Invasive Cancer

Infiltrating Ductal Carcinoma

 The most common histologic type of breast cancer, accounts for 80% of all
cases.
 The tumors arise from the duct system and invade the surrounding tissues.
 They often form a solid irregular mass in the breast.
Infiltrating Lobular Carcinoma
 Accounts for 10% to 15% of breast cancers.
 The tumors arise from the lobular epithelium and typically occur as an area of
ill-defined thickening in the breast.
 They are often multicentric and can be bilateral.
Medullary Carcinoma
 Accounts for about 5% of breast cancers
 More often in women younger than 50 years of age.
 The tumors grow in a capsule inside a duct.
 They can become large and may be mistaken for a fibroadenoma.
Mucinous Carcinoma
 Accounts for about 3% of breast cancers
 Often presents in postmenopausal women 75 years of age and older.
 Tumor is slow growing and thus the prognosis good

Tubular Ductal Carcinoma

 Accounts for about 2% of breast cancers.
 Because axillary metastases are uncommon with this histology, prognosis is
usually excellent.

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 Inflammatory Carcinoma
 Rare (1% to 3%) and aggressive type of breast cancer that has unique
symptoms.
 The cancer is characterized by diffuse edema and brawny erythema of the skin,
often referred to as peau d’orange (blocking of the lymph channels), mass may
or may not be present
 Can be confused with an infection because of its S&S.
 Chemotherapy, radiation and surgery may be useful.

Paget’s Disease
 Accounts for 1% of diagnosed cases of breast cancer.
 Symptoms typically include a scaly, erythematous, pruritic lesion of the nipple.
 Paget’s disease often represents DCIS of the nipple but may have an invasive
component.
 If no lump can be felt in the breast tissue and the biopsy shows DCIS without
invasion, the prognosis is very favorable.
Survival Rates
 Five-year overall survival rates:
o Localized: 97%.
o Regional: 78.7%.
o Distant: 23.3%.

 Lymph node status is the most important prognostic indicator of disease-free

survival.
 Age, staging (tumor size, lymph node status, and distant metastasis), nuclear
grade, histological differentiation, and treatment are important prognostic
factors for survival

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 While incidence rates are increasing, mortality is declining 1% to 2% . This
may be related to:
o Change in lifestyle such as diet
o Early diagnosis increased use of screening mammography
o Improved treatment.