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I remember that somebody once said: God has bestowed each of us a skeleton and a limited life.
It is up to us all to do our best within this limited life span and to emit as much heat and light as
possible so as to illuminate the whole world while providing warmth to ourselves before the
candle of life dies out. The saying brings me home that life is limited, but love and relentless
efforts can be a torch that kindles it and makes it most valuable. For me, this torch is nothing
other than biology. I remember that when I was a little child, I would often go to a nearby pond
in the afternoon to observe the little fish, shrimps, snails and the waterweeds in it. Their tranquil
and free life would always arouse my great admiration. In the evening, by the roadside lamps, I
would try to catch some crickets to be kept in a pot to enjoy their beautiful music. When I started
to go to school, my teacher of the Nature course gave me some graines. I took great care of them
and watched them develop from larvae to adult insects until finally they produced their own
graines. I would go to the field to pick folium mori to feed them. This can serve as a good
indication of a child's love of life. Being mischievous, I dug out the flower trees my father
planted in pots to observe their root system and sometimes poured hot water into the pots. On
other occasions, I would open up the belly of the fish that my mother was preparing for food to
observe their viscera. This also reflects the strong desire of a teenager to probe into the mysteries
of life. It was with those inborn impulses that I have chosen life science as the objective of my
career.
After my college matriculation examination, I applied for biochemistry and molecular biology
and was admitted into Nankai University. During the four-year studies in the famous university
in China, I worked hard at all the subjects and was granted scholarships for four years. I did not
feel contented with what I had achieved because I gradually realized that, in order to be a real
scientist, it was far from enough to master the conventional knowledge. The most important
thing was to discover new knowledge and the latest information. In this account I made extensive
extracurricular readings and reflections to sponge up all range of knowledge so as to upgrade my
comprehensive capacity and placed importance on fostering creativity of new ideas, a broader
professional vision and an insight into the frontier areas. In addition, as member of our
university's Biology Association, I often participated in activities publicizing scientific
knowledge, allowing the general public to know about the science of life and to understand the
secrets of life so that they can treasure the life of ourselves and of our fellow creatures.
With relentless efforts ,In September 1999 I entered Peking University as a graduate student.
(only four out of a total of 150 students were qualified) In this most famous university in China, I
became even more absorbed in the biological world. During this period, I presided over a pest-
resistant corn study project and took part in many academic conferences and reports. Such an
experience not only upgraded my lab experiment capacity, but also opened up my vision,
familiarizing me with the frontier dynamics of the faculty. But as I delved deeper into my
scientific research, a disaster that happened to our family deprived me of the financial support
from my family, forcing me to quit my studies at Peking University. After much careful
consideration, I abandoned the Ph.D. degree program at Peking University. Nevertheless, on
account of my outstanding performance at Peking University, I was recommended by my advisor
to work at National Lab of Molecular Oncology, Cancer Institute, China Academy of Medical
Science & Peking Union Medical College headed by Prof. Min Wu, an academician. At this
most prestigious lab in China and under the guidance of the country's most accomplished
specialist in cell molecular biology, I learned not only how to conduct experiments but also how
to undertake scientific research, laying a solid foundation for my future study.
All these studies have helped upgrade my theoretical and experimental capacity. Meanwhile,
with the deepening of my research work, I have realized that the complete conquest of cancer
necessitates a breakthrough in modern biological theory, especially in molecular, cellular and
developmental biology. We must first understand the laws governing the various intracellular
activities, such as genetics and gene expression and DNA duplication and mutation before we
can find out the real cause of cancer and its therapy.
Thanks to such an experience, I became aware that I should continue with my basic theoretical
studies and improve my lab experimental expertise. From this, I struck upon the idea to pursue
an advanced degree program. After much investigation, I have come to the conclusion that XXX
University is my ideal choice for undertaking this program. The long history, beautiful campus,
and stimulating academic atmosphere are what fascinate me most. I carefully looked at the
research orientations of various professors and found that some of those orientations are in
perfect accordance with my interests. I have become all the more interested after reading some
abstracts of their research papers. More importantly, my theoretical knowledge and experimental
skills can qualify me for the completion of those professors' projects. X x x University enjoys
worldwide reputation for its scientific research level in modern biology. Its unique educational
system, strong academic atmosphere and leading lab facilities in particular have long deeply
attracted me. I am especially eager to probe into the expression and regulation of genes, the
duplication and repair of DNA and the laws governing the transmission of cellular signals and
achieve significant academic attainments in these areas.
Upon completing my Ph.D. program, I plan to return to China to work at a prestigious university
like Peking University or Tsinghua University as a professor engaged in research and teaching. I
know the importance of education and as a scientist, however academically and professionally
accomplished, his contributions are limited because his lifespan is limited. The development of
science requires the efforts of generations of scientists. However, the academic levels of Chinese
professors are low compared to their American counterparts, resulting in low academic level and
lack of creativity of the undergraduate and graduate students. The students under China's system
of graduate education do not become scientists, but merely conductors of experiments. That is
why I abandoned the Ph. D program at Peking University. In order to change this situation, I will
impart to my students all that I have acquired so that they can be informed of the latest academic
development without having to go abroad.
I come from Ningxa Province, the most impoverished area in China’s West. The pathetically
backward medical conditions there spurred me to become an accomplished physician who could
make contributions in alleviating the pains of the local residents. With exceptional scholastic
efforts, I distinguished myself in my region which was equally backward in education level and
entered the Department of Clinical Medicine, Peking University of Medical Science, one of the
most prestigious universities in China. Here I started my formal academic pursuit. During my
undergraduate studies, with perseverance and efficacious learning strategies, I managed to reach
No. 2 ranking in my class in terms of scholastic aptitudes, with especially outstanding
performance in the courses in my specialty.
However, during my clinical internships, I discovered that the theoretical knowledge I learned
from textbooks was often incongruent with, and sometimes even diametrically opposite to what I
actually discovered. This made me develop a skeptical mind in academic research. In the project
Helicobacter pylori induces the synthesis of cyclooxygenase-2 in human gastric epithelial
carcinoma cell line BGC-823, I found in the majorities of my experiments that, in screening
positive recombinants, the rate of detecting positive clones was not as high as was imagined.
Sometimes, bacterial colonies produced through self-correlation outnumber those of correlation
products, which meant that the workload in screening clones would be significant increased. I
think that I will always carry with me this spirit of skepticism in my academic research because
it gives me courage to cast doubt on established viewpoints and to probe into the real truth of the
matter.
Another important learning habit of mine is the problem-oriented mentality. Having participated
in some simple research work, I discovered that the process of recombinant DNA screening was
overcomplicated and inefficient. To solve the problem, I consulted relevant technical literature
and conducted repeated experiments, the result of which was the development of the Rapid
Screening Recombinations by Clone Groups, a much simpler and more efficient method to
screen recombinant DNA. This initial research success, however insignificant in retrospection,
gave me a strong sense of pride. Under the instruction of Prof. Wang XX, I completed my thesis
The Effect of Angiotension II on the Heme Oxygenase Gene Expression in Spontaneous
Hypertensive Rats.
As I delved deeper into my studies, I realized that clinical medicine at its present technical level
faces some problems that are difficult to solve, such as the etiology and the mechanism of
diabetes, tumor, and cardiovascular diseases. As far as I am concerned, the ultimate solution to
those problems lies in Basic Medicine, which allows us to observe the changes in the cellular and
molecular level of those diseases. In my spare time, I further consulted a large quantity of
technical literature and textbooks on the techniques of cell and molecular biology and decided
that I would attempt at research projects in Basic Medicine, those projects that were virtually
impossible for clinical doctors. Therefore, immediately after my undergraduate program and
exempted from an entrance examination, I embarked on a Master’s program in the Cell and
Molecular Biology specialty at the School of Basic Medicine, Peking Union Medical College.
I am very proud of my academic performance during my Master’s Program, which has been
more impressive than my undergraduate performance. In all the specialty courses I have become
the top student in my class. My solid foundation in theoretical knowledge has provided me with
a sound basis to expand my research horizons and to search for innovative research
methodologies. My labwork focuses on the interplay between proteins and I have participated in
three major research projects: a) study on the proteasome subunits (which are closely related to
protein degradation in the Ubiquitin/Proteasome) and catalytic zymoprotein sponsored by State
Natural Sciences Foundation; b) study on the common characteristics of proteins that interact
with Ubc9 in the proteasome-conjugating system by means of information science; and c) the
establishment of SH2 Protein Library (which has applied for patent from the State Patent Office).
I will write a couple of research papers based on the findings of those projects and hopefully
publish them in some leading academic journals in those fields.
Difficulties also abound in my studies. I have found that although the bi-hybridization system of
the yeast is an effective and efficient way to analyze the interaction between proteins, it has its
limitations. For instance, the system is located within the nucleus, in which reactions like 糖基化
and the formation of disulfide bond are impossible. For another instance, there is the problem of
“pseudo positive” expression. Therefore, how to transfer, with more perfect techniques, the bi-
hybridization system of the yeasts to organisms with eucaryon (which are higher than
saccharomycettes) so as to make the processing of proteins, their refinement, and interaction
closer to real processes and to reduce pseudo positive results constitutes one of our urgent tasks.
On the other hand, to construct the chart of yeast protein interactions and to undertake molecular
biological studies related to pathology by exploiting the properties of the genes within the yeast
that bear close resemblance to human genes will also be a fascinating field of study. The United
States plays a leading role in the development of life science. It is a universal dream of all
biological researchers to carry out thorough research there, including myself.
Looking back on my research experience, I realize that I have gone through important changes in
my understanding of scientific research. As an undergraduate, I regarded research simply as a
way of finding the best scientific and technological means. I assumed that all problems could
automatically be solved with the discovery of updated and sophisticated approaches. During my
Master’s program, my understanding deepened and it was Prof. Guo XX, my supervisor, who
helped me develop this deepened understanding. A Ph.D. and a visiting scholar at Harvard and
with many achievements, Prof. Guo returned to China and launched (this word means “created
and started”. It does not mean “was employed”) Peking Union Medical College’s Protein
Research Center. He not only brought back from the United States many advanced research
facilities but also exposed me to brand-new ways of thinking and problem-solving
methodologies. His knowledge and concepts have made me realize how insufficient I am in my
knowledge and technical competence. His constant encouragement has reinforced my
determination to seek an advanced degree program in the United States to develop myself into an
accomplished medical professional like him. My hope is to learn much more professional
knowledge in the field of Cell and Molecular Biology and related experimental techniques, to
renovate my existing concepts and the conventional mode of thinking.
With this Personal Statement, I want to indicate unequivocally my purpose of pursuing a Ph.D.
program in Cell and Molecular Biology at Harvard University (John Hopkins University,
Stanford University). Your university comes on top of my priorities because it enjoys an
unparalleled position in this field both within the United States and in the world. It is my
conviction that the superior research facilities, the nurturing academic environment, strong
faculty and a quality education will fulfill my aspiration to become a scientist with important
achievements in the future in my chosen field. I plan to further my studies in the fundamental
theoretical knowledge of the relevant subjects, keep myself abreast with the latest developments,
and venture into new realms based on the knowledge and the skills that I have accumulated. I
would like to devote myself especially to those important projects which are just in their
incipient development and enjoy tremendous potentials. I will avail myself of the ample
academic activities to exchange and to learn from leading specialists, and to develop new
perspectives. In this way I hope to achieve some innovative research results and produce several
high-quality research papers. I expect that the research-intensive Ph.D. training there will help
me become well prepared for careers in biomedical research, biotechnological and
pharmaceutical industries.
Five years of my pharmacy education further strengthened my desire for research. Ibne Sina,
Alexander Fleming, Har Gobind Khorana and Rosalind Franklin are few of the many names that
have continually inspired me. The Idea of Exploring the unknown has always been enticing me.
Pharmacology,Pathology,Physiology Biochemistry and clinical pharmacy are the subjects who
always attracted me towards them. In this regard, I wish to research in Cellular and molecular
medicine, especially on Diabetes,Cancer,Neurodegenerative diseases and complications related
to them.I know it is difficult but M.Sc program of the University of Ottawa is holistic as well as
well structured and meets all the requirements that I aspire to be part of.
My pursuit for excellence led me consistently rank among the top five of my Pharm D class in
past 5 years. I was exposed to various subjects during this time. Etiology and Pathophysiology of
diseases, the whole process of drug discovery, pharmacodynamic and pharmacokinetic aspects of
drug kept me captivated from the very outset.
Being curious, determined, and an avid reader certain puzzles always intrigues me. For example,
why we are still helpless to cure 'common cold' like common disease or why we are still
managing but not curing a silent killer like diabetes even with so much advancement in medical
science. Thought of putting my heart and soul to discover a drug which might one day save lives
give me confidence which I believe one should get from his profession.
During my studies, I also participated in research work on these diseases voluntarily and learned
different techniques like patch clamp method, optical mapping, gel electrophoresis and DNA
sequencing with Sanger's method. After looking at my interest in these topics , my teachers gave
me different class projects on Cardiovascular diseases, Diabetes, Cancer and neurodegenerative
diseases. Through these project, I was able to study different aspects of these diseases. I collected
data for my these projects by, Studying research papers of professors working on these topics
both in my university and in other universities, visiting many hospitals and pharmacies.I also
presented one of my projects at the first ever pharmacy conference of our university on
improving health outcomes by best Pharmacotherapeutic Practices. In 8th semester of my class, I
did an internship at District Headquarter Hospital Gujrat. Where I came to know the problems
being faced by poor people of my area and HCP's Problems in treating diseases.
These conferences provided me opportunities to meet and learn latest things going on in these
fields.
Upon completion of my degree, I started working as Community pharmacist and now I was
testing my theoretical knowledge in practical field. Whenever I interacted with a patient my
desire to become scientist was reaching to new heights. To observe patients more closely and
current therapy patterns , I joined as a medical educator in the medical education department of a
multinational company and now this job is playing its part in improving my knowledge day by
day both practically and theoretically.
The goal of education is the advancement of knowledge and dissemination of truth and this is
what I expect from a graduate program. It's my believe that knowledge knows no boundaries. My
acceptance into the graduate program of Cellular and molecular medicine at University of
Ottawa will not only help me to mould my character, but guidance provided by such great
professors and connoisseurs in the sphere of research, will definitely play their role in honing my
skills as a researcher and analyst as well. After a few years from now I'm looking myself as
playing my role in research in the field of cellular and molecular medicine and want to help
people of my country and other poor countries that are suffering from these diseases without
sufficient sources.
In order to achieve my goal, first step will be to work under the supervision of a professor among
the pool of dynamic researchers of uOttawa as an apprentice on projects related to Study of
Growth, Development maturation of diseased cell in Cancer, Diabetes, Cardiovascular diseases
and Neurodegenerative diseases, therapies used to treat them and etiology of the these diseases.
I believe that the interpersonal skills, confidence, and intellectual abilities which I will get from
this institute will not only help me to progress in research, but will also be a stepping stone in
making my dream true of making my mark in the field of Cellular and molecular medicine. I
look forward to being a part of the University of Ottawa summer 2017 class.
I realized that being a good scientist takes more than just a good theoretical
background and skillful hands, which my mentors believe I have. It takes breaking
through emotional barriers, keeping personal life separate from the academy and
heading towards the discovery at full speed at all times, no matter what the
“weather” is. I also realized that a non-ceasing self- improvement is an essential
part of being successful as a scientist. One has to find the inherent weaknesses and
fix them, upgrading the “discovery-making machine” – what I believe I am (or at
least, about to become) as a scientist.
Name:
Major: MS in Bio medical Engineering
STATEMENT OF PURPOSE
The wonders that science and technology have unfolded before us are not limited to time and space. My
aim in life is to accumulate this diverse knowledge from all over the world. With this cherished goal in my
mind, I wish to state in the following paragraphs, my viewpoints and the rationale behind my application
to the graduate studies program in Bio-Medical Instrumentation at **** university.
Throughout my ten years of school life and two years of high school study, I have maintained a
consistent and good academic record and was always amongst the top five of my class. Coming to extra-
curricular activities, I was the head sports captain for girls and also participated in the state level
U.N.Celebrations. Aspiring for the best undergraduate course that all good science students do and also
influenced bythe fact that I come from a family of engineers and scientists-I appeared for the EAMCET
( Engineering and Medical Common Entrance Test)and opted for Instrumentation and Control
Engineering at ***** College, affiliated to JNTU , Hyderabad in Andhra Pradesh.
During my undergraduate years I could learn the fundamentals in Transducers and Instrumentation
Components, Electrical and Electronic measurements, Electronic Equipment design, Analytical
Instrumentation, Process Control Instrumentation, Power plant Instrumentation , Digital and optimal
Control Systems. I observed on various occasions , especially in transducers and instrumentation
components which is a vast subject, that there existed a wide enough rift between learning and practical
implementation. While the undergraduate courses enable a student to grasp the fundamentals involved in
a particular discipline of engineering, they do not present the opportunity to learn the ropes with new
technologies that are current within the industry. Specialization becomes a necessity to understand new
technologies and to improve upon the existing ones. It is to achieve this sophistication that I set out to
pursue my post-graduate (M.S.) studies in Bio-Medical Instrumentation. During my third year holidays I
have done a project on Computerized respiration analysis through embedded systems, a part of Bio-
Medical instrumentation, one of the electives in the final year. This short stint has given me invaluable
practical experience. It has given me the confidence to pursue a master’s degree and also kindled a
desire to do research. The undergraduate course in Instrumentation and Control Engineering and with
the advice of widely respected teachers at the college has given me the motivation to pursue a career in
Bio-medical Instrumentation .
The sharing of ideas and new findings has always been a part of my undergraduate life. Presentations
and seminars were a perfect opportunity for me to explore beyond the syllabus and were instrumental in
giving me a competitive edge over my peers. I relish a chance to indulge my creative side and gaining a
deeper understanding of my work in process of presentations. I enjoy diving into a flood of data, picking
out relevant information and delivering it all to an appreciative audience! In second year of my under-
graduation I got a chance to present a paper at national-level on the topic Robotics. The dynamic
nature of scientific research was revealed to me as I worked on my presentation. Often new theories
were replaced by old ones so fast that I was updating my work right up till the morning I had to present.
By this experience I could learn that before beginning the first robotics project, prospective robotic
hobbyist and robotic sports enthusiasts must have a basic understanding of the field of robotics and the
issues surrounding robotic systems, including mechanical design, sensory systems, electronic control and
software. A basic understanding of micro-controller systems including serial and memory-mapped
interfacing, as well as some available open source software options should also be high on the list.
Quest for knowledge needs considerable persistence and an unquenchable desire to learn. Whatever I
have achieved till now can be attributed to my diligence and perseverance, which I have learned from my
close knit family and culture. With the same indefatigable spirit, I am ready to utilize and direct all my
physical and mental abilities to achieve the same in my future studies and research work.
I believe the field of instrumentation offered so immense a potential that given me an opportunity to opt
for Bio-Medical Instrumentation, I would be interested to work in the area of bio-medical instrumentation
which deals with its development. I bring along a strong grasp of fundamentals, an aptitude for teaching
and team work, a zest for challenges and an enthusiastic desire to learn all I can. In addition I would like
to take with me a network of strong and lasting relationships that I maintain with my teachers and fellow
students. I hope that my qualifications and background are found suitable for MS in Bio-Medical
Instrumentation at ******* university.
Having been enlightened by many professors and several graduating seniors about the rigorous course
work besides possessing state-of-the-art research facilities, I had no dilemma in choosing **** university
as my dream university for pursuing my graduate studies. I am sure that *** university with dynamic
faculty, well equipped laboratories and world renowned graduate programs would definitely help me in
achieving my goals and contribute something of my own in my field of interest. I believe that with my
capacity for hardwork, commendable logic and dedication to achieve my goals, I will be able to do very
well in my Graduate course. I aver that I take it as a challenge and spare no effort of mine in utilizing the
resources available at your university. I am sure that you will share my confidence and give me an
opportunity to continue with my further studies at your esteemed university.