Week 2 Quiz - Contributes 8% Towards Your Final Grade: Congratulations! You Passed! To Pass Grade

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Week 2 quiz - contributes 8% towards your final grade
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1.Question 1
Which of the following statements about histone acetylation are true? Select all correct options.
1 / 1 point
Histone acetylation can activate or silence gene expression, depending on which histones are modified.
Histone acetylation activates gene expression.
Correct
This option is correct.
Histone acetylation can act as a docking site for other proteins that open chromatin.
Correct
2.Question 2
You find that the gene you are studying shows histone methylation at the promoter. What does this indicate
about the expression state of the gene?
1 / 1 point
The gene is likely to be transcriptionally silent.
The gene is likely to transcriptionally active.
You are unable to tell, as histone methylation does not influence transcriptional activity.
You are unable to tell, as histone methylation can be associated with either transcriptional activity or
transcriptional silencing.
Correct
3.Question 3
Which of the following epigenetic modifications are associated with heterochromatin?
0 / 1 point
H3K4 methylation and DNA methylation.
H3K9 methylation and H3K4 methylation.
H3K9 methylation and histone acetylation.
DNA methylation.
Incorrect
H3K4 methylation is associated with euchromatin.
4.Question 4
Which of the following statements about chromatin remodellers are true? Select all correct options.
1 / 1 point
Chromatin remodellers use energy from ATP to move nucleosomes.
Correct
Chromatin remodellers are recruited to chromatin via specific sequences in the DNA.
Chromatin remodellers generate ATP by moving nucleosomes.
Chromatin remodellers cause changes in chromatin compaction.
Correct
5.Question 5
You find a mutation in a patient that alters lysine 27 of histone 3 so that it cannot be methylated. What
biological effects do you predict this would have? Select all correct options.
1 / 1 point
The patient will not be able to effectively silence gene expression.
Correct
Histone 3 will be present in the chromatin but the H3K27 methylation mark will be absent.
Correct
The patient will not be able to effectively activate gene expression.
Histone 3 will be missing from the chromatin.
6.Question 6
You design an experiment to silence gene X using a miRNA. What is the best way of testing if the silencing
has worked?
0 / 1 point
Examine either RNA or protein, the result will always be the same.
Examine expression of gene X at the protein level.
Examine the DNA methylation pattern at the promoter of gene X.
Examine whether RNA polymerase is recruited to the promoter of gene X.
Incorrect
miRNAs can act by cleaving their target mRNA, which would be detected at the RNA level. miRNAs can also
act by repressing translation, which would be detected at the protein level but not the RNA level.
7.Question 7
How do piRNAs promote genome stability? Select all correct options.
1 / 1 point
piRNAs promote the degradation of transposon RNA.
Correct
piRNAs interact with histone variants to promote DNA repair.
piRNAs interact with DNA methyltransferases to mediate the silencing of transposon DNA.
Correct
piRNAs interact with DNA demethylases to mediate the silencing of transposon DNA.
8.Question 8
Which of the following types of RNA can directly lead to epigenetic changes in chromatin? Select all correct
options.
1 / 1 point
lncRNAs.
Correct
rRNA.
mRNA.
piRNAs.
Correct
9.Question 9
The promoter of gene X is transcribed to produce a lncRNA that accumulates at the promoter, recruiting
epigenetic factors that silence the chromatin in cis. You design an experiment to reduce the expression of
the lncRNA. What effect do you predict this would have?
1 / 1 point
There would be no effect on gene X but genes on other chromosomes would show increased expression.
lncRNAs have no effect on transcription, they always act post-transcriptionally.
Expression of gene X would decrease.
There would be less recruitment of silencing complexes to gene X.
Correct
10.Question 10
Your gene of interest is located near the periphery of the nucleus. What predictions would you make about
this gene? Select all correct options.
1 / 1 point
The gene is likely to be lowly expressed.
Correct
The gene is likely to be in heterochromatin.
Correct
The gene is likely to be in euchromatin.
The gene is likely to be in a transcription factory.

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Histone acetylation activates gene expression.

The gene is likely to be transcriptionally silent.

The gene is likely to transcriptionally active.

H3K4 methylation and DNA methylation.

H3K9 methylation and H3K4 methylation.

H3K9 methylation and histone acetylation.

Chromatin remodellers use energy from ATP to move nucleosomes.

Chromatin remodellers generate ATP by moving nucleosomes.

Chromatin remodellers cause changes in chromatin compaction.

The patient will not be able to effectively silence gene expression.

The patient will not be able to effectively activate gene expression.

Histone 3 will be missing from the chromatin.

Examine expression of gene X at the protein level.

Examine the DNA methylation pattern at the promoter of gene X.

Examine whether RNA polymerase is recruited to the promoter of gene X.

piRNAs promote the degradation of transposon RNA.

piRNAs interact with histone variants to promote DNA repair.

lncRNAs have no effect on transcription, they always act post-transcriptionally.

Expression of gene X would decrease.

There would be less recruitment of silencing complexes to gene X.

The gene is likely to be lowly expressed.

The gene is likely to be in heterochromatin.

The gene is likely to be in euchromatin.

The gene is likely to be in a transcription factory.

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