A Cute 5-part

BC-5150 Competition 2013

IVD BU, International Marketing
Competition Landscape
Key Competitor Candidates

XS-500i XS-800i XS-1000i

Other:

AcT 5diff

MEK-7222 Mythic 22

Pentra 60
Competition analysis
Working principle
Weakness
Comparison table
Product portfolio

XE-5000

XN-1000
XE-2100 XN-2000

HST system

PocH-100i

XT-4000i

XN-9000

KX-21N

XT-1800i
XT-2000i
XS-800i XS-500i
XS-1000i
Sysmex product pyramide

Samples per day

>400 XN-9000
HST
>240 XN-1000 & XN-2000
XE-5000
XE-2100
>120 XT-4000i
XT-2000i
XT-1800i
>60 XS-500i
XS-800i
XS-1000i
>20 Poch 100i
KX-21N
Competition analysis
Working principle
Weakness
Comparison table
XS-500i/XS-800i/1000i Specifications
Manufacturer Sysmex
Target group Small workload (below 50 samples/day);

XS-500i Parameters 24: WBC, LYMPH(#,%), NEUT(#,%),

MONO(#,%), EO(#,%), BASO(#, %); RBC, HCT,
HGB, MCV, MCH, MCHC, RDW-SD, RDW-CV;
PLT, PCT, PDW, P-LCR, MPV;
Research parameters 4: IG#, IG%, Other#, Other%
XS-800i Number of analytical DIFF, RBC/PLT-I, HGB
channels
Histogram RBC, PLT, WBC (CBC mode)
Scattergram DIFF
XS-1000i CP Principle Fluorescence flow cytometry for differential
and impedance for RBC and PLT

Sample volume Open vial/Cap piercing: 20ul

Autoloader: 20ul
XS-1000i AL LIS/HIS Bi-directional
XS-500i/XS-800i/1000i Specifications
Sampler XS-500i: open vial
XS-800i: open vial;
XS-1000i CP: cap piercing;
XS-1000i AL: autosampler, 20 tubes
XS-500i Data storage Up to 10000 test results and 5000 patient records;
Up to 21 QC files;
Throughput XS-500i: 60 samples/hr;
XS-800i: 60 samples/hr;
XS-1000i CP: 49 samples/hr;
XS-800i
XS-1000i AL: 20 samples/23 minutes;
Reagent systems 4 analytical reagents and 1 maintenance reagent;
Control and Calibrator E-Check Control;
Operation External PC
XS-1000i CP
Main unit size XS-500i: 320 x 503 x 413mm;
XS-800i: 320 x 503 x 385 mm;
XS-1000i: 320 x 403 x 385 mm;
Sampler: 280 x 400 x 355 mm;
XS-1000i AL 24.0 kg.
Main unit weight
Fluorescence Flow Cytometry

Fluorescence flow cytometry

Principle tree

Fluorescence Flow Cytometry DC impedance

RBC

STROMATOLYSER-4DL CELLPACK

DIFF RBC

CBC+DIFF
STROMATOLYSER-4DS

SULFOLYSER

IMI HGB

CELLCLEAN
SLS method
Competition analysis
Working principle
Weakness
Comparison table
Basophil analysis

Comparing with XT- and XE- series, there are no BASO detection channel
and no BASO detection reagent on XS- instruments.
Basophil analysis

Lymphocyte The results of basophils on

XS- instruments are based on
Monocyte software calculation.
Basophil
Neutrophil
Eosinophil
XS-500i/XS-800i/1000i Reagents
Shelf life Consumption/
Name Size Function
(months) test (ml)

Cellpack 10/20L Diluent, sheath solution 18 32

Stromatolyser WBC differential diluent and

2L 12 2
4DL RBC lysis
Stromatolyser
42mL WBC differential stain 12 0.03
4DS

Lysis of all blood cells and

Sulfolyser 500mL 12 0.5
complex formation with HGB

Cellclean 50mL Detergent 8 0

✓ Short shelf life: less than 24 months.

✓ Expensive: fluorescence reagents and cost per test.
✓ Large dead volume: Stromatolyser 4DS must be replaced after 1200 tests
which results in 6ml of leftover amounts to 14% of its original volume;
Prediluted mode

40 µl of 160 µl of
Blood Diluent

In order to do capillary mode test, operators have to dispense diluent manually by

pipette, and also need to do other manual work.
Paper supporter

Paper Most reagents are

Supporter packed by paper
boxes, which are
using paper supporter
to hold reagent cap
components.

But they are easy to

be bent, this will lead
to insufficient reagent
aspiration which may
cause incorrect
sample result and
high dead volume.
Software limitations

Only L-J, X-Bar and X-M QC programs with only 21 files

storage;

Only 10000 results storage and 5000 patient information

record;
No statistics function, no customization on reference range
and printout template;

Re-start the instrument if accidentally close the PC

software;
No ZAP unclogging program;
Manual check on waste level;
Competition analysis
Working principle
Weakness
Comparison table
XS-500i/XS-800i/1000i Summary
BC-5150 XS-500i/XS-800i/1000i
Sample volume 15/15/20 20/20/20
Total parameters 25+4 24+4
Throughput 60 60/49/52
Data storage 40000 10000
QC files 60 20
Customization on reference range Yes No
Customization on print-out template Yes No
Waste sensor Yes Optional
ZAP unclogging Yes No

© 2012 Mindray Confidential

XS-500i/XS-800i/1000i Summary
BC-5150 XS-500i/XS-800i/1000i
Running cost Economical Expensive
Basophil measurement Impedance Calculation
Scattergrams 3 1
Working temperature 10-30 15-30
Humidity 20%-85% 30%-85%
Touch screen 10.4 inch full-color TFT NO
Dimensions 400 x 320 x 410mm 503 x 320 x 413mm
Routine reagent 3 4
Lyse reagent Built-in External

© 2012 Mindray Confidential

Competition analysis
Working principle
Weakness
Comparison table
Product portfolio

Pentra 120 Retic

Pentra DF 120
Pentra 120

Pentra DX 120
Pentra XL 80

Pentra DX 120 SPS

Micros 60
Pentra 80

Micros ES 60

Pentra 60 C+
Pentra 60
Horiba product pyramide

Samples per day

>400

>240
Pentra DX 120

>120 Pentra DF 120

Pentra 120 Retic
Pentra 120
>60 Pentra 80
Pentra 60
>20 Micros ES 60
Micros 60
Competition analysis
Working principle
Weakness
Comparison table
Pentra 60 Specifications
Manufacturer Horiba Medical
Year of Launch 2000 / 2009 (Pentra ES 60)
Target group Small labs;
Parameters 22: WBC, LY(#,%), NE(#,%), MO(#,%), EO(#,%),
Pentra 60 BA(#, %); RBC, HCT, HGB, MCV, MCH, MCHC,
RDW; PLT, PCT, PDW, MPV;
Research parameters 4: ATL(#,%), LIC (#,%)
Number of analytical LMNE, RBC/PLT, WBC/BASO, HGB
channels
Pentra 60 C+ Histogram RBC, PLT, WBC/BASO
Scattergram LMNE
Principle Absorbance cytochemistry with Volume (AcV)
for WBC differential;
Impedance for RBC/PLT;

Pentra ES 60 Sample volume 53 uL

Pentra 60 Specifications
Sampler Pentra 60/ES 60: open vial
Pentra 60 C+: cap piercing
LIS/HIS Pentra 60: Uni-directional;
Pentra ES 60/C+: Bi-directional;
Pentra 60 Data storage Pentra 60: 500;
Pentra ES 60/C+: 10000;
Throughput 60 samples/hr;
Reagent systems 4 analytical reagents and 2 maintenance
reagent;
Pentra 60 C+ Control and Calibrator ABX Difftrol, ABX Minotrol;
ABX Minocal;
Operation Pentra 60: Monocolor screen (16 lines)
Pentra ES 60/C+: External PC
Main unit size 444 x 516 x 481 mm;
Pentra ES 60 Main unit weight 35.0 kg.
Principle tree
Chemical dye
Tungsten lamp RET
NRBC

Leucodiff

LMNE NRBC
BASO
Fluocyte Basolyse

CBC+DIFF
DC Impedance

Diluent

IMI
HGB RBC
Alphalyse or Lysebio

Cleaner
Company profile
Competition analysis
Working principle
Weakness
Comparison table
 Pentra 60 Principles
Absorbance

Eosinophils

LIC
Neutrophil

Lymphocyte Monocyte

ATY Volume

Fixed discriminator would render incorrect differentiation results for some abnormal samples.
Low technology

The optical system for LMNE(WBC

4-DIFF) is using tungsten lamp,
which has short life and operators or
engineers have to adjust the
intensity frequently.

The basophil measurement is using

DC impedance method, which can
only detect the size of cells. It are
not able to prevent the interference
from some abnormal cells.
Risky design

The chambers in the pictures of Pentra

60 have open design, which are surely
bring dust or something else inside.
This is potential risk for users.

Manual maintenance to the open

counting bath everyday when the
workload is more than 100 per day.
Unfriendly interface

Pentra 60 has a mono-color screen

which only shows 16 lines of
information, Users have to operate
the instrument by the hard keypad.

Pentra 60 gives flags by abbreviation. Flags are very helpful information for
operators to analyze samples and make the further decisions.

Plus, there is no short cut key in the software to access the common menus.
Short shelf life for reagents
Shelf life Consumption/
Name Size Function
(months) test (ml)
ABX Diluent 10/20L Diluting blood cells 12 26
Lyse RBC and determine
ABX Lysebio 400mL 12 0.4
HGB
Cytochemical reagent
ABX Eosinofix 1L containing the active 9 1
principle Chlorazole Black
Lyse RBC and count
ABX Basolyse II 1L 12 2.1
basophils
ABX Cleaner 1L Enzymatic cleaning 12 0.9

ABX Minoclair 500mL Cleaning and bleaching 12 0

➢ Short shelf life: less than 12 months.

➢ Strict storage condition (18 - 25 ℃) and away from light.
Competition analysis
Working principle
Weakness
Comparison table
Pentra 60 Summary
BC-5150 Pentra 60
Total Parameters 25+4 22+4
Sampling volume 15/15/20 53
Counting bath Close Open
Data storage 40000 10000
Customization on reference range Yes No
Customization on print-out template Yes No
Fresh blood calibration Yes No
ZAP unclogging Yes No
Reagent condition ℃ 10 - 30 18 - 25

© 2012 Mindray Confidential

Pentra 60 Summary
BC-5150 Pentra 60
Basophil measurement Optical Impedance
Scattergrams 3 1
Working temperature 10-30 15-34
Humidity 20%-85% 30%-85%
Touch screen 10.4 inch full-color TFT Small mono-color screen
Routine reagent 3 5
Dimensions 400 x 320 x 410mm 445 x 515 x 480mm
Weight 24kg 35kg

© 2012 Mindray Confidential

Competition analysis
Working principle
Weakness
Comparison table
Product portfolio

LH780
LH755

DXH 800
LH750

LH1500 Ac.T Diff

LH500

Ac.T Diff 2
Ac.T 5Diff CP

HmX Ac.T 5Diff OV

Ac.T 5Diff AL
BCI product pyramide

Samples per day

>400
LH 1500

>240 DXH 800

LH 780
LH 750
>120 LH 500
HmX
>60 Ac.T 5Diff AL
Ac.T 5Diff CP
Ac.T 5Diff OV
>20 Ac.T Diff 2
Ac.T Diff
Competition analysis
Working principle
Weakness
Comparison table
Ac · T 5diff Specifications
Manufacturer Horiba Medical (OEM)
Year of Launch 2000
Target group Small labs;
Parameters 22: WBC, LY(#,%), NE(#,%), MO(#,%), EO(#,%),
BA(#, %); RBC, HCT, HGB, MCV, MCH, MCHC,
RDW; PLT, PCT, PDW, MPV;
Ac · T 5diff OV Research parameters 4: ATL(#,%), IMM (#,%)
Number of analytical LMNE, RBC/PLT, WBC/BASO, HGB
channels
Histogram RBC, PLT, WBC/BASO
Scattergram LMNE
Principle Absorbance cytochemistry with Volume (AcV)
Ac · T 5diff CP for WBC differential;
Impedance for RBC/PLT;
Sample volume 53 uL
Ac · T 5diff Specifications

Sampler Ac · T 5diff OV: open vial

Ac · T 5diff CP: closed tube
LIS/HIS Bi-directional;
Data storage Up to 10000 test results;
Throughput 60 samples/hr;
Ac · T 5diff OV Reagent systems 4 analytical reagents and 2 maintenance
reagent;
Control and Calibrator Ac · T 5diff Control Plus
Ac · T 5diff Cal
Operation Ac · T 5diff OV: Monocolor screen
Ac · T 5diff CP: External PC
Ac · T 5diff CP Main unit size 444 x 580 x 501 mm;
Main unit weight 37.0 kg.
Principle tree
Chemical dye
Tungsten lamp RET
NRBC

Fix reagent

LMNE NRBC
BASO
WBC lyse

CBC+DIFF
DC Impedance

Diluent

IMI
HGB RBC
HGB lyse

Rinse
Competition analysis
Working principle
Weakness
Comparison table
 Ac · T 5diff Principles
Absorbance

Eosinophils

LIC
Neutrophil

Lymphocyte Monocyte

ATY Volume

Fixed discriminator would render incorrect differentiation results for some abnormal samples.
Low technology

The optical system for LMNE(WBC

4-DIFF) is using tungsten lamp,
which has short life and operators or
engineers have to adjust the
intensity frequently.

The basophil measurement is using

DC impedance method, which can
only detect the size of cells. It are
not able to prevent the interference
from some abnormal cells.
Risky design

The chambers in the pictures of Ac·T

5diff have open design, which are
surely bring dust or something else
inside. This is potential risk for users.

Manual maintenance to the open

counting bath everyday when the
workload is more than 100 per day.
Unfriendly interface

Ac · T 5diff has a mono-color screen

which only shows 16 lines of
information, Users have to operate
the instrument by the hard keypad.

Ac · T 5diff gives flags by abbreviation. Flags are very helpful information for
operators to analyze samples and make the further decisions.

Plus, there is no short cut key in the software to access the common menus.
Short shelf life for reagents

Shelf life
Name Size Function
(months)
Diluent 20L Diluting blood cells 12

HGB lyse 400mL Lyse RBC and determine HGB 12

WBC lyse 1L Lyse RBC and count basophils 12

Fix 1L Lyse erythrocytes, fix leukocytes, and differentially WBC 12

Rinse 500mL An enzymatic solution with proteolysis action 12

➢ Short shelf life: less than 24 months.

➢ Strict storage condition (18 - 25 ℃) and away from light.
Competition analysis
Working principle
Weakness
Comparison table
Ac · T 5diff Summary

BC-5150 Ac · T 5diff
Total Parameters 25+4 22+4
Sampling volume 15/15/20 53
Counting bath Close Open
Data storage 40000 10000
Fresh blood calibration Yes No
ZAP unclogging Yes No
Reagent condition ℃ 10 - 30 18 - 25

© 2012 Mindray Confidential

Ac · T 5diff Summary

BC-5150 Ac · T 5diff
Basophil measurement Optical Impedance
Scattergrams 3 1
Working temperature 10-30 15-34
Humidity 20%-85% 30%-85%
Touch screen 10.4 inch full-color TFT Small mono-color screen
Routine reagent 3 5
Dimensions 400 x 320 x 410mm 445 x 515 x 480mm
Weight 24kg 35kg

© 2012 Mindray Confidential

Competition analysis
Working principle
Weakness
Comparison table
Product portfolio

MEK-8222

MEK-7222

MEK-6318

MEK-6400
Nihon Kohden product pyramide

Samples per day

>400

>240

>120

>60 MEK-7222
MEK-8222

>20 MEK-6400
MEK-6318
Competition analysis
Working principle
Weakness
Comparison table
MEK-7222/CELLTAC E Specifications

Manufacturer Nihon Kohden

Year of Launch 2003
Target group Small labs;
Parameters 22: WBC, LY(#,%), NE(#,%), MO(#,%), EO(#,%),
BA(#, %); RBC, HCT, HGB, MCV, MCH, MCHC,
RDW; PLT, PCT, PDW, MPV;
Research parameters /
Number of analytical WBC, Impedance, HGB
MEK-7222 channels
(CELLTAC E) Histogram RBC, PLT
Scattergram 3
Principle Laser scatter measuring;
Sample volume 55 uL
MEK-7222/CELLTAC E Specifications

Sampler Open vial

Optional cap piercing unit
LIS/HIS Bi-directional;
Data storage 400 test results, 50 graphs;
Throughput 60 samples/hr;
Reagent systems 3 analytical reagents and 2 maintenance
reagent;
Control and Calibrator MEK-5D control
MEK-7222
(CELLTAC E)
Operation Monocolor screen
Optional DMS software
Main unit size 444 x 580 x 501 mm;
Main unit weight 37.0 kg.
Principle tree
RET
Chemical dye
NRBC
Laser scatter

Hemolynac 5

WBC

CBC+DIFF
Colorimetry DC Impedance

Hemolynac 3 Isotonac

HGB
IMI RBC

Cleanac Cleanac 3
Competition analysis
Working principle
Weakness
Comparison table
 MEK-7222/CELLTAC E Principles
Monocyte Neutrophil Basophil

Suspicious Eosinophil counting

Lymphocyte Eosinophil
side scatter
detecter
1 3
Fresnel lens

Flow-cell
Forward small
angle 2
detecter Laser diode

Forward large Fresnel lens

angle detecter
MEK-7222/CELLTAC E Reagents

Shelf life Consumption/

Name Size Function
(months) test (ml)
Isotonac 3 18L Diluting blood cells 12 43.5
Hemolynac 3 500mL Measure HGB 12 0.56
Hemolynac 5 500mL Measure WBC differential 12 0.31
Cleanac 5L General cleaning 12 0.6
Cleanac 3 5L Enhanced cleaning 12 0.4

➢ Short shelf life: less than 24 months.

➢ Automatic rinse for every 10 tests.
MEK-7222/CELLTAC E Operation

60t/h ?

MEK-7222
(CELLTAC E)

22 reportable parameters and

75-80 second to finish one test no research parameter
MEK-7222/CELLTAC E Operation

➢ 5.7’ black and white screen;

➢ Sub-menus to display total
parameter and graphics
information;
➢ Only 400 data storage;
MEK-7222/CELLTAC E Operation

Ceramic counting aperture, Peristaltic-pump and aging tubes,

not endurable need frequent maintenance;
MEK-7222/CELLTAC E Operation

Cumbersome maintenance
Competition analysis
Working principle
Weakness
Comparison table
MEK-7222/CELLTAC E Summary

BC-5150 MEK-7222
Total Parameters 25+4 22+6
Sampling volume 15/15/20 55/20
Data storage 40000 400 (with 50 graphs)
Counting aperture Ruby Ceramic
Customization on reference range Yes No
Customization on print-out template Yes No
Maintenance Simple Complicated

© 2012 Mindray Confidential

MEK-7222/CELLTAC E Summary

BC-5150 MEK-7222
Counting channel for WBC 2 1
Built-in lyse reagent Yes No
Working temperature 10-30 15-30
Humidity 20%-85% 30%-85%
Touch screen 10.4 inch full-color TFT 5.7 inch black and white screen
USB port 4 /
Dimensions 400 x 320 x 410mm 520 x 380 x 485mm
Weight 24kg 38kg

© 2012 Mindray Confidential

Competition analysis
Working principle
Weakness
Comparison table
Product portfolio

Mythic 22
OT
Mythic 22
AL

Mythic 22
CT

Mythic 18
Mythic 18
Vet
Orphee product pyramide

Samples per day

>400

>240

>120

Mythic 22 CT
>60
Mythic 22 OT
Mythic 22 AL
>20 Mythic 18
Competition analysis
Working principle
Weakness
Comparison table
Mythic 22 Specifications
Manufacturer Cormay
Year of Launch Unknown
Target group Small workload (below 50 samples/day);
Parameters 22: WBC, LYM(#,%), NEU(#,%), MON (#,%), EOS
Mythic 22 OT (#,%), BAS (#,%), RBC, HGB, HCT, MCV, MCH,
MCHC, RDW-CV, PLT, MPV, PDW, PCT
Research parameters /
Number of analytical DIFF, RBC/PLT, WBC/HGB
channels
Histogram RBC, PLT, WBC
Mythic 22 CT
Scattergram DIFF
Principle Optical Cytometry Hydrofocus Free (OCHF) for
differential and impedance for RBC and PLT

Sample volume Open vial/Cap piercing: 15.7ul

Autoloader: 18.2 ul
Mythic 22 AL
Mythic 22 Specifications

Sampler Mythic 22 OT: Open vial

Mythic 22 CT: Closed tube
Mythic 22 AL: Autoloader 5*10 racks
LIS/HIS Bi-directional;
Mythic 22 OT
Data storage 1500 test results and patient records;
Up to 6/12 QC files;
Throughput Mythic 22 OT/CT: 60 samples/hr;
Mythic 22 AL: 80 samples/hr;
Reagent systems 2 analytical reagents and 1 maintenance reagent;

Mythic 22 CT Operation Built-in color touch screen

Main unit size Mythic 22 OT/CT: 350 x 250 x 340 mm
Mythic 22 AL: 500 x 410 x 430 mm
Main unit weight Mythic 22 OT/CT: 11.0 kg
Mythic 22 AL: 25.0 kg

Mythic 22 AL
Principle tree
RET
OCHF

Onlyone lyse solution

DIFF

CBC+DIFF
Colorimetry DC Impedance

Onlyone lyse solution Diluent

IMI RBC
HGB
PLT

Cleanser
Competition analysis
Working principle
Weakness
Comparison table
Mythic 22 Principles

ALL

Lymphocyte
Monocyte
Basophil
Neutrophil
Eosinophil

FSC
No dedicated BASO channel.
Mythic 22 Reagents

Shelf life Consumption/

Name Size Function
(months) test (ml)
Diluent M22 18L Diluting blood cells 36 19.0
Destroys the RBC and
OnlyOne lyse 500mL 18 0.75
measure HGB
Cleanser M22 5L General cleaning 12 0.45

Short shelf life: less than 24 months

Mythic 22 Operation

60t/h ?
Aspirate
needle

Mythic 22

Diluent leaks away from

75 second to finish one test aspirate needle.

No original Quality Control and Calibrator

Mythic 22 Operation

Software limitations:
➢ Simple statistics function
➢ No customization on print-
out template
➢ No fresh blood calibration
➢ No ZAP
….
Mythic 22 Operation
Item Daily Weekly Half-yearly Yearly
Reagent Leftover √
Start up √
Auto wash √
Concentrated wash √
Shut up √
Shell wash √
Piston lubricated √ √
Change aspirate needle √
Change tubing √
Motor maintenance √
* For WBC/HGB counting bath, it needs to be washed by concentrated NaClO (12%) weekly.

Complicated maintenance
Competition analysis
Working principle
Weakness
Comparison table
Mythic22 Summary

BC-5150 Mythic 22
Total Parameters 25+4 22
Dedicated Baso channel Yes No
Data storage 40000 500
QC files 60 6
Customization on print-out template Yes No
Statistic function Powerful Simple
Fresh blood calibration Yes No
ZAP unclogging Yes No
Maintenance Simple Complicated

© 2012 Mindray Confidential

Mythic22 Summary

BC-5150 Mythic 22
Sample volume Open vial/Cap piercing: 15.7ul
15/15/20
Autoloader: 18.2 ul
Scattergrams 3 1
Working temperature 10-30 18-34
Humidity 20%-85% 50%-80%
Touch screen 10.4 inch full-color TFT 8.5 inch color screen
USB port 4 2
Dimensions 400 x 320 x 410mm 350 x 250 x 340mm
Weight 24kg 11kg

© 2012 Mindray Confidential

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