NCS UNIVERSITY SYSTEM

Department of Health sciences

Midterm Examination Spring 2019

Discipline (MLT-04) (VIROLOGY &MYCOLOGY)

Student roll no: ______________ Invigilator sign: ___________________

Time allowed: 60 minutes
Total marks: 50 Date: ___________________________

1) Incubation period of c. Hepatitis C

a. Mumps is three days d. Hepatitis D
b. Viral hepatitis type B is two days e. Hepatitis E
c. Influenza is 60 to 90 days 6) Vaccination for this hepatic disease is with
d. Measles is 90 to 200 days viral surface antigen and usually provides
e. Viral hepatitis type C is 6 to 12 immunity.
weeks a. Hepatitis A
2) The incubation period of viral hepatitis type b. Hepatitis B
A is c. Hepatitis C
a. 360 to 900 days d. Hepatitis D
b. 10 to 50 days e. Hepatitis E
c. 5 to 10 days 7) A day or 2 before the rash appears, the
d. 3 to 5 day patient develops small red-based lesions with
e. 1 to 3 days blue white centers in the mouth called
3) Delta hepatitis only occurs in patients who Koplik's spots is Pathognomic of which virus
also have either acute or chronic infection a. Measles virus
with hepatitis B virus. The delta agent is b. Influenza virus
a. An incomplete hepatitis B virus c. Respiratory syncytial virus
b. Related to hepatitis A virus d. Parainfluenza virus
c. A hepatitis B mutant e. Adenovirus
d. An incomplete RNA virus 8) A 3-year-old child presents at the
e. Hepatitis C physician’s office with symptoms of coryza,
4) IgM antibody to the viral particle is the conjunctivitis, low-grade fever, and Koplik’s
method of choice for laboratory diagnosis of spots. The causative agent of this disease
which one of the following hepatitis viruses? belongs to which group of viruses?
a. Hepatitis A a. Adenovirus
b. Hepatitis B b. Herpesvirus
c. Hepatitis C c. Picornavirus
d. Hepatitis D d. Orthomyxovirus
e. Hepatitis E e. Paramyxovirus
5) This virus belongs to the family of 9) Hepatitis E, a hepatitis virus, is best
flaviviruses and its reservoir is strictly human. described by which of the following
Transmission is blood-borne so the blood statements?
supply is routinely screened for this virus. a. Its transmission occurs by faecal–
a. Hepatitis A oral route
b. Hepatitis B
 b. It is a major cause of blood-borne d. Respiratory syncytial virus
hepatitis e. Mumps
c. It is prevalent in North America 16) Orchitis, which may cause sterility, is a
d. It is a single-stranded DNA virus possible manifestation of which of the
e. The disease resembles hepatitis C following?
10) The presence of Negri inclusion bodies in a. Rabies
host cells is characteristic of b. Rhinovirus
a. Mumps c. Cytomegalovirus
b. Infectious mononucleosis d. Respiratory syncytial virus
c. Congenital rubella e. Mumps
d. Aseptic meningitis 17) A structural component that is found in all
e. RabieS viruses is:
11) Hepatitis D virus is a defective virus that a. The envelope
can replicate only in cells already infected b. DNA
with which of the following viruses? c. Capsid
a. Hepatitis A virus d. Tail fibers  
b. Epstein-Barr virus e. Spikes
c. Hepatitis G virus 18) In AIDS, HIV kills
d. Hepatitis B virus A.Bone-Marrow cells
e. HIV B.T-Helper cell
12) A patient has all the gastrointestinal C. Antibody molecule
symptoms of infection with hepatitis A virus D.T-Cytotoxic cell
(HAV), yet all the tests for HAV-IgG and HAV- 19) The non-living characteristic of viruses is
IgM are nonreactive. A possible cause of this A. ability to undergo mutation
infection is B. ability to cause diseases in the host
a. Hepatitis B surface antigen C. ability to multiply only inside the
b. Hepatitis C host
c. Hepatitis D D. ability to be crystallized
d. Hepatitis E 20) German Measles in an infection of
e. Rotavirus a. Measles
13) Which of the following markers denotes b. Rubella
highly infective Hapatitis B disease? c. Polio
a. HBeAg d. Mumps
b. HBsAg e. Cytomegalo virus
c. HBcAg 21)Dengue virus has how many serotypes
d. Anti-HBc a. One
e. HbeAb b. Four
14) Which of the following may be the only c. Six
detectable serological marker during the early d. Five
phase of HBV infection (window phase)? e. Seven
a. HBeAg 22)The WHO case definition of Dangue
b. HBsAg Hemolytic Fever is a patient with four
c. HBcAg criteria,which one is not of them:
d. Anti-HBc Ag a. Acute sudden onset of high fever for
e. HbeAb 2–7 days.
b. Haemorrhagic manifestations with at
15) Which one of the following viruses is the least a positive torniquit
cause of congenital malformations? c. Platelet count ,100 *109/l.
a. Rabies d. Haemoconcentration (rising packed
b. Rhinovirus cell volume >20%)
c. Rubella e. Vomiting for three days
 D) In cytocidal infection, cell usually
23.. Classification of viruses is made by: die
A. Complement fixation serolog E) Several RNA viruses can cause
B. Electron microscopy persistent infection
C. Nucleic acid composition 30. In viral properties circle the WRONG
D. Cellular inclusion bodies STATEMENT:
A) The viral envelope contain
24. Which virus is the most common Lipoprotein
etiological agent B) Viruses can replicate in non-
of viral respiratory diseases in infants and living media
children? C) Viruses need live cells to grow
A. Respiratory syncytial virus (RSV) D) Viruses have no ribosome
B. Measles virus E) Contain either RNA or DNA
C. Coxsackie A virus 31. Regarding poliovirus, circle the WRONG
D. Coxsackie B virus STATEMENT:
25.Which virus belonging to the Reoviridae A) Two vaccine are available
group B) There is no vaccine for polio
causes gastroenteritis in infants and young C) Can be isolated from throat swab
children but an asymptomatic infection in or stool
adults? D) Sub-clinical infection are
A. Coxsackie B virus common
B. Rotavirus E) Three serotypes exist
C. Respiratory syncytial virus 32. In structure and classification of viruses,
D. Rhabdovirus circle the WRONG STATEMENT:
26. Hepatitis B virus can be transmitted by: A) Icosahedral symmetry have 12
A. Acupuncture vertices
B. Tattoos B) Helical symmetry such as
C. Sexual contact Othomyxo virus
D. All of these options C) The viruses contain protein and
27. A clinical test used for the detection and nuclic acid
identification of viral infections other than D) Transcription is the formation of
culture is: protein
A. Hemagglutination E) Translation is the formation of
B. Hemadsorption protein
C. Viral antigen detection 33. The following viruses are transmitted by
D. All of these options the fecal-oral route EXCEPT ONE:
28. The following diseases are caused by A) HAV
enteroviruses EXCEPT ONE: B) HEV
A) Pleurodynea C) HDV
B) Glomerulonephritis D) Entero
C) Paralysis E) Astro
D) Meningitis 34.Th e following viruses can be transmitted
E) Pericarditis sexually EXCEPT ONE:
29. The viral pathogenesis, circle the WRONG A) HIV
STATEMENT B) HBV
A) Spread of virus in the body C) HSV-2
through different route e.g. Blood, Saliva d) Rubella
B) Humoral immunity but not cell 35. In HCV and HBV, circle the correct answer:
mediated immunity (CMI) act against viruses A) HBV is dsRNA
C) Inclusion bodies produced by B) HCV is ssRNA
viruses can be single or many
 C) Both viruses can grow in cell a.Pentagon
culture b. Cube
D) HBV has not chronicity c. Icosahedron
complication d. Pyramid
E) Hemodialysis but not e. Sphere
hemophiliacs are at risk for HCV 43. Enteroviruses differ from rhinoviruses
36. Regarding viral hepatitis, circle the mainly in their:
WRONG ANSWER: a.Type of nucleic acid
A) HCV-Abs can’t be diagnosed in b. Size
the lab. by EIA test c. Capsid shape
B) The risk factor for hepatocellular d. Ability to survive acidic conditions
carcinoma by HCV are: underlying 44. What types of viruses contain the
liver disease, alcohol, age enzyme lysozyme to aid in their
C) HCV-DNA integrate into liver cell infection?
chromosomes in most HCC a.Bacteriophage
patients. b. Animal Viruses
D) Cell entry and replication of c. Plant Viruses
delta hepatitis (HDV) take place by the d. Fungal Viruses
presence of HBV 45. Bacteriophage are readily counted by
E) The RNA and protein of HDV is the process of:
surrounded by HBsAg a.Immunoassays
37. what does HBEAG mean……? b. ELISA
a) Envelope antigen c. Plaque assays
b) Cover antigen d. Tissue cell culture
c) Capsid antigen 46. A type of cell culture that can
d) Surface antigen reproduce for an extended number of
38. Co-infection and super-infection is generations and is used to support
related to ………. viral replication is a :
a) HDV a. Primary cell culture
b) HBV b. Continuous cell line
c) HEV c. Cell strain
39. Viruses range in size from: d. Diploid fibroblast cell
a.1-100 nm 47. Which of the following is not an RNA
b. 25-300 nm virus?
c. 10-100 μm a.Retrovirus
d.400-1000 nm b. Enterovirus
40. A structural component that is found c. Rhabadovirus
in all viruses is: d. Adenovirus
a.The envelope 48. Detection of HBsAg in patient serum
b. DNA indicates…..
c. Capsid a) Acute infection
d. Tail fibers b) Chronic infection
41. A chemical component that is found c) Active infection
in all viruses is: d) All of the above
a.Protein 49. Which of the following are double
b. Lipid stranded RNA virus …..
c. DNA a) Picornaviridie
d. RNA b) Poxviridie
e. Glycoproteins c) Reoviridie
42. A common polyhedral capsid shape of d) All of these
viruses is a :
50. Which of the following is single
stranded DNA virus….
a) Poxviridie
b) Parvoviridie
c) Reoviridie
d) None of these