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I.

Horbachevsky Ternopil National Medical University

DEPARTMENT OF PATHOLOGY
with sectional course and forensic medicine

ALBUM
FOR AUDITORY AND INDEPENDENT WORKs

General pathological processes

Student ________________________
(name)

International Students’ Faculty,


group №_______, course 3.

_________________
(Students’ Signature)

– Ternopil 2020 –
THEMATIC PLAN OF PRACTICAL CLASSES
№ Topics page
Introduction The subject and tasks of pathomorphology. The development of pathomorphology in
1
Ukraine. Methods of pathomorphological investigation. Basic tanathology. Signs of death.
Cellular pathology: cell response to stress and toxic damage. Selective death of specialized cells.
2
Necrosis. Pathological anatomy of organ insufficiency.
Adaptive cellular responses to damage - atrophy, hypertrophy, hyperplasia, metaplasia, autophagy,
3
apoptosis.
4 Regeneration. Wound healing. Pathology of regeneration and healing.
INDEPENDENT WORK TO SECTION 1
10

Morphology of reversible and irreversible damage to cells and tissues. Intracellular accumulation of
5
proteins, carbohydrates and lipids.
Pathology of the extracellular matrix: pathomorphology of accumulation of complex proteins and
6
fats. Pathology of nucleoproteins, pigments, minerals.
7 Hemodynamic disorders: hyperaemia, anemia. Stasis. Water disbalance.
8 Bleeding, thrombosis, embolism, shock, infarction. Disturbances of lymphatic flow.
INDEPENDENT WORK TO SECTION 2
19

9 Morphology of acute (exudative) inflammation.


10 Morphology of chronic ( proliferative) inflammation. Specific inflammation. Granulomatosis.
Pathomorphology of the immune system. Autoimmune diseases. Hypersensitivity reactions.
11
Immunodeficiencies. HIV infection. Transplant rejection reaction. Amyloidosis.
INDEPENDENT WORK TO SECTION 3
26

Neolasia. Nomenclature and classification. Characteristic of tumours. Morphological features of


12
mesenchymal tumors.
Nomenclature and morphological features of epithelial tumors. Nervous system tumors. Features
13
of childhood tumors. Dysontogenetic tumors.
Skin pathology. Nomenclature and morphological features melanocytic tumors. Epidermal and
14
dermal lesions. Skin manifestations of somatic diseases.
INDEPENDENT WORK TO SECTION 4
34

PRINCIPLES OF DESCRIPTION OF MACRO- AND MICROPREPARATIONS

Macroscopic research
At macroscopic research of organs or tissue (name) are revealed that its surface ………....., character of
relief _________, presence of deformations, formation; change of volume, consistency, pathological
includings.
On a cut parenchima (to specify a color, characteristic macroscopic signs of pathological process).
CONCLUSION: according to results of macroscopic research it is necessary to consider (to specify a
pathological process or illness)

Microscopic research
At the histological research are revealed the tissue (to name an organ). About it testifies the presence of
(to specify structurally functional unit). Preparation is stained by (to specify the method of staining). At
the microscopic examination it is set (DESCRIBE the morphological changes of parenchima and stromal
composites). The basic morphological changes are ………….., that is expressed by ... .
CONCLUSION: according to results of microscopic examination it is necessary to consider (to specify a
pathological process or disease).

© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
2
PRACTICAL LESSON 1 "____" _____________ 2020

TOPIC: Introduction The subject and tasks of pathomorphology. The development of pathomorphology
in Ukraine. Methods of pathomorphological investigation. Basic tanathology. Signs of death.
Definition of pathology
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Health and disease
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Investigative methods of modern pathology
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Subjects of pathology
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Definition of etiology?
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Definition of pathogenesis?
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Definition of morphogenesis?
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Definition of thanatogenesis?
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
What is the iatrogenic?
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
_______________________ _______________________ _______________________ ______________________
Main methods of morphology research

Autopsy tasks

Determination of death and its types depending on the cause__________________________________________________


______________________________________________________________________________________________________
______________________________________________________________________________________________________
Determination of clinical death _________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Definition of biological death and its signs________________________________________________________________
______________________________________________________________________________________________________

Student's signature _____________________ Teacher signature _____________________

© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
3
PRACTICAL LESSON 2 "____" _____________ 2020
TOPIC: Cellular pathology: cell response to stress and toxic damage. Selective death of specialized cells.
Necrosis. Pathological anatomy of organ insufficiency.
I. Theoretical self-preparation program (PREAUDITORIUM WORK)

Definition of necrosis ____________________________________________________________________________________


______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Microscopic signs of necrosis (changes in a nucleus and cytoplasm)_______________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Types of necrosis ______________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Liqufaction (colliqative) necrosis __________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of coagulative necrosis ________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of caseous necrosis ___________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Description of dry gangrene _______________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
.Morphology of fat necrosis _______________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of fibrinoid necrosis __________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Consequences and values of necrosis _______________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Identification and causes of critical cell alteration _____________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Types selective death of specialized cells ____________________________________________________________________
_____________________________________________________________________________________________________
_____________________________________________________________________________________________________
_____________________________________________________________________________________________________
Morphology of dry gangrene______________________________________________________________________________
_____________________________________________________________________________________________________
_____________________________________________________________________________________________________
Morphology of wet gangrene______________________________________________________________________________
_____________________________________________________________________________________________________
_____________________________________________________________________________________________________
Morphology of bedsore__________________________________________________________________________________
_____________________________________________________________________________________________________
_____________________________________________________________________________________________________
Definition and causes of infarction_________________________________________________________________________
_____________________________________________________________________________________________________
_____________________________________________________________________________________________________
Classification of infarction according to:
 Color _________________________________________________________________________________________
______________________________________________________________________________________________
 Form __________________________________________________________________________________________
______________________________________________________________________________________________

© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
4
II. AUDITORIUM WORK

DESCRIBE MACROPREPARATION “Dry gangrene of the foot”


______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________

DRAW MICROPREPARATION “Necrotic nephrosis”

Preparation: NECROTIC NEPHROSIS 1. Necrotized area.


Stain: Haematoxylin & Eosin 2. Saved tissue of kidney

DESCRIBE MICROPREPARATION "Necrotic nephrosis"


______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________

DESCRIBE MACROPREPARATION "Tuberculosis of adrenal"


______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________

Signature of student _________________ Signature of teacher________________

© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
5
PRACTICAL LESSON 3 "____" _____________ 2020
TOPIC: Adaptive cellular responses to damage - atrophy, hypertrophy, hyperplasia, metaplasia,
autophagy, apoptosis.
I . Theoretical self-preparation program (PREAUDITORIUM WORK)

Definition of adaptation and compensation __________________________________________________________________


______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Mechanisms of cellular adaptation__________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Essence and morphology of dysplasia _______________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Cytologic changes in epithelial dysplasia____________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Definition of metaplasia __________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Squamous metaplasia____________________________________________________________________________________
______________________________________________________________________________________________________
_____________________________________________________________________________________________________
Columnar metaplasia_(osseous metaplasia)___________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Definition of hyperplasia_________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Physiologic and pathologic hyperplasia______________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Essence and morphology of encapsulation____________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Definition and classification of hypertrophy __________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Reasons and stages myocardium hypertrophy ________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Definition and classification of atrophy ______________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphogenesis of inactivity atrophy _____________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphogenesis of blood insufficiency atrophy_____________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphogenesis of atrophy from pressure__________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphogenesis neuropathic atrophy and atrophy of action of physical and chemical factors_____________________________
______________________________________________________________________________________________________
_____________________________________________________________________________________________________
Determination of the apoptosis _________________________________________________________________________
______________________________________________________________________________________________________
© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
6
______________________________________________________________________________________________________
Stages of the apoptosis _______________________________________________________________________________
_____________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphological essence of autophagy________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________

II. AUDITORIUM WORK

DESCRIBE MACROPREPARATION "Concentric and eccentric hypertrophy of the heart "___________________________


______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
DESCRIBE microPREPARATION " metaplasia of epitilium of cervix uteri"_______________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
DRAW MICROPREPARATION
Preparation: METAPLASIA OF EPITILIUM OF CERVIX UTERI 1. Gladular epitilium.
Stain: Haematoxylin & Eosin 2. Growth of glands

Preparation: EMPHYSEMA OF LUNGS 1. Alveoles.


Stain: Haematoxylin & Eosin 2. Destroyed membranes.

DESCRIBE MACROPREPARATION "Bullous emphysema "___________________________________________________


______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
DESCRIBE microPREPARATION "Emphysema of lungs"_____________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________

Student Signature _____________________ Teacher Signature _____________________


© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
7
PRACTICAL LESSON 4 "____" _____________ 2020
TOPIC: Regeneration. Wound healing. Pathology of regeneration and healing.

I . Theoretical self-preparation program (PREAUDITORIUM WORK)

Definition of regeneration ________________________________________________________________________________


______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Classification and types of regeneration _____________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Characteristic of physiological regeneration___________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Characteristic of reparative (regenerative) regeneration__________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of substitution _______________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of restitution ________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Aberrations of regeneration _______________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Types of wound healing __________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of healing by first intention_____________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of healing by secondary intention ________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Regeneration of liver_____________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Regeneration of peripheral nerves __________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Regeneration of bones ___________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Regeneration of connective tissue __________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Regeneration of mycardium__________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Regeneration of skin _______________________________________________________________________________
____________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Regeneration of brain ______________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________

© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
8
II. AUDITORIUM WORK

DESCRIBE MACROPREPARATION "Trophic ulcer of the lower extremity "__________________________________


______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
DESCRIBE microPREPARATION "Cardiosclerosis"__________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
DRAW MICROPREPARATION
Preparation: CARDIOSCLEROSIS 1. Fibres of cardiomyocytes.
Stain: Haematoxylin & Eosin 2. Vessels.
3. Connective tissue

Preparation: GRANULATION TISSUE 1. Vessels


Stain: Haematoxylin & Eosin 2. Collagen fibres
3. Cells infiltration

DESCRIBE MACROPREPARATION "Cyst of brain "___________________________________________________


______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
DESCRIBE microPREPARATION "Granulation tissue"_____________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________

Student Signature _____________________ Teacher Signature _____________________

© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
9
INDEPENDENT WORK TO SECTION 1

DRAW (schematically) the cell and mark its base structural components

1. nucleus
2. nucleolus
3. cytoplasm
4. cell membrane
5. endoplasmic grid
6. ribosome
7. mitochondria
8. Golgi apparatus
9. lysosomes
10. secretory vacuoles

Morphological signs of pathology cell nucleus ______________________________________________________________


______________________________________________________________________________________________________
______________________________________________________________________________________________________
Etiology of cell injury:
a)

b)

c)

d)

e)

f)

g)
Morphology regeneration of skin _____________________________________________________________________
______________________________________________________________________________________________________
Morphology regeneration of bones ____________________________________________________________________
_______________________________________________________________________________________________
________________________________________________________________________________________________
Morphology regeneration of liver _____________________________________________________________________
_______________________________________________________________________________________________
_______________________________________________________________________________________________
Morphology regeneration of lungs _____________________________________________________________________
______________________________________________________________________________________________________
_______________________________________________________________________________________________
Morphology regeneration of pancreas___________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________

© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
10
PRACTICAL LESSON 5 "____" _____________ 2020
TOPIC: Morphology of reversible and irreversible damage cells and tissues. Intracellular accumulation
of proteins, carbohydrates and lipids.
I. Theoretical self-preparation program (PREAUDITORIUM WORK)
Determination of dystrophy _____________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphogenic mechanisms of dystrophy:
1.____________________________________________________________________________________________________
2.____________________________________________________________________________________________________
3.____________________________________________________________________________________________________
4.____________________________________________________________________________________________________
Classification of dystrophy:
1) according to localization__________________________________________________________________________
2) according to predominance of the metabolism disturbance _________________________________________________
3) depending on genetic factors____________________________________________________________________________
4) according to process prevalence ________________________________________________________________________
Definition of intracellular injury _______________________________________________________________________
_____________________________________________________________________________________________________
Definition of reversible and irreversible cell injury_________________________________________________________
_______________________________________________________________________________________________
_______________________________________________________________________________________________
Morphology of reversible cell injury:___________________________________________________________________
______________________________________________________________________________________________________
_______________________________________________________________________________________________
Types of intracellular accumulation of hyaline_______________________________________________________________
______________________________________________________________________________________________________
_______________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology and consequences of hydropic dystrophy _______________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Characteristics intracellular accumulation of lipids: causes, mechanisms of development, consequences
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Basic mechanisms of development of lipid dystrophy of myocardium, liver and kidneys ___________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Intracellular accumulation of glycogen:__________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Change in the glomerulus of kidney in diabetes mellitus ______________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Changes in the liver in diabetes mellitus ________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
What is glycogen storage disease? Give examples___________________________________________________________
______________________________________________________________________________________________________
________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of mucoviscidosis ________________________________________________________________________
_______________________________________________________________________________________________
Morphology of haemosiderosis _______________________________________________________________________
_______________________________________________________________________________________________
_______________________________________________________________________________________________
Morphology of jaundice ____________________________________________________________________________
_______________________________________________________________________________________________
_______________________________________________________________________________________________
_______________________________________________________________________________________________
Causes of intracellular accumulation of lipofuscin _________________________________________________________
_______________________________________________________________________________________________
© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
11
Classification of parenchymal carbohydrate dystrophy _____________________________________________________
______________________________________________________________________________________________________

II. AUDITORIUM WORK

DESCRIBE MACROPREPARATION "Fatty Dystrophy of Liver" _______________________________________________


______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________

DRAW MICROPREPARATION
Preparation: FATTY DYSTROPHY OF LIVER 1. Central vein.
Stain: sudan ІІІ 2. Drops of lipid.

DESCRIBE MICROPREPARATION "Fatty Dystrophy of Liver" ________________________________________________


______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________

DRAW MICROPREPARATION

Preparation: Glycogen deposits in epithelium of distal tubules of the kidney 1. Deposits of glycogen
Stain: PAS - reaction

DESCRIBE MICROPREPARATION " Glycogen deposits in epithelium of distal tubules of the kidney________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________

Signature of student _________________ Signature of teacher________________


© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
12
PRACTICAL LESSON 6 "____" _____________ 2020
TOPIC: Pathology of the extracellular matrix: pathomorphology of accumulation of complex proteins
and fats. Pathology of nucleoproteins, pigments, minerals.

I. Theoretical self-preparation program (PREAUDITORIUM WORK)


Localization of pathological process at mesenchymal dystrophy _________________________________________________
______________________________________________________________________________________________________
Structure of hystion ____________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Mechanisms of extracellular accumulation _______________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Classification of extracellular accumulation ______________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Types of extracellular disproteinosis_______________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Mucoid swelling: causes, mechanisms of development, _______________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Mucoid swelling: morphology and consequences ____________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Fibrinoid swelling: causes and macroscopic characteristics ____________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Fibrinoid swelling: microscopic characteristics and consequences _______________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Essence of hyalinosis and its classification _________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Which organs vessels are destroyed at a system hyalinosis ____________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Classification of obesity:
а) according to etiology __________________________________________________________________________________
______________________________________________________________________________________________________
b) according to external displays ___________________________________________________________________________
______________________________________________________________________________________________________
c) according to morphological characteristic __________________________________________________________________
______________________________________________________________________________________________________
d) according to the mechanism of development________________________________________________________________
______________________________________________________________________________________________________
Essence of myxoid degeneration ______________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Essence of mixed dystrophy ____________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
What haemoglobin pigments appear at the increased destruction of erythrocytes at pathological condition _______________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Basic clinic-morphological manifestations of gemoglobin pigments exchange violation _______________________________
______________________________________________________________________________________________________
_______________________________________________________________________________________________
_______________________________________________________________________________________________
At which diseases the general hemosiderosis is developed? ___________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
13
II. AUDITORIUM WORK

DESCRIBE MACROPREPARATION "Biliary Cirrhosis of Liver "_______________________________________________


______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________

DRAW MICROPREPARATION "Liver at Mechanical Icterus"

Preparation: LIVER AT MECHANICAL ICTERUS. 1. Hepatic lobulus.


Stain: Haematoxylin & Eosin 2. Central vein.
3. Triads.
4. Bilious thrombus.

DESCRIBE MICROPREPARATION "Liver at Mechanical Icterus"______________________________________________


______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
DESCRIBE MACROPREPARATION "Hyalinosis spleen capsule "_______________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________

DRAW MICROPREPARATION “Hyalinosis spleen artery”

Preparation: HYALINOSIS SPLEEN ARTERY 1. Lymphoid follicles


Stain: Haematoxylin & Eosin 2. Hyalinosis central
artery

DESCRIBE MICROPREPARATION “Hyalinosis spleen artery”


______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________

Signature of student _________________ Signature of teacher________________


© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
14
PRACTICAL LESSON 7 "____" _____________ 2020
TOPIC: Hemodynamic disorders: hyperaemia, anemia. Stasis. Water disbalance.

I Theoretical self-preparation program (PREAUDITORIUM WORK)

Classification of hyperemia and congestion __________________________________________________________________


______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of active hyperemia ______________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Types of passive (venous) hyperemia ___________________________________________________________________
_______________________________________________________________________________________________
_______________________________________________________________________________________________
Morphology of passive lung hyperemia _________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of passive (general) liver hyperemia __________________________________________________________
_______________________________________________________________________________________________
_______________________________________________________________________________________________
Morphology of passive (local) liver hyperemia ____________________________________________________________
________________________________________________________________________________________________
Morphology of passive kidney hyperemia _______________________________________________________________
_______________________________________________________________________________________________
_______________________________________________________________________________________________
Morphology of passive spleen hyperemia ________________________________________________________________
_______________________________________________________________________________________________
_______________________________________________________________________________________________
Description of plethora _____________________________________________________________________________
_______________________________________________________________________________________________
_______________________________________________________________________________________________
Description of erythroemia _____________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Definition of ischemia______________________________________________________________________________
______________________________________________________________________________________________________
Types of ischemia _________________________________________________________________________________
_______________________________________________________________________________________________
Definition, causes and manifestation of stasis_____________________________________________________________
______________________________________________________________________________________________________
_______________________________________________________________________________________________
Morphology of renal oedema ________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
_______________________________________________________________________________________________
Morphology of cardiac oedema _______________________________________________________________________
_____________________________________________________________________________________________________
_______________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of pulmonary oedema ____________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of cerebral oedema ______________________________________________________________________
_______________________________________________________________________________________________
_______________________________________________________________________________________________
Definition, causes and manifestations of dehydration _______________________________________________________
______________________________________________________________________________________________________
_______________________________________________________________________________________________

II.AUDITORIUM WORK

DESCRIBE microPREPARATION "Stasis in Cerebrum Capillaries" _____________________________________________


______________________________________________________________________________________________________
© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
15
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________

DRAW MICROPREPARATION

Preparation: STASIS IN CEREBRUM CAPILLARIES 1. Vessel.


Stain: by Heidenhain 2. Red cells

DESCRIBE microPREPARATION "Brown Induration of Lung" ________________________________________________


______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________

DRAW MICROPREPARATION
Preparation: BROWN INDURATION OF LUNGS 1. Alveoles.
Stain: Haematoxylin & Eosin 2. Interalveolar membranes.
3. Macrophages with
hemosiderinum.

DESCRIBE MACROPREPARATION "Brown Induration of Lung" ______________________________________________


______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________

DESCRIBE MACROPREPARATION "Varicose Veins of the Esophagus" _________________________________________


______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________

Signature of student _____________________ Signature of teacher_____________________

© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
16
PRACTICAL LESSON 8 "____" _____________ 2020
TOPIC: Bleeding, thrombosis, embolism, shock, infarction. Disturbances of lymphatic flow.
I Theoretical self-preparation program (PREAUDITORIUM WORK)

Determination of bleeding ______________________________________________________________________________


______________________________________________________________________________________________________
______________________________________________________________________________________________________
LATIN NAMES OF …
cough with blood – ______________________________ bleeding from a uterus – ________________________________
bleeding from a nose – ____________________________ vomit by blood – ____________________________________
blood in defecating – _____________________________ blood in joint – _______________________________________
blood in pleural space – __________________________ blood in abdominal cavity– ______________________________
blood in pericardium– ____________________________
Classification of haemorrhage __________________________________________________________________________
______________________________________________________________________________________________________
Types of haemorrhages according to causes_______________________________________________________________
_______________________________________________________________________________________________
_______________________________________________________________________________________________
Determination of thrombosis. Dynamics of mechanism of thrombus formation (stages)_____________________________
________________________________________________________________________________________________
_______________________________________________________________________________________________
Causes of thrombosis ______________________________________________________________________________
_______________________________________________________________________________________________
_______________________________________________________________________________________________
Morphological forms of thrombus _____________________________________________________________________
________________________________________________________________________________________________
_______________________________________________________________________________________________
_______________________________________________________________________________________________
Consequences of thrombosis _________________________________________________________________________
_______________________________________________________________________________________________
_______________________________________________________________________________________________
Causes of (DIC) disseminated intravascular coagulation syndrome _____________________________________________
_______________________________________________________________________________________________
_______________________________________________________________________________________________
_______________________________________________________________________________________________
Morphology of DIC syndrome ________________________________________________________________________
_______________________________________________________________________________________________
________________________________________________________________________________________________
Determination of embolism and classification_____________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
_______________________________________________________________________________________________
Morphology of lung thromboembolism ________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Amniotic embolism _______________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Fat embolism ____________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Gas embolism ____________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Determination of infarction __________________________________________________________________________
______________________________________________________________________________________________________
Types of infarction ________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
17
Stages of myocardial infarction _______________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Consequences of myocardial infarction _________________________________________________________________
______________________________________________________________________________________________________
_____________________________________________________________________________________________________
Morphological manifestation of lymph flow disturbance ___________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________

II.AUDITORIUM WORK

DESCRIBE microPREPARATION " FATTY EMBOLISM OF LUNGS VESSELS”


______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________

DRAW MICROPREPARATION

Preparation: FATTY EMBOLISM OF LUNGS VESSELS 1. Vessel.


Stain: sudan ІІІ 2. Fat drop.

DESCRIBE MACROPREPARATION " Ischemic necrosis of the spleen" _________________________________________


______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
________________________________________________________________________________________________

DESCRIBE MACROPREPARATION " Thromboembolism of the pulmonary artery " _______________________________


______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________

DESCRIBE MACROPREPARATION " Gangrene of the intestine”


______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________

Signature of student _____________________ Signature of teacher_____________________

© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
18
INDEPENDENT WORK TO SECTION 2
Determination of haematoma ____________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Distinguishing features of thrombus and postmortem blood clot _______________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Determination of heart attack ___________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of Cardiogenic shock ______________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of Hypovolemic shock _____________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of Septic shock ___________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology stages of Shock __________________________________________________________________________
______________________________________________________________________________________________________
List the forms of lymphatic system insufficiency ____________________________________________________________
______________________________________________________________________________________________________
The causes of mechanical forms of lymphatic system insufficiency ______________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Reasons of dynamic form of lymphatic system insufficiency ___________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Reasons of resorbtive form of lymphatic system insufficiency __________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphological manifestations of lymphatic failure (insufficiency) ______________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
What is lymphedema? Classification of lymphedema _________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Common cause of acute lymphedema _____________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Common cause of chronic lymphedema ___________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Causes of congenital and acquired chronic regional lymphedema ______________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphological manifestations of chronic lymphedema _______________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Causes and Types of limforrhage ________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Macroscopic changes in the skin, subcutaneal tissue, internal organs at edema ____________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Microscopic changes of tissue at edema __________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Causes and pathogenesis stagnant edema _________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________

Signature of student _____________________ Signature of teacher_____________________

© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
19
PRACTICAL LESSON 9 "____" _____________ 2020
TOPIC: Morphology of acute (exudative) inflammation.
I Theoretical self-preparation program (PREAUDITORIUM WORK)
Determination of inflammation ____________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphological and clinical signs of inflammation _____________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Stages of inflammation___________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Characteristic of alterative stage ___________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Name the mediators of inflammation ________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Characteristic of exudative stage ___________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Reaction of vascular wall at inflammation ___________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
What is the different between phagocytosis and endocytobiosis? __________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Determination the exudate and transudate ____________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Characteristic of proliferative stage_________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphological forms of inflammation _______________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Specify the organ (tissue anatomical formation), where is localized next inflammation:
Blepharitis – _______________________________
Myositis – _________________________________
Epididymitis – ______________________________
Valvulitis – ________________________________
Osteomyelitis – _____________________________
Colitis – ___________________________________
Hydradenitis – ______________________________
Pancreatitis – _______________________________
Lymphadenitis – ____________________________
Gingivitis – ________________________________
Parotitis – _________________________________
Meningitis – ______________________________
Glossitis – ________________________________
Peritonitis – _______________________________
Phlebitis – ________________________________
Gonitis – _________________________________
Salpingitis – _______________________________
Funiculitis – _______________________________
Dacryocystitis – ____________________________
Tendinitis – ________________________________
Cholangitis – _______________________________
Determination and localization of fibrinous inflammation (subtypes) ______________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Signs of diphtheritic inflammation__________________________________________________________________________
______________________________________________________________________________________________________
© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
20
______________________________________________________________________________________________________
Components and types of purulent inflammation_______________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
What is the empyema?___________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of hemorrhagic inflammation ___________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________

II. AUDITORIUM WORK

DESCRIBE the MACROPREPARATION "Croupous Pneumonia"


______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________

DRAW microPREPARATION
Preparation: CROUPOUS PNEUMONIA 1. Alveoles.
Stain: Haematoxylin & Eosin 2. Filaments of fibrin.
3. Leucocytes.
4. Vessels.

Preparation: HAEMORRHAGIC INFLAMMATION IN LUNGS IN INFLUENZA 1. Alveoli


Stain: Haematoxylin & Eosin 2. Red blood cells
3. Neutrophils

DESCRIBE microPREPARATION "Croupous Pneumonia"


______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
DESCRIBE microPREPARATION " HAEMORRHAGIC INFLAMMATION IN LUNGS IN INFLUENZA
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________

Signature of student _____________________ Signature of teacher_____________________


© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
21
PRACTICAL LESSON 10 "____" _____________ 2020
TOPIC: Morphology of chronic ( proliferative) inflammation. Specific inflammation. Granulomatosis.

I Theoretical self-preparation program (PREAUDITORIUM WORK)

Determination of productive inflammation____________________________________________________________________


______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of interstitial inflammation _____________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Determination of granulomatous inflammation ________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Etiology of granulomatous inflammation_____________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Stages of granulomas development _________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
The structure differences between foreign body giant cells and Langhans’ giant cells _________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Draw schematically the foreign body giant cells and Langhans’ giant cells

FOREIGN BODY GIANT CELLS LANGHANS’ GIANT CELLS

The types of nonspecific granulomas ________________________________________________________________________


______________________________________________________________________________________________________
______________________________________________________________________________________________________
What are the specific granulomas?__________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphological signs of tuberculous granuloma ________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphological signs of syphilitic granuloma _________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Structure of granuloma in leprosy __________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of polyp____________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of condyloma acuminatum _____________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Consequences of productive inflammation____________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________

© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
22
II. AUDITORIUM WORK

DESCRIBE MACROPREPARATION " MILIARY TUBERCULOSIS OF LUNG"


______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________

DRAW microPREPARATION
Preparation: MILIARY TUBERCULOSIS OF LUNG 1. Alveoli.
Stain: Haematoxylin & Eosin 2. Caseous necrosis;
3. Epithelioid cells;
4. Lymphocytes;
5. Langans’ cells.

Preparation: CHRONIC ABSCESS OF LIVER 1. Cavity abscess


Stain: Haematoxylin & Eosin 2. Wall of abscess:
2a) pyogenic membrane;
2b) granulation tissue;
2c) connecting tissue.
3. Hepatocytes.

DESCRIBE microPREPARATION "Miliary Tuberculosis of Lung"


______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________

DESCRIBE microPREPARATION "Chronic Abscess of Liver"


______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________

Signature of student _____________________ Signature of teacher_____________________

© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
23
PRACTICAL LESSON 11 "____" _____________ 2020
TOPIC: Pathomorphology of the immune system. Autoimmune diseases. Hypersensitivity reactions.
Immunodeficiencies. HIV infection. Transplant rejection reaction. Amyloidosis.
I Theoretical self-preparation program (PREAUDITORIUM WORK)
Immunity – is__________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Components of immune response __________________________________________________________________________
______________________________________________________________________________________________________
Types of immune response _______________________________________________________________________________
______________________________________________________________________________________________________
Definition of autoimmune diseases _________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Types of autoimmune diseases and short characteristic their_____________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Determination of immunological hypersensitivity _____________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology and mechanism of development hypersensitivity type I_______________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology and mechanism of development hypersensitivity type II _____________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology and mechanism of development hypersensitivity type III ____________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology and mechanism of development hypersensitivity type IV _____________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Definition and classification of immunodeficiency states _______________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
The essence and characteristic of primary (innate) immunodeficiency states _________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
The essence and characteristic of secondary (acquired) immunodeficiency states _____________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
List the periods (stage) of HIV infection _____________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Main syndromes and causes of death in AIDS patients __________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
The reaction of transplant rejection. ________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Course and characteristics of types reaction of transplant rejection ________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Definition of amyloidosis ________________________________________________________________________________
______________________________________________________________________________________________________
Compnents of amyloid___________________________________________________________________________________
_____________________________________________________________________________________________________
© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
24
Types of amyloidosis ___________________________________________________________________________________
_____________________________________________________________________________________________________
Characteristics of secondary systemic amyloidosis_____________________________________________________________
_____________________________________________________________________________________________________
______________________________________________________________________________________________________

II. AUDITORIUM WORK


DESCRIBE MACROPREPARATION " Amyloidosis of Spleen"____________________________________________
_____________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________

DESCRIBE microPREPARATION "Lupus nephritis"__________________________________________________________


______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________

DRAW MICROPREPARATION
Preparation: LUPUS NEPHRITIS 1. Glomerulus of capillaries.
Stain: Haematoxylin & Eosin 2. Symptom "wire loops".
3. Fibrinoid necrosis of
capillaries walls.

Preparation: HASHIMOTO GOITER 1. Thyroid follicles.


Stain: Haematoxylin & Eosin 2. Diffuse lymphocytic
infiltration.

DESCRIBE microPREPARATION "Hashimoto goiter"________________________________________________________


______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
_____________________________________________________________________________________________________
______________________________________________________________________________________________________

Student Signature _____________________ Teacher Signature _____________________

© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
25
INDEPENDENT WORK TO SECTION 3

Morphology of catarrhal inflammation______________________________________________________________________


_____________________________________________________________________________________________________
_____________________________________________________________________________________________________
Morphology of fibrinuos inflammation______________________________________________________________________
_____________________________________________________________________________________________________
_____________________________________________________________________________________________________
Morphology of suppurative inflammation ___________________________________________________________________
_____________________________________________________________________________________________________
_____________________________________________________________________________________________________
Morphology of furuncle _________________________________________________________________________________
_____________________________________________________________________________________________________
_____________________________________________________________________________________________________
Morphology of carbuncle ________________________________________________________________________________
_____________________________________________________________________________________________________
_____________________________________________________________________________________________________
Characteristics inflammation in newborn____________________________________________________________________
_____________________________________________________________________________________________________
_____________________________________________________________________________________________________
Difference between complete and incomplete phagocytosis _____________________________________________________
_____________________________________________________________________________________________________
_____________________________________________________________________________________________________
Regulation of inflammation_______________________________________________________________________________
_____________________________________________________________________________________________________
_____________________________________________________________________________________________________
Causes and morphology brain abscess ______________________________________________________________________
_____________________________________________________________________________________________________
_____________________________________________________________________________________________________
Causes and morphology lung abscess _______________________________________________________________________
_____________________________________________________________________________________________________
_____________________________________________________________________________________________________
Causes and morphology liver abscess ______________________________________________________________________
_____________________________________________________________________________________________________
_____________________________________________________________________________________________________
Morphology of granuloma in sarcoidosis ____________________________________________________________________
_____________________________________________________________________________________________________
_____________________________________________________________________________________________________
Forms of primary immunodeficiency diseases ________________________________________________________________
_____________________________________________________________________________________________________
_____________________________________________________________________________________________________
Forms of secondary immunodeficiency diseases ______________________________________________________________
_____________________________________________________________________________________________________
_____________________________________________________________________________________________________
Routes of HIV transmission ______________________________________________________________________________
_____________________________________________________________________________________________________
_____________________________________________________________________________________________________
Stages of HIV infection __________________________________________________________________________________
_____________________________________________________________________________________________________
_____________________________________________________________________________________________________
Pathological changes in lymphoid tissue in HIV ______________________________________________________________
_____________________________________________________________________________________________________
_____________________________________________________________________________________________________
Major and minor signs of immunosupression _________________________________________________________________
_____________________________________________________________________________________________________
_____________________________________________________________________________________________________
Cases of death in HIV ___________________________________________________________________________________
_____________________________________________________________________________________________________
_____________________________________________________________________________________________________

Signature of student _____________________ Signature of teacher_____________________

© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
26
PRACTICAL LESSON 12 "____" _____________ 2020
TOPIC: Neolasia. Nomenclature and classification. Characteristic of tumours. Morphological features of
mesenchymal tumors.
I Theoretical self-preparation program (PREAUDITORIUM WORK)
Determination of tumors__________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Classification of tumors __________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Nomenclature of tumors__________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Predisposition to neoplasia________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Types of growth ________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Types of anaplasia_______________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of cell anaplasia______________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of tissue anaplasia ____________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Grading of tumors ______________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Characteristic of expansive tumors growth____________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Characteristic of invasive tumors growth____________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphological differences of benign and malignant tumors

Metastasis (distant spread) of tumors ________________________________________________________________________


______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Microscopic structure of tumors____________________________________________________________________________
______________________________________________________________________________________________________
© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
27
TNM staging __________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Diagnostics methods of tumors____________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of fibroma___________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of fibrosarcoma ______________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of lipoma ___________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of liposarcoma _______________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of leiomyoma _______________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of leiomyosacoma____________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of haemangioma _____________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of chondroma _______________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________

II. AUDITORIUM WORK


DESCRIBE THE MACROPREPARATION "Osteosarcoma" _________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________

DRAW MICROPREPARATION
Preparation: LIPOMA 1. Lipocytes.
Stain: Haematoxylin & Eosin 2. Connective-tissue septum.

© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
28
Preparation: SARCOMA METASTASIS INTO LUNG 1. Alveolars
Stain: Haematoxylin & Eosin 2. Atypical cells.

DESCRIBE the microPREPARATION "Lipoma" ____________________________________________________________


______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
DESCRIBE the microPREPARATION "Sarcoma metastasis into lung" ___________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________

Signature of student _____________________ Signature of teacher_____________________

© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
29
PRACTICAL LESSON 13 "____" _____________ 2020
TOPIC: Nomenclature and morphological features of epithelial tumors. Nervous system tumors.
Features of childhood tumors. Dysontogenetic tumors.

I Theoretical self-preparation program (PREAUDITORIUM WORK)

Classification of epithelial tumors__________________________________________________________________________


______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of papilloma_________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of adenoma, kinds of adenomas__________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Histogenetic classification of cancers______________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of “cancer in situ”____________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of squamous cell carcinoma_____________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of adenocarcinoma, types of adenocarcinomas, grading ______________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Features of tumor growth in childhood_______________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of teratoma__________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of teratoblastoma_____________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of astrocytoma______________________________________________________________________________
______________________________________________________________________________________________________
Nomenclature of nervous tissue tumors______________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of neuroblastoma_____________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of glioblastoma____________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of meningioma_______________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of schwannoma (neurilemmoma)_________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of meningioma ______________________________________________________________________________
______________________________________________________________________________________________________
Morphology of meduloblastoma____________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
30
Embryonal tumours and their types. ________________________________________________________________________
_____________________________________________________________________________________________________

II. AUDITORIUM WORK


DESCRIBE THE MACROPREPARATION "Lung cancer" ___________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
DESCRIBE the macroPREPARATION "Fungiform cancer of tomach" ___________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
_______________________________________________________________________________________________
DESCRIBE the macroPREPARATION "Glioma" _______________________________________________________
_______________________________________________________________________________________________
_______________________________________________________________________________________________

DRAW MICROPREPARATION
Preparation: SQUAMOUS CELL CARCINOMA 1. The multi-layered flat cell
Stain: Haematoxylin & Eosin epithelium
2. Basal membrane
3. Cancer’s pearls
4. Cellular atypism

Preparation: SHWANNOMA 1. Verocay bodies.


Stain: Haematoxylin & Eosin

DESCRIBE the microPREPARATION " SQUAMOUS CELL CARCINOMA " ___________________________________


_______________________________________________________________________________________________
_______________________________________________________________________________________________
_______________________________________________________________________________________________
________________________________________________________________________________________________
_______________________________________________________________________________________________
______________________________________________________________________________________________________
DESCRIBE the microPREPARATION " Shwannoma " _______________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________

Signature of student _____________________ Signature of teacher_____________________

© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
31
PRACTICAL LESSON 14 "____" _____________ 2020
TOPIC: Skin pathology. Nomenclature and morphological features melanocytic tumors. Epidermal and
dermal lesions. Skin manifestations of somatic diseases.
I Theoretical self-preparation program (PREAUDITORIUM WORK)
Disorders of pigmentation ________________________________________________________________________________
_______________________________________________________________________________________________
_______________________________________________________________________________________________
_______________________________________________________________________________________________
Characteristic of vitiligo ____________________________________________________________________________
_______________________________________________________________________________________________
_______________________________________________________________________________________________
Characteristic lentigo _______________________________________________________________________________
_______________________________________________________________________________________________
_______________________________________________________________________________________________
Definition and classification of nevus ___________________________________________________________________
_______________________________________________________________________________________________
_______________________________________________________________________________________________
Morphology of junction nevus _______________________________________________________________________
________________________________________________________________________________________________
_______________________________________________________________________________________________
Morphology of compound nevus _____________________________________________________________________
_______________________________________________________________________________________________
_______________________________________________________________________________________________
Morphology of intradermal nevus _____________________________________________________________________
_______________________________________________________________________________________________
_______________________________________________________________________________________________
Morphology of blue nevus __________________________________________________________________________
_______________________________________________________________________________________________
_______________________________________________________________________________________________
Morphology of dysplastic nevus ______________________________________________________________________
_______________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology of melanoma_________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Metastasis of melanoma__________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphological classification of melanoma____________________________________________________________________
______________________________________________________________________________________________________
_______________________________________________________________________________________________
Skin manifestation of lupus erythematosus_______________________________________________________________
_______________________________________________________________________________________________
_______________________________________________________________________________________________
Skin manifestation of lupus scleroderma _____________________________________________________________________
_______________________________________________________________________________________________
_______________________________________________________________________________________________
Morphology of seborrheic keratosis ____________________________________________________________________
_______________________________________________________________________________________________
_______________________________________________________________________________________________
Morphology of psoriasis ____________________________________________________________________________
_______________________________________________________________________________________________
_______________________________________________________________________________________________
Morphology of bullous pemphigoid ___________________________________________________________________
_______________________________________________________________________________________________
_______________________________________________________________________________________________
Morphology of eczema _____________________________________________________________________________
_______________________________________________________________________________________________
_______________________________________________________________________________________________
Morphology of basal cell carcinoma ___________________________________________________________________
_______________________________________________________________________________________________
_______________________________________________________________________________________________

© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
32
II. AUDITORIUM WORK
DESCRIBE THE MACROPREPARATION "Melanoma metastasis in liver" ___________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
DESCRIBE THE MACROPREPARATION "Melanoma metastasis in lung" _______________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
_______________________________________________________________________________________________

Preparation: Melanoma, stage III of Klark. 1.Atypical melanocytes


Stain: Haematoxylin & Eosin 2. Derma

Preparation: Basal cells carcinoma 1. Basaloid cells


Stain: Haematoxylin & Eosin with a palisading growth
pattern

DESCRIBE the microPREPARATION " Melanoma, stage III of Klark " ______________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
_______________________________________________________________________________________________
DESCRIBE the microPREPARATION " Basal cells carcinoma " ____________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
_______________________________________________________________________________________________
________________________________________________________________________________________________

Signature of student _____________________ Signature of teacher_____________________

© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
33
INDEPENDENT WORK TO SECTION 4
Morphology of sarcoma Kaposi____________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
_______________________________________________________________________________________________
Morphology of hemangiopericytoma________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Localization of metastases of mammary gland cancer___________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
_______________________________________________________________________________________________
Morphology of hypernephroid kidney cancer _________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
_______________________________________________________________________________________________
List organo-nonspecific benign ovarian tumors________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
List organo-specific malignant ovarian tumors________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Forms of thyroid cancer__________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Differences morphogenesis of the central and peripheral lung cancer_____________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Histological types of lung cancer________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Ways of metastasis of stomach cancer __________________________________________________________________
_______________________________________________________________________________________________
_______________________________________________________________________________________________
_______________________________________________________________________________________________
What is the Krukenberg cancer?_______________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Morphology and ways of prostate cancer metastasis_________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
Clinical and morphological features of Wilms' tumor________________________________________________________
______________________________________________________________________________________________________
______________________________________________________________________________________________________
_______________________________________________________________________________________________
______________________________________________________________________________________________________
Tumours of appendages of skin ______________________________________________________________________
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Morphology of dermatitis herpetiformis _____________________________________________________________________
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Signature of student _____________________ Signature of teacher_____

© SHEI "Ternopil State Medical University by I.Ya. Horbachevsky of MPH of Ukraine", 2020
34

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