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Perception and practice of routine medical check-up by tertiary health


workers at a tertiary health facility in south-west Nigeria

Article  in  International Journal of Medicine and Biomedical Research · August 2018

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Oluwatosin Oluwagbenga Oguntoye Kabir Adekunle Durowade


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International Journal of Medicine and Biomedical Research
Volume 6 Issue 3 September – December 2017
www.ijmbr.com
© Oguntoye et al.; licensee Michael Joanna Publications

Original Paper Open Access

Perception and practice of routine medical check-up by health


workers at a tertiary health facility in South-West Nigeria
1* 1 2
Oguntoye O.O , Yusuf M , Durowade K.A
1
Department of Internal Medicine, Federal Teaching Hospital, Ido-Ekiti, Ekiti State, Nigeria.
2
Department of Community Medicine, Federal Teaching Hospital, Ido-Ekiti, Ekiti State, Nigeria.

*Corresponding author: proflast@yahoo.com

Received: 14.03.17; Accepted: Accepted: 27.10.17; Published: 03.08.18

ABSTRACT

Background: Routine medical check-up is the periodic medical evaluation of


apparently healthy individuals with the view to detect abnormalities. Aim: This
study investigated the perception and practice of routine medical check-up by
health workers at the Federal Teaching Hospital, Ido-Ekiti, Nigeria. Methods: A
structured questionnaire was used to collect the socio-demographic data and
responses of 184 consenting members of staff of the institution on the subject
matter. Results: A total of 184 respondents participated in the study; 101
(54.9%) males and 83 (45.1%) females. The age range of the participants was
22–63years with a mean (±SD) of 35.73±7.718. The respondents include 88
(47.8%) doctors, 10 (5.4%) pharmacists, 43 (23.4%) nurses and 43 (23.4%)
other health workers. All the 184(100%) respondents knew about routine medical
check-up and its potential benefits and 170 (92.4%) of them had actually had a
medical check-up done before. Only 61 (35.9%) of them had it done for pre-
employment purpose while the rest did it for other reasons. One hundred and
twenty six (74.1%) out of the 170 respondents who had had a check-up done
repeated the check regularly and 58 (34.1%) of them were subsequently referred
to a specialist based on abnormal results. Conclusions: The level of awareness
and practice of routine medical check-up is remarkably high among health
workers. This is useful in assessing the baseline health indices of individuals as
well as for early detection of abnormalities which may not be symptomatic, hence
preventing the burden of the diseases that would have otherwise resulted.

Key words: Preventive medicine, morbidity and mortality, health workers,


medical check-up, occupational health, infectious diseases

This is an Open Access article distributed under the terms of the creative commons Attribution 4.0 licence
(http://creativecommons.org/licenses/by/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the
original work is properly cited.
Oguntoye et al.: Routine medical check-up by health workers

INTRODUCTION include socio-demographic factors, income,


access to health insurance and accessibility to
[5-14]
Routine medical check-up is the periodic health care facility.
medical evaluation of apparently healthy
individuals with the view to detect The fact that health care workers work in a
[1] “ health facility where the human resources and
abnormalities. It is also known as periodic
health evaluation, annual facilities for a medical check-up are available,
physical, comprehensive medical exam, general the fact that health care workers are more
health check or preventive health knowledgeable than the general public about
[2] health matters and the importance of disease
examination”. The purpose of routine medical
check-up is to evaluate the health status of prevention, and the fact that they also have
asymptomatic individuals who have no known ready access to health insurance should
health problems, to screen for risk factors and ordinarily translate into a better health care
diseases in them, and to provide preventive utilization in comparison with the general public.
counseling and interventions in an age- This may remain an assumption and may not
[2] truly be the case unless a study is conducted to
appropriate manner. Routine medical check-
up is expected to be performed on a regular prove this hypothesis. There is however paucity
basis by all apparently healthy individuals of information on the utilization of health
including health care workers. services by health care workers in Nigerian
health institutions.
Health care workers are individuals involved with
patient care in various health establishments Therefore, there is a need to look into how
and affiliates and they include doctors, health care workers make use of the services
physiotherapists, pharmacists, medical they provide. This study investigated the
laboratory scientists, nurses, radiographers, perception and practice of routine medical
public/community health professionals, health check-up by health care workers at the Federal
[3] Teaching Hospital, Ido-Ekiti, Nigeria. It also
attendants and other allied health workers.
Health care workers are equally at risk of determined the opinion of the respondents about
developing various medical conditions like other compulsory pre-employment medical check-up.
members of the general population and so they This study provided the much needed
also require periodic medical evaluation. information as well as scientific data for further
research.
Routine medical check-up provides the
opportunity to evaluate individuals’ health status METHODOLOGY
in their healthy states. Any departure from the
normal is a good pointer of disease process Selection of study subjects
onset and the results obtained can also be used This was a cross-sectional study that was
for follow-up studies. Early identification of carried out at the Federal Teaching Hospital,
abnormalities in asymptomatic individuals Ido-Ekiti, Ekiti state in the South Western
through routine medical check-up will aid prompt geopolitical zone of Nigeria between January
intervention if need be, thus preventing or 2016 and June 2016. The inclusion criteria for
reducing associated attendant complications. this study consisted of members of staff of the
This would reduce the overall morbidity and institution who belong to one health related
mortality associated with various disease professional or non-professional group who
conditions. have contact with patients. This includes
doctors, nurses, pharmacists, medical laboratory
Unfortunately, health care services are usually scientists, physiotherapists, health attendants,
only sought for after an escalation of the community health extension workers and other
[4]
complaints of illness. The possible factors that allied health workers who must have given
can influence the utilization of health care written informed consent to be recruited.
services have been documented amongst
different groups in the literature and these

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Oguntoye et al.: Routine medical check-up by health workers

The following categories of people were were doctors (47.8%) while nurses constitute
excluded from the study; those who were not 23.4% of the participants. The other socio-
members of staff, patients, students, demographic characteristics are as shown on
administrative staff and other support staff. A table 1.
total of 184 study subjects were recruited for the
study. Selection of subjects for the study was by Table 2 describes the general knowledge of the
consecutive selection of consenting individuals. respondents about routine medical check-up. All
Ethical approval was obtained from the Ethics (100%) the participants knew about routine
and Research Committee of the institution. medical check-up and their source of knowledge
being the respective academic/professional
Evaluation of study subjects training they received while 51.1% believe that it
A structured questionnaire was designed for the should be done every 6months, 46.2% were of
study which was used to collect the the opinion that it should be done yearly.
demographic data and the responses of the Majority were of the opinion that blood pressure
participants on the subject matter. The subjects check, blood glucose check, urinalysis and lipid
were initially interviewed to ensure that they profile tests should be part of routine medical
fulfill the set inclusion criteria for the study. The check-up. Half (50%) of the respondents believe
nature and scope of the research was explained that medical check-up should be funded by the
to the subjects and a written informed consent employer, 31.0% feels it should be by the
was obtained before they were recruited. All the individual while 19.0% believe it should by
participants understood English and there was health insurance.
no need for translation.
When asked about the benefits of routine
Informed consent medical check-up, the respondents gave
Informed consent was obtained from all the multiple perceived benefits: 78.8% believe that it
study participants and Ethical Approval was can help to detect undiagnosed diseases, 66.3%
obtained from the Ethics and Research believe that it can detect risk factors for
Committee of the institution. diseases, 56.5% believe that it promotes
longevity while 60.9% believe that it can prevent
Statistical analysis untimely or sudden death.
The data obtained was analyzed using the
Statistical Package for the Social Sciences The attitude of the respondents towards routine
(SPSS) version 21.0 computer software medical check-up was also determined in this
package (SPSS Chicago Inc. IL U.S.A). study. A total of 92.4% (170 out of 184) of the
Descriptive statistics used included frequency respondents had gone for a routine medical
tables, means and standard deviations. The check-up, 81.2% of whom had it done because
statistical significance of the findings was they believe it is important for their health while
determined using appropriate statistical tests. 35.9% had a medical check-up done for pre-
2
The non-parametric test, chi-square (χ ) test, employment purpose, 8.2% had it done for travel
was employed for the analysis of qualitative purpose, 19.0% had it pre-marital reasons and
variables. A p-value of less than 0.05 was 1.6% had it done based on the advice of a
considered as statistically significant. health worker. The remaining 14 (7.6%)
respondents who had never had a medical
RESULTS check-up done gave various reasons which
included; “I consider myself healthy” (64.3%), “I
A total of 184 respondents participated in the just never thought about it” (50.0%), “I don’t
study; 101 (54.9%) males and 83 (45.1%) have enough money” (28.6%), and “I just don’t
females. The age range of the participants was have time for it” (21.4%).
22–63years with a mean (±SD) of 35.73±7.718.
Majority (74.5%) of the respondents attained Table 3 depicts the perception and attitude of
tertiary level of education, 22.8% had the respondents towards compulsory pre-
postgraduate education while only 2.7% had just employment medical screening. 83.2% (153 out
secondary education. Most of the respondents of 184) of the respondents believe that pre-

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153
Oguntoye et al.: Routine medical check-up by health workers

employment medical screening should be the respondents had been screened for. 89.1%
compulsory while the remaining 16.8% (31 (164) had been screened for HIV, 81.5% (150)
respondents) do not believe it should be for Hepatitis B virus and only 42.4% (78) for
compulsory and their reasons are as shown in Hepatitis C virus infections.
table 3. There was a statistically significant
relationship between the level of education (p < DISCUSSION
0.001) and the designation (p= 0.006) of the
respondents and their attitude towards All the respondents in this study were aware of
compulsory pre-employment medical screening the importance of routine medical check-up and
as shown in Table 4. There was no such its potential benefits. This can largely be
significant relationship in the age, sex, religion or attributed to the fact that majority of the
tribe of the respondents (table 4). respondents were educated, having up to
tertiary level of education and beyond. Another
Table 5 depicts the practice of routine medical reason is because this study was conducted
check-up by the respondents. 33.7% of the among health workers in a tertiary health
respondents undergo routine medical check-up institution and these are people who are at the
every 6months and 34.8% every year. For forefront of medical care and are very
dental check-up, 22.8% undergo it every knowledgeable about the importance of
6months while 20.6% undergo it every year. The preventive medicine which is what routine
frequency of blood pressure and blood glucose medical check-up is all about, to identify the risk
checks is as shown on table 5. factors of diseases early before they manifest or
cause complications. Routine medical check-up
The experience of the respondents during helps to detect undiagnosed diseases, promotes
routine medical check-up is shown on Table 6. longevity and prevents sudden or untimely
More than three-quarters (78.2%) of the death.
respondents who had had a routine medical
check-up done had it done in a tertiary hospital The respondents being health care workers who
while only 9.4% had theirs done in a primary are knowledgeable could explain why majority of
health centre. Majority (88.8%) of the them had a medical check-up done before in the
respondents funded their medical check-up bill past (92.4%) for various reasons. Majority of
by themselves while 16.5% had theirs funded by them had the check-up done based on their
their employers and so they didn’t have to pay personal belief that it is important for their health
for the tests. The range of the estimated (81.2%) as against the other major reason which
expense of the medical check-up was N0 – was that of pre-employment purpose (35.9%).
N30,000 with a mean±SD of This means that pre-employment medical
N5,233.00±5,725.00. screening rate is low among the respondents,
which may be due to the fact that the health
The various tests done during the check-up are institution in which they are working did not
as shown on table 6. Blood pressure check, make it compulsory or the institution does not
fasting plasma glucose and urinalysis were the have in place an effective pre-employment
most common tests done during the medical medical screening programme for her staff.
check-ups with a frequency of 65.3%, 51.8% Even though majority of the respondents
and 40.0% respectively. All the 170 (100%) (83.2%) believe that pre-employment medical
respondents who had had a medical check-up screening should be compulsory for various
done found the obtained results beneficial; 58 good reasons, only some of the respondents
(34.1%) of whom were referred to see a actually had their medical check-up done for
specialist based on the results of their tests pre-employment purpose (35.9%). The fear of
while the remaining 112 (65.9%) did not require stigmatization or job loss if found unfit were
any specialist consultation. Forty (69.0%) of some of the reasons given by the respondents
those referred to see a specialist were very who oppose compulsory pre-employment
regular with their clinic appointments, 14 medical screening.
(24.1%) were fairly regular while 4 (6.9%) were
not regular. Figure 1 depicts the major infections

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Oguntoye et al.: Routine medical check-up by health workers

Table 1: Socio–demographic characteristics of respondents


Variable Frequency Percentage
N = 184 (%)
Age group (in years)
Less than 30 37 20.1
30 – 34 54 29.3
35 – 39 29 15.8
40 – 44 39 21.2
45 and above 25 13.6
Mean age ± SD 35.73 ± 7.718
Range 22 - 63
Sex
Male 101 54.9
Female 83 45.1
Marital Status
Single 55 29.9
Married 123 66.8
Divorced/ Separated 6 3.3
Level of Education
Secondary 5 2.7
Tertiary 137 74.5
Post - graduate 42 22.8
Religion
Christianity 171 92.9
Islam 13 7.1
Tribe
Yoruba 159 86.4
Hausa 4 2.2
Igbo 11 6.0
Other 10 5.4
Designation
Consultant 23 12.5
Resident 39 21.2
Medical Officer 26 14.1
Pharmacist 10 5.4
MLS 8 4.3
Physiotherapist 4 2.2
Radiographer 5 2.7
Nurse 43 23.4
Comm. Health Ext. Worker (CHEW) 10 5.4
Medical Record Officer 7 3.8
Health Attendant 5 2.7
Other (Not specified) 4 2.2
MLS: Medical Laboratory Scientist

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Oguntoye et al.: Routine medical check-up by health workers

Table 2: General knowledge of respondents about routine medical check – up


Variable Frequency Percentage
N = 184 (%)
Do you know about medical check – up?
Yes 184 100.0
Source of knowledge
Through training 184 100.0
How routinely should it be done
Every 6 months 94 51.1
Yearly 85 46.2
Every 2 years 3 1.6
Every 3 years 2 1.1
What are the tests involved in routine medical check – up #
Blood pressure check 168 91.3
Blood glucose check 162 88.0
Urinalysis 150 81.5
Fasting lipid profile 142 77.2
Mammography 128 69.2
Pap smear 115 62.5
Prostate Specific Antigen 111 60.3
Chest X – ray 100 54.3
Electrocardiography 105 57.1
Others** 59 32.1
Dental check – up should be done
Every 6 months 114 62.0
Yearly 64 34.8
Every 2 years 6 3.2
Eye examination should be done
Yearly 152 82.6
Every 2 years 30 16.3
Every 3 years 2 1.1
Blood pressure check should be done
Yearly 164 89.1
Every 2 years 20 10.9
Cholesterol check should be done
Every 6 month 64 34.8
Yearly 108 58.7
Every 2 years 12 6.5
Blood glucose level should be done
Monthly 65 35.3
Every 6 months 85 46.2
Yearly 34 18.5
#Multiple response
**The “others” include HIV(Human Immunodeficiency Virus), HBsAg(Hepatitis B surface antigen), Anti-
HCV(Hepatitis C Virus), E,U&Cr(Electrolytes, Urea and Creatinine) and FBC(Full Blood Count).

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Oguntoye et al.: Routine medical check-up by health workers

Table 3: Respondents’ perception and attitude towards compulsory pre–employment medical


screening
Variable Frequency Percentage
N = 184 (%)
Pre – employment medical screening should be compulsory
Yes 153 83.2
No 31 16.8
Main reason, if yes (n = 153)
It may be the only opportunity one has 14 9.2
It helps to know health status 87 56.8
It helps to have a fit work force 22 14.4
It helps to prevent transmission of infections 23 15.0
It helps the employer in rightful job allocations 7 4.6
Main reason, if no (n = 31)
There should be freedom of choice 12 38.7
It can cause stigmatization if found unfit 9 29.0
Employee may lose his/her job if found unfit 5 16.1
It is not necessary 3 9.7
It is stressful 2 6.5

Figure 1: Bar chart showing the major infections the respondents had been screened for
(N = 184)

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Oguntoye et al.: Routine medical check-up by health workers

Table 4: Relationship between the socio–demographic characteristics of the respondents and


their attitude towards compulsory pre–employment medical screening
Pre – employment medical –
screening should be compulsory

Yes No
2
n = 153 n = 31 ᵪ p
Age group (in years)
Less than 30 29 (78.4) 8 (21.6) 3.356 0.500
30 – 34 44 (81.5) 10 (18.5)
35 – 39 26 (89.7) 3 (10.3)
40 – 44 31 (79.5) 8 (20.5)
45 and above 23 (92.0) 2 (8.0)
Sex
Male 85 (84.2) 16 (15.8) 0.162 0.687
Female 68 (81.9) 15 (18/.1)
Marital Status
Single 41 (74.5) 14 (25.5) 4.203 0.122
Married 107 (87.0) 16 (13.0)
Divorced/ Separated 5 (83.3) 1 (16.7)
Level of Education
Secondary 1 (20.0) 4 (80.0) 18.805 <0.001
Tertiary 112 (81.8) 25 (18.2)
Post - graduate 40 (95.2) 2 (4.8)
Religion
Christianity 142 (83.0) 29 (17.0) 0.021 0.884
Islam 11 (84.6) 2 (15.4)
Tribe
Yoruba 132 (83.0) 27 (17.0) 3.947 0.267
Hausa 2 (50.0) 2 (50.0)
Igbo 10 (90.9) 1 (9.1)
Other 9 (90.0) 1 (10.0)
Designation
Consultant 22 (95.7) 1 (4.3) 26.188 0.006
Resident 37 (94.9) 2 (5.1)
Medical Officer 20 (76.9) 6 (23.1)
Pharmacist 9 (90.0) 1 (10.0)
MLS 6 (75.30) 2 (25.0)
Physiotherapist 3 (75.0) 1 (25.0)
Radiographer 4 (80.0) 1 (20.0)
Nurse 36 (83.7) 7 (16.3)
Comm. Health Ext. Worker (CHEW) 8 (80.0) 2 (20.0)
Medical Record Officer 5(71.4) 2(28.6)
Health Attendant 1 (20.0) 4 (80.0)
Other 2 (50.0) 2 (50.0)

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Oguntoye et al.: Routine medical check-up by health workers

Table 5: Respondents’ practice of routine medical check – up


Variable Frequency Percentage
N = 184 (%)
Do you even think it is important to do routine medical check – up
Yes 184 100.0
How often do you go for medical check – up
Every 6 months 62 33.7
Yearly 64 34.8
Every 2 years 7 3.8
Every 3 years 1 0.5
I don’t do it routinely 50 27.2
How often do you go for dental check up
Every 6 months 42 22.8
Yearly 38 20.6
Every 2 years 11 6.0
Every 3 years 11 6.0
I don’t do it routinely 82 44.6
How often do you check your blood pressure
Less than 6 monthly 25 13.6
Every 6 months 96 52.2
Yearly 14 7.6
Every 2 years 2 1.1
Every 3 years 1 0.5
I don’t do it routinely 46 25.0
How often do you check your blood glucose
Less than 6 monthly 9 4.9
Every 6 months 73 39.7
Yearly 55 29.9
Every 2 years 2 1.1
Every 3 years 2 1.1
I don’t do it routinely 43 23.4

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Oguntoye et al.: Routine medical check-up by health workers

Table 6: Respondents’ experience during routine medical check–up


Variable Frequency Percentage
N = 170 (%)
Where was the check – up done? **
Private hospital 27 15.9
Primary health centre 16 9.4
Secondary health centre 19 11.2
Tertiary hospital 133 78.2
Who funded it? **
Personal 151 88.8
Employer 28 16.5
NGO 1 0.6
Others 2 1.1
Estimated cost
Free 25 14.7
Less than N5, 000 74 43.5
N5, 000 - < N10, 000 30 17.6
N10,000 - < N15,000 24 14.1
N 15,000 and above 17 9.2
Mean cost ± SD N 5,233.0 ± 5,725.0
Range N 0 – N 30,000
Tests done during the check – up**
Chest X-Ray 68 40.0
FBC 42 24.7
BP 111 65.3
Urinalysis 68 40.0
ECG 29 17.1
FPG 88 51.8
Genotype 24 14.1
E,U&Cr 22 12.9
Spirometry 10 5.9
FLP 17 10.0
Echocardiography 9 5.3
Eye examination 13 7.6
Dental check 5 2.9
Mammography 8 4.7
Others 16 8.7
KEY: NGO- Non-Governmental Organization, ECG- Electrocardiography, BP- Blood Pressure, FBC-
Full Blood Count, FPG- Fasting Plasma Glucose, E,U&Cr- Electrolytes, Urea and Creatinine, FLP-
Fasting Lipid Profile.
**Multiple response

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Oguntoye et al.: Routine medical check-up by health workers

[1]
Akande et al. in a study in 2004 at the the tests done regularly as required. This could
University of Ilorin Teaching Hospital, Ilorin, be due to the cost implication of some of the
Nigeria on 274 hospital workers on the practice tests which would make the respondents to
of periodic medical examination, reported that perform only those they can afford and if found
82.8% of them had had a medical examination to be normal they may not wish to repeat the
done since being employed in the hospital. tests regularly as required. Another reason could
20.6% of them had the medical examination be due to lack of a standard protocol of the tests
done for pre-employment purpose and only expected to be done during a routine medical
14.1% of them had a pre-employment medical check-up at the institution where the check-up
examination done before assumption of duty. was done.
This pre-employment screening rate obtained
12years ago is much lower than what was In this study majority of the respondents had
obtained in this study. their check-up done in a tertiary hospital and it
was funded mostly through out of pocket
[15]
In another study by Opeodu et al. in 2014 at payment since the average estimated cost from
the University College Hospital, Ibadan, Nigeria this study was N5,233 which is relatively not too
on 110 members of staff in the dental clinic on expensive.
the practice of comprehensive medical check-
up. 58.1% of the respondents had their medical It is interesting to note from this study that
check-up done as part of a mandatory pre- majority of the respondents had been screened
employment requirement while 27.6% had it in the past for HIV infection much more than
done as a result of personal concern for their Hepatitis B virus infection and to a much lesser
health. extent Hepatitis C virus infection. This is a
reflection of the level of awareness of the
In this study, the respondents with a higher level respondents, a sub-set of the larger society,
of education and designation were strongly in about these viruses. The awareness campaign
support of compulsory pre-employment medical in Nigeria for HIV infection is much more than for
screening and this was found to be statistically the other viruses, despite the fact that the
significant. Consultants are the highest in rank Hepatitis B virus is far much more prevalent in
among health care workers, they have Nigeria than HIV and it is also much more highly
postgraduate qualifications that make them the infectious and causes more morbidity and
most knowledgeable and experienced health mortality than HIV. It is also vaccine preventable
personnel and this explains the reason why they and HIV is not.
value the importance of compulsory pre-
employment medical screening more than the In this study, all the respondents who had had a
other health workers. medical check-up done found the obtained
results beneficial and some of them were
The respondents have a good knowledge of the consequently referred to a specialist based on
various important tests that should be done the findings. This further confirms the
during a routine medical check-up which importance of a routine medical check-up in
includes blood pressure check, blood glucose diagnosing disease conditions for which
check, lipid profile, urinalysis, individuals may not yet be symptomatic thereby
electrocardiography, chest radiograph, serology preventing or reducing the morbidity and
(HBsAg, Anti-HCV and HIV), electrolytes, urea mortality that could have resulted.
and creatinine, prostate specific antigen (for
males), mammography and pap smear (for CONCLUSIONS AND
females). These tests are expected to be done RECOMMENDATIONS
every 6months to 1year. Eye examination and
dental check-up are believed to be part of Early identification of abnormalities in
routine medical check-up. However, only some asymptomatic individuals through routine
of these tests were done by the respondents at medical check-up will aid prompt intervention if
the time of their check-up and only some had need be, thus preventing or reducing attendant

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Oguntoye et al.: Routine medical check-up by health workers

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ensuring that they are all enrolled under the Health Reports 2007;18:23-35.
national health insurance scheme. 15. Opeodu O.I and Gbadebo S.O. Medical services
utilization: experience of members of staff in a tertiary Dental
Clinic. International Journal of Sciences: Basic and Applied
Facilities for a routine medical check-up should Research 2014;13:68-78.
also be made available at secondary and
possibly primary health facilities and individuals
who have established abnormal results should
be referred to the appropriate specialist for
further evaluation and care. Finally, there is also
a need to further enhance public awareness doi: http://dx.doi.org/10.14194/ijmbr.6.3.5
about the Hepatitis B virus which is vaccine
How to cite this article: Oguntoye O.O, Yusuf M,
preventable and highly prevalent in Nigeria.
Durowade K.A. Perception and practice of routine
medical check-up by health workers at a tertiary
ACKNOWLEDGEMENT health facility in South-West Nigeria. Int J Med
Biomed Res 2017;6(3):151-162.
Special thanks to the House Officers and Residents of
Internal Medicine Department for their support towards Conflict of Interest: None declared
making this research a success.

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Accessed September 30, 2016 • User-friendly online submission
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