1. —– relates the rate of elimination to the plasma concentration? Clearance
2. Half life is the property of —- order elimination? First 3. Fraction of administered drug that reaches circulation is called ? Bioavailability 4. Drugs give IV have —–percent bioavailability? 100% 5. Frequency of dosing Is affected by —-? Half life 6. Constant amount of drug eliminated per unit time indicates which order elimination ?? Zero order elimination 7. Phase I metabolism of drugs usually yields? Slightly polar , water soluble metabolites 8. Maximal effect a drug can produce is called ? Efficacy 9. Amount of drug needed for a given effect is called? Potency 10. Therapeutic index is—>? Measurement of drug safety 11. Partial action of morphine is at which opioid receptor? mu 12. Adrenal medulla are part of which nervous system? Sympathetic nervous system 13. Botulinum toxins blocks release of neurotransmitter at which terminals ? Cholinergic 14. Mydriasis is the action of which receptors? a1 15. Dec heart rate and contractility of atria is the action of which receptors? M2 16. Inc gastric secretion is the action which receptors? H2 17. Dec uterine Is the action of which receptor? B2 18. Which vasopressin receptor involve in inc vascular smooth muscle contraction? V1 19. Challenge test for diagnosis of asthma? Methacholine 20. Which drug activate bowel and bladder?? Bethanecol 21. Clinical application of donePezil? Alzheimer’s disease 22. Diagnosis of myasthenia gravis done by? Edrophonium 23. In chronic myasthenia gravis , drug of choice is? Pyridostigmine 24. Antidote of cholinesterase inhibitor poisoning? Pralidoxime 25. Adrenal medulla is innervated by which fibres? Cholinergic fibres 26. Potent stimulator of sweat, tests and saliva? Pilocarpine 26. Atropine effect on eye is? Mydriasis and cycloplegia 27. Isoproterenol action is on which receptors? b1 and b2 28. Dobutamine mainly effects on which receptor? b1 29. Drug used to reduce premature uterine contraction? Terbutaline 30. Attention deficit disorder can be treated by? Amphetamine 31. Ne centrally acting a2 agonists? Clonidine and methyl dopa 32. Toxicity of phenoxybenzamine is? Orthoststic hypotension , reflex tachycardia 33. Name selective b-antagonist? Pindolol, acebutalol 34. Drugs used in urinary retention in BPH? Prazosin, terazosin and doxasozin 35. What is the effect of b-blocker in angina pectoris? Dec heart rate and contractility 36. Antidote of opioid poisoning is? Naloxone/ naltrexone 37. Atropine toxicity antidote? Physostigmine salicylate 38. Antidote for benzodiapzipine? Flumazinil 39. Drugs causing dialated cardiomyopathy? Doxorubicin and daunoeubicin 40. Direct Coombs positive hemolytic anemia is caused by which drug? Methyl dopa 41. Chloremphinicol causes which syndrome? Gray baby syndrome 42. ACE inhibitors main side effect ? Cough and angodema 43. Drug causing pseudo membranous colitis? Clindamycin 44. Vitamin causing hyperglycemia? Niacin 45. Name drugs causing SLE-like syndrome? Hydralazine, INH, Procainamide and phenytoin 46. Tardive dyskinesia is side effect of??? Antipsychotics 47. Name ATT drug which is P-450 inducer? Rifampin 48. Antidote for warfarin toxicity? Vit K , FFP 49. Side effect of isoniazid ? Neurotoxicity and hepatotoxicity 50. Drug which decreases triglycerides ?fibrates 51. Drug protective against diabetx nephropathy? ACE inhibitors 52. Drug which can cause cyanide toxicity ? Nitroprusside 53. Hydralazine dec ? Afterload/preload 54. Action of glitazone? Inc insulin sensitivity in peripheral tissue 55. Sulfonyureas closes which channels in b-cells? K+channe l 56. First line therapy of Type 2 DM? Metformin 57. Which drug is teratogen ? Carbimazole/ methemazole/ propyl thiouracil 58. Drug used in SIADH? Demeclocycline 59. Mechanism of PPI? Irreversibly inhibit H+/K+ATPase in stomach parietal cells 60. Carcinoid tumor is treated by? Octreoride 61. Name antacids causes diarrhea? Magnesium hydroxide 62. The powerful centrally acting antiemetic is? Ondansetron 63. Metaclopromide is which receptor antagonist ? D2 64. Myeloaupression caused by methotrexate is rescued by whih drug? Leucovori 65. Anti Breast cancer drug having endometrial antagonist action is? Raloxifene 66. Myelosuppresion cause by 5 florouracil is rescued by? Thymidine 67. Hemorrhagic cystitis is side effect of ? Cyclophosphamide 68. Nephrotoxicity caused by cisplatin is prevented by? Amifostine 69. Name the drug which is Philadelphia chromosome tyrosine kinase inhibitor ? Imatinib 70. Monoclonal antibody against CD20 is ? Rituximab 71. Probenecid inhibits reabsorption of Uric acid in which part of nephron? Proximal convulated tubule 72. Febuxostat inhibits? Xanthine oxidase 73. Antidote of acetaminophen ? N-acetylecystiene 74. Name anti-TNF antibody commonly used in crohn disease? Infliximab 75. Mechanism of aspirin? Irreversibly inhibit both COX 1 and COX 2 76. Warfarin effects which pathway ? Extrinsic pathway 77. Site of action of heparin? Blood 78. Heparin toxicity is treated by? Protamin sulphate 79. Clopidogrel toxicity cause which hematological deficiency? Neutropenia 80. Abciximab binds to which glycoproteins receptor? IIb/IIIa 81. Which drug is used or maintenance programe for opioid addicts? Methadone 82. Opioid used as cough suppressant ? Dextromethorphan 83. Drug of choice for absence siezures? Ethosuxemide 84. 1st line treatment of eclampsia? Mgso4 85. 1st line of treatment for acute epilepsy? Diazepam 86. Fetal hydantoin syndrome is teratogenicity caused by? Phenytoin 87. Neural tube defects caused by which drug? Valproic acid 88. Barbiturates facilitate GABA action by——of Cl channel ? Duration 89. Which inhaled anesthetic is hepatotoxic? Halothane 90. Most common drug used for endoscopy? Midazolam 91. IV anesthetic used for rapid and short procedures? Propofol 92. Main complication of succinylcholine ? Hypercalcemia and hyperkalemia 93. Malignant hyperthermia is treated hyperthermia ? Dantrolene 94. Benztropin improves——in parkinson disease ? Tremors and rigidity 95. Carbidopa is converted to —- in CNS? Dopamine 96. Selegiline selectively inhibits ??? MAO-B 97. Half life of sumatriptan ?? <2 hours 98. Marked respiratory depression is caused by which depressants ? Barbiturates 99. Maurijuana can be detected in urine upto ——- months of last use? 1 month 100. Treatment of wernickie korsakoff syndrome is? IV Vitamin B1 101. Treatment of delerium tremens?? Benzodiazepines 102. Drug of choice for ADHD? Methylphenidate 103. Social phobias are treated with ? SSRI 104. Drug of choice for obsessive compulsive disorder is ? Clomipramine 105. All typical antipsychotics block which receptors? D2 receptors 106. Corneal deposits is side effect of which antipsychotics ? Chlorpromazine 107. Treatment of neuroleptic malignant syndrome? Dantrolene 108. Which atypical antipsychotic May cause agranulocytosis ? Clozapine 109. Teratogenicity caused by lithium ? Ebstein anomaly 110. Generalized anxiety disorder is treated by? Buspirone 111. Drug of choice of bedwetting patient is? Imipramine 112. Main toxicity of tricyclics antidepressants? Convulsion , coma and cardio toxicity. 113. How much time antidepressant need to have its effect? 4-8weeks 114. Antidepressant used for diabetic peripheral neuropathy is? Duloxetine 115. Drug used for altitude sickness? Acetazolamide 116. Name osmotic diuretic ? Mannitol 117. What is the effect of loop diuretic on calcium in the blood? Hypocalcemia 118. Gout is side effect of which diuretic? Loo diuretic 119. Idiopathic hypercalciuria is treated with? Thiazide diuretics 120. While using ACE inhibitor what will be the effect on renin??? Renin level increases 121. Drug inhibits steroid synthesis ? Ketoconazole . 122. Contraindications of estrogens??? ER positive breast cancer and history of DVTs 123. a1-agonist used to treat BPH ? Tamsulosin 124. Mechanism of action of sildenafil? Inhibit cyclic GMP phosphodiesterse 125. Name 2 drugs of 2nd generation of H1 blockers?? Fexofenadine, citrizine , loratidine, desloratidine 126. What is the action of b2- agonist on bronchial muscle? Bronchial smooth muscle relaxation 127. Name the mast cell stabilizer? Cromolyn 128. Drug that blocks conversion of arachidonic acid to leukotrienes? Zileuton 129. Drug that can loosen mucous plug in Cystic fibrosis patient is? N-acetylcystiene 130. Brochoconstriction is mediated by——and——-? Inflammatory and sympathetic tone 131. Bipolar disorder is treated with? Lithium 132. Drug of choice for cytomegalovirus? Ganciclovir 133. Acute promyelocytic leukemia (M3) treated by? All-trans retinoids acid 134. Common treatment of buergers disease? Smoke cessation 135. Prophylaxis for Hemophilus influenza (B)? Rifampin 136. Treatment if hemorrhagic cystitis is ? Mesna 137. Medical abortion is done by? Mifepristone 138. Drug of choice for migraine? Sumatriptan 139. Treatment of Neisseria gonorrhea? Ceftriaxone 140. Neural tube defect prevention done by? Folic aid ( folate) 141. Drug of choice for PDA? Indomethacin 142. Prostate carcinoma is treated with? Flutamide 143. Drug used in pulmonary hypertension? Bonestan 144. Breast cancer in postmenopausal woman is treated by? Aromatase inhibitor 145. First line drug for depression? SSRIs 146. Imipenem always administered with ? Cilastatin 147. Red man syndrome is side effect of? Vancomycin 148. Main side effects of aminoglycoside ?? Nephrotoxicity , ototoxicity and teratogen 149. Trimethoprim inhibits bacterial? Dihydrofolate reductase 150. Fluoroquinolones damages to cartilage 151. Metallic taste is by which anti microbial drug? Metronidazole 152. Optic neuropathy is side effect? Ethambutol 153. Endocarditis with surgical or dental procedure —-prophylaxis? Penicillins 154. Empiric Therapy for community acquired pneumonia of outdoor patient setting? Macrolides 155. Drug of choice Cryptococcal meningitis in AIDS patient? Fluconazole 156. Drug which inhibit cell wall synthesis by inhibiting synthesis of b-glucan? Caspofungin 157. Terbinafine used to treat ??? Onchomycosis 158. Leishmaniasis is treated by sodium stibogluconate 159. CMV retinitis in immuno compromised patient when ganciclovir fails? Foscarnet 160. Orange body fluids is side effect of? Rifampin