Scribd Logo
Upload

Welcome to Scribd!

  • Supplementary Table S5. Number of Protein-Coding Genes Affected by Loss-Of-Function Variants With An Allele Frequency of 1%

    Uploaded by

    kjhgfghjk
    20 views2 pages
    This table summarizes the number of protein-coding genes affected by rare loss-of-function variants in different numbers of participants. It shows that as the number of participants increases, the total and percentage of genes affected decreases. For example, over 15,000 genes (81%) were affected in at least 1 participant, while only around 2,800 genes (15%) were affected in 20 or more participants. It also lists the numbers of affected genes that are considered highly intolerant to loss-of-function from the pLI metric.

    Original Description:

    Original Title

    41422_2020_322_MOESM12_ESM

    Copyright

    © © All Rights Reserved

    Available Formats

    XLSX, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    This table summarizes the number of protein-coding genes affected by rare loss-of-function variants in different numbers of participants. It shows that as the number of participants increases, the total and percentage of genes affected decreases. For example, over 15,000 genes (81%) were affected in at least 1 participant, while only around 2,800 genes (15%) were affected in 20 or more participants. It also lists the numbers of affected genes that are considered highly intolerant to loss-of-function from the pLI metric.

    Copyright:

    © All Rights Reserved
    Download as XLSX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as xlsx, pdf, or txt
    20 views2 pages

    Supplementary Table S5. Number of Protein-Coding Genes Affected by Loss-Of-Function Variants With An Allele Frequency of 1%

    Uploaded by

    kjhgfghjk
    This table summarizes the number of protein-coding genes affected by rare loss-of-function variants in different numbers of participants. It shows that as the number of participants increases, the total and percentage of genes affected decreases. For example, over 15,000 genes (81%) were affected in at least 1 participant, while only around 2,800 genes (15%) were affected in 20 or more participants. It also lists the numbers of affected genes that are considered highly intolerant to loss-of-function from the pLI metric.

    Copyright:

    © All Rights Reserved
    Download as XLSX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as xlsx, pdf, or txt
    of 2

    Supplementary Table S5.

    Number of protein-coding genes affected by loss-of-fu


    Number of affected genes
    Number of participants All, n (%) Het, n (%)
    N >= 1 15,048 (81.3317%) 15,022 (81.1912%)
    N >= 5 8,775 (47.4273%) 8,758 (47.3354%)
    N >= 10 5,441 (29.4076%) 5,425 (29.3212%)
    N >= 20 2,835 (15.3227%) 2,819 (15.2362%)
    affected by loss-of-function variants with an allele frequency of <=1%
    cted genes Number of LOF intolerant genes (pLI >= 0.9)
    Hom, n (%) All, n (%) Het, n (%) Hom, n (%)
    627 (3.3888%) 1,983 (10.7178%) 1,979 (10.6961%) 29 (0.1567%)
    55 (0.2973%) 540 (2.9186%) 539 (2.9132%) 0 (0.0000%)
    30 (0.1621%) 222 (1.1999%) 222 (1.1999%) 0 (0.0000%)
    13 (0.0703%) 99 (0.5351%) 99 (0.5351%) 0 (0.0000%)

    You might also like