Brand Name

Cap: Doxy - A 100 mg

Generic Name

Doxycycline

Manufacturer

Acme Laboratories Ltd.

Mechanism of action

Doxycycline, like minocycline, is lipophilic and can pass through the lipid bilayer of bacteria.
Doxycycline reversibly binds to the 30 S ribosomal subunits and possibly the 50S ribosomal
subunit(s), blocking the binding of aminoacyl tRNA to the mRNA and inhibiting bacterial
protein synthesis. Doxycycline prevents the normal function of the apicoplast of Plasmodium
falciparum, a malaria causing organism.

Uses

Doxycycline is used to treat many different bacterial infections, such as acne, urinary tract
infections, intestinal infections, eye infections, gonorrhea, chlamydia, periodontitis (gum
disease), and others. Doxycycline is also used to treat blemishes, bumps, and acne-like lesions
caused by rosacea. It will not treat facial redness caused by rosacea. Some forms of doxycycline
are used to prevent malaria, to treat anthrax, or to treat infections caused by mites, ticks, or lice.

Side effects

Epigastric distress, abdominal discomfort, nausea, and vomiting may occur. Long term therapy
with it may produces changes in the peripheral blood. Various skin reaction including rashes,
urticarial, exfolative dermatitis.
Contraindication

It is contradicted to patient with known hypersensitivity to any of the tetracyclines. It is also

contradicted in severe hepatic disorder and patient with lupas erythematosus. Concomitant intake
of alkalis, antacids and iron may interfere with the absorption of it. It is also advisavle to avoid
giving doxycycline in conjunctin with penicillin.