PERHITUNGAN BAHAN

1. Vial
R/ Paracetamol 1%
Sistein HCl 0,25%
Benzalkonium chlorida 0,1%
Na sitrat 0,07 %
WFI ad 15 mL
m.f. inj. Vial ad 15 mL

Perhitungan zat :
Volume sediaan = 15 ml + 20% = 18 ml
A. Untuk 1 vial

1. Paracetamol = x 18 ml

= 0,18 ml

2. Sistein HCl = x 18 ml

=0,045

3. Benzalkonium Cl = x 18

= 0,018 ml

4. Na sitrat = x 18 ml

= 0,0126 ml
5. WFI = 18 ml – (0,18+ 0,045+0,018+0,0126)
= 17,75 ml
B. Untuk 5 Vial
1. Paracetamol = 0,18 ml x 5
= 0,9 ml
2. Sistein HCl = 0,045 ml x 5
= 0,225 ml
3. Benzalkonium Cl =0,018 ml x 5
 = 0,09
4. Na sitrat = 0,0126 ml x 5
= 0,063 ml
5. WFI = 17,75 ml x 5
= 88,75 ml
Perhitungan Persen Bahan

1. Paracetamol = x 100 % = 1%

= 1 gram/ml x 10 ml/L
= 10 g/L

2. Sistein HCl = x 100 % = 0,25 %

= 2,5 gram/ml x 10 ml/L

= 25 g/L

3. Benzalkonium Cl = x 100 % = 0,1 %

= 0,1 gram/ml x 10 ml/L

= 1 g/L

4. Na sitrat = x 100 % =0,07 %

= 0,07 gram/ml x 10 ml/L

= 0,7 g/L

2. AMPUL
R/ Paracetamol 16 %
Sistein HCl 0,25%
Na sitrat 0,07 %
WFI ad 3 mL
m.f. inj. Ampoule ad 3 mL

Perhitungan zat :
Volume sediaan = 3 ml + 20% = 3,8 ml
A. Untuk 1 Ampul

6. Paracetamol = x 3,8 ml

= 0,608 ml

7. Sistein HCl = x 3,8 ml

= 0,0095 ml

8. Na sitrat = x 3,8 ml

= 0,0026 ml
9. WFI = 3,8 ml – (0,6 + 0,0095+0,0026)
= 2,99 ml
B. Untuk 4 Ampul
6. Paracetamol = 0,6 ml x 4
= 2,4 ml
7. Sistein HCl = 0,0095 ml x 4
= 0,038 ml
8. Na sitrat = 0,0026 ml x 4
= 0,01 ml
9. WFI = 2,99ml x 4
= 11,96 ml
Perhitungan Persen Bahan

5. Paracetamol = x 100 % = 16%

= 16 gram/ml x 10 ml/L
= 160 g/L

6. Sistein HCl = x 100 % = 0,25%

= 0,25 gram/ml x 10 ml/L

= 2,5 g/L

7. Na sitrat = x 100 % =0,07 %

= 0,07 gram/ml x 10 ml/L
= 0,7 g/L