Invation of other RBC + development of gametocytes which are taken up by mosquito during

feeding time

Rapidly rising fever and profuse sweating

Coagulation defect Anemia

Liver and renal function Pulmunary and cerebral edema Shock

DEATH
 Female Anopheles
mosquito ingest parasite Infected hepatocytes
matures and raptures Infected RBCs raptures
during blood feeding from a
releasing merozoites into the releasing merozoites
host’s blood
circulationinfecting RBCs

Parasites will sexual

Hemozoins and other toxic
reproduce inside the Sporozoites migrates to the
factors stimulates macrophages
mosquito’s stomach host’s liver and infects
and other cells to produce
hepatocytes
cytokines

After 10-18 days

sporozoites will be formed
Sporozoites migrates to
and migrates to the
the host’s liver and infects Onset of signs and symptoms
mosquito’s salivary gland
hepatocytes

Mosquito bites a host Anticoagulant saliva will be

Invation of other RBC + development of gametocytes
injected together with the
which are taken up by mosquito during feeding time
sporozoites into the host