LECTURE NO 6:

T C E L L - M E D I AT E D
IMMUNITY AND ITS
EFFECTOR
MECHANISM
PA R T 2
JAREL ELGIN M. TOLENTINO
B I O L O G Y F A C U LT Y, A D A M S O N U N I V E R S I T Y
jmtolentino4@up.edu.ph
 S T I M U L I F O R A C T I V AT I O N O F
C D 8 +T C E L L S

In response to antigen and

costimulators, T
lymphocytes, especially
CD4 T cells, rap- idly
+

secrete the cytokine IL-2.

 C L O N A L E X PA N S I O N

T lymphocytes activated by
antigen and costimulation
begin to proliferate within 1 or
2 days, resulting in expansion
of antigen-specific clones.
 D I F F E R E N T I AT I O N O F N A I V E T
CELLS INTO EFFECTOR CELLS

Some of the progeny of

antigen-stimulated,
proliferating T cells
differentiate into effector cells
whose function is to eradicate
infections.
D I F F E R E N T I AT I O N O F N A I V E T
CELLS INTO EFFECTOR CELLS

CD4 helper T cells activate

phagocytes and B
lymphocytes through the
action of plasma membrane
proteins and by secreted
cytokines.
TOPIC NO. 4

M I G R AT I O N O F T
LY M P H O C Y T E S I N
C E L L - M E D I AT E D
IMMUNE
REACTIONS
TOPIC NO.5

TYPE OF CELL-
M E D I AT E D
IMMUNE
REACTIONS
Two main types of cell-mediated immune
reactions eliminate different types of
microbes: CD4 helper T cells secrete
+

cytokines that recruit and activate other

leukocytes to phagocytose (ingest) and
destroy microbes, and CD8 cytotoxic T
+

lymphocytes (CTLs) kill any infected cell

containing microbial proteins in the
cytosol, eliminating cellular reservoirs of
infection.
TOPIC NO.6

DEVELOPMENT
AND FUNCTIONS
OF CD4 EFFECTOR
+

T LY M P H O C Y T E S
CD4+ helper T cells may
differentiate into three
major subsets of effector
cells that produce distinct
sets of cytokines that
perform different functions
in host defense.
The functions of the
CD4+T cell subsets reflect
the actions of the
cytokines they produce.
Each subset of CD4+T
cells develops in response
to the types of microbes
that subset is best at
eradicating.
 TH1 CELLS
The Th1 subset is
induced by microbes
that are ingested by and
activate phagocytes,
and Th1 cells stimulate
phagocyte-mediated
killing of ingested
microbes.
 TH2 CELLS

Th2 cells are induced in

parasitic worm infections and
promote IgE-, mast cell- and
eosinophil-mediated
destruction of these parasites.
The relative activation of
Th1 and Th2 cells in
response to an infectious
microbe may determine
the outcome of the
infection.
 TH17 CELLS

Th17 cells develop in bacterial

and fungal infections and induce
inflammatory reactions that
destroy extracellular bacteria
and fungi and may contribute to
several inflammatory diseases.
TOPIC NO.7

DEVELOPMENT
AND FUNCTIONS
OF CD8 +

CYTOTOXIC
T LY M P H O C Y T E S
TOPIC NO.8

R E S I S TA N C E O F
PAT H O G E N I C
MICROBES TO
C E L L - M E D I AT E D
IMMUNITY
END