Joint MD Program

College of Medicine and Health Sciences

Palestine Polytechnic University (PPU)

Exercise 4 Clinical Chemistry Chapter 2 Protein 28.06.2020 Dr Salamah Alwahsh

I. Fill in the blank

1. In healthy person, ~80% of iron is transported in the circulation from the intestine to the sites of
metabolism in the body by …………………

2. Wilson's disease and Menkes disease are inborn errors of ……………….. metabolism

3. Cells bearing MHC class I plus peptide (endogenous antigen) are targets for specific …………….
cells

4. ………………….. is a serum protein that is produced solely by parenchymal cells of the liver

5. …………….. are proteins that suppress the secretion of follicle-stimulating hormone (FSH)

6. ……………………. is the commonest cause of anemia that cause of a microcytic, hypochromic

anemia

7. ……………….. is a vitamin involved in iron absorption. It prevents of the formation of insoluble

and un-absorbable iron compounds and is involved in the reduction of ferric to ferrous ‫السبانخ والليمون‬

8. The risk of respiratory distress syndrome (RDS) is inversely related to gestational age at the time of
birth, and the infants require O2 supply and mechanical ventilation. The disorder is caused by a
deficiency of ………………….

II. Indicate whether the following sentences are True or False

T F 1. Relative to males, females are more susceptible to autoimmune disease such as SLE, also estrogenic
oral contraceptives can exacerbate an autoimmune disease

T F 2. Normal adult man iron requirement is 0.5–1.0 mg/day

T F 3. Transferrin can bind 2 ferric (Fe3+) ions, and it is usually between 25-30% saturated with iron

T F 4. Artificial antibodies are mostly IgM are acquired by transplacental passage from the mother

T F 5. All 25 selenoproteins contain selenocysteine. There is a specific codon (UGA) in the mRNA of
selenoproteins coding for the insertion of this amino acid

T F 6. Phenylalbuminuria (PKU) is a disorder characterized by the accumulation of phenylalbumin in blood

that results from the absence of phenylalanine oxidase activity leading to production of ketones that are
excreted in urine

T F 7. Homocystinuria is an inherited autosomal recessive disorder of the metabolism of the amino acid
methionine due to a deficiency of cystathionine beta synthase

The end of the exercise

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