Total No. of Questions : 08] [Total No.

of Printed Page : 02
EXAMINATION – JUNE 2019
MASTER OF SCIENCE (M.Sc. Chemistry)
Final Year - Semester-III 3M.Sc. 4
Drug & Heterocyclic Compd -[D.H.C.]

Time : 3 Hours Max Marks : 70

Min. Marks : 25
Note : Attempt any five questions. All question carry equal marks.

Q.1. Write the reaction mechanism and products (any ten): 10  2.5 = 25

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Q.2. (a) What are the objectives of drug design?
(b) What is lead compound? How is it useful in drug discovery?
(c) What are the types of antibiotics?

Q.3. (a) What is anti-inflammatory drug?

(b) Synthesize ibuprofen.
(c) Synthesize narcotic analgesic meperidine hydrochloride.

Q.4. (a) Write the synthesis of anti-malarial drug trimethoprim.

(b) What is anaesthetic? And how it works?
(c) Write the synthesis of anaesthetic lidocaine hydrochloride.

Q.5. (a) What is tranquilizer and how it affects the body?

(b) Write the synthesis diazepam.
(c) What is anti-neoplastic agent? Write the synthesis of
mechloraethamine.

Q.6. (a) Write short note on Fischer indole synthesis.

(b) What will happen if you treat indole with DMF and POCl3 at 50 ºC?

Q.7. (a) Why thiopyrylium is more stable than pyrylium?

(b) Why nucleophile attack at C2, C4 and C6 of pyrylium salt where as at
only C2 of α-pyrones?
(c) Write the Hantzsch type synthesis of pyrylium salt.

Q.8. (a) Synthesize 2,4,6-triaminopyrimidine from diethyl malonate.

(b) Write the synthesis of quinoxaline from o-phenylenediamine.
(c) What will happen for the following reaction?

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