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20-21 - M - ENG - Part - 1 - PDF
20-21 - M - ENG - Part - 1 - PDF
DEPARTMENT OF PATHOLOGY
with sectional course and forensic medicine
ALBUM
FOR AUDITORY AND INDEPENDENT WORKs
Student ________________________
(name)
_________________
(Students’ Signature)
– Ternopil 2020 –
THEMATIC PLAN OF PRACTICAL CLASSES
№ Topics page
Introduction The subject and tasks of pathomorphology. The development of pathomorphology in
1
Ukraine. Methods of pathomorphological investigation. Basic tanathology. Signs of death.
Cellular pathology: cell response to stress and toxic damage. Selective death of specialized cells.
2
Necrosis. Pathological anatomy of organ insufficiency.
Adaptive cellular responses to damage - atrophy, hypertrophy, hyperplasia, metaplasia, autophagy,
3
apoptosis.
4 Regeneration. Wound healing. Pathology of regeneration and healing.
INDEPENDENT WORK TO SECTION 1
10
Morphology of reversible and irreversible damage to cells and tissues. Intracellular accumulation of
5
proteins, carbohydrates and lipids.
Pathology of the extracellular matrix: pathomorphology of accumulation of complex proteins and
6
fats. Pathology of nucleoproteins, pigments, minerals.
7 Hemodynamic disorders: hyperaemia, anemia. Stasis. Water disbalance.
8 Bleeding, thrombosis, embolism, shock, infarction. Disturbances of lymphatic flow.
INDEPENDENT WORK TO SECTION 2
19
Macroscopic research
At macroscopic research of organs or tissue (name) are revealed that its surface ………....., character of
relief _________, presence of deformations, formation; change of volume, consistency, pathological
includings.
On a cut parenchima (to specify a color, characteristic macroscopic signs of pathological process).
CONCLUSION: according to results of macroscopic research it is necessary to consider (to specify a
pathological process or illness)
Microscopic research
At the histological research are revealed the tissue (to name an organ). About it testifies the presence of
(to specify structurally functional unit). Preparation is stained by (to specify the method of staining). At
the microscopic examination it is set (DESCRIBE the morphological changes of parenchima and stromal
composites). The basic morphological changes are ………….., that is expressed by ... .
CONCLUSION: according to results of microscopic examination it is necessary to consider (to specify a
pathological process or disease).
© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
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PRACTICAL LESSON 1 "____" _____________ 2020
TOPIC: Introduction The subject and tasks of pathomorphology. The development of pathomorphology
in Ukraine. Methods of pathomorphological investigation. Basic tanathology. Signs of death.
Definition of pathology
______________________________________________________________________________________________________
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Health and disease
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Investigative methods of modern pathology
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Subjects of pathology
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Definition of etiology?
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Definition of pathogenesis?
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Definition of morphogenesis?
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Definition of thanatogenesis?
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What is the iatrogenic?
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_______________________ _______________________ _______________________ ______________________
Main methods of morphology research
Autopsy tasks
© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
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PRACTICAL LESSON 2 "____" _____________ 2020
TOPIC: Cellular pathology: cell response to stress and toxic damage. Selective death of specialized cells.
Necrosis. Pathological anatomy of organ insufficiency.
I. Theoretical self-preparation program (PREAUDITORIUM WORK)
© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
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II. AUDITORIUM WORK
© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
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PRACTICAL LESSON 3 "____" _____________ 2020
TOPIC: Adaptive cellular responses to damage - atrophy, hypertrophy, hyperplasia, metaplasia,
autophagy, apoptosis.
I . Theoretical self-preparation program (PREAUDITORIUM WORK)
© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
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II. AUDITORIUM WORK
© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
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INDEPENDENT WORK TO SECTION 1
DRAW (schematically) the cell and mark its base structural components
1. nucleus
2. nucleolus
3. cytoplasm
4. cell membrane
5. endoplasmic grid
6. ribosome
7. mitochondria
8. Golgi apparatus
9. lysosomes
10. secretory vacuoles
b)
c)
d)
e)
f)
g)
Morphology regeneration of skin _____________________________________________________________________
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Morphology regeneration of bones ____________________________________________________________________
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Morphology regeneration of liver _____________________________________________________________________
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Morphology regeneration of lungs _____________________________________________________________________
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Morphology regeneration of pancreas___________________________________________________________________
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© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
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PRACTICAL LESSON 5 "____" _____________ 2020
TOPIC: Morphology of reversible and irreversible damage cells and tissues. Intracellular accumulation
of proteins, carbohydrates and lipids.
I. Theoretical self-preparation program (PREAUDITORIUM WORK)
Determination of dystrophy _____________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphogenic mechanisms of dystrophy:
1.____________________________________________________________________________________________________
2.____________________________________________________________________________________________________
3.____________________________________________________________________________________________________
4.____________________________________________________________________________________________________
Classification of dystrophy:
1) according to localization__________________________________________________________________________
2) according to predominance of the metabolism disturbance _________________________________________________
3) depending on genetic factors____________________________________________________________________________
4) according to process prevalence ________________________________________________________________________
Definition of intracellular injury _______________________________________________________________________
_____________________________________________________________________________________________________
Definition of reversible and irreversible cell injury_________________________________________________________
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Morphology of reversible cell injury:___________________________________________________________________
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Types of intracellular accumulation of hyaline_______________________________________________________________
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Morphology and consequences of hydropic dystrophy _______________________________________________________
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Characteristics intracellular accumulation of lipids: causes, mechanisms of development, consequences
______________________________________________________________________________________________________
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Basic mechanisms of development of lipid dystrophy of myocardium, liver and kidneys ___________________________
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Intracellular accumulation of glycogen:__________________________________________________________________
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Change in the glomerulus of kidney in diabetes mellitus ______________________________________________________
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Changes in the liver in diabetes mellitus ________________________________________________________________
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What is glycogen storage disease? Give examples___________________________________________________________
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Morphology of mucoviscidosis ________________________________________________________________________
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Morphology of haemosiderosis _______________________________________________________________________
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Morphology of jaundice ____________________________________________________________________________
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Causes of intracellular accumulation of lipofuscin _________________________________________________________
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© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
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Classification of parenchymal carbohydrate dystrophy _____________________________________________________
______________________________________________________________________________________________________
DRAW MICROPREPARATION
Preparation: FATTY DYSTROPHY OF LIVER 1. Central vein.
Stain: sudan ІІІ 2. Drops of lipid.
DRAW MICROPREPARATION
Preparation: Glycogen deposits in epithelium of distal tubules of the kidney 1. Deposits of glycogen
Stain: PAS - reaction
DESCRIBE MICROPREPARATION " Glycogen deposits in epithelium of distal tubules of the kidney________________
______________________________________________________________________________________________________
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II.AUDITORIUM WORK
DRAW MICROPREPARATION
DRAW MICROPREPARATION
Preparation: BROWN INDURATION OF LUNGS 1. Alveoles.
Stain: Haematoxylin & Eosin 2. Interalveolar membranes.
3. Macrophages with
hemosiderinum.
© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
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PRACTICAL LESSON 8 "____" _____________ 2020
TOPIC: Bleeding, thrombosis, embolism, shock, infarction. Disturbances of lymphatic flow.
I Theoretical self-preparation program (PREAUDITORIUM WORK)
II.AUDITORIUM WORK
DRAW MICROPREPARATION
© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
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INDEPENDENT WORK TO SECTION 2
Determination of haematoma ____________________________________________________________________________
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Distinguishing features of thrombus and postmortem blood clot _______________________________________________
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Determination of heart attack ___________________________________________________________________________
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Morphology of Cardiogenic shock ______________________________________________________________________
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Morphology of Hypovolemic shock _____________________________________________________________________
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Morphology of Septic shock ___________________________________________________________________________
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Morphology stages of Shock __________________________________________________________________________
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List the forms of lymphatic system insufficiency ____________________________________________________________
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The causes of mechanical forms of lymphatic system insufficiency ______________________________________________
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Reasons of dynamic form of lymphatic system insufficiency ___________________________________________________
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Reasons of resorbtive form of lymphatic system insufficiency __________________________________________________
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Morphological manifestations of lymphatic failure (insufficiency) ______________________________________________
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What is lymphedema? Classification of lymphedema _________________________________________________________
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Common cause of acute lymphedema _____________________________________________________________________
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Common cause of chronic lymphedema ___________________________________________________________________
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Causes of congenital and acquired chronic regional lymphedema ______________________________________________
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Morphological manifestations of chronic lymphedema _______________________________________________________
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Causes and Types of limforrhage ________________________________________________________________________
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Macroscopic changes in the skin, subcutaneal tissue, internal organs at edema ____________________________________
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Microscopic changes of tissue at edema __________________________________________________________________
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Causes and pathogenesis stagnant edema _________________________________________________________________
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© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
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PRACTICAL LESSON 9 "____" _____________ 2020
TOPIC: Morphology of acute (exudative) inflammation.
I Theoretical self-preparation program (PREAUDITORIUM WORK)
Determination of inflammation ____________________________________________________________________________
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Morphological and clinical signs of inflammation _____________________________________________________________
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Stages of inflammation___________________________________________________________________________________
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Characteristic of alterative stage ___________________________________________________________________________
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Name the mediators of inflammation ________________________________________________________________________
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Characteristic of exudative stage ___________________________________________________________________________
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Reaction of vascular wall at inflammation ___________________________________________________________________
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What is the different between phagocytosis and endocytobiosis? __________________________________________________
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Determination the exudate and transudate ____________________________________________________________________
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Characteristic of proliferative stage_________________________________________________________________________
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Morphological forms of inflammation _______________________________________________________________________
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Specify the organ (tissue anatomical formation), where is localized next inflammation:
Blepharitis – _______________________________
Myositis – _________________________________
Epididymitis – ______________________________
Valvulitis – ________________________________
Osteomyelitis – _____________________________
Colitis – ___________________________________
Hydradenitis – ______________________________
Pancreatitis – _______________________________
Lymphadenitis – ____________________________
Gingivitis – ________________________________
Parotitis – _________________________________
Meningitis – ______________________________
Glossitis – ________________________________
Peritonitis – _______________________________
Phlebitis – ________________________________
Gonitis – _________________________________
Salpingitis – _______________________________
Funiculitis – _______________________________
Dacryocystitis – ____________________________
Tendinitis – ________________________________
Cholangitis – _______________________________
Determination and localization of fibrinous inflammation (subtypes) ______________________________________________
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Signs of diphtheritic inflammation__________________________________________________________________________
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© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
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Components and types of purulent inflammation_______________________________________________________________
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What is the empyema?___________________________________________________________________________________
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Morphology of hemorrhagic inflammation ___________________________________________________________________
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DRAW microPREPARATION
Preparation: CROUPOUS PNEUMONIA 1. Alveoles.
Stain: Haematoxylin & Eosin 2. Filaments of fibrin.
3. Leucocytes.
4. Vessels.
© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
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II. AUDITORIUM WORK
DRAW microPREPARATION
Preparation: MILIARY TUBERCULOSIS OF LUNG 1. Alveoli.
Stain: Haematoxylin & Eosin 2. Caseous necrosis;
3. Epithelioid cells;
4. Lymphocytes;
5. Langans’ cells.
© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
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PRACTICAL LESSON 11 "____" _____________ 2020
TOPIC: Pathomorphology of the immune system. Autoimmune diseases. Hypersensitivity reactions.
Immunodeficiencies. HIV infection. Transplant rejection reaction. Amyloidosis.
I Theoretical self-preparation program (PREAUDITORIUM WORK)
Immunity – is__________________________________________________________________________________________
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Components of immune response __________________________________________________________________________
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Types of immune response _______________________________________________________________________________
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Definition of autoimmune diseases _________________________________________________________________________
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Types of autoimmune diseases and short characteristic their_____________________________________________________
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Determination of immunological hypersensitivity _____________________________________________________________
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Morphology and mechanism of development hypersensitivity type I_______________________________________________
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Morphology and mechanism of development hypersensitivity type II _____________________________________________
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Morphology and mechanism of development hypersensitivity type III ____________________________________________
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Morphology and mechanism of development hypersensitivity type IV _____________________________________________
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Definition and classification of immunodeficiency states _______________________________________________________
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The essence and characteristic of primary (innate) immunodeficiency states _________________________________________
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The essence and characteristic of secondary (acquired) immunodeficiency states _____________________________________
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List the periods (stage) of HIV infection _____________________________________________________________________
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Main syndromes and causes of death in AIDS patients __________________________________________________________
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The reaction of transplant rejection. ________________________________________________________________________
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Course and characteristics of types reaction of transplant rejection ________________________________________________
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Definition of amyloidosis ________________________________________________________________________________
______________________________________________________________________________________________________
Compnents of amyloid___________________________________________________________________________________
_____________________________________________________________________________________________________
© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
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Types of amyloidosis ___________________________________________________________________________________
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Characteristics of secondary systemic amyloidosis_____________________________________________________________
_____________________________________________________________________________________________________
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DRAW MICROPREPARATION
Preparation: LUPUS NEPHRITIS 1. Glomerulus of capillaries.
Stain: Haematoxylin & Eosin 2. Symptom "wire loops".
3. Fibrinoid necrosis of
capillaries walls.
© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
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INDEPENDENT WORK TO SECTION 3
© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
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PRACTICAL LESSON 12 "____" _____________ 2020
TOPIC: Neolasia. Nomenclature and classification. Characteristic of tumours. Morphological features of
mesenchymal tumors.
I Theoretical self-preparation program (PREAUDITORIUM WORK)
Determination of tumors__________________________________________________________________________________
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Classification of tumors __________________________________________________________________________________
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Nomenclature of tumors__________________________________________________________________________________
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Predisposition to neoplasia________________________________________________________________________________
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Types of growth ________________________________________________________________________________________
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Types of anaplasia_______________________________________________________________________________________
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Morphology of cell anaplasia______________________________________________________________________________
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Morphology of tissue anaplasia ____________________________________________________________________________
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Grading of tumors ______________________________________________________________________________________
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Characteristic of expansive tumors growth____________________________________________________________________
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Characteristic of invasive tumors growth____________________________________________________________________
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Morphological differences of benign and malignant tumors
DRAW MICROPREPARATION
Preparation: LIPOMA 1. Lipocytes.
Stain: Haematoxylin & Eosin 2. Connective-tissue septum.
© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
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Preparation: SARCOMA METASTASIS INTO LUNG 1. Alveolars
Stain: Haematoxylin & Eosin 2. Atypical cells.
© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
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PRACTICAL LESSON 13 "____" _____________ 2020
TOPIC: Nomenclature and morphological features of epithelial tumors. Nervous system tumors.
Features of childhood tumors. Dysontogenetic tumors.
DRAW MICROPREPARATION
Preparation: SQUAMOUS CELL CARCINOMA 1. The multi-layered flat cell
Stain: Haematoxylin & Eosin epithelium
2. Basal membrane
3. Cancer’s pearls
4. Cellular atypism
© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
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PRACTICAL LESSON 14 "____" _____________ 2020
TOPIC: Skin pathology. Nomenclature and morphological features melanocytic tumors. Epidermal and
dermal lesions. Skin manifestations of somatic diseases.
I Theoretical self-preparation program (PREAUDITORIUM WORK)
Disorders of pigmentation ________________________________________________________________________________
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Characteristic of vitiligo ____________________________________________________________________________
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Characteristic lentigo _______________________________________________________________________________
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Definition and classification of nevus ___________________________________________________________________
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Morphology of junction nevus _______________________________________________________________________
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Morphology of compound nevus _____________________________________________________________________
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Morphology of intradermal nevus _____________________________________________________________________
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Morphology of blue nevus __________________________________________________________________________
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Morphology of dysplastic nevus ______________________________________________________________________
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Morphology of melanoma_________________________________________________________________________________
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Metastasis of melanoma__________________________________________________________________________________
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Morphological classification of melanoma____________________________________________________________________
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Skin manifestation of lupus erythematosus_______________________________________________________________
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Skin manifestation of lupus scleroderma _____________________________________________________________________
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Morphology of seborrheic keratosis ____________________________________________________________________
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Morphology of psoriasis ____________________________________________________________________________
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Morphology of bullous pemphigoid ___________________________________________________________________
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Morphology of eczema _____________________________________________________________________________
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Morphology of basal cell carcinoma ___________________________________________________________________
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© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
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II. AUDITORIUM WORK
DESCRIBE THE MACROPREPARATION "Melanoma metastasis in liver" ___________________________________
______________________________________________________________________________________________________
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DESCRIBE THE MACROPREPARATION "Melanoma metastasis in lung" _______________________________________
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DESCRIBE the microPREPARATION " Melanoma, stage III of Klark " ______________________________________
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DESCRIBE the microPREPARATION " Basal cells carcinoma " ____________________________________________
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© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
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INDEPENDENT WORK TO SECTION 4
Morphology of sarcoma Kaposi____________________________________________________________________________
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Morphology of hemangiopericytoma________________________________________________________________________
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Localization of metastases of mammary gland cancer___________________________________________________________
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Morphology of hypernephroid kidney cancer _________________________________________________________________
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List organo-nonspecific benign ovarian tumors________________________________________________________________
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List organo-specific malignant ovarian tumors________________________________________________________________
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Forms of thyroid cancer__________________________________________________________________________________
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Differences morphogenesis of the central and peripheral lung cancer_____________________________________________
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Histological types of lung cancer________________________________________________________________________
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Ways of metastasis of stomach cancer __________________________________________________________________
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What is the Krukenberg cancer?_______________________________________________________________________
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Morphology and ways of prostate cancer metastasis_________________________________________________________
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Clinical and morphological features of Wilms' tumor________________________________________________________
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Tumours of appendages of skin ______________________________________________________________________
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Morphology of dermatitis herpetiformis _____________________________________________________________________
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© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
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