PEPITO, RICA ALYSSA M.

UNIVERSITY OF CEBU SCHOOL OF MEDICINE Source: Harrison’s Principles of Internal Medicine 20 th Edition

Principles of Cancer Treatment (Ch. 69)

SYSTEMIC LOCALIZED TREATMENT
SUPPORTIVE TREATMENT
DETECTION CANCER CANCER RESISTANCE
CARE APPROACHES
TREATMENT TREATMENT MECHANISMS

Cytotoxic Targeted Cancer Systemic Surgery— Myelosuppr Multidrug

Physical Chemothera
Chemothera Chemothera Biologic Radiation most ession - resistance Surgery Radiation
examination py
py Agents py Therapy Therapy effective antibiotics, (mdr) gene
Radiation Colony
(Radiation stimulating
Hormone factors, Increased Conventiona
DNA- Antibody Biology & Preservation
Receptor Blood expression Staging Mechanism Determinant l “cytotoxic” Targeted Hormonal Biologic
interactive Mediated Medicine, of organ Debulking Delivery
Imaging (CT, Directed component of a drug's information of action s chemothera agents therapy therapy
Agents Therapeutic Localized function
UTZ, Xray, Therapy transfusion target py agents
Radiation
PET, MRI) Therapy)
Diagnosticall
Loss of the R0 - Causes Total Antibody Immune cell
Antitumor y Guided Approaches Endoscopy Nausea and Microtubule Diagnosticall Steroid
cellular complete breaks in absorbed Teletherapy DNA effects mediated Cytokines mediated
Antibiotics Targeted Cytokines Techniques vomiting - effects y guided hormone
apoptotic excision DNA dose approach therapies
and Therapy anti-emetics protein receptor-
mechanism
Topoisomera kinase related
activated
se Poisons R1 - Generation antagonists molecules
Oncogenicall Immune Cell after Tumor Transfer of
Radiofreque Diarrhea - engagement microscopic of free Number of Brachythera Alkylating Vinca
y Activated Mediated regulatory IFN-alpha allogeneic T
ncy Ablation hydration, of a drug’s surgical radicals from fraction py agents alkaloids
Pathway Therapies antibodies cells
Electrolyte target by margin cell water Organ
replacement drug Diagnosticall resection/ab
Biopsy Antimetaboli , Antimotility
tes R2 - y guided lation
(Excisional, drugs retinoids Immunoregu Transfer of
Incisional, macroscopic Time of Systemic Anti-tumor IL-2 related
Cryosurgery Sequencing Taxanes latory autologous T
Core-needle, surgical treatment therapy antibiotics molecules
of the antibodies cells
FNAB) margin
Mucositis - targets of
Mitotic Topical Tumor
Spindle agents Multikinase
Hematoporp anesthetics, directed at Indirect inhibitors vaccines
Inhibitors hyrins and Barrier DNA- Antibody aimed at
oncogenic Epothilones
Phototherap creating kinases interacting conjugates boosting T
y preparations agents cell
, immunity
Keratinocyte Proteasome
Upregulation inhibitors
growth of alternate Antimitotic
factor means of agents
activating
the pathway Histone
Alopecia - targeted by deacetylase
Scalp the agent
temperature inhibitors
reduction,
psychologica
l support mTOR
inhibitors
Gonadal
dysfunction -
Sperm Miscellaneo
banking/Egg us (Arsenic
preservation trioxide,
Vismodegib)

Pregnancy -
Avoid
chemothera
py in 1st
trimester,
antimetaboli
te drugs
should not
be given
throughout
entire
pregnancy