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LPL - LPL-ROHINI (NATIONAL REFERENCE LAB)

SECTOR - 18, BLOCK -E ROHINIDELHI 110085

Name DUMMY N062 Collected 28/7/2020 11:45:00AM

Received 28/7/2020 2:34:09PM

Lab No. 153672183 Age: 26 Years Gender: Male Reported 29/7/2020 2:45:52PM

A/c Status P Ref By: UNKNOWN Report Status Final

TEST CONDUCTED t(1;19) (q23;p13.3); TCF3- BX1(E2A-PBX1), PCR QUALITATIVE

(Real Time PCR)

RESULTS

t (1;19) (q23 ;p13.3); TCF3-PBX1(E2A- PBX1)

Negative

Comments
Precursor B-cell Acute Lymphoblastic Leukemia (ALL) accounts for 85% Acute leukemias in children
and 20% in adults. Most patients with ALL show an abnormal clone by conventional cytogenetic
studies.The common chromosome translocations in pediatric ALL include t(1;19)(q23;p13.3);
TCF3-PBX1(E2A-PBX1), t(12;21) (p13;q22); ETV6-RUNX1(TEL-AML1) & MLL gene rearrangement. All
these translocations are important to detect as they are important prognostic markers. Detection of
translocation t(1;19) shows improved outcome with intensive chemotherapy.

Uses
· Quantifying disease before treatment and after therapy for patients with ALL
· Assessing residual disease after treatment

Dr Anand Chandrasekaran Annan Dr Atul Thatai

MD (American Board of Pathology) PhD, Biotechnology
PhD (Molecular & Cellular Pathology) HOD Molecular Diagnostics
HOD - Oncopathology NRL - Dr Lal PathLabs Ltd

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(#) Sample drawn from outside source.

PatientReportSCSuperPanel.FLOWCYTO_DYNAMIC_SC (Version: 6)

*153672183*
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