Risk factors:

Age
Smoking and Alcohol

APC Gene Mutation DNA Repair Gene Mutation

Fast epithelial cell division

Adenomatous Polyp
Serrated Polyp

P53 gene and k-Ras Mutation

Malignant Transformation

mass with invasion of nearby tissue

May ulcerate , obstruct

friable fungating mass lesion which occupied and bleed
almost 50% of the luminal diameter seen on
Colonoscopy
Hematochezia

Colorectal Cancer Stages

Pale palpebral conjunctiva
Stage 0: In situ low hemoglobin hemtocrit

Stage 1:Beyond the mucosa

No Lymph nodes

Stage 2: mass grown through

the wall . has not spread to the
nearby lymph nodes or
elsewhere 
 Several well-defined hypodense
foci seen on CT SCAN
Stage 3: grown through the
muscle layers, has spread to
lymph nodes, no distant Epigastric pain, non-radiating
metastasis

Stage 4: metastatic, reached

distant organs Metastasis via the portal Increased AST, ALT, ALP
circulation