Engineering: Biomedical

BIOMEDICAL
ENGINEERING
2012-2013 ANNUAL REPORT

HIGHLIGHTS
2 Synthetic Biology
5 $9 Million Dollar Grant
OVERVIEW
6 BME Overview
7 Overview
& Administration
8 New BME Faculty
9 Faculty Awards
Contents
and Honors
10 Significant Events
During the Year
FACULTY & STAFF

Boston University
Department of Biomedical Engineering 12 Primary Faculty
15 Research Faculty & Emeritus
Annual Report 2012-2013 & Professor of Practice
16 Affiliated Faculty
© 2013, Boston University 17 Adjunct Faculty & Postdocs
& Research Staff
Design and Layout: Kathryn Blair
kcblair@bu.edu RESEARCH
Content: BME faculty and staff
18 External Research Funding
23 Coulter Foundation Translational
Partnership
This report provides a description of the instructional and research activities of the Department
of Biomedical Engineering at Boston University during the 2012-2013 academic year. GRADUATE PROGRAM
Boston University’s policies provide for equal opportunity and affirmative action in employment 24 Graduate Enrollment
and admission to all programs in the university. 25 Graduate Degrees Awarded &
Admissions
For more information or to download this report as a PDF, please visit our website at: 26 Graduate Student Awards & Theses
bu.edu/bme
UNDERGRADUATE PROGRAM
28 Mission, Objective & Outcome
30 Undergraduate Enrollment
31 Undergraduate Degrees Awarded
32 Student Awards
34 Student Organizations
& Research Activities
36 Senior Design Experience
38 Senior Design Project Conference
NOTES
40 Notes
HIGHLIGHTS
BU’S SYNTHETIC BIOLOGY DREAM TEAM (from left) Wilson Wong, James Collins, Douglas Densmore, and Ahmad “Mo” Khalil.
James Collins says synthetic biology is “genetic engineering on steroids.” Photos by Kalman Zabarsky
BU is poised to become a synthetic biology powerhouse The researchers described the achievement in a paper
(Excerpted from article By Art Jahnke, Bostonia) published in Nature in January 2000, an issue that also
described a three-gene oscillating circuit built with the
same genetic components by two Princeton physicists.
As biologists continue the decades-long race to map the Exactly 10 years later, Nature described the work done at
genomes of living things, a group of forward-thinking BU BU and Princeton as the “defining pair of experiments”
engineers is asking the kind of questions that engineers that mark the start of synthetic biology.
can’t help but ask: what if we built a different genome?
Known as synthetic biologists, they believe that with
some skillful genomic tweaks, living organisms, such as In those days, says Collins, who is also a Howard Hughes
cells and microbes, can be put to work doing things that Medical Institute investigator, the Human Genome
are too dangerous or not even possible for higher life- Project had captured the attention of cutting-edge
forms like ourselves. biologists, as well as of the press. It would be years before
the appellation “synthetic biology” entered the vernacular,
The age of synthetic biology was turned on, literally, with and more important, before the science was distinguished
a switch built by two BU researchers 13 years ago. James from genetic engineering. Today, he says, the difference
Collins, now a William Fairfield Warren Distinguished between the two fields is almost as clear as on and off.
Professor and a College of Engineering professor of “What genetic engineers were doing was cutting and
biomedical engineering, and his graduate student Timothy pasting,” says Collins. “They were introducing genes to
Gardner (BME’00) altered the genes of E. coli bacteria enable organisms to be production organisms—they were
so that they could be made to produce proteins or not essentially swapping a red lightbulb for a green lightbulb.”
produce proteins, essentially creating a two-gene on/off By contrast, he says, synthetic biologists design and build
switch for a biological circuit. the circuits that power the bulb. “Introducing the lightbulb
is not engineering. That’s home design. Designing
the circuit is engineering. Synthetic biology is genetic
engineering on steroids.”
4 5
HIGHLIGHTS
$9 MILLION NIH Grant Founds Bu-Based Center

Collins’ standard definition of the field goes like
this: “Synthetic engineering is a new field that is FTCC funding will advance their research, and if it’s
bringing together engineers and biologists who
design and construct biomolecular components
“You could build it around the successful, help develop a prototype that is disposable
and affordable.
and synthetic gene networks to reprogram cells,
endowing them with novel functions.”
four of us,” Collins says. Klapperich herself is working with San Francisco–based
The novel functions he refers to include “And I don’t think there’s much Wave 80 Biosciences to develop a blood test to detect
liver cancer. The researchers are designing a cartridge
that would separate the nucleic acid RNA from blood or
the production of new fuels and medical
treatments. Collins was recently awarded a Bill doubt that BU is a major player plasma samples and use isolated nucleic acid to flag liver
cancer, which kills more than 20,500 yearly in the United
in this exciting new field.”
& Melinda Gates Foundation grant to engineer
a yogurt bacterium that will respond to, and kill, States, according to the American Cancer Society.
cholera bacteria in the human intestine. Rhoda Alani, MED’s Herbert Mescon Professor and
Chair of dermatology, chief of BMC’s department of
Synthetic biology has intrigued scientists at dermatology, hopes to develop a similar technology with
dozens of research institutions, but the field’s colleagues from the University of Texas at Austin that will
alpha schools are generally considered to be Center of Synthetic Biology (CoSBi) analyze RNA within patients’ blood samples to determine
the University of California, Berkeley, and the the likelihood of a recurrence of melanoma.
University of California, San Francisco, on the On April 15, 2013 University Provost Jean Morrison Catherine Klapperich, Associate Professor
West Coast, and Harvard and MIT on the of Biomedical Engineering and Director of the Center
The center’s fifth seed project, a collaboration between
approved the charter for launching a new Center MIT and Michigan State University called My LifeCloud,
East. Recently, however, with encouragement for Future Technologies in Cancer Care (FTCC)
from President Robert A. Brown, as well as of Synthetic Biology (CoSBi) Synthetic Biology is is a cell phone–based system aimed at empowering
Jean Morrison, University provost and chief bringing together engineers, biologists, and other $9 million NIH Grant Founds BU-Based Center patients at risk for colorectal cancer—particularly the
academic officer, and Kenneth Lutchen, ENG (By Leslie Friday) African American population, which the American
scientists to specify, design and construct molecular Cancer Society says has the highest incidence of, and
dean, Collins has been strengthening the ranks
of synthetic biology expertise at BU. biological systems and use these systems to Imagine a world where a simple mouth swab could predict mortality rate from, colorectal cancer of all racial groups
rewire and reprogram organisms. The center will lung cancer, a blood test could warn of a recurrence in the United States.
Douglas Densmore, came to BU two years bring faculty members that bridge diverse areas of melanoma, and a rectal scan could tell if you would
ago from UC Berkeley. Ahmad “Mo” Khalil, benefit from a colonoscopy. That world is the vision Over the five-year NIBIB grant period, Klapperich says
of synthetic biology research, including microbial the center will encourage several new proposals, weed
joined BU last fall. Also last fall, Collins helped of the Center for Future Technologies in Cancer Care
to recruit Wilson W. Wong, previously a engineering, immuno-engineering, computer aided (FTCC), founded here in July with help from a five-year, out a few, and provide funding for an annual summer
postdoctoral scholar in cellular and molecular design (CAD) and automation, stem cell engineering, $9 million grant from the National Institute of Biomedical innovation fellowship to transition lab research to a
pharmacology at UC San Francisco. The Imaging and Bioengineering (NIBIB) at the National working prototype.
single cell analysis, and dynamical systems modeling.
recruits, who like Collins work in a large, new Institutes of Health. The center will foster collaboration
The core faculty include: Prof James Collins, Founding among doctors, engineers, and public health and business The grant will also allow another NIBIB co–principal
state-of-the-art lab at 36 Cummington Mall,
belong to a happily incestuous community: Director, Assistant Professor Douglas Densmore, professionals at BU and elsewhere who hope to develop investigator, Bennett Goldberg, a CAS professor of
Khalil earned a PhD at MIT, which is a member Assistant Professor Ahmad “Mo” Khalil, Deputy technology to diagnose, screen, and treat a variety of physics, an ENG professor of biomedical engineering,
of SynBERC, the Synthetic Biology Engineering cancers faster, cheaper, and better than is done now. and director of the Center for Nanoscience and
Director, and Assistant Professor Wilson W. Wong. Nanobiotechnology, to lead training workshops and
Research Center, where Densmore was a
postdoc. Collins is also affiliated with Harvard BU is one of three recipients, with Harvard and Johns informal meetings at BU and around the country
through that university’s Wyss Institute for Hopkins University, of a U54 award, given by NIBIB’s for students, clinicians, and faculty interested in an
Biologically Inspired Engineering. Point-of-Care Technologies Research Network (POCTRN). interdisciplinary approach to tackling cancer.
Catherine Klapperich, the FTCC director, says this isn’t
the first time that BU engineers and clinicians have The other two NIBIB co–principal investigators are David
collaborated to tackle major health problems. The FTCC Seldin, a MED professor of medicine and microbiology
effort is unique, however, in its focus on cancer care. and BMC’s chief of hematology-oncology, and Arthur
The new center will draw expertise from programs like Rosenthal, a professor of the practice of biomedical
the W. H. Coulter Translational Partnership Program and engineering and former director of the Coulter
the Boston University/Fraunhofer Alliance for Medical Translational Partnership Program.
Devices, Instrumentation and Diagnostics and will try to
develop and commercialize promising prototypes. Franklin Huang, a fellow in the department of medical
The center’s first five seed projects focus on lung, colon, oncology at the Dana-Farber Cancer Institute, will guide
skin, and liver cancers. the public health side of the center’s pursuits, determining
population needs and assessing which advances might
Avrum Spira (ENG’02), a School of Medicine professor have the greatest impact.
of medicine, pathology, and bioinformatics and a
pulmonologist at Boston Medical Center (BMC), with help “One criterion for screening technology,” says the
from the FTCC, he hopes to develop a blood test or mouth CGHD’s Simon, “is that the movement forward of science
or nose swab that could reveal a high risk of lung cancer. should to the greatest extent possible benefit the largest
Irving Bigio and Satish Singh, a MED assistant professor numbers of people.” Klapperich echoes Simon’s objective
of medicine and a BMC gastroenterologist, have teamed to do the greatest good. As engineers, she says, she and
up to develop a prescreening tool for colon cancer, the her colleagues could sit around and “impress each other
second leading cause of death by cancer in the United with the stuff that we made,” or they could apply their
States. Bigio developed a fiber-optic probe that uses expertise in ways that will do the greatest good.
6 light and a spectrometer to detect potentially cancerous 7
polyps, and thus signal a real need for a colonoscopy.
BME Department Overview
OVERVIEW
OVERVIEW
Administration
In academic year 2012-2013 the BME Department added one new faculty member
During the last CHAIRMAN
(with 2 more starting July 1, 2013). Assistant Professor Darren Roblyer arrived July 1, Dr. Solomon R. Eisenberg
fiscal year the

2012 and Professor Christopher Chen and Assistant Professor Allison Dennis will join
the department on July 1, 2013. Cassandra Smith retired at the end on June 2103. The ASSOCIATE CHAIR FOR
department received confirmation that Prof Joyce Wong will be promoted to Full Professor GRADUATE PROGRAM
of Biomedical Engineering effective September 1, 2013, and the Dr. Irving Bigio
department added Assistant Professor Laertis Ikonomou, from
The BME Ph.D. Program
the Department of Medicine at the BU School of Medicine, as an
affiliate member of the BME Faculty. awarded IN 18 degrees this DU year, 36 primary BME faculty ASSOCIATE CHAIR FOR
NIH
ST Dr. Muhammad Zaman
RY
In FY13 the BME Faculty numbered 36, making the department bringing
OTH
ER G our total
1% Ph.D. degrees
52% attracted over $26
OVT
one of the largest in the country awarded to 210 1% since the DIRECTOR OF
in terms of primary faculty. GRADUATE ADMISSIONS
program began in 1991. Dr. Kamal Sen
FOUNDATIONS 10%
27 MS degrees were awarded in
million in extramural
The BME Graduate Program was led by Prof Irving Bigio as the
Associate Chair for Graduate Programs. The BME Ph.D. Program
AY2012-2013 as well as 9 MEng DIRECTOR
awarded 18 degrees this year, bringing our total Ph.D. degrees 13% Matthew Barber
D
awarded to 210 since the program began in 1991. degrees. Our
DO graduate programs
currently enroll 142 students funds available for
4%
9%
27 MS degrees were awarded as well as 9 MEng degrees. COULTER PROGRAM DIRECTOR
Our graduate programs enrolled 142 students (115 PhD students; 3 MD/PhD; Alessandra Pavesio
NSF 1
Student
(115 PhD students; 3 MD/PhD; 10 MS; 14 MEng).
10 MS; 14 MEng).
expenditure this year.
Support
Graduate student recruitment was led by the Director of Graduate
Admissions, Prof. Kamal Sen. In the Fall 2013 we expect 49 new
graduate students (33 PhD, 16 MEng). Our Ph.D. applicant pool BME Department Staff
continues to be competitive with other top tier Biomedical
This translates
Administrative
Engineering Programs. In the 2012 – 2013 recruiting season we
received 610 applications. The quality of the students matriculating Bailey, Christen, Graduate Program Administrator
remains very high with a mean GPA of 3.7 (US students only). Cunningham, Laura, Undergraduate Program Administrator
Dolan, Debbie, Financial Manager
The Associate chair for the BME Undergraduate Program was Prof Muhammad Zaman.
The BME Undergraduate Program awarded 107 Bachelor of Science degrees and enrolled
to over Fernandes, Fallon, Senior Program Coordinator
Ford, Nicole, Financial Manager, HHMI
Magni, Nicole, Center Administrator, HRC
545 students. We expect an incoming freshman class of 155, slightly lower than last year. McDonald, Tara, Financial Administrator
During 2012-2013 the 36 primary BME faculty attracted over $26 million in extramural
funds available for expenditure during the year. This translates to over $720,000 per
$720,000 Newhall, Susan, Senior Program Coordinator
Orzechowski, Irene, Financial Manager
Palmer, Mary-Ellen, Administrative Assistant to the Chair
faculty member. Our faculty is comprised of world renowned scientists and engineers who Prusaitis, Laura, Financial Manager
work across every scale of biology and in a wide spectrum of bioengineering subspecialties.
Their research is driven by advancing fundamental understanding of biology and
physiology in health and disease and then translating these principles to new technologies
per faculty Sands, Nancy, Financial Manager
technical
Allen, Phil, Manager, Micro/Nano Imaging Core Facility
member.
that impact the human condition and the practice of medicine. The research laboratories
Brown, Xin, Manager, Biointerface Technologies Core Facility
of the research active faculty members are listed on our web site (www.bu.edu/bme/
Broude, Natalia, Senior Engineer/Instructor
research/labs/) and they also participate in six interdisciplinary research centers that
Feit, Ze’ev, Manager of Clean Room Core Facility
are directed or co-directed by BME faculty: Biomolecular Engineering Research Center
(BMERC), Center for Computational Neuroscience and Neural Technology (CompNet),
Center for Nanoscience and Nanobiotechnology (CNN), Center of Synthetic Biology
(CoSBi), Hearing Research Center (HRC), and Neuromuscular Research Center (NMRC).
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New BME Faculty
OVERVIEW
Faculty Awards and Honors
BME faculty members continue to be recognized by various national and international scientific
Darren Roblyer
organizations and media. Here are some of the accolades:
Dr. Roblyer’s Roblyer’s expertise is in developing and using diffuse optical technologies for
translational applications. Specifically, he develops new instrumentation for frequency-
domain diffuse optical spectroscopic imaging (DOSI) which his group then uses to
measure quantitative values of oxyhemoglobin, deoxyhemoglobin, water and fat quantities The National Academy of Sciences’ IEEE Engineering in Medicine and Biology Professor Herb Voigt was elected Senior
from tumor tissue. These quantities are tracked over time to predict if patients are Institute of Medicine (IOM), which provides Society (EMBS), the world’s largest Member of IEEE/EMBS
responding to chemotherapy treatments. Dr. Roblyer is significantly influencing this field information and advice concerning health international society of biomedical
by investigating unprecedented early timepoints during treatment and relating optical and science policy, elected Professor James engineers, has selected Associate Professor
changes to tumor and host immune responses to cytotoxic agents. This work has the J. Collins as one of 70 new members at its Muhammad Zaman as the 2013 recipient
potential to inform new chemotherapy scheduling and dosing and could provide a tool
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to test new agents rapidly in vivo to personalize treatments. His group at BU is rapidly 42nd annual meeting. of its Early Career Achievement Award. Professor Joyce Wong was elected to be
building the scientific infrastructure to develop new imaging technologies, test new clinical Intended for current EMBS members a member of Board of Directors of the
devices, and test basic science hypotheses in preclinical models. within 10 years of completing their highest Biomedical Engineering Society
degree, the award recognizes significant
Timothy Barbari The National Academy of Inventors (NAI) contributions to the field of biomedical
elected Professors James Collins and engineering as demonstrated by innovative
Dr. Barbari joins the Faculty of the Biomedical Engineering Department and the Boston
University leadership as the Associate Provost for Graduate Affairs. Dr. Barbari’s research Mark Grinstaff as Charter Fellows, a high research, product development, patents Professor Muhammad Zaman and
and publications have been in the general areas of sorption, transport and separation professional distinction that recognizes and/or publications. his counterfeit drug detection work
of small molecules using polymer membranes. His current efforts focus on new academic innovators who have created were featured in several national and
fundamental theories for sorption and diffusion in glassy polymers and the measurement or facilitated outstanding inventions that international media outlets
of diffusion coefficients using FTIR-ATR spectroscopy. His most recent work has been on have made a tangible impact on society
the transport of biomolecules and in the biomaterials area. He has consistently published
in high quality journals over his career, has consistently secured research funding from and have been a named inventor on at Professor Edward Damiano and his Bionic
a variety of federal and industrial sources, and has given dozens of invited talks. He has least one patent issued by the U.S. Patent Pancreas Project were featured in several
made an impact and is an expert in diffusion and sorption of molecules in polymeric and Trademark Office (USPTO). They are national and international media outlets Assistant Professor Xue Han received
materials. Many researchers at laboratories around the world have picked up on Dr. among 98 innovators to receive this honor. a 2012 National Institutes of Health
Barbari’s work and have adopted his methods. His most significant achievement to date (NIH) Director’s New Innovator Award,
is the use of FTIR-ATR spectroscopy to evaluate polymer films.
which supports exceptionally creative,
Professor Simon Kasif was elected as a early-career researchers pursuing highly
The Association for Research in Fellow of the American Institute for Medical innovative projects with the potential to
Christopher Chen Otolaryngology (ARO) has selected and Biological Engineering (AIMBE) transform their field of endeavor and bring
Dr. Christopher Chen is a widely recognized world leader in the areas of tissue engineering Professor H. Steven Colburn as the 2014 about improved health outcomes.
and mechanobiology. He has already established himself as a super-star in these areas, recipient of its Award of Merit, a lifetime
and his career trajectory continues on a steep upward slope. His research focuses on achievement award recognizing outstanding
applying microfabrication and nanotechnology techniques to cell and tissue engineering, contributions to the study of the ear, nose Professor Barbara Shinn-Cunningham
and regenerative medicine. He has been instrumental in the development of engineered and throat. was selected (June 2013) to receive the Professor Catherine Klapperich was
microenvironements used to engineer cell function and guide cell and tissue growth.
The goal of his research is to identify the underlying mechanisms by which cells interact Acoustical Society of America Mentorship one of three recipients, with Harvard
with materials and with each other to construct tissues, and to use this knowledge in the Award (selected from 13 nominees), to and Johns Hopkins University, of a U54
areas of stem cell biology, tissue vascularization, regenerative medicine and cancer. His be awarded at the Fall Meeting of the award, given by NIBIB’s Point-of-Care
interests and expertise complement the research of a number of faculty within the College, Assistant Professor Xue Han was among Acoustical Society of America in San Technologies Research Network (POCTRN).
and there are numerous opportunities for Chris to develop research collaborations with a select group of leading neuroscientists Francisco. The 5 year $9M award allows for the
investigators in the new Center of Synthetic Biology, the Materials Science and Engineering
invited to the White House on April 2 to establishment of the Center for Future
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Division, the Medical Campus, as well as other major centers within the University and the
COMING ON
Boston area. Dr. Chen will be moving from the University of Pennsylvania, where he served hear President Barack Obama announce Technologies in Cancer Care (FTCC), which
as Skirkanich Professor of Innovation in Bioengineering and was founding director of the $100 million initial funding for a research will foster collaboration among doctors,
Center for Engineering Cells and Regeneration. He holds an M.D. from Harvard Medical initiative that seeks to revolutionize our Professor Barbara Shinn-Cunningham was engineers, and public health and business
School, a PhD in Medical Engineering and Medical Physics from the Harvard-MIT Health elected Vice-President of the Acoustical
understanding of the human brain. professionals at BU and elsewhere who
Sciences and Technology Program, and an M.S. in Mechanical Engineering from MIT.
Chris has received the Presidential Early Career Award for Scientists and Engineers, the Society of America, June 2013 hope to develop technology to diagnose,
Mary Hulman George Award for Biomedical Research, the Herbert W. Dickerman Award screen, and treat a variety of cancers faster,
for Outstanding Contribution to Science, and several other honors. He is a Fellow of the cheaper, and better than is done now.
American Institute for Medical and Biological Engineering and editor of the Journal of Cell
Science. Assistant Professor Xue Han was named as
Professor Jerome Mertz was profiled in
the December 7, 2013 edition of the journal a NARSAD Young Investigator by the Brain
Allison Dennis Nature Methods. The article describes his & Behavior Research Foundation Scientific Ahmed ‘Mo’ Khalil was voted Professor
Dr. Dennis’ has an impressive background in nanomaterials synthesis, functionalization and research and how the Prof Mertz became Council from 1,030 researchers NARSAD of the Year by the 2013 BME Senior Class.
conjugation, organic/polymer synthesis, and protein engineering, expression and purification. interested in the field of optics. Grants are among the most competitive in
In addition, she has extensive experience in the optical characterization (fluorescence biomedical research because of the great
spectroscopy and microscopy) of quantum dots (QDs) and fluorescent proteins, including ability and career success of the applicants.
in-depth studies and optimization of QD-protein energy transfer processes. She also
The grants are helpful in funding innovative
received numerous awards in recognition of her novel work into coupled QD-fluorescent
protein pairs, including the 2009 Biomedical Engineering Society Extended Abstract Award, research, research that would otherwise not
an Ocean Optics Young Investigator of the Year Award, SPIE BioS 2008, and the prestigious get funded.
National Defense Science and Engineering Graduate Fellowship.
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MicroFluidics 2.0
Significant Events During the
OVERVIEW The Klapperich Laboratory and the Boston University Department of Biomedical Engineering hosted the
second annual workshop on capillary based microfluidics for bioanalysis conference on November 30,
and December 1, 2012. Day one consisted of lectures and a poster session and day two included several
2012-2013 Academic Year hands on demonstrations and laboratory sessions.
Day 1
Dr. Richard Crooks, Department of Chemistry & Biochemistry, The University of Texas at Austin, “Amplification and
Electrochemical Detection Strategies Implemented in
Origami-based Paper Fluidic Devices.”
Coulter Birthday Celebration Dr. Karen Gleason, Alexander and I. Michael Kasser Professor of Chemical Engineering, MIT, “Paper Photovoltaics.”
On February 27, the BME Department convened a special Dr. Ratmir Derda, Department of Chemistry, University of Alberta, ““Paper Petri Dishes”: Point-of-Care Production,
poster session and dinner to celebrate the Boston University- Culture, and Antibiotic Screening.”
Coulter Translational Partnership (BU-CTP) program, a joint
effort between the Biomedical Engineering Department and the Jose Gomez-Marquez, MIT- Little Devices Group, Cambridge, MA, “Design for Hack in Paper Diagnostics.”
Wallace H. Coulter Foundation to support collaborations between
BME researchers and clinicians seeking to upgrade patient Dr. John D. Brennan, Canada Research Chair in Bioanalytical Chemistry, Department of Chemistry, McMaster
care through technological innovation. Since 2006, dozens of University, “Bioactive Paper Diagnostics for Assessing Food and Water Safety.”
advances have been funded, in part, by the BU-CTP program.
Drawing 140 guests including BME faculty, undergraduate and Dr. Bernhard Weigl, PATH, Seattle, WA, “2DPN and Other Non-Instrumented Assay Methods for Global Health
graduate students, BU Office of Technology Development staff, Applications”
and representatives of the Coulter Foundation, the gathering
Hands-on Demonstrations (College of Engineering Building at 44 Cummington St.)
highlighted the societal impact of biomedical technologies
Dr. Jacqueline Linnes, Department of Biomedical Engineering, Boston University, “Adher.io TB, A Paper-Based Drug
supported by the BU-CTP program and featured several posters Adherence Monitor.”
describing funded projects. The celebration is also part of the
Foundation’s yearlong celebration of the 100th anniversary of Dr. Marya Lieberman, Department of Chemistry and Biochemistry, University of Notre Dame, “Fast screening for Low-
Wallace H. Coulter’s birth, and explored the impactful work of Quality Pharmaceuticals with Paper Millifluidic devices.
Wallace H. Coulter, the inventor of the Coulter Principle, which
became the reference method for counting and sizing microscopic Dr. Barry Lutz, Department of Bioengineering, University of Washington, Seattle, WA, “Programming Paper Networks
particles suspended in a fluid, and led to one of today’s most for Automated Point of Care Assays.”
common medical diagnostic tests: the complete blood count.
Day 2
Dr. Charlie Mace, Diagnostics for All, Cambridge, MA, “A Paper-Based Point-of-Care Test for Liver Function.”
Visiting Committee
Dr. Marya Lieberman, Department of Chemistry and Biochemistry, University of Notre Dame, “Making and Testing a
The BME Visiting Committee convenes approximately every 18 months to review BME Academic Programs and provide Paper Device to Detect Low-Quality Pharmaceuticals.”
feedback to the department. They met on May 2, 2013 for a daylong session with the Department Leadership, and a
dinner with the entire faculty. The Chair gave an overview of the department and each Associate Chair (Graduate and Dr. Ratmir Derda, Department of Chemistry, University of Alberta,“Paper Petri Dishes.”
Undergraduate) discussed their programs; and the Graduate Admissions Director discussed recruitment. Also presenting
were Jim Collins on the new Center of Systems Biology and Cathie Klapperich on her Center for Future Technologies in Dr. Paul Yager Laboratory, Department of Bioengineering, University of Washington, Seattle, WA, “Flow visualization by
electrochemical marking.”
Cancer Care. Feedback was provides to the Chair and Dean. Many of the Visiting Committee remained in Boston for
the Senior Project Conference on May 3rd. Dr. Paul Yager Laboratory, Department of Bioengineering, University of Washington, Seattle, WA, “Controlled Release
of Patterned Dry Reagents“
BME Visiting Committee
Dr. John Brennan, “Bioactive Paper Diagnostics for Assessing Food and Water Safety.”
Ravi Bellamkonda*, PhD Professor & Chair BME, Georgia Institute of Technology
Becky Bergman*, PhD Vice President, New Therapies & Diagnostics Cardiac Rhythm Disease Management, Medtronic
James Burns, PhD Head of Sanofi Boston R&D Hub Genzyme, a Sanofi Company
Robert Clarke, PhD CEO Pulmatrix, Inc. Center of Synthetic Biology (CoSBi)
Art Coury*, PhD Consultant
On April 15, 2013 University Provost Jean Morrison approved the charter for launching a
Todd Giorgio, PhD Professor & Chair BME, Vanderbilt University
new Center of Synthetic Biology (CoSBi) Synthetic Biology is bringing together engineers,
Steven Girouard, PhD Managing Director Ten15 Ventures biologists, and other scientists to specify, design and construct molecular biological systems
and use these systems to rewire and reprogram organisms. The center will bring faculty
Warren Grill, PhD Professor BME, Duke University
members that bridge diverse areas of synthetic biology research, including microbial
Sheila Hemeon-Heyer, PhD President Heyer Regulatory Solutions, LLC engineering, immuno-engineering, computer aided design (CAD) and automation, stem cell
engineering, single cell analysis, and dynamical systems modeling. The core faculty include:
Patrick Loughlin, PhD Professor Bioengineering, University of Pittsburgh
Prof James Collins, Founding Director, Assistant Professor Douglas Densmore, Assistant
Kristina Ropella, PhD Professor & Executive Associate Dean College of Engineering, Marquette University Professor Ahmad “Mo” Khalil, Deputy Director, and Assistant Professor Wilson W. Wong.
( * did not attend May 2, 2013 meeting)
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Primary Faculty Contd.
Primary Faculty
XUE HAN AMIT MELLER
Assistant Professor, Biomedical Engineering Associate Professor, Biomedical Engineering
PhD, Physiology, University of Wisconsin-Madison; PhD, Msc, Physics, Weizmann Institute of Science,
Timothy Barbari CARLO J. DE LUCA BS, Biophysics, Beijing University Rehovot Israel, BS, Tel Aviv University
Professor, Biomedical Engineering, Professor, Biomedical Engineering & Neurology,
Associate Provost for Graduate Affairs Research Professor Electrical and Computer Neuroengineering Lab bu.edu/meller/
PhD, Chemical Engineering, University of Engineering; Director, NMRC bu.edu/neuroengineering Nanopore force spectroscopy of RNA folding
Texas at Austin. BASc, U of British Columbia, MSc, U of Neurotechnology, optical neural modulation, kinetics, DNA switches and transcription
New Brunswick, PhD, Queens University (Canada) optogenetics, neural prosthetics, neural network initiation kinetics, RNA helicase activity,
bu.edu/provost/about/administration/timothy-barbari/
Motor Unit Lab dynamics, brain rhythms, neurological and transcription factor/DNA interaction ultra fast
Biomaterials, hydrogels, membranes, biomolecular
bu.edu/bme/research/labs/mu psychiatric diseases, cognition. DNA sequencing optical methods for single
transport and binding, biosensors
Motor control of normal and abnormal muscles; molecule detection.
objective evaluation of muscle fatigue, objective
assessment of functional activities in humans; ANDREW C. JACKSON
biosignals. Professor, Biomedical Engineering
JEROME MERTZ
BS, MS, Mechanical Engineering, University of Nevada,
IRVING J. BIGIO Professor,
MICAH DEMBO PhD, Biophysics and Physiology,
Professor, Biomedical Engineering, Biomedical Engineering & Physics
Professor, Biomedical Engineering University of Mississippi Medical School
Electrical and Computer Engineering; and Physics PhD, Physics, Université Paris VI &
BS, Mathematics, Allegheny College, Respiratory Research
FACULTY
PhD, Physics, University of Michigan University of California, Santa Barbara,

PhD, Biomathematics, Cornell University
Biomedical Optics Lab bu.edu/bme/research/labs/rr BA, Physics Princeton University
Cellular and Sub-cellular Mechanics Lab
bu.edu/bme/research/labs/bo Respiratory physiology; respiratory mechanics,
bu.edu/bme/research/labs/csm Biomicroscopy Lab
Medical applications of optics, lasers and role of airway closure in asthma.
Statistical mechanics in biological systems; cell bu.edu/bme/research/labs/bl
spectroscopy; biomedical optics and biophotonics; information processing and signal transduction; Development and application of new optical microscopy
biomolecular dynamics; applied spectroscopy, especially to thermodynamics and mechanics of cell adhesion; techniques to biological imaging.
biomedical problems; nonlinear optics, quantum electronics SIMON KASIF
biophysics of cell deformation, active motility.
and laser physics. Professor, Biomedical Engineering
BSc, Mathematics, Tel Aviv University; DAVID C. MOUNTAIN
MS & PhD, Computer Science, Professor, Biomedical Engineering & Otolaryngology
H. STEVEN COLBURN SOLOMON EISENBERG
Professor, Biomedical Engineering, University of Maryland MS, PhD, Electrical Engineering,
Professor & Chair Biomedical Engineering; Professor,
Director, Hearing Research Center Computational Genomics University of Wisconsin
Electrical and Computer Engineering, Assoc Dean
SB, SM, PhD, Electrical Engineering, MIT for Undergrad Programs, College of Engineering bu.edu/bme/research/labs/cg Auditory Biophysics and Simulation Lab
SB, SM, ScD, Electrical Engineering, MIT Bioinformatics, Computational Genomics, bu.edu/bme/research/abs
Binaural Hearing Lab
Fields and Tissues Lab Algorithm Design, Artificial Intelligence, High Auditory information processing; sensory biophysics;
bu.edu/bme/research/labs/bh
Electrically mediated phenomena in tissues and biopolymers; Performance Systems. computer simulation; biomedical electronics; biomedical
Measurement and modeling of binaural hearing
cartilage biomechanics; computational modeling of electric signal processing; environmental engineering.
performance. Modeling the activity of auditory
field distributions in the human thorax and heart during
brainstem neurons and measurement and modeling of defibrillation; transcranial magnetic stimulation. AHMAD (MO) KHALIL
Assistant Professor, Biomedical Engineering
JASON RITT
spatial attributes of sound perception.
Assistant Professor, Biomedical Engineering
BS, Mechanical Engineering, Stanford University;
BS, MA Mathematics, PhD Neuroscience
JAMES J. COLLINS M.S & PhD, Mechanical Engineering, Massachusetts
Boston University
Professor, Biomedical Engineering; MAXIM D. FRANK-KAMENETSKII Institute of Technology
University Professor Professor, Biomedical Engineering bu.edu/khalillab/ Ritt Lab
AB, Physics, College of the Holy Cross; MSc, PhD, Biophysics, Moscow Physical-Technical Institute, Synthetic biology; systems biology; bu.edu/bme/research/labs/ritt-lab/
PhD, Medical Engineering, University of Oxford ScD (IVth degree), Physical and Mathematical Sciences, programmable microfluidics; transcription Neuroscience of sensorimotor behaviors; biological active
regulation, mechanobiology; single-cell analysis; sensing; role of embodiment in neural computation; brain
Collins Lab Institute of Chemical Physics, USSR
single-molecule biophysics, machine interfaces; sensory prosthetics.
bu.edu/bme/research/labs/abd bu.edu/bme/people/primary/frankkamenetskii/
Synthetic biology; systems biology; engineered gene DNA structures; DNA topology; DNA functioning, PNA
networks. (peptide nucleic acid) Darren Roblyer
CATHERINE KLAPPERICH
Associate Professor, Primary Appointment Assistant Professor of Biomedical Engineering.
EDWARD DAMIANO Mechanical Engineering PhD, bioengineering, Rice University;
Associate Professor, Biomedical Engineering PhD, Mechanical Engineering, UC, Berkeley; SM, BS, Biomedical Engineering, Johns Hopkins
JAMES GALAGAN
PhD, Applied Mechanics, RPI; Engineering Sciences, Harvard University Biomedical Optical Technologies Lab
Associate Professor, Biomedical Engineering
http://www.bu.edu/botlab/
MS, Mech Eng, Washington Univ; and Microbiology, BUSM, Associate Director, Biomedical Microdevices and Microenvironments
Optical Functional Imaging, Diffuse Optics, Near
BS, Biomedical Engineering, RPI Systems Biology of Infectious Disease Core NEIDL bu.edu/bme/research/labs/bmm
Infrared Spectroscopy, Monitoring of Emerging
Vascular Interface and Microhemofluidics Lab PhD, Computational Neuroscience, MIT Her research is focused on the design of
Targeted and Cytotoxic Therapies in Oncology,
bu.edu/bme/people/primary/damiano National Emerging Infectious Diseases Laboratory new molecular diagnostics and appropriate Non-Invasive Monitoring of Tumor Metabolism.
Integrated cellular and extracellular biomechanics; bu.edu/neidl technologies for healthcare.
biofluid dynamics; microhemofluidics; microcirculation; Develop efficient and accurate methodologies for the analysis
vestibular biomechanics; non-Newtonian rheology; of genomic data, with a particular focus on infectious diseases. KAMAL SEN
closed-loop blood-glucose regulation. KENNETH R. LUTCHEN
Associate Professor, Biomedical Engineering;
Professor, Biomedical Engineering,
Hearing Research Center
CHARLES DELISI Dean, College of Engineering
BA, Physics, Bates College,
Metcalf Professor of Science and Engineering; BS, Engineering Science, University of Virginia,
MA, PhD, Physics, Brandeis University
Dean Emeritus, College of Engineering MARK GRINSTAFF MS, PhD, Biomedical Engineering, Case Western
Respiratory and Physiological Systems Natural Sounds and Neural Coding
BA, Physics, City College of New York, Professor, Biomedical Engineering & Chemistry
PhD, University of Illinois at Urbana-Champaign; Identification bu.edu/bme/research/labs/nsnc
PhD, Physics, New York University
bu.edu/bme/research/labs/rpsi Electrophysiological recording of neural responses in auditory
Biomolecular Systems Lab AB, Chemistry Honors, Occidental College
Airway and lung tissue mechanics and ventilation; processing. theoretical methods to characterize neuronal
bu.edu/bme/research/labs/bmolec bu.edu/bme/people/primary/grinstaff/ Computational modeling of structure-function encoding. computational models of natural sound processing.
Developing and applying computational/mathematical Biomaterials, tissue engineering, drug delivery, relations in the lung; Mechanical ventilation;
macromolecular chemistry and engineering, Integrated biomechanics of the lung; linear and
methods, and high throughput experimental methods
nonlinear systems identification,
for inferring the structure and function of protein self-assembly, nanodevices.
blood-glucose regulation.
networks.
Primary Faculty Contd.
Research Faculty
BARBARA G. SHINN-CUNNINGHAM LUCIA M. VAINA
Dimitri Beglov
Professor, Biomedical Engineering Professor, Biomedical Engineering & Neurology IRINA V. SMOLINA
MS, U. Timisoara and Urbino; PhD Mathematical Research Assistant Professor Research Assistant Professor, Biomedical Engineering
ScB EE Brown University,
MS & PhD EE and Computer Science, MIT Logic, Sorbonne, Doctorat d’Etat ès Sciences & MS, Chemistry, Moscow Physical and Technical Institute BS in Applied Mathematics and Physics, Moscow Institute of
Médecine (Neurologie), Human & Computational PhD, Molecular Biophysics, Moscow Physical and Technical Physics and Technology, Moscow, Russia; MSc in Biophysics,
Auditory Neuroscience
Vision, Institut National Politechnique de Toulouse Institute Moscow Institute of Physics and Technology, Moscow, Russia; PhD
bu.edu/bme/research/labs/ans in Molecular Biology, Institute of Bioorganic Chemistry, Russian
Binaural and spatial hearing, perceptual effects of echoes Brain and Vision Lab Computational chemistry and biology; protein structure
Academy of Science, Moscow, Russia
and reverberation, speech and signal intelligibility in noise bu.edu/bme/research/labs/bv and function; computational characterization and Development of novel sensitive and selective techniques for
and reverberation, source segregation, auditory and cross- Computational visual neuroscience; biological and prediction of biomolecular interactions. molecular diagnostics; exploring the possible use of biological and
computational learning; functional and structural neuroimaging. synthetic DNA analogs for applications in bioengineering, molecular
modal attention, plasticity and learning in spatial perception. imaging and single-molecule analysis; new methodologies for
multiplexed detection and target quantification.
SANDOR VAJDA NATALIA BROUDE
CASSANDRA L. SMITH Research Professor, Biomedical Engineering
Professor, Biomedical Engineering THOMAS L. SZABO
Professor, Biomedical Engineering; BS, MS Organic Chemistry, Moscow State
MSc, Electrical Eng, Gubkin Institute (Former USSR), Research Professor, Biomedical Engineering
Biology, & Pharmacology University; PhD, Organic Chemistry,
MSc, Applied Mathematics, Éötvös Lorand U. (Hungary), PhD, PhD, Physics, University of Bath, UK; MS, Electrical Engineering,
BA, Biology & MS, Medical Microbiology, DSci Molecular Biology, Institute of
Chemistry, Hungarian Academy of Science University of Rochester; BS, Electrical Engineering, University of
West Virginia University Medical School, Bioorganic Chemistry
Structural BioInformatics Virginia School of Medicine
PhD, Genetics, Texas A&M University Functional genomics, structure/function relationships
bu.edu/bme/research/labs/sb Medical imaging, diagnostic ultrasound, tissue
FACULTY
FACULTY
Molecular Biotechnology Lab Scientific computing applied to problems in engineering, in nucleic acids, development of advanced methods for
bu.edu/bme/research/labs/mbl genomic studies. characterization, transduction, biomedical signal
biochemistry, and biology, with focus on molecular
Molecular Biotechnology and Genomics. processing, wave propagation, nonlinear acoustics.
mechanics, protein structure determination,
protein-ligand interactions, docking, and drug design. MARIO CABODI
Research Assistant Professor,
MICHAEL L. SMITH HERBERT F. VOIGT Biomedical Engineering
Assistant Professor, Biomedical Engineering PhD Cornell University, 2003, MSc Imperial
Emeritus
Professor, Biomedical Engineering; Associate Research Professor,
BS Mechanical Engineering University of Memphis, Otolaryngology, School of Medicine College of Science and Technology, London, UK
MS & PhD, Biomedical Engineering, PhD, Biomedical Engineering, Johns Hopkins Microfluidic devices; tissue engineering,
University of Virginia, 2004 University BE (EE), City College of New York and biomaterials.
Michael Smith Lab Auditory Neurophysiology Lab CHARLES CANTOR, PhD
bu.edu/bme/people/primary/smithm bu.edu/bme/research/labs/anp
Cellular mechanotransduction through the extracellular Auditory neurophysiology; neural circuitry; neural modeling. Professor Emeritus; Biomedical Engineering
matrix; fibronectin structural biology; and microfabricated DANIEL EHRLICH crcantor@bu.edu
surfaces for engineering cell function. Research Professor, Biomedical Engineering
BS Physics, PhD Optical Engineering,
JOYCE WONG University of Rochester, 1977
DIMITRIJE STAMENOVIĆ
Associate Professor, Biomedical Engineering Optics, lithography, biosensors and biomolecular
Associate Professor, Biomedical Engineering
SB, Materials Science and Engineering, MIT, assays, with a current emphasis on microfluidic
Dipl. Ing., Mechanical/Aeronautical Engineering, University of
Belgrade (Yugoslavia), MS, PhD, PhD, Materials Science and Engineering, instruments for high-content, high-throughput
Mechanics, University of Minnesota Program in Polymer Science and Technology, MIT cell-based assays and deep-UV imaging.
Cell and Tissue Mechanics Lab Biomimetic Materials Engineering Lab TEMPLE F. SMITH, PhD
bu.edu/bme/research/labs/ctm bu.edu/bme/research/labs/wong
Biomaterials, tailoring cell-material interfaces for drug Professor Emeritus; Biomedical Engineering
Respiratory mechanics; cell mechanics; rheology of soft EVAN EVANS
delivery and tissue engineering applications; direct, Research Professor, Biomedical Engineering tsmith@bu.edu
tissues; mechanics of foam-like structures.
quantitative measurement of biological interactions. BS, MS, Engineering Physics, Rensselaer Polytechnic Institute, PhD,
Engineering Science,
WILSON WONG University of CA at San Diego
BÉLA SUKI
Assistant Professor, Biomedical Engineering Cellular and Subcellular Mechanics Lab
Professor, Biomedical Engineering
MS, Physics, and PhD, Biomechanics, Jozsef Attila University,
BS, Chemical Engineering, University of California Berkeley, bu.edu/bme/research/labs/csm
PhD, University of California Los Angeles 2007 Nano-microscale biomechanics; ultra-sensitive force probes,
Szeged (Hungary)
bu.edu/wilsonwonglab/ extreme resolution optical techniques; material properties of
Cell and Tissue Mechanics Lab cellular structure; role of structural forces in cell biochemistry.
Synthetic and Systems Biology in immune cells
Professor of
bu.edu/bme/research/labs/ctm
Mechanical properties of living tissues; modeling the ODED GHITZA
dynamic and nonlinear behavior of complex biological Research Professor, Biomedical Engineering
systems; pulmonary physiology.
MUHAMMAD ZAMAN
BSc, MSc, PhD Electrical Engineering,
Tel Aviv University Practice
bu.edu/bme/research/labs/decoding_speech
JOE TIEN Associate Professor, Biomedical Engineering Dr. Ghitza’s current research focuses on the ARTHUR ROSENTHAL, PhD
Associate Professor, Biomedical Engineering BS, Arkansas Tech Univ. SM, Chemistry and formulation of cortical computation principles that Professor of Practice; Biomedical Engineering
BS, Physics, BS, Mathematics, University of California, PhD, Physical Chemistry University of Chicago 2003 underlie the speech decoding process and that are
capable of predicting human performance in speech arosenth@bu.edu
Irvine, AM, PhD, Physics, Harvard University Lab for Engineering Education & Development
Tien Lab bu.edu/leed perception tasks.
bu.edu/bme/research/labs/tien-lab Comprehensive and quantitative approaches to develop
New techniques to vascularize biomaterials; focus on a multiscale understanding of cell-matrix interactions for DMYTRO KOZAKOV
synthesis of microfluidic biomaterials (materials that fundamental biological and applied clinical research. Research Assistant Professor,
contain open channels for perfusion), the quantitative Biomedical Engineering
physiology of engineered microvessels, and the BS & MS Applied Math and Physics, Moscow
computational design of vascular systems. Inst of Physics and Tech;
PhD Biomedical Engineering Boston University, 2006
Development of protein-protein and protein-ligand
docking algorithms, fast and efficient scoring
functions for screening large number of potential
docked complexes, protein homology models
suitable for docking.
Affiliated Faculty MICHELE RUCCI, PhD Adjunct Faculty
CHRISTOPHER CONNOR,
MD, PhD
JOEL HENDERSON, MD, PhD
Assistant Professor;
Associate Professor;
Psychology,
Biomedical Engineering
POSTDOCS SYLVAN GIOUX, PhD
Adjunct Assistant Professor; Biomedical
Engineering, Beth Israel Deaconess
Assistant Professor; Pathology & Laboratory Barakov, Roman, Postdoctoral Associate (Mertz)
Medical Center for Molecular Imaging
Anesthesiology, Medicine, Baritaux, Jean Charles, Postdoctoral Associate (Mertz)
Biomedical Engineering Biomedical Engineering Bashor, Caleb, Postdoctoral Associate (Collins) DAVID KACZKA, MD/PhD
Belenky, Ryan, Postdoctoral Associate (Collins) Adjunct Assistant Professor; Biomedical
DANIEL SEGRÈ, PhD
Bhargava, Prerna, Postdoctoral Associate (Collins) Engineering Beth Israel Deaconess Medical
Associate Professor; Biology, Brynildsen, Mark, Postdoctoral Associate (Collins)
DOUGLAS DENSMORE, PhD ALLYN E. HUBBARD, PhD Center Department of Anesthesia, Critical
Biomedical Engineering Burrill, Devin, Postdoctoral Associate (Collins)
Professor; Electrical & Care & Pain Medicine
Assistant Professor; Electrical & Calabro, Finnegan, Postdoctoral Associate (Vaina)
Computer Engineering, Computer Engineering,
Cameron, Ewen, Postdoctoral Associate (Collins) JONATHAN ROSEN, PhD
Biomedical Engineering Biomedical Engineering
Chan, Clement, Postdoctoral Associate (Collins) Adjunct Professor; Biomedical Engineering
Choi, Han-Pil, Postdoctoral Associate (Kasif) Director of Technology Innovation Education
SATISH K. SINGH, MD Cohen, Nadia, Postdoctoral Associate (Collins) Program, College of Engineering
THOMAS EINHORN, MD Laertis ikonomou, PhD
Assistant Professor; Costello, James, Postdoctoral Associate (Collins)
Chairman; Orthopedic Surgery, Assistant Professor; Medicine, Gastroenterology, Dusconchet, Julien, Postdoctoral Fellow (Collins) HERNAN JARA, PhD
FACULTY
Professor; Orthopedic Surgery, Biomedical Engineering Fan, Andy, Senior Postdoctoral Associate (Klapperich) Adjunct Associate Professor, Biomedical
Biomedical Engineering Gramse, Verena, Postdoctoral Fellow (Vaina) Engineering, Associate Professor of Radiology,
Hayashi, Gosuke, Postdoctoral Associate (Collins) Boston University School of Medicine
W. CLEMENT KARL, PhD H. EUGENE STANLEY, PhD Hosseinidoust, Zeinab, Postdoctoral Fellow (Collins)
Professor; Electrical & Professor; Physics, Hu, Yingying, Postdoctoral Associate (Suki)
SHYAMSUNDER Computer Engineering, Huang, Shichu, Postdoctoral Associate (Klapperich)
Chemistry,
RESEARCH STAFF
ERRAMILLI, PhD Biomedical Engineering Biomedical Engineering
Jehl, Stefan, Postdoctoral Associate (Vaida)
Professor; Physics, Kalghagti, Sameer, Postdoctoral Associate (Collins)
Biomedical Engineering Keung, Albert, Postdoctoral Associate (Khalil)
Kohman, Richard, Postdoctoral Associate (Han)
Krueger, Andrew, Postdoctoral Associate (Galagan) A’amar, Ousama, Senior Research Engineer (Bigio)
NANCY KOPELL, PhD MARTIN STEFFEN, PhD Anderson, David, Research Engineer (Mountain)
Kumar, Roshan, Postdoctoral Fellow (Collins)
Professor; Mathematics, Assistant Professor; Atas, Evrim, Research Scientist (Meller)
BENNETT GOLDBERG, PhD Lee, Elaine, Postdoctoral Fellow (Wong, J.) Bartolak-Suki, Elizabeth, Senior Research Scientist (Suki)
Biomedical Engineering Pathology & Laboratory
Lee, Jeong Wook, Postdoctoral Associate (Collins) Beg, Quasim, Research Scientist (Segre)
Professor; Physics, Medicine,
Lepzelter, David, Postdoctoral Associate (Zaman) Berardino, Alexander, Laboratory Assistant (Ritt)
Biomedical Engineering Biomedical Engineering
Levy-Moonshine, Amy, Postdoctoral Associate (Kasif) Brughera, Andrew, Research Engineer, (Mountain)
Li, Hu, Postdoctoral Associate (Collins) Canham, Amy, Laboratory Assistant (Zaman)
ELISE F. MORGAN, PhD
Lin, Jianxun, Postdoctoral Associate (Meller) Cariani, Peter, Senior Research Scientist (Colburn)
Associate Professor; MALVIN C. TEICH, PhD Linnes, Jaqueline, Postdoctoral Associate (Klapperich) Cheung, Man Ching, Research Scientist (Ehrlich)
Mechanical Engineering, Professor Emeritus; Electrical & Lobritz, Michael, Postdoctoral Fellow (Collins) Chinnala, Jyothsna, Laboratory Assistant (Unlu)
LEE GOLDSTEIN, MD, PhD Biomedical Engineering Computer Engineering, Chirn, Gung Wei, Research Scientist (Kasif)
Majumdar, Arnab, Postdoctoral Associate (Suki)
Associate Professor; Psychiatry, Physics, Delhorne, Lorraine, Senior Research Scientist (Colburn)
Mamonov, Artem, Postdoctoral Associate (Vajda)
Neurology, Opthalmology, Dellon, Brian, Research Engineer (Colburn)
Biomedical Engineering Meylan, Sylvain, Postdoctoral Fellow (Collins)
Pathology & Laboratory Medi- Dwyer,Dan, Senior Research Scientist (Collins)
Mineava, Olga, Postdoctoral Associate (Goldstein) El-Khatib, Firas, Senior Research Scientist (Damiano)
cine, Modi, Sheetal, Postdoctoral Associate (Collins)
S. HAMID NAWAB, PhD Fernandes, Andrea, Laboratory Assistant (Zaman)
Biomedical Engineering O’Gorman, David, Senior Postdoctoral Associate (Colburn)
Professor; Electrical & Freedman, Daniel, Research Engineer (Ritt)
M. SELIM ÜNLÜ, PhD Oh, Herin, Postdoctoral Associate (Smith, C.) Guerra, Kevin, Laboratory Assistant (Han)
STEPHEN GROSSBERG, PhD Computer Engineering,
Professor; Electrical & Computer Oliveria, Claudio, Postdoctoral Fellow (Suki) Imada, Alicia, Laboratory Assistant (Ritt)
Professor; Mathematics, Engineering, Parameswaran, Harikrishnan, Senior Postdoctoral Associate (Lutchen) Irani Shemirani, Atena, Laboratory Assistant (Zaman)
Psychology, Biomedical Engineering Pardee, Keith, Postdoctoral Associate (Collins) Isenberg, Brett, Research Assistant (Wong)
Biomedical Engineering, Park, Yoonjee, Postdoctoral Associate (Wong, J.) Istfan, Raeef, Laboratory Assistant (Roblyer)
Jiang, John, Research Scientist (Damiano)
Peng, Zhiyong (Jerry), Postdoctoral Associate (Collins)
MATTHEW NUGENT, PhD Kuznetsov, Igor, Research Scientist (Evans)
Perrone, Benjamin, Postdoctoral Associate (Ritt) MacDonald, Cody, Laboratory Assistant (Collins)
Professor; Biochemistry,
FRANK GUENTHER, MS, PhD YU (BRANDON) XIA, PhD Shapiro, Rebecca, Postdoctoral Fellow (Collins) McKenna, Brian, Research Engineer (Ehrlich)
Ophthalmology,
Associate Professor; Sargent Col- Assistant Professor; Slomovic, Shimyn, Postdoctoral Associate (Collins) McKeon, Katherine, Laboratory Assistant (Damiano)
lege, Speech Language & Hearing Chemistry, Solski, Patricia, Postdoctoral Associate (Wong) Molla, Michael, Research Scientist (Kasif)
Science, Biomedical Engineering Biomedical Engineering Soncini, Roseli, Postdoctoral Fellow (Suki) Orucoglu, Rozana, Laboratory Assistant (Collins)
Takahashi, Ayuko, Postdoctoral Associate (Suki) Pyenson, Nora, Laboratory Assistant (Collins)
Truslow, James, Postdoctoral Associate (Tien) Ramanlal, Shreshtha, Laboratory Assistant (Han)
TYRONE M. PORTER, PhD Ramey, Kirk, Research Engineer (Damiano)
Tseng, Hua-an, Postdoctoral Associate (Han)
Associate Professor; Vega, Nicole, Postdoctoral Associate (Collins) Schwarz, Eric, Laboratory Assistant (Collins)
JAMES A. HAMILTON, PhD KATHERINE YANHANG Telian, Greg, Laboratory Assistant (Ritt)
Mechanical Engineering, Walsh, Anthony, Postdoctoral Associate (Wong, W.)
Professor; Physiology &
Biomedical Engineering ZHANG, PhD Tubelli, Andrew A., Laboratory Assistant (Mountain)
Biophysics,
Winkler, Jonathan, Postdoctoral Associate (Collins) Voysey, Graham, Research Engineer (Mountain)
Associate Professor;
Wong, Keith, Postdoctoral Associate (Tien) Zosuls, Alex, Research Engineer (Mountain)
Mechanical
Wong, Sharon, Postdoctoral Associate (Klapperich)
Engineering,
Yang, Jason, Postdoctoral Associate (Collins)
18 Biomedical Engineering
B O S TO N U N I V E R S I T Y D E PA R T M E N T O F B I O M E D I C A L E N G I N E E R I N G 2 0 1 2 - 2 0 1 3 A N N U A L R E P O R T
Zhou, Jiamin, Postdoctoral Associate (Han) 19
BME GRANT FUNDING BY AGENCY The largest funding source is NIH (52%) followed by
External Research Funding NSF (19%) then DOD (13%), Foundations (10%), Industry
(1%) and other Government Sources (1%). 4% of the

IND
NIH
The Biomedical Engineering Department maintains a vibrant research program in its approximately 68,000 square US
TR funding received in FY13 was dedicated to graduate student
feet of space at 24-44 Cummington St., on Boston University’s Charles River Campus. We are comprised of 34 OTH Y
ER G 1%
52%
separate research laboratories and 6 research centers. The research can be characterized by a combination of: OVT funding through 3 training grants and funding from local
1%
area hospitals and universities.
• empirical and theoretical work with an attention to explicit mathematical
models for the phenomena under study, FOUNDATIONS 10%
• intensive computer use for experimental and theoretical work,

BME Graduate Student Training Grants:
• a basic scientific flavor to the fundamental questions being asked, 13% Quantitative Biology and Physiology (NIH, Bigio PI)
D
• an attention to the applications of the work to the improvement of health care, DO 7 students
and a thorough understanding of the underlying physiological processes.
RESEARCH
Translations Research in Biomaterials (NIH, Grinstaff PI)
4%
9%
4 students
NSF 1
Student
RESEARCH AREAS IN BME Training in Computational Neuroscience (NIH, Mountain PI)
1 student
Support
Synthetic Biology and Systems Biology Biomedical Application of Nanotechnology
Neural Engineering and Hearing Research Biomedical Optics and Imaging
Subcellular, Cellular and Systems Biomechanics Biomaterials and Tissue Engineering
Molecular Bioengineering Engineering Global Health
NIH AWARDS
Principal
TITLE OF PROJECT INSTITUTE Amount
Investigator
The 36 primary faculty and 9 research faculty received I. Bigio OPTICAL IMAGING OF CHEMOTHERAPY FOR BRAIN TUMORS (subcontract Columbia U) NCI 100,880
$26,127,082
I. Bigio ENHANCED INTRAARTERIAL DELIVERY OF CHEMOTHERAPEUTIC DRUGS TO THE BRAIN (subcontract Columbia U) NCI 91,672
I. Bigio MARGIN GUIDANCE FOR ORAL CANCER RESECTION USING LIGHT SCATTERING SPECTROSCOPY (subcontract BMC) NIDCR 123,220
S. Colburn CORE CENTER GRANT - SOUND FIELD LABORATORY (CORE 1) NIDCD 207,979
S. Colburn BILATERAL COCHLEAR IMPLANTS: PHYSIOLOGY AND PSYCHOPHYSICS (subcontract MEEI) NIDCD 59,519
S. Colburn CORE CENTER GRANT - ENGINEERING (CORE 3) NIDCD 230,850

new research funding during the period 7/1/2012 through 6/30/2013 from
S. Colburn BINAURAL HEARING NIDCD 581,167
85 n ew and cont i nui ng f und i ng awa rd s . J. Collins BOSTON OAIC: A TRANSLATIONAL APPROACH TO FUNCTION PROMOTING ANABOLIC THERAPIES (subcontract BMC) NIA 32,737
Th ey su b mitted ove r $1 3 4 M i n re s e a rc h p rop os al s . J. Collins CUSTOMIZED STEM CELLS FOR CLINICAL APPLICATION IN BLOOD DISORDERS (subcontract CHB) NIDDK 171,735
E. Damiano CLINICAL TRIALS OF A CLOSED-LOOP CONTROL SYSTEM FOR TYPE 1 DIABETES MANAGEMENT NIDDK 13,65,773
E. Damiano TRANSLATIONAL STUDIES OF A BIONIC PANCREAS FOR OUT-PATIENT DIABETES MANAGEMENT NIDDK 647,999
B M E FACU LTY AN N UAL TOTAL G RAN T FUN D I N G
$30 mil C. Delisi VISANT-PREDICTOME: A SYSTEM FOR INTEGRATION, MINING, VISUALIZATION AND ANALYSIS NIGMS 778,477
M.Dembo CORE C: TRACTION FORCE MICROSCOPY (subcontract U Rochester) NHLBI 20,265

GR A N T I N CO M E
$25 mil
D. EHRLICH HIGH THROUGHPUT BIOMEMS DNA SEQUENCING NHGRI 702,204
$20 mil E. Evans KINETIC AND MECHANICAL PROPERTIES OF ALB2 INTEGRIN (subcontract Georgia Tech) NIH 70,344
$15 mil J. Galagan A SYSTEMS BIOLOGY APPROACH TO INFECTIOUS DISEASE RESEARCH (subcontract Stanford) NIAID 1,061,999
J. Galagan FUNCTIONAL ANALYSIS AND SYSTEMS BIOLOGY OF FILAMENTOUS FUNGI (subcontract Dartmouth) NIGMS 335,864
$10 mil
M. Grinstaff FLEXIBLE, CONFORMAL, POLYMERIC FILMS FOR LUNG RESECTION MARGINS NCI 326,094
$5 mil M. Grinstaff CHARACTERIZING ELECTROSTATIC INTERACTIONS BETWEEN GLYCOSAMINOGLYCANS AND CATIONIC SMALL MOLECULES NIH 300,144
2004 2005 2006 2007 2008 2009 2010 2011 2012 2013
20 B O S TO N U N I V E R S I T Y D E PA R T M E N T O F B I O M E D I C A L E N G I N E E R I N G 2 0 1 2 - 2 0 1 3 A N N U A L R E P O R T
F ISCA L Y E A R w w w . b u . e d u / b m e /a b o u t /a n n u a l r e p o r t
NIH AWARDS (cont.) AWARDS FROM FOUNDATIONS
Principal Title of Project institute Amount
Investigator Principal Title of Project FOUNDATION Amount
A PORTABLE WOUND HEMOSTASIS SYSTEM USING A HYDROGEL POLYMERIC FOAM (subcontract BIDMC) 81,792
Investigator
M. Grinstaff NIBIB
J. Collins COLLINS LAB WYSS FUNDS WYSS INST 300,000
X. HAN STRIATAL ORIGIN OF PATHOLOGICAL BETA OSCILLATIONS IN PARKINSON’S DISEASE NINDS 245,550
E. DAMIANO CLOSED-LOOP, MICRODOSE GLUCAGON ADMINISTRATION FOR THE AUTOMATED PREVENTION AND AMERICAN DIABETES 42,134
X. HAN LIGHT CONTROLLABLE NANOROBOT FOR UNCAGING ARBITRARY BIOACTIVE MOLECULES NINDS 491,100
TREATMENT OF HYPOGLYCEMIA (subcontract MGH) ASSOCIATION
S. KASIF DIABETES RESEARCH CENTER-GENOMICS CORE (subcontract Joslin Diabetes Center) NIDDK 236,689 NEUROMUSCULAR RESEARCH
C. DELUCA NMRC SPONSORED RESEARCH AGREEMENT
FOUNDATION 500,000
S. KASIF EXPANSION OF THE DIABETES RESEARCH CENTER’S PILOT AND FEASIBILITY PROGRAM NIDDK 66,666
(subcontract Joslin Diabetes Center) X. HAN NEURAL CIRCUIT MECHANISMS OF ATTENTION THE PEW CHARITABLE TRUSTS 240,000
S. KASIF SUPPORT POSTDOC (Joslin Diabetes Center) NIDDK 15,769 BRAIN & BEHAVIOR RESEARCH
X. HAN THALAMOCORTICAL CIRCUIT DYSFUNCTION IN SCHIZOPHRENIA 30,000
FOUNDATION
S. KASIF SUPPORT POSTDOC (Joslin Diabetes Center) NIDDK 44,634
X. HAN MDR1/P-GP OVEREXPRESSION AND NEGATIVE FEEDBACK INSENSITIVITY IN CRSWNP (subcontract MEEI) AMERICAN RHINOLOGIC SOCIETY 14,989
C. Klapperich BACTERIAL DRUG SUSCEPTIBILITY IDENTIFICATION BY SURFACE ENHANCED RAMAN MICROSCOPY NIAID 85,000
X.HAN NON-INVASIVE STRIATAL DELIVERY OF GLIAL DERIVED NEUROTROPHIC FACTOR (GDNF) VIA A NOVEL MJ FOX FOUNDATION 93,636
HETEROTOPIC MUCOSAL GRAFTING TECHNIQUE (subcontract MEEI
C. Klapperich INTEGRATED MOLECULAR DIAGNOSTIC SYSTEM FOR POINT-OF-CARE NIAID 104,073
RESEARCH
(subcontract Biohelix Corp.) J. RITT CAREER AWARD AT SCIENTIFIC INTERFACE BURROUGHS WELLCOME FUND 120,000
C. Klapperich CENTER FOR INNOVATION IN POINT OF CARE TECHNOLOGIES FOR THE FUTURE OF CANCER CARE NIBIB 1,929,735 REAL-TIME NON-INVASIVE OPTICAL MARKERS OF CHEMOTHERAPY RESPONSE FOR
D.ROBLYER AMERICAN CANCER SOCIETY 30,000
PERSONALIZED ADAPTIVE CANCER TREATMENT
K. LUTCHEN FACTORS DETERMINING HYPERRESPONSIVENESS FOR INTACT AIRWAYS NHLBI 421,167
M. ZAMAN PHARMACHECK NATIONAL COLLEGIATE 5,000
INVENTORS AND INNOVATORS
I. SMOLINA DEVELOPMENT OF NOVEL FIELD-APPROPRIATE DIFFERENTIAL DIAGNOSTICS OF NIAID 222,129 ALLIANCE (NCIIA)
MULTIPLE PATHOGENS AND THEIR DRUG SENSITIVITIES BASED ON PNA-RCA METHOD
AND DNA APTAMER BIOSENSORS
B. SUKI REGULATORY ROLES OF VARIABLE MECHANICAL STIMULI IN CELL FUNCTION NHLBI 465,252
AWARDS FROM DOD

B. SUKI ENDOGENOUS SURFACTANT THERAPY FOR THE DEVELOPING LUNG NHLBI 485,783
S. VAJDA COMPUTATIONAL MAPPING OF PROTEINS FOR THE BINDING OF LIGANDS NIGMS 343,258
Principal Title of Project Granting Agency Amount
S. VAJDA A MULTISTAGE APPROACH TO PROTEIN-PROTEIN DOCKING NIGMS 284,681 Investigator
J. WONG MODELS TO PREDICT PROTEIN BIOMATERIAL PERFORMANCE (subcontract Tufts) NIBIB 212,788 J. COLLINS UTILIZING SYNTHETIC BIOLOGY TO CREATE PROGRAMMABLE MICRO-BIO-ROBOTS DOD/ONR 750,000
M. ZAMAN MECHANICS OF MONOLAYER MIGRATION (subcontract Harvard) NHLBI 81,626 J. COLLINS SYNTHETIC MAMMALIAN GENE REGULATORY CIRCUITS FOR IN VIVO BIOMEDICAL APPLICATIONS DOD/ARO 1,154,472
CENTER FOR SYSTEMATIC MODELING OF CANCER DEVELOPMENT PILOT PROJECT: MULTI-SCALE NCI 50,000
M. ZAMAN J. COLLINS GENETIC SYSTEMS FOR RECORDING MISUSE AND ESCAPE OF MICROBES (subcontract Harvard) DOD/DARPA 477,031
MODELING OF MOLECULAR AND CELLULAR EVENTS IN 3D TUMOR CELL MIGRATION (subcontract
Methodist Hospital Research Inst.)
J. COLLINS REDUNDANT SAFETY SWITCHES FOR THE ENVIRONMENTAL CONFINEMENT OF ENGINEERED SPACE & NAVAL WARFARE 106,071
MODELING BI-DIRECTIONAL SIGNALING AND CYTOSKELETAL DYNAMICS IN NCI 493,300 ORGANISMS (subcontract MIT) SYSTEMS CENTER
M. ZAMAN 3D CELL MIGRATION O. GHITZA CASCADING OSCILLATORS IN DECODING SPEECH: REFLECTION OF A CORTICAL COMPUTATION DOD/AFOSR 249,123
D. MOUNTAIN UNDERWATER HEARING: WHALES AND DOLPHINS DOD/ONR 74,300
B. SHINN- DOD/ONR 600,000
MANAGING ACOUSTIC COMMUNICATIONS IN HIGH-STRESS SETTINGS
CUNNINGHAM
NSF AWARDS
Principal
Investigator
Title of Project DIRECTORATE Amount AWARDS FROM OTHER GOVERNMENT AGENCIES
Principal Title of Project Granting Agency Amount
B. SHINN- Social, Behavioral & Economic
CUNNINGHAM
SLC CENTER: CELEST: A CENTER FOR LEARNING IN EDUCATION, SCIENCE AND TECHNOLOGY 3,750,000 Investigator
Sciences( SBE)
B. SHINN- Information and Intelligent DEVELOPING SUPERIOR SCREENING TECHNOLOGY FOR MEDICINES QUALITY CONTROL IN LOW
COMPUTATIONAL AUDITION WORKSHOP 27,000 M. ZAMAN USAID 100,000
CUNNINGHAM Systems (IIS) RESOURCE COUNTRIES subcontract US Pharmacopeial Conv.)
M. SMITH Chemical, Bioengineering,
CAREER: REGULATION OF MULTICELLULAR BEHAVIOR WITH AN EXTRACE 90,000 M. ZAMAN SEED GRANT-ARAB AMERICAN FRONTIERS (subcontract National Academy of Sciences) USAID 3,050
Environmental, and Transport
Systems (CBET)
M. ZAMAN PHARMACHECK: COUNTERFEIT AND SUBSTANDARD DRUG DETECTOR DEVICE FOR USAID 249,998
S. VAJDA ABI DEVELOPMENT: REFINEMENT ALGORITHMS AND SERVER FOR PROTEIN DOCKING THE DEVELOPING WORLD
Biological Infrastructure (DBI) 184,068
PESO: ENGINEERED PLATFORMS TO INVESTIGATE MOLECULAR DETERMINANTS OF TUMOR
J.WONG METASTASIS TO TARGETED NICHE SITES Materials Research (DMR) 740,000
CHARACTERIZING CELL MORPHOLOGY, ADHESION, AND MIGRATION IN 2.5 AND 3D 210,000
M. ZAMAN CELL-DERIVED EXTRACELLULAR MATRICES
Materials Research (DMR)
AWARDS FROM INDUSTRY Coulter Foundation
Principal
Investigator
Title of Project GRANTING AGENCY
WEATHERFORD
Amount
Translational Partnership
T. SZABO MULTIWAVE IMAGING OF THE SUBSURFACE TO IMPROVE SPATIAL RESOLUTION (subcontract MIT) 88,000
INTERNATIONAL
J.WONG COMPUTATIONAL MAGNETIC, SUB-PORE SCALE METAL OXIDE PARTICLES FOR ENHANCED MAGNETIC 138,773 For the past seven years, the mission of the
UNIVERSITY OF TEXAS • PharmaCheck: A robust, high-throughput
RESONANCE AND OPTICAL CHARACTERIZATION OF ROCK PORE STRUCTURE AND FLUID COMPOSITION Coulter Translational Partnership (CTP)
microfluidic platform for rapid testing of
IN RESERVOIR ROCK program has been to promote, develop, and
counterfeit and substandard drugs
support translational research collaborations
(M. Zaman/C. Gill)
between biomedical engineers and clinicians
in order to accelerate the successful
Significant translational successes of the
translation of appropriate innovations to
Coulter program to date include:
improve patient care. For the past 2 years the
• Flex Biomedical, Inc., a corporation created
Coulter Foundation commitment provides
FUNDING FOR STUDENT SUPPORT

around the technology developed by Grinstaff
$500,000 per year with an equivalent cost
for the treatment of osteoarthritis and funded
share provided by the university.
by the Coulter program in 2007-2008 raised
Principal Amount an additional $160K from angel investors
RESEARCH
Title of Project GRANTING AGENCY Funding was provided to the following projects
Investigator to pursue development of a preclinical test.
for 2012-2013:
As a result of this targeted effort, a total Since its inception, Flex has raised more
M. Grinstaff TRAINING IN TRANSLATIONAL RESEARCH IN BIOMATERIALS NIBIB 169372 • Point-of-care diagnostic chip for rapid
of 18 new proposals were received with than $2.67M in angel investment and more
antibiotic susceptibility testing using reactive
NIH/NIDA outstanding translational quality. than 100K from a strategic industrial partner
D. MOUNTAIN TRAINING IN COMPUTATIONAL NEUROSCIENCE: INTEGRATING EXPERIMENT, THEORY, AND TECHNOLOGY 326,103 oxygen species (ROS) in the clinical setting (A.
78% of the proposals were submitted by seeking to license the technology.
UT-BATTELLE, LLC/OAK Khalil/ M. Klempner/ J. Collins)
I. BIGIO OFF CAMPUS FUNDING FOR KEVIN SHIUAN (BIDMC) 24,880 investigators that were new to the Coulter
RIDGE NATIONAL LABO • Boston University’s bihormonal bionic
• Phase microscopy on hand held device for Program. A total of 22 projects were
I. BIGIO DRAPER LABORATORY FELLOW - CARLOS SEGURA 40,954 pancreas system has undergone tremendous
DRAPER LABORATORY, INC. malaria detection (J. Mertz/ C. Gill) submitted for review by the Coulter Oversight
progress since its support from the Coulter
OFF CAMPUS FUNDING FOR HAO LI (MGH) 33,992 Committee which included individual market
I. BIGIO NIH/NIBIB • FNA Tools for Elastic Scattering program in 2009-2010. The group has raised
and IP analysis prepared by the Coulter team.
OFF CAMPUS FUNDING FOR SAM PEVZNER (Dana Farber) 32,643 Spectroscopy (ESS): Clinical application to a total of $8.3M (and an additional $3.2M
J. COLLINS NIH/NHGRI
thyroid cancer (I. Bigio/ J. Rosen/ S. Lee) pending) in follow-on funding. The research
After two rounds of selections, five new
C. DELISI OFF CAMPUS FUNDING FOR SOWMYA IYER (UMASS Worcester)
NIH/NHGRI 33,697 group is about to start another transitional
• PharmaCheck: A robust, high-throughput projects were selected for funding and two
trial this summer and plans to follow with their
J. MERTZ OFF CAMPUS FUNDING FOR WHAN WOOK CHANG (MGH) 23,835 microfluidic platform to detect counterfeit and renewal applications of previously funded
DOD/AFOSR final transitional study before they move on to
substandard pharmaceuticals projects were approved.
J. MERTZ OFF CAMPUS FUNDING FOR HAO WANG (MGH) MERCK, SHARP & DOHME 35,621 their pivotal study in 2015, and submit for FDA
CORP (M. Zaman/ C. Gill)
approval of the bionic pancreas in 2016. The
The new projects funded include:
D. STAMENOVIC OFF CAMPUS FUNDING FOR MINGXIN ZHENG (BIDMC)
DOD/ARO 18,678 • Compound multimodality breast biopsy clip group estimates a commercial launch in 2017.
• Diagnostic biomarker localized in the nose
(N. Bloch/ M. Grinstaff) for non-invasive lung cancer diagnosis and as
B. SUKI OFF CAMPUS FUNDING FOR LISA CAMPANA (BWH)
BWH -3,705 • A market field test has been conducted
• Clinical testing of variable ventilation enabling technology for deciding CT Scan with the IRIS point of care allergen technology
B. SUKI OFF CAMPUS FUNDING FOR JOHN CASEY OLSON (BIDMC)
BIDMC 35,611 (A. Spira/ M. Lenburg)
compared to continuous ventilation in acute funded by the Coulter program in 2010-2012
B. SUKI OFF CAMPUS FUNDING FOR JACOB HERRMANN (BIDMC) 32,373 respiratory failure (B. Suki/ A. Walkey) where direct market feedback was collected
BIDMC • Biopsy device for calcified breast biopsy
from a panel of 7 allergists. This activity
• In vivo testing of AhR formulators as harvesting that will streamline workflow and
B. SUKI OFF CAMPUS FUNDING FOR TYLER WELLMAN (MGH)
NIH/NHLBI 42,166 was the first of its kind to be conducted
therapeutics for triple negative breast cancer reduce need for capital equipment
JOANNA M. NICOLAY at BU on Coulter projects and provided
J. WONG 2012 RESEARCH SCHOLAR AWARD: CHENTIAN ZHENG 10,000 (M. Grinstaff/ D. Sherr) (J. Brooks/ J. McDaniel)
MELANOMA FOUNDATION valuable information on the appeal of the
J.WONG OFF CAMPUS FUNDING FOR KEVIN MCHUGH (Schepens Eye Research Inst) NIH/NEI 45,048 • Lipid micro bubble formulation of drug • Optical spectroscopy guidance in thyroid product concept, likelihood of product
combinations to prevent post-surgical surgery: identifying parathyroid and adoption and price sensitivity. The outcome
J. WONG MECHANICAL CONDITIONING OF TISSUE ENGINEERED BLOOD VESSELS FOR ATHEROSCLEROSIS (NRSA) NIH/NHLBI 51,614 neighboring tissues (I. Bigio/ J. Rosen) of the discussion was of great value to the
adhesion formation (J. Wong/ A. Stucchi)
investigators.
M. ZAMAN U.S. PHARMACOPEIAL FELLOWSHIP FOR DARASH DESAI US PHARMACOPEIAL CONV 50,000 • Non-cylindrical dental implant system for
• Constant therapy- a tablet based therapy for
aphasia (C. Stepp/ S. Kiran) patients with narrow alveolar ridge including • Constant Therapy, a start-up based on an
Piezo technology to prepare the implant bed IT project funded by Coulter in 2012-2013 has
The updated calendar for the 2013-2014 cycle (R. Gyurko/ S. Dibart/ A. Sauer-Budge) been selected for a $150K BU OTD Launch
and improved guidelines and instructions award, subject to the company identifying
• Reversible, hydrogel-based aerosolized
for proposal submission were posted on professional funding of at least $350K.
sealant dressing for burn treatment
the Coulter BME website in early January (M. Grinstaff/F. Brolsch) • License negotiations on the anti-tumor
2013. Thereafter, targeted marketing of technology based on AhR inhibitors for triple
the program was conducted by means of The approved renewed applications include: negative breast cancer, a technology funded by
personalized emails and dedicated meetings • Point-of-care diagnostic chip for the rapid the Coulter program in 2012-2013 are nearing
with translational faculty at the College of identification of bacterial susceptibility to conclusion.
Engineering and the BU Medical Campus. antibiotic therapies (A. Khalil/ M. Klempner)
Graduate ENROLLMENT FOR AY 2012-2013 Graduate Degrees Awarded
Enrollment
USA INTERNATIONAL TOTAL
DEGREES AWARDED PhD

MENG 8 3 1 2 14 30 MS
6 2 0 2 10
18
MS
25 MEng
59 23 21 12 115
GRADUATE PROGRAM
PHD 20
students received their
3 0 0 0 3
PhD
DEGREES
MD/PHD 15
76 28 22 16 142 10
9
5
0
GRADUATE PROGRAM POPULATION ACADEMIC YEAR 2009 2010 2011 2012 2013
MEng
MEng MS MD/PhD PhD
180
ADMISSION RESULTS FOR AY 2012-2013
APPLICANTS MATRICULATIONS
27
160
MEng MS PhD Total MEng MS PhD Total
21 33 167 221 9 3 11 23
STUDENTS
140 US
MS 21 16 88 125 3 1 8 12
120
100
INT’L 22 26 96 144 1 0 4 5
80
13 33 79 125 3 0 3 6
60
TOTAL 77 108 430 615 16 4 26 46
210
40
20
PhD’s awarded since ADMISSION PROJECTIONS FOR FALL 2013

1991
2009 2010 2011 2012 2013
ACADEMIC YEAR APPLICANTS MATRICULATIONS
MEng MS PhD Total MEng MS PhD Total
Graduate Funding ay 2012-2013 PhD MS
47 40 154 241 7 0 9 16
42
US
Research Assistants 67 10
BME Distinguished Fellowships 17
Dean’s Fellowships
Sargent College Dean’s Fellowship
2
1
26 17 93 136 6 0 11 17
NIH Quantitative Biology and Physiology Training Grant 7
MEng’s awarded since
NIH Biomaterials Training Grant 3 INT’L 21 30 85 136 2 0 6 8
2009 NIH Computational Neuroscience Training Grant 1
NIH Biomolecular Pharmacology Training Grant 1
NIH NRSA Fellowship
NIH Training Grant at BUSM 4
1 18 25 59 102 1 0 7 8
NSF Fellowship 2
NSF XTNC Training Grant 4
3
TOTAL 112 112 391 615 16 0 33 49
NSERC Fellowship
Lawrence Livermore National Laboratory Fellowship 1
26 US Pharmacopeial Fellowship 1 B O S TO N U N I V E R S I T Y D E PA R T M E N T O F B I O M E D I C A L E N G I N E E R I N G 2 0 1 2 - 2 0 1 3 A N N U A L R E P O R T 27
TOTAL 115 10 w w w . b u . e d u / b m e /a b o u t /a n n u a l r e p o r t
Ph.D GRADUATES 2013: Thesis Title & Advisor(s) MS GRADUATES 2013: Thesis Title & Advisor(s)
Sunmin Ahn Performance Improvement of Label-Free Margo Renee Highly Sensitive and Multiplexed Platforms Brett Nels Engineering biomimetic pores for enhanced Srikant Sarangi Detection and Characterization
1/25/2013 Biosensors and their Applications in DNA and Monroe for Allergy Diagnostics Anderson single-molecule to whole-cell sensing 5/19/2013 of Alzheimer’s Disease Molecular
Protein Microarrays 5/19/2013 Prof Selim Unlu 1/25/2013 Prof Amit Meller Pathology in the Lens of the Eye
Prof Selim Unlu by Noninvasive Quasielastic Light
George Gaby Nanoparticle Sensing Platform for Pathogen Scattering
Eduard Reznik The Dynamics of Metabolic Regulation Daaboul Detection and Identification Prof Lee Goldstein
Katherine Weaver Improved Mathematical and Computational Tools 5/19/2013 Prof Daniel Segre 1/25/2013 Prof Selim Unlu
Calabro for Modeling Photon Propagation in Tissue Kelvin L.S. Chan Genipin crosslinked collagen
1/25/2013 Prof Irving Bigio Paul Christopher A high-throughput in vitro binding 9/25/2012 microfluidic scaffolds form stable
Robert Jason Regulation of Blood Vessel Stiffness by Focal Iazzetti characterization of Mycobacterium tuberculosis microvessels in vitro with human
Saphirstein Adhesions of Vascular Smooth Muscle 1/25/2013 transcription factors endothelial cells
Le Wang A Modeling Study of Responses to Sinusoidally 5/19/2013 Profs Kathleen Morgan (SAR) and Joyce Prof James Galagan Prof Joe Tein
1/25/2013 Amplitude-Modulated Stimuli in High Frequency Wong
GRADUATE PROGRAM
Neurons in the Auditory Brainstem Joseph Stefano The influence of cell-extracellular matrix Balaji Goparaju High Level Motion: Neural Correlates
Prof H Steven Colburn Maffei interactions on cell behavior 9/25/2012 and Functional Connectivity
Lenny Alex Psychophysical and Electrophysiological 1/25/2013 Prof Muhammad Zaman Prof Lucia M Vaina
Varghese Investigations into the Mechanisms
Kyle Rouse Engineering Solutions to Persistent Bacteria 5/19/2013 Supporting Everyday Communication Elizabeth Peruski Cellular responses to mechanical stimuli via Kevin Shiue Shiuan Development of an Ultrasound System
Allison Prof James Collins Prof Barbara Shinn-Cunningham Canovic different adhesion complexes and different 9/25/2012 to Measure in vivo Dynamic Cervical
1/25/2013 1/25/2013 cytoskeletal filaments Spine Intervertebral Disc Mechanics
Profs Dimitrije Stamenovic and Michael Smith Profs Brian Snyder (BIDMC) and
Whan Wook Functional Optical Coherence Tomography for Dimitrije Stamenovic
Chang Clinical Otolaryngology Jared C. Saffie Microfluidic evaporator chip for concentration of
1/25/2013 Profs Seok Hyun Yun and Jerome Mertz Grad Student Awards 1/25/2013 bacterial samples for SERS identification Aaron Henry Colby Novel Drug Delivery Systems: pH-
Lin Jin Prof Catherine Klapperich 9/25/2012 Responsive Expansile Nanoparticles &
• AAUW International Fellowship for ‘13-14 Drug Concentrating Devices as Tools for
Michelle Elizabeth Tunable Silk: Using Microfluidics to Investigate Joseph Bradley Control of Active Touch by Somatosensory Treating Cancer
Kinahan Sequence-Structure-Property Relationships Schroeder Cortex Prof Mark Grinstaff
1/25/2013 Prof Joyce Wong
Kevin McHugh
• Biomedical Engineering Society Student Travel Award, 2012 1/25/2013 Prof Jason Ritt
• Coulter College 2012 Project Award, 2nd Place Darash Desai Robust Device for Counterfeit and
• Coulter College Travel Stipend, Wallace H. Coulter Foundation, 2012 Kayle Sarah Determining the Optimal Cell Source for a Tissue 9/25/2012 Substandard Medicines Screening in
Benjamin James Time and Distance Coding by the Hippocampus Shapero Engineered Heart Valve Developing Regions
Kraus and Medial Entorhinal Cortex Kyle Allison 1/25/2013 Profs Michael Smith, John Mayer (CHB), Joyce Prof Muhammad Zaman
1/25/2013 Profs John White and Howard Eichenbaum (PSY) • BME Best Dissertation Award Bischoff (CHB)
Suma Jaini Understanding the Transcription Factor
Eduard Reznik Grace Wu A Paper-Based Electrochemical Device for 9/25/2012 regulation in Mycobacteria
Caroline Marie Synthesis, Characterization, and Evaluation of 1/25/2013 Salivary Analysis in Low-Resource Settings Prof James Galagan
• BME Best Dissertation Award
LaManna Photo-Active Amphiphiles for Gene Delivery Prof Muhammad Zaman
1/25/2013 Applications Hao Li Jason Paul Keller A Microfluidic Platform for Quantitative
Prof Mark Grinstaff Xirui Zhang An improved high-throughput biosensor platform 9/25/2012 Studies of Regulatory Network
• CaIC YIA Symposium Third Place Winner
1/25/2013 for in vitro detection and quantification of DNA- Dynamics in Mycobacteria
Aaron Colby protein interactions Profs James Galagan and Catherine
Sheetal Modi Systems Biology Approaches to Mechanisms of Prof Selim Unlu Klapperich
• Selective drug delivery to tumors via pH-responsive expansile
1/25/2013 Bacterial Stress Adaptation
nanoparticles improves survival in a murine model of peritoneal
Prof James Collins Miguel Dario Effects of spatial separation on across-frequency Joshua Christian Accurate Assessment of Synchronous
mesothelioma – QBP/TRB Graduate Research Symposium,
February 2013 – Oral Presentation – awarded Best Presentation. Cepeda grouping in narrowband speech Kline Motoneuron Firings: Implications for the
5/19/2013 Prof Barbara Shinn-Cunningham 9/25/2012 Source of Synchronization
David Andrew A Novel Technique for Measuring the Tim Ford Prof Carlo De Luca
Wellman Physiological Traits Causing Obstructive Sleep • BME Graduate Student Paper of the Year, 2013 (awarded 12/2012) Chian Yang Derivation of Purified Smooth Muscle Cells from
1/25/2013 Apnea 5/19/2013 Mouse induced Pluripotent Stem (iPS) Cells Benjamin Alan Developing a cationic contrast agent
Prof Andrew Jackson Prof Joyce Wong Lakin for computed tomographic imaging
Stephanie Lien
• Best Paper Award from the Advances in Quantitative 9/25/2012 of articular cartilage and synthetic
Brian Fallica Cancer Cell Drug Response in a 3D Collagen biolubricants for early diagnosis and
Tyler James Relation of Regional Tidal Lung Expansion with Laryngology, Voice and Speech Research Conference.
5/19/2013 Environment treatment of osteoarthritis
Wellman Inflammatory Activation in Early Ventilation- Prof Muhammad Zaman Profs Brian Snyder (BIDMC) and Mark
1/25/2013 Induced Lung Injury: A PET Imaging Approach Jason Keller
• Chemical and Biological Microsystems Society Student Fellowship Grinstaff
Profs Marcos Vidal Melo (MGH) and Bela Suki Brian Christopher Mechanical Determinants of Intact Airway
• Carl Storm Underrepresented Minority (CSURM) Fellowship
Harvey Responsiveness Kevin James Porous Poly (E-caprolactone) Tissue
• Best Poster Presentation - BME QBP/TRB Symposium 2013
5/19/2013 Prof Kenneth Lutchen McHugh Engineering Scaffolds for Retinal
Raphael Yao The Effects of Mechanical Stimulation on 9/25/2012 Pigment Epithelial Transplantation in
1/25/2013 Controlling and Maintaining Marrow Stromal Cell Elizabeth Shenk
Michael T. Mee Engineering synthetic microbial consortia Age-Related Macular Degeneration
Differentiation into Vascular Smooth Muscle Cells • Joanna M. Nicolay Melanoma Foundation Research Scholar Award through the modulation of metabolism, exchange
5/19/2013 Profs Magali Saint-Genies and Joyce
Prof Joyce Wong and spatial structure Wong
Raphael Turcotte
Profs George Church and James Collins
• Wellman Center for Photomedicine, MGH Graduate Fellowship
• Turcotte R, Alt C, Wu J, Silberstein L, Kung L A and Lin P C. Samuel Robert How Mechanical and Environmental
Stefan Thomas Superhydrophobic Materials for Drug Delivery
Yohe Prof Mark Grinstaff (2012) Optical Delivery of single cells in live animals. Gordon
Research Conference - Lasers in biology and medicine 2010,
MEng Graduates Polio
9/25/2012
Cues Regulate Extracellular Matrix
Remodeling
1/25/2013 Anh Tuan Dinh (1/25/13) Prof Michael Smith
New-Hampshire, USA (outstanding poster award) Senem Sezgi (5/19/2013)
Amauche Emenari (5/19/2013) Ting-Huan Shen (1/25/13)
George Gaby Interferometric Biosensing Platform for
Daaboul Multiplexed Digital Detection of Viral Pathogens Brent Takashi Honda (1/25/13) Wendell Ronald Su (5/19/2013)
5/19/2013 and Biomarkers Courtney Lee Joe (5/19/2013) Wei-Lun William Tsang (5/19/2013)
Prof Selim Unlu Maxwell Mean (5/19/2013)
Mission, Objectives & Outcomes PROGRAM EDUCATIONAL OBJECTIVES
Graduates of our undergraduate program are expected:
• to become successful practitioners of biomedical

engineering or other professions (e.g., medicine,
MISSION STATEMENT law, management) drawing upon and guided by their
The Mission of the Biomedical knowledge of biomedical engineering;
Engineering Department is to • to continue improving and expanding their technical and

professional skills through formal or informal means
pursue excellence in biomedical (e.g., continuing education and training, attending
conferences, learning new tools and methods); and
engineering education, research
• to contribute to community and professional groups
and innovation; creating and using the unique competencies provided by their
imparting knowledge for biomedical engineering educational experiences.
improving society, human

health and health care. To PROGRAM OUTCOMES
achieve our educational a) an ability to apply knowledge of mathematics,
science and engineering;
mission, we cultivate our b) an ability to design and conduct experiments, as well as to analyze and
interpret data;
students’ problem-solving and
c) an ability to design a system, component, or process to meet desired
communication skills, nurture

needs within realistic constraints such as economic, environmental,
social, political, ethical, health and safety, manufacturability and
sustainability;
their creativity, promote their
d) an ability to function on multi-disciplinary teams;
ability to think critically and
e) an ability to identify, formulate and solve engineering problems;
independently, and help them f) an understanding of professional and ethical responsibilities;
to understand scientific and g) an ability to communicate effectively;
engineering approaches.
h) the broad education necessary to understand the impact of
engineering solutions in a global, economic, environmental and
societal context;
i) a recognition of the need for, and an ability to engage in life-long

learning;
j) a knowledge of contemporary issues;
k) an ability to use techniques, skills, and modern engineering tools

necessary for engineering practice;
Undergraduate Enrollment Degrees Awarded
545 BS DEGREES BREAKDOWN
Number of BME students
enrolled this year, 38% of the total enrollment of the
College of Engineering.
The percent of female & male students COLLEGE
BS DEGREES BME
was 40% and 60%, respectively.
TOTAL (2012-2013)
107 281
ENROLLMENT FOR AY 2012-2013 TOTAL (2011-2012)
94 282 The Department
TOTAL TOTAL TOTAL (2010-2011)
81 272 awarded 107 Bachelor
FRESHMAN 74 81 155 109 286 395
97 247
BIOMEDICAL
of Science degrees this

ENGINEERING
TOTAL (2009-2010)
ENGINEERING
COLLEGE OF
SOPHOMORE 53 90 143 89 251 340
academic year, 39%
JUNIOR 50 89 139 113 267 380
TOTAL (2008-2009)
96 257 of all the BS degrees
SENIOR 39 69 108 79 222 301
TOTAL (2007-2008)
78 269 awarded by the College.
TOTAL 216 329 545 390 1026 1416 TOTAL (2006-2007)
57 252
TOTAL (2005-2006)
70 266
BME ENROLLMENT HISTORY
Seniors Juniors Sophomores Freshmen 9000
BME TEACHING HISTORY
8000
500
7000
6000
CREDIT HOURS
400
5000
STUDENTS
4000
300
3000
2000
200
1000
100 2003-4 2004-5 2005-6 2006-7 2007-8 2008-9 2009-10 2010-11 2011-12 2012-13
ACADEMIC YEAR
The BME department was responsible for teaching 66 courses during the AY 2012-13. The student credit hours
2003-4 2004-5 2005-6 2006-7 2007-8 2008-9 2009-10 2010-11 2011-12 2012-13 for these courses total 8,652. The trend in annual credit hours taught over the past ten years is illustrated above
ACADEMIC YEAR in “BME Teaching History.”
Student Awards In 2013, several of the BME seniors were recognized for
achievements and contributions to the Boston University
community and BME profession.
Ging S. Lee Community Presented to a graduating senior in the College of Engineering to recognize
Service Award: outstanding community service. This year the award was presented to Jennifer
Marie Ryan.
Anita Cuadrado Presented to a graduating senior in the College of Engineering to

Memorial Award: recognize her enthusiasm and devotion to the college. This year the
award was presented to Ana Sofia Camacho.
Ging Lee Award Cuadrado Award Alumni Association Student Leader Awards
Winner Winner
Engineering Alumni Presented to seniors who have made outstanding contributions to the College
Association Student and University through their involvement in activities and organizations.
Among the six award winners this year were BME seniors Veronica Faller
Leader Award: and Luai Zakaria.
Outstanding Three of the four award winners this year were BME seniors Kelsey Evans,
Dean’s Host Awards: Veronica Faller and Varuna Rao.
Outstanding Senior The team of Patrick Carney, Veronica Faller and Luai Zakaria were recognized
Project Award: with the Department’s 2013 Outstanding Senior Design Project Award for
their project “CPAP Machine for Treating Childhood Pneumonia in Developing
Countries” under the supervision of Professor Muhammad Zaman (BME). Student Advisor Awards Dean’s Host Award Winners
Societal Impact Second place was awarded to a senior project performed by BME seniors:
Capstone Project Rebecca LaCroix and Michelle Wong with “Microfluidic System for Sample
Concentration and Extraction”.
Awards:
Sudent Student Advisor Among the 17 ENG winners for outstanding assistance in advising this year,
the following BME seniors were recognized: Patrick Carney, Veronica Faller,
Award: Erik Frazier, Carolynn Gaut, Christopher Lim, Jo-ann Loh, Obiananma
Nwokike, Varuna Rao and Luai Zakaria.
BME Senior Design Winners BME Societal Impact Award Winners
Research Activities
Student Organizations for Undergraduates
The BME Department, College of Each year, 10 Lutchen Fellows from faculty mentor to participate in full-
Boston University Student Chapter of the Biomedical Engineering Society Engineering and Boston University the Kenneth R. Lutchen Distinguished time research during the summer
have several programs that allow Fellowship Program spend the (summer courses are not allowed).
The purpose of the Biomedical Engineering Society is: “To promote the undergraduates to participate in summer engaged in a transformative
increase of biomedical engineering knowledge and its utilization.” The research activities. research experience under the The College of Engineering
student chapter at Boston University works towards this goal in all of guidance of a faculty member. Supplemental Undergraduate
its activities. The Biomedical Engineering Society provides a focus for Under the FIRST and Trustee Students must maintain a 3.0 average Research Funds (SURF) program
community building among BME students with activities which strengthen Scholarships the recipients are to be eligible for the fellowship, and encourages faculty to involve
their understanding of and interest in Biomedical Engineering. The Society eligible for research funding for up to may conduct their projects during undergraduates in their research
provides students with literature, field trips, films and guest lectures, which 10 hours of research a week for one the summer following either their programs during the academic
provide them with a “resource center” concerning such vital areas as career semester. sophomore or junior year. year by providing matching funds
opportunities and graduate study in Biomedical Engineering. for undergraduate students who
The Presidential/Engineering College of Engineering are working on faculty-sponsored
Scholars Program (Presidential/ undergraduates engaged in faculty- research. Requests for SURF funds
BMES Officers AY 2012-13
ENG Scholars) is a merit award given mentored full-time research are made by individual students
President – Bhavesh Patel ‘13 to students at the time of admission experiences during the summer when they have found positions in
to Boston University. Presidential/ may apply for the Summer Term faculty labs.
Vice President – Kristian Thomas ‘13 Engineering Scholars receive a Alumni Research Scholars (STARS)
Secretary – Ben Hertz ‘13 package of benefits, including funding program. STARS participants will The Undergraduate Research
for up to 10 hours of research per receive 10 or 12 weeks of housing in Opportunities Program (UROP) is a
Treasurer – Allison Marn ‘13 week for one semester during the a Boston University residence hall University-wide academic program
Social Chair – Kristen O’Leary ‘13 academic year, and automatic OR up to $2750 towards off-campus which promotes participation by
admission to a Boston University housing costs (reimbursement is Boston University undergraduates
College Master’s of Engineering for actual cost of housing). To be in faculty-mentored research across
program (provided students maintain eligible, students must receive a all disciplines and throughout the
a 3.40 grade point average). weekly stipend from an engineering calendar year.
Alpha Eta Mu Beta, Biomedical Engineering Honor Society
Alpha Eta Mu Beta is the honor society for Biomedical Engineering. The
society promotes an understanding of the profession and recognizes
and encourages excellence within the field. The purpose of the society Lutchen Fellows SURF AY2012-2013 Fall 2012 BME Spring 2013 BME
is to bring into closer union and to mark in an outstanding manner those Summer 2012 Elam, Matthew UROP Awards UROP Awards
biomedical engineers who have manifested a deep interest and marked Bauer Lesavage Gunnels, Taylor Pavan Mehat Shivem Shah
ability in their chosen life work so as to promote an understanding of their Raleigh Linville Hosur, Krutika Matthew Elam David Lin
profession and to develop its members professionally. Veronica Faller Lo, Justine Prakash Iyer Jeremy Rosenthal
Robert Lebourdais Mathews, Connor Allen Yen Natalia Vargas-Montoya
AEMB Officers AY 2012-2013 Alberto Purwada Rosenthal, Jeremy Bradley Sauln Michael Persaud
Stueber, Gabriella Laura Windmuller Allen Yen
President – Jason We Yen Pui ‘13 Tabattanon, Kamolnat Anoop Ravilla Gabrielle Arguelles
STARS Summer 2012 Wheatley, Francis Natalia Vargas-Montoya Angela Lai
Vice President – Veronica Faller ‘13 Courtney Ellenson Kamil Makhnejia Kavon Karrobi
Secretary – Alberto Purwada ‘13 Isha Zinzuwadia Rebecca Thompson Yuankai Shen
Rebecca LaCroix Michael Persaud Hersh Bendre
Treasurer – Michael Wexler ‘13 Luai Zakaria Aaron Silva Brian Barry
Kristian Thomas Yuankai Shen
Joseph Schlatter William Moik
Vincent Lin Kavon Karrobi
Angela Lai
36 37
ENGMEDIC
The ENGMEDIC program is an early selection program that
leads to a BS in Engineering and an MD from the Medical
School. This program is offered and administrated in REGISTERED COMPANIES 2013
collaboration with our School of Medicine and is designed
to train biomedical engineers who have the MD as their
ultimate degree objective. ENGMEDIC admits to the 3M Covidien Navinet
School of Medicine a small number of highly qualified Accenture Life Sciences Cynosure Neuroptix Corporation
students who have completed two years of the premedical Advanced Instruments, Inc. Davol - C.R. Bard, Inc. NuOrtho Surgical, Inc.
option of the biomedical engineering curriculum. The AltraBio Decision Resources Optasia Medical, Inc.
program is not designed to accelerate the engineering or Altran DEKA Research and Development O’Shea Getz PC
the medical training but rather to effect a better transition Applied Medical Resources Corporation Parexel
from undergraduate engineering study to graduate medical ArQule, Inc. DePuy Spine, Inc. Perceptive Informatics
training. The BS in Biomedical Engineering is normally Atrium Medical DocBox, Inc. Pfizer
earned after 4 years of undergraduate study and the MD Avedro, Inc. Draeger Medical Systems, Inc. Philips Healthcare
after an additional 4 years of study at the Boston University BD Medical Eastman Kodak Company Praxis Advisors LLC
Medical School. Beth Israel Deaconess Eaton-Peabody Laboratory Pulmatrix, Inc.
Medical Center Elm Electrical & Automation Raytheon
BioTrove, Inc. EndoCore Respiratory Motion, Inc.
Boston Engineering Essex Orthopedics & Optima Sports Sapient
Boston Medical Center, Medicine Schepens Eye Research Institute
Senior Design Project Experience Department of Clinical

Engineering
Boston Scientific
Fellers Snider et al.
Fraunhofer USA-CMI
GE Healthcare
Solace Therapeutics, Inc.
St. Jude Medical
Teleflex Medical
A major strong point of our advisor (with a BME faculty co- course includes experience in Boston University School of Gems Sensors Ten15Ventures
undergraduate program continues supervisor). The project is then planning, establishing priorities Management Genzyme Corporation Toxikon Corporation
to be the Senior Design Project. carried out with the guidance of and formal training in technical Boston University School of Goodyear-Veyance Technologies, Inc. Tufts University
Every BME senior is required to the student’s technical advisor. communication including Public Health Harvard Business School UMASS
develop a project proposal with an This brings together elements proposal, abstract, progress Brandeis University University of Texas at Austin
Harvard Medical School
individual faculty member, local of engineering science and reports and oral and written
Brigham and Women’s Hospital Harvard University University of Wisconsin-Madison
area scientific mentor, or even a engineering design. In coordination presentations of the final work.
Broad Institute Harvard-MIT Division of Health US Army Institute of Environmental
bioengineering corporate technical with the technical work, this In conjunction with the BME
Bruker Daltonics Sciences and Technology Hologic Medicine
Department’s Industrial Advisory
CAE Healthcare Iandiorio Teska & Coleman USA Research Institute of
Board, we have additional
lectures from our industry Center for Global Health Image Stream Medical Environmental Medicine
partners to expose the students and Development Integra LifeSciences VA Boston Healthcare System
to elements of entrepreneurship, Charles Stark Draper Laboratory iWorx Systems, Inc. Vantage Management Group
business plans, intellectual Children’s Hospital Boston JH Technologies Vertex Pharmaceuticals
property, marketing, and clinical CIMIT Johnson & Johnson Veterans Administration
regulatory issues. The project CKD Associates Lux Research Veterans Affairs Boston Healthcare
continues over the full academic Clark & Elbing LLP Massachusetts Eye and Ear Infirmary System
year and culminates in a Senior Cleveland Clinic Massachusetts General Hospital Worcester Polytechnic Institute
Design Project Conference that Codman Neuro, Johnson & Johnson Massachusetts Institute of Wyss Institute for Biologically
is attended by students, faculty, Columbia University, College of Technology Inspired Engineering
and representatives from BME Physicians and Surgeons Medtronic, Inc. Xcellerex
industry, hospitals and other Comprehensive Health Management METI
academic institutions. The Inc. Minnesota State University, Mankato
proceedings cover is shown ConforMIS, Inc. National Instruments
here and the companies that
registered for this year’s
conference are listed on the next
page, followed by a listing of the
project presentations.
38 B O S TO N U N I V E R S I T Y D E PA R T M E N T O F B I O M E D I C A L E N G I N E E R I N G 2 0 1 2 - 2 0 1 3 A N N U A L R E P O R T 39
SESSION I: SESSION IIb: SESSION IlIb:
Is it real?: Biomaterials, Tissue Models Small Stuff: Molecules, Cells and Nanothings Small rivers: Microfluidics
and Tissue Engineering
Session Chair: Prof. Michael Smith Session Chair: Prof. Catherine Klapperich
Session Chair: Prof. Solomon Eisenberg
Development of Microfluidic Devices for Microscale
Ultrasound Contrast Agents as Theranostics for Chemical Reactions
Microfluidics-based Perfusion Bioreactor for Stem Cell Atherosclerosis Saeed Ahmed
Differentiation Diana Miniovich, Anna Cristina Shivers
Thiagu Meyyappan, Alberto Purwada Microfluidic Chip for Thyroid Cancer Diagnosis
System to Assess Cancer Cell Morphology with Scattered Lena Liu, Matthew Scott
Pore-Cast Scaffold for Vascular Tissue Engineering Light
Aimal Khankhel, Michael Zhang John Gawedzinski, Kripa Patel, Hussan Shareef Design and Characterization of an Integrated
Microfluidic System for Sample Concentration and

Linear Stretch Bioreactor Incorporating a Gel-Grip siRNA-Microbubble Conjugates for Ultrasound-Mediated Extraction
Mechanism siRNA Delivery Rebecca LaCroix, Michelle Wong
Lijia Jin, Joonnyong Lee, Yujie Zhou Obiananma Nwokike, Elaine Steranka Ultrasonic Filtering and Detection for Microfluidic
Devices
Boston University Microfluidic Bioreactor for Assessment of Cardiac Toxicity Targeted Nanoparticles for Sustained Intracellular Drug Andrew Beckenbach, Brittany Culpepper, Anjanesh
Ayush Jain, Snehaseel Kakileti, Jake Kallarackal Release Venkatesh
Department Of Biomedical Engineering David Conegliano, Jale Manzo, Emily Polson
Errors and Artifacts Associated with the Calculation of the Integration of Microfluidics with Multiplexed
27th Annual Senior

Intrinsic Properties of Cancellous Bone Genetic Modification of Brain Cells Using Non-Viral Plasmonic Biosensors
Cory Haselmayer, Peter McGuirk Methods John Barrett, Erik Frazier, Dylan Stevens
Fiona Raso, Alexander Yoon
Design Project In Vitro Mucosal Membrane Culture Model for Drug Delivery
Ulises Alvarez, John Hoang Semiconductor Nanosensor for Cancer Fingerprinting –
Optimization of a Polyolefin Surface for the
Immobilization of Biotin
Conference Electrospun Coaxial Fiber Meshes for Cancer Treatment

Diagnosis and Monitoring
Daniel Kim
Chun Hin Tang, Jeanne Tran
Blood Glucose Monitoring System for Use in

Benjamin Cohen, Luka Grujic Developing Countries
FRIDAY, MAY 3, 2013 Visual Detection of Emerging Pathogens Socrates Boutsikaris, Shannon O’Neill
Krista Rochussen, Meghan Schreiner
SESSION IIa: SESSION IV:

Measurements on the living (and previously living) SESSION IlIa: We Have the Technology: high-tech solutions
& treatments Through a glass darkly: Imaging Large and Small to real problems
Session Chair: Prof. Herbert Voigt Session Chair: Prof. Thomas Szabo Session Chair: Prof. Irving Bigio
Classification of Imagined Speech Engineering Size and Shape Specific Nanoparticles for Design of Noninvasive Technology for Real-time
Vincent Lin, Courtney Pacheco Computed Tomography Contrast Agents Estimation of Hyolaryngeal Kinematics for Videogame
Christopher Fan, Trong-Huy Vo, Allen Yen Control
The Effect of Humeral Positioning on Glenohumeral Emily Bonazelli, Lynne Messina
and Subacromial Forces in a Cadaveric Model of Binary Probe for Fluorescent Detection of Nucleic Acids
Simulated Pitching in Live Cells Design and Testing of a New Nebulizer
Benjamin Hertz, Michael Wexler Iris Kao, Angelica Ochoa Andreas Kapfhammer, Christopher Lim
A Real-time Feedback System for Landing Pattern AlternaGel: The Alternative Ultrasound Gel for Resource- Stochastic Resonance Ankle Brace for Improving Balance
Modification of the Injured Runner Limited Settings Corey Kronman, Bhavesh Patel
Kelsey Evans, Kyle Jones, Kristen O’Leary Suvomita Ghosh, Sydney Moy
Mobility Aid for the Blind
Creating Virtual Environments by Recording and Cell Phone Based Phase Contrast Imaging Christian Dorman, Ghassan El Kara, Ralph Sayad
Analyzing Typical Everyday Listening Situations Ana Sofia Camacho, Michael Francis, Douglas Webster
Kristian Thomas, Robert Tona Making Robots Roam: Interface Between a Biologically
Design and Development of a Fast MRI Pulse Sequence Inspired Goal Directed Navigation Model and a Robot
Characterization Device for Esophageal Atresia Surgeries for the Quantification of Tissue Iron in vitro and in vivo Tariq Bugrara, Collin Neill
Katherine Marcaccio, Kelsey Petersen Robert Dalgarno, Soon Bin Kwon, Ashley Stein
Making Robots See: Development of a Robotic Visual
CPAP Machine for Treating Childhood Pneumonia in Design of a Flow Chamber Compatible with Traction Sensing Module for Biologically Inspired Goal Directed
Developing Countries Force Microscopy Navigation
Patrick Carney, Veronica Faller, Luai Zakaria, Bhumica Amin, Varuna Rao, Jennifer Ryan Matthew Kramer, Sean Manton
Developing a Diagnostic for Syphilis in Resource-limited Design of an Image Processing System to Improve Reconfigurable Endoscopic Capsule Minibots Using
Settings Measurement of Cellular Traction Forces Modular Assembly
Jo-ann Loh, Gregory Njus Diana Aksyonova, Carolynn Gaut Jason Pui, Suraj Rama, Benjamin Szewczyk
Boston University
Department of Biomedical Engineering
Annual Report 2012-2013
© 2013, Boston University
Design and Layout: Kathryn Blair

kcblair@bu.edu
Content: BME faculty and staff
This report provides a description of the instructional and research activities of the Department
of Biomedical Engineering at Boston University during the 2012-2013 academic year.
Boston University’s policies provide for equal opportunity and affirmative action in employment
and admission to all programs in the university.
For more information or to download this report as a PDF, please visit our website at:
bu.edu/bme
44 Cummington Street
Boston, MA 02215
617.353.2805
bu.edu/bme

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BIOMEDICAL

2012-2013 ANNUAL REPORT

FACULTY & STAFF

$9 MILLION NIH Grant Founds Bu-Based Center

fiscal year the

2012-2013 Academic Year hands on demonstrations and laboratory sessions.

PhD, Physics, University of Michigan University of California, Santa Barbara,

(1%) and other Government Sources (1%). 4% of the

• intensive computer use for experimental and theoretical work,

Translations Research in Biomaterials (NIH, Grinstaff PI)

S. Colburn CORE CENTER GRANT - ENGINEERING (CORE 3) NIDCD 230,850

M.Dembo CORE C: TRACTION FORCE MICROSCOPY (subcontract U Rochester) NHLBI 20,265

AWARDS FROM DOD

FUNDING FOR STUDENT SUPPORT

DEGREES AWARDED PhD

TOTAL 77 108 430 615 16 4 26 46

PhD’s awarded since ADMISSION PROJECTIONS FOR FALL 2013

• to become successful practitioners of biomedical

Engineering Department is to • to continue improving and expanding their technical and

improving society, human

i) a recognition of the need for, and an ability to engage in life-long

j) a knowledge of contemporary issues;

k) an ability to use techniques, skills, and modern engineering tools

of Science degrees this

Anita Cuadrado Presented to a graduating senior in the College of Engineering to

BME Senior Design Winners BME Societal Impact Award Winners

Senior Design Project Experience Department of Clinical

Microfluidic System for Sample Concentration and

27th Annual Senior

Conference Electrospun Coaxial Fiber Meshes for Cancer Treatment

Blood Glucose Monitoring System for Use in

SESSION IIa: SESSION IV:

Annual Report 2012-2013

© 2013, Boston University

Design and Layout: Kathryn Blair

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