KI67 CYTOLOGY HR-HPV
1-Specificity
Sensitivity Specificity P16/Ki67 Cytology HR-HPV
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RESULTS p16INK4a/Ki67 dual staining had high specificity of CIN2 or greater lesions
for patients with ASC-US and LSIL in cytology test
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RESULTS p16INK4a/Ki67 dual staining had high specificity of CIN2 or greater lesions
for patients with ASC-US and LSIL in cytology test
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RESULTS p16INK4a/Ki67 dual staining had high specificity to detect CIN2+ lesions in patients
with positive high-risk HPV test
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CONCLUSIONS
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