Supplementary Table S13.

Analysis of important SNPs related to alcohol and caffe

CHROM POS rs ID Gene REF

chr4 99307860 rs2066702 ADH1B G

chr4 99318162 rs1229984 ADH1B T

Alcohol Metabolism

chr4 99318162 rs1229984 ADH1B T

chr12 111803962 rs671 ALDH2 G

chr12 111803962 rs671 ALDH2 G

Caffeine Metabolism chr15 74749576 rs762551 CYP1A2 C

Caffeine Metabolism chr15 74749576 rs762551 CYP1A2 C
ated to alcohol and caffeine metabolism
ALT Function Transcript Population AC AF
AFR 4574 0.190965
AMR 304 0.008836
ASJ 84 0.008274
ChinaMAP 6 0.000283
NM_000668.5:p.Ar gnomAD 5260 0.018983
A missense_variant g370Cys/c.1108C>
T EAS 2 0.000106
FIN 4 0.000155
NFE 191 0.001508
OTH 56 0.008663
TOPMed 7569 0.060278
AFR 23743 0.988550
AMR 32485 0.943892
ASJ 7419 0.731080
ChinaMAP 6609 0.312099
NM_000668.5:p.His
C missense_variant gnomAD 251204 0.906435
48Arg/c.143A>G
EAS 4915 0.260604
FIN 25674 0.995348
NFE 121928 0.962640
OTH 5814 0.900000
C,G - - TOPMed 114864;1159
0.914755,0.00923006
AFR 5 0.000215
AMR 13 0.000390
ChinaMAP 4581 0.216330
NM_000690.3:p.Gl gnomAD 4751 0.017655
A missense_variant u504Lys/c.1510G> EAS 4688 0.256511
A FIN 2 0.000079
NFE 3 0.000024
OTH 31 0.004935
TOPMed 1960 0.015609
- - - ASJ 0 0.000000
AFR 5220 0.601382
AMR 601 0.717184
ASJ 211 0.708054
ChinaMAP 13216 0.624103
NM_000761.4:c.-9- gnomAD 20559 0.666245
A intron_variant
154C>A
 NM_000761.4:c.-9-
A intron_variant
154C>A EAS 1052 0.650990
FIN 2377 0.681089
NFE 10438 0.697914
OTH 660 0.673469
TOPMed 84317 0.671485
 AN Genotype infomation
23952 GG (65.4726%);GA (30.8617%);AA (3.6657%)
34404 GG (98.2560%);GA (1.7207%);AA (0.0233%)
10152 GG (98.3452%);GA (1.6548%)
21176 GA (0.0567%);GG (99.9433%)
277090 GG (96.5232%);GA (3.1571%);AA (0.3198%)
18868 GG (99.9788%);GA (0.0212%)
25790 GG (99.9690%);GA (0.0310%)
126680 GG (99.6985%);GA (0.3015%)
6464 GG (98.2673%);GA (1.7327%)
125568 GG (90.1806%);GA (9.8194%)
24018 TC (2.2899%);CC (97.7101%)
34416 TT (0.3661%);TC (10.4893%);CC (89.1446%)
10148 TT (7.8636%);TC (38.0568%);CC (54.0796%)
21176 TC (41.7359%);CC (10.3419%);TT (47.9222%)
277134 TT (4.2470%);TC (10.2189%);CC (85.5341%)
18860 TT (54.6023%);TC (38.6744%);CC (6.7232%)
25794 TC (0.9304%);CC (99.0696%)
126660 TT (0.2321%);TC (7.0077%);CC (92.7601%)
6460 TT (1.6409%);TC (16.7183%);CC (81.6409%)
125568 multiple allele
23262 GG (99.9570%);GA (0.0430%)
33308 GG (99.9219%);GA (0.0781%)
21176 AA (4.4957%);GA (34.2747%);GG (61.2297%)
269102 GG (96.9209%);GA (2.6273%);AA (0.4519%)
18276 GG (55.3513%);GA (37.9952%);AA (6.6535%)
25392 GG (99.9842%);GA (0.0158%)
122756 GG (99.9951%);GA (0.0049%)
6282 GG (99.0131%);GA (0.9869%)
125568 GG (97.6300%);GA (2.3700%)
9992 GG (100%)
8680 CC (15.8065%);CA (48.1106%);AA (36.0829%)
838 CC (9.0692%);CA (38.4248%);AA (52.5060%)
298 CC (10.7383%);CA (36.9128%);AA (52.3490%)
21176 AA (39.3937%);CC (14.5731%);CA (46.0332%)
30858 CC (11.1025%);CA (44.5460%);AA (44.3515%)
 1616 CC (12.1287%);CA (45.5446%);AA (42.3267%)
3490 CC (9.5129%);CA (44.7564%);AA (45.7307%)
14956 CC (8.8125%);CA (42.7922%);AA (48.3953%)
980 CC (10.2041%);CA (44.8980%);AA (44.8980%)
125568 CC (56.7740%);CA (43.2260%)