INSTITUTE of CHEMISTRY

COLLEGE of SCIENCE
University of the Philippines, Diliman, Quezon City

COURSE SYLLABUS
CHEM 26 INTRODUCTION TO QUANTITATIVE CHEMICAL ANALYSIS

A. Course Catalogue Description

1. Course Number : Chem 26

2. Course Title : Introduction to Quantitative Chemical Analysis

3. Course Description : Principles and techniques of analysis with emphasis on volumetric

methods and stoichiometry; survey on common instrumental
methods

4. Prerequisite : Chem 16

5. Semester Offered : 1st Semester, 2nd Semester, Midyear Term

6. Course Credit : 3.0 u

7. Number of Hours : 48 hours (16 weeks)

8. Meeting Type : Lecture

9. Course Goal/s : To develop sufficient understanding of the key concepts and skills
to solve quantitative chemical analysis problems

B. Course Content

Course Topics No. of Hours

Part I – Review and Introduction to Chemical Kinetics and Chemical Equilibrium

I. Review 3
A. Solution Thermodynamics
B. Concentration Expressions
II. Chemical Kinetics 6.0
A. Factors affecting the rate of chemical reaction
B. Reaction Rate and Rate Law
1. Rates of Reaction
2. Rate and Concentration
3. Rate and Stoichiometry
4. Rate Measurements
5. Rate Law and Reaction Order
C. Rate Theories
 1. Collision Theory
2. Transition State Theory
D. Temperature and Rate: Arrhenius Equation
E. Catalysis
1. Homogeneous Catalysis
2. Heterogeneous Catalysis
III. Dynamic Chemical Equilibrium 4.5
A. Concept of Equilibrium
B. Equilibrium Constant Expression, Keq
1. Concentration, Kc
2. Pressure, Kp
3. Magnitude of Keq
4. Reaction Quotient, Q
5. Heterogeneous Equilibria
C. Le Châtelier’s Principle
1. Concentration, Pressure & Volume, Temperature Changes
2. Catalyst Effect
IV. Ionic Equilibrium 9
A. Types of Ionic Equilibria
1. Kw
2. Ka
3. Kb
4. Ksp
5. Kf
B. Acids and Bases
1. Arrhenius Theory
2. Brønsted-Lowry Theory
a. Hydronium Ion
b. Proton-Transfer Reactions
c. Conjugate Acid-Base Pairs
3. Lewis Theory
C. Acid-Base Behavior
1. Strengths of Conjugate Acid-Base Pairs
2. Molecular Structure and Strength
a. Binary Acids
b. Oxyacids
c. Carboxylic Acids
D. Autoionization of Water: Ion Product of Water and pH
E. Acid-Base Systems
 1. Strong Acids and Bases
2. Weak Acids
3. Polyprotic Acids
4. Weak Bases
5. Ka and Kb Relationship
6. Acid-Base Properties of Salt Solutions
a. Monofunctional Acids and Bases
b. H3PO4, H2SO4, H2CO3
F. Buffers
1. Composition and Action
2. Buffer Capacity
V. Solubility Equilibria 4.5
A. Solubility Product Constant, Ksp and Solubility

B. Factors Affecting Solubility

1. Common-Ion Effect
2. pH
3. Formation of Complex Ions
a. Kformation and Kassociation
4. Amphoterism
C. Precipitation and Separation of Ions
VI. Introduction to Coordination Compounds 3.0
A. Structure of Complexes
1. Charges, Coordination Numbers and Geometries
2. Chelates
B. Nomenclature
VII. Electrochemistry 4.5
A. Review: Oxidation-Reduction Reactions
B. Electrochemical Cells
1. Galvanic
2. Electrolytic
C. Cell Potentials
1. Standard Reduction Potentials
2. Oxidizing and Reducing Agents
D. Spontaneity of Redox Reactions
1. Free Energy Change
 E. Cell EMF and Concentration
1. Nernst Equation
2. Concentration Cells
3. Equilibrium Constants
F. Electrolysis
1. Molten Salts and Aqueous Solutions
2. Faraday’s Law
Part II – Introduction to Analytical Chemistry
I. Introduction 4.5
A. Stoichiometry
1. Calculations in Gravimetric Analysis
a. Moisture Calculations
2. Calculations in Volumetric Analysis
a. mmole/meq Approaches
II. Volumetric Analysis 6
A. Introduction
1. Equivalence Point and End Point
2. Primary Standards
3. Standard Solutions
4. Titration Curves
B. Acid-Base Titration
1. Acid-Base Indicators
2. Titration Curves
a. Strong Acids and Strong Bases
b. Weak Acids and Weak Bases
i. Concentration Effects
ii. Completeness of Reaction Effects
iii. Feasibility of Titration
3. Applications and calculations including titration of alkali mixtures
C. Precipitation Titrations
1. Titration Curves
a. Concentration Effects
2. Argentometric Titrations
a. Mohr, Fajans and Volhard Methods
D. Complexometric Titrations
1. Liebig Method
2. EDTA Titrations
a. EDTA Properties
b. Complexes of EDTA
c. Titration Curves
d. Indicators
 e. Water Hardness
E. Redox Titrations
1. Permanganimetry and Ceric Process
2. Dichromate Process
3. Iodometry/Iodimetry
III. Introduction to Potentiometry 3
A. General Principles
B. Reference Electrodes
1. Calomel Electrode
2. Silver/Silver Chloride Electrode
C. Indicator Electrodes
1. Metallic Electrodes
2. Membrane Electrodes
a. pH meter
b. Ca2+ Membrane Electrodes
IV. Introduction to Absorption Spectroscopy 3
A. Interaction of Radiation and Matter
1. Electromagnetic Spectrum
2. Spectroscopic Measurements
B. Radiation Absorption
1. Absorption Process
a. Spectrum
i. Qualitative Information: λmax
ii. Quantitative Information: absorbance
b. Beer’s Law
C. Instrumentation
1. Basic Components
2. UV-Vis Instruments
a. Single Beam
b. Double Beam
c. Multichannel Instruments
V. Introduction to Separation Techniques 3
A. Separation by Extraction
1. Principles
a. Distribution Coefficient
B. Chromatographic Separation
1. General Description and Classification
2. Elution and Column Chromatography
3. Chromatograms
 a. Qualitative Information: Retention Time
b. Quantitative Information: Peak Area or Peak Height

D. Course Requirements

Short Quizzes (incl. homework, 100 points

seatwork, recitation, etc.)

Long Examination I 100 points

Long Examination II 100 points

Long Examination III 100 points

Final Examination 200 points

Exemption Grade Pre-final grade of 2.5

Passing 330 points (55%)

E. References

Brown, T.L., LeMay, H.E., Bursten, B.E., Murphy, C.J., Woodward, P.M. and Stoltzfus, M.W. (2017). Chemistry The
Central Science 14th ed. UK: Pearson Education
Christian, G. D., Dasgupta, P.K. and Schug, K.A. (2013) Analytical Chemistry, 7th ed. Wiley Global Education.
Harris, D.C., Lucy, C.A. (2015) Quantitative Chemical Analysis, 9th ed. New York: W. H. Freeman and Company.
Petrucci R., Hering F., Madura J. and Bissonette C. (2011). General Chemistry: Principles and Modern Applications,
10th ed. Boston, MA: Pearson Learning Solutions
Silberberg M.S. (2013). Principles of General Chemistry, 3rd ed. USA: McGraw-Hill Companies, Inc.
Skoog, D.A., West, D.M., Holler, F. J. and Crouch, S. R. (2014) Fundamentals of Analytical Chemistry, 9th ed.
Belmont, CA, USA: Brooks Cole Cengage Learning
Skoog, D.A., West, D.M., Holler, F. J., Crouch, S. R. and Chen, S.C. (2012) Introduction to Analytical Chemistry, 8th
ed. Singapore: Cengage Learning Aisa Pte. Ltd.
Zumdahl S. S. and Zumdahl S. A. (2013). Chemistry, 9th ed. Belmont CA, USA: Brooks Cole.

Grade Scale:

95 – 100 1
89 – 94 1.25
84 – 88 1.5
80 – 83 1.75
75 – 79 2
70 – 74 2.25
65 – 69 2.5
60 – 64 2.75
55 – 59 3
49 – 54 4
≤ 48 5

Intellectual dishonesty – any fraudulent act performed by a student to achieve academic

advantage or gain for oneself or others, including but not limited to:

a. Plagiarism, defined as “the appropriation of another person’s ideas, processes, results or words
without giving appropriate credit” ;
b. Fabrication, defined as “making up data or results” ; falsification, or “manipulating research
materials, equipment, or processes or changing or omitting data or results such that the research
is not accurately represented in the research record”; distortion and/or destruction of data;
c. Copying or providing the means or accessing means to copy exam answers, homework,
projects, laboratory experiments, term papers, etc.; possession and/or use of cheat devices during
an examination; allowing another person to take an examination in one’s name, and/or
impersonating another student or allowing someone to impersonate oneself in an academic
activity; and manipulating a corrected exam paper;
d. Submission of the same work in two or more courses without the instructors’ consent; and
e. Other acts analogous to a, b, c, and/or d (2012 Student Handbook).
Acts of Misconduct and Corrective Measures are also contained in the Student Handbook.