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Takayasu'S Arteritis: Dr. Aishwarya
Takayasu'S Arteritis: Dr. Aishwarya
Dr. Aishwarya
DEFINITION
Uncommon disease.
Annual incidence rate 1.2-2.6 cases/million
Prevalent in adolescent and young women
M.C. in Asia
No racial/geographical distribution.
Race
Panarteritis,inflammmatory mononuclear
infiltrates,occasionally giant cells
Marked intimal proliferation ,fibrosis ,scarring
and vascularisation of media
disruption,degeneration of elastic lamina
Narrowing of lumen +/- thrombus
Pathology in the chronic phase of Takayasu’s Arteritis showing
fibrosis in all the layers of the vessel wall and markedly
thickened intima
Contd.
Constitutional symptoms :
Headache (50%-70%)
Malaise (35%-65%)
Arthralgias (28%-75%)
Fever (9%-35%)
Weight loss (10%-18%)
Cardiac and vascular features
Bruit, with the most common location being the carotid artery
(80%)
Blood pressure difference of extremities (45%-69%)
Claudication (38%-81%)
Carotodynia or vessel tenderness (13%-32%)
Hypertension (28%-53%; 58% with renal artery stenosis in one
series)
Aortic regurgitation (20%-24%)
Raynaud’s syndrome (15%) .Pericarditis (< 8%) ,Congestive
heart failure (< 7%) , Myocardial infarction (< 3%).
NEUROLOGICAL FEATURES
Headache (50%-70%)
Visual disturbance (16%-35%) - Strong
association with common carotid and
vertebral artery disease
Stroke (5%-9%)
Seizures (0%-20%)
DERMATOLOGICAL
MANIFESTATIONS
2.Common 58 VISUAL
carotid CHANGES,TIA,STROKE,SYNCOPE
AORTIC COARCTATION
ATHEROSCLEROSIS
BEHCET’S DISEASE
BUERGER’S DISEASE (THROMBANGITIS OBLITERANS)
GIANT CELL ARTERITIS
KAWASAKI DISEASE
RHEUMATOID ARTHRITIS
SARCOIDOSIS
AMERICAN COLLEGE OF
RHEUMATOLOGY – CLASSIFICATION
CRITERIA
3 OF 6 NECESSARY
1.Age < 40 yr onset
2.Claudication of extremities
3.Decreased pulsation in one/both brachial arteries
4.Diff of at least 10mm of hg SBP between arms
5.Bruit over one/both sub cl art /abd aorta
6.Arteriografic narrowing/occlusion of entire abd
aorta,its primary br. Or large arteries of both UL and LL
LABORATORY STUDIES
» Abstract
Carotid angioplasty and stenting is increasingly becoming a safe
and efficacious modality of treatment in the management of
carotid artery stenosis. Although atherosclerosis is the
predominant cause of this morbid disease, Takayasu arteritis
assumes special importance in south east Asia. The diffuse nature
of this disease with associated inflammation and scarring of the
vessel make revascularisation difficult. We report a case of
Takayasu arteritis tid stenting was done in a single sitting.
JAPI, feb 2006
Coexistence of Takayasu’s Arteritis with Ulcerative
Colitis
Abstract
Research Article
Lackof Antilipoprotein Lipase Antibodies in Takayasu's
Arteritis
Abstract
Abstract
Abstract
Abstract