a.

Data uji disolusi tablet piroksikam

Menit Ke- Tablet 1 Tablet 2 Tablet 3

5 0,1652 0,2186 0,2482

10 0,3319 0,4143 0,4277

15 0,4600 0,3893 0,3975

20 0,6323 0,4720 0,4109

25 0,4440 0,4181 0,3585

30 0,4962 0,4514 0,3481

y = 0,070914x + 0,023990
r2 = 0,9931

Tablet 1
1. t = 5 menit
Absorban (A) =0,1652
y = 0,070914x + 0,023990
0,1652 = 0,070914x + 0,023990
X = 1,9912 µg/mL
µg 10
1,9912 ×900 mL×( )
mL 2
Kadar= =8,9604 mg
1000
8,9604 mg
% kadar= × 100 %=1,7920 %
500 mg

2. t = 10 menit
Absorban (A) = 0,3319
y = 0,070914x + 0,023990
0,3319 = 0,070914x + 0,023990
x = 4,3420 µg/mL
10
4,3420 µg /mL× 900 mL ×( )
2
Kadar= =19,539 mg
1000
10 mL
FK= ×8,9604 mg =0,09956 mg
900 mL
Kadar total = 19,539 mg + 0,09956 mg = 19,6385 mg
19,6385mg
% terdisolusi= × 100 %=3,9277 %
500mg
3. t = 15 menit
Absorban (A) = 0,4600
y = 0,070914x + 0,023990
0,4600 = 0,070914x + 0,023990
x = 6,1484 µg/mL
10
6,1484 µg /mL × 900 mL×( )
2
Kadar= =27,6678 mg
1000
10 mL
FK= ×19,539 mg=0,2171 mg
900 mL
Kadar total = 27,6678 mg + 0,2171 mg = 27,8849 mg
27,8849mg
% terdisolusi= ×100 %=5,57698 %
500mg
4. t = 20 menit
Absorban (A) = 0,6323
y = 0,070914x + 0,023990
0,6323 = 0,070914x + 0,023990
x = 8,5781 µg/mL
10
8,5781 µg /mL ×900 mL ×( )
2
Kadar= =39,4114 mg
1000
10 mL
FK= ×27,6678 mg=0,3074 mg
900 mL
Kadar total = 39,4114 mg + 0,3074 mg = 39,7188 mg
 39,7188mg
% terdisolusi= ×100 %=7,94376 %
500mg
5. t = 25 menit
Absorban (A) = 0,4440
y = 0,070914x + 0,023990
0,4440 = 0,070914x + 0,023990
x = 5,9228 µg/mL
10
5,9228 µg /mL×900 mL×( )
2
Kadar= =26,6526 mg
1000
10 mL
FK= ×39,4114 mg=0,4379 mg
900 mL
Kadar total = 26,6526 mg + 0,4379 mg = 27,0905 mg
27,0905 mg
% terdisolusi= ×100 %=5,4181 %
500 mg
6. t = 30 menit
Absorban (A) = 0,4962
y = 0,070914x + 0,023990
0,4962 = 0,070914x + 0,023990
x = 6,6589 µg/mL
10
6,6589 µg /mL ×900 mL ×( )
2
Kadar= =29,9650 mg
1000
10 mL
FK= ×26,6526 mg=0,2961 mg
900 mL
Kadar total = 29,9650 mg + 0,2961 mg = 30,2611 mg
30,2611 mg
% terdisolusi= ×100 %=6,0522 %
500 mg

Tablet 2
1. t = 5 menit
Absorban (A) =0,2186
y = 0,070914x + 0,023990
0,2186 = 0,070914x + 0,023990
X = 2,7443 µg/mL
µg 10
2,7443 ×900 mL×( )
mL 2
Kadar= =12,3493 mg
1000
12,3493 mg
% kadar= ×100 %=2,4698 %
500 mg

2. t = 10 menit
Absorban (A) = 0,4143
y = 0,070914x + 0,023990
0,4143 = 0,070914x + 0,023990
x = 5,5039 µg/mL
µg 10
5,5039 ×900 mL×( )
mL 2
Kadar= =24,7675 mg
1000
10 mL
FK= ×12,3493 mg=0,1372 mg
900 mL
Kadar total = 24,7675 mg + 0,1372 mg = 24,9047 mg
24,9047 mg
% terdisolusi= ×100 %=4,9809 %
500 mg
3. t = 15 menit
Absorban (A) = 0,3893
y = 0,070914x + 0,023990
0,3893 = 0,070914x + 0,023990
x = 5,1514 µg/mL
10
5,1514 µg /mL × 900mL ×( )
2
Kadar= =23,1813 mg
1000
10 mL
FK= ×24,7675 mg=0,2751 mg
900 mL
Kadar total = 23,1813 mg + 0,2751 mg = 23,4564 mg
23,4564 mg
% terdisolusi= ×100 %=4,6912%
500 mg
4. t = 20 menit
 Absorban (A) = 0,4720
y = 0,070914x + 0,023990
0,4720 = 0,070914x + 0,023990
x = 6,3176 µg/mL
10
6,3176 µg /mL×900 mL×( )
2
Kadar= =28,4292 mg
1000
10 mL
FK= ×23,1813 mg=0,2575 mg
900 mL
Kadar total = 28,4292 mg + 0,2575 mg = 28,6867 mg
28,6867 mg
% terdisolusi= ×100 %=5,7373 %
500 mg
5. t = 25 menit
Absorban (A) = 0,4181
y = 0,070914x + 0,023990
0,4181 = 0,070914x + 0,023990
x = 5,5575 µg/mL
10
5,5575 µg /mL ×900 mL×( )
2
Kadar= =25,0087 mg
1000
10 mL
FK= ×28,4292 mg=0,3158 mg
900 mL
Kadar total = 25,0087 mg + 0,3158 mg = 25,3245 mg
25,3245 mg
% terdisolusi= ×100 %=5,0649 %
500 mg
6. t = 30 menit
Absorban (A) = 0,4514
y = 0,070914x + 0,023990
0,4514 = 0,070914x + 0,023990
x = 6,0271 µg/mL
10
6,0271 µg/mL × 900 mL×( )
2
Kadar= =27,1219 mg
1000
 10 mL
FK= ×25,0087 mg=0,2778 mg
900 mL
Kadar total = 27,1219 mg + 0,2778 mg = 27,3997 mg
27,3997 mg
% terdisolusi= ×100 %=5,4799 %
500 mg

Tablet 3
1. t = 5 menit
Absorban (A) =0,2482
y = 0,070914x + 0,023990
0,2482 = 0,070914x + 0,023990
X = 3,1617 µg/mL
µg 10
3,1617 × 900 mL ×( )
mL 2
Kadar= =14,2276 mg
1000
14,2276 mg
% kadar= ×100 %=2,84552 %
500 mg

2. t = 10 menit
Absorban (A) = 0,4277
y = 0,070914x + 0,023990
0,4277 = 0,070914x + 0,023990
x = 5,6929 µg/mL
µg 10
5,6929 ×900 mL×( )
mL 2
Kadar= =25,6180 mg
1000
10 mL
FK= ×14,2276 mg=0,1580 mg
900 mL
Kadar total = 25,6180 mg + 0,1580 mg = 25,776 mg
25,776 mg
% terdisolusi= ×100 %=5,1552 %
500 mg
3. t = 15 menit
Absorban (A) = 0,3975
y = 0,070914x + 0,023990
0,3975 = 0,070914x + 0,023990
x = 5,2670 µg/mL
10
5,2670 µg /mL×900 mL×( )
2
Kadar= =23,7015 mg
1000
10 mL
FK= ×25,6180 mg=0,2846 mg
900 mL
Kadar total = 23,7015 mg + 0,2846 mg = 23,9861 mg
23,9861mg
% terdisolusi= × 100 %=4,79722 %
500 mg
4. t = 20 menit
Absorban (A) = 0,4109
y = 0,070914x + 0,023990
0,4109 = 0,070914x + 0,023990
x = 5,4560 µg/mL
10
5,4560 µg /mL ×900 mL×( )
2
Kadar= =24,552 mg
1000
10 mL
FK= ×23,7015 mg=0,2633 mg
900 mL
Kadar total = 24,552 mg + 0,2633 mg = 24,8153 mg
24,8153 mg
% terdisolusi= ×100 %=4,9630 %
500 mg
5. t = 25 menit
Absorban (A) = 0,3585
y = 0,070914x + 0,023990
0,3585 = 0,070914x + 0,023990
x = 4,7171 µg/mL
10
4,7171 µg /mL ×900 mL ×( )
2
Kadar= =21,2269 mg
1000
10 mL
FK= ×24,552 mg=0,2728 mg
900 mL
Kadar total = 21,2269 mg + 0,2728 mg = 21,4997 mg
 21,4997 mg
% terdisolusi= ×100 %=4,2999 %
500 mg
6. t = 30 menit
Absorban (A) = 0,3481
y = 0,070914x + 0,023990
0,3481 = 0,070914x + 0,023990
x = 5,0781 µg/mL
10
5,0781 µg/mL × 900 mL×( )
2
Kadar= =22,8514 mg
1000
10 mL
FK= ×21,2269 mg=0,2358 mg
900 mL
Kadar total = 22,8514 mg + 0,2358 mg = 23,0872 mg
23,0872mg
% terdisolusi= × 100 %=4,6174 %
500 mg
Hasil Disolusi Tablet
Formulasi Waktu Absorban
Kadar (mg) % terdisolusi
5 menit 0,1652 8,9604 mg 1, 7920 %
10 menit 0,3319 19,539 mg 3, 9277 %
15 menit 0,4600 27,6678 mg 5, 57698 %
Tablet 1
20 menit 0,6323 39,4114 mg 7, 94376%
25 menit 0,4440 26,6526 mg 5, 4181%
30 menit 0,4962 29,9650 mg 6, 0522%
5 menit 0,2186 12,3493 mg 2, 4698%
10 menit 0,4143 24,7675 mg 4, 9809%
15 menit 0,3893 23,1813 mg 4, 6912 %
Tablet 2
20 menit 0,4720 28,4292 mg 5, 7373 %
25 menit 0,4181 25,0087 mg 5, 0649 %
30 menit 0,4514 27,1219 mg 5, 4799 %
5 menit 0,2482 14,2276 mg 2, 84552 %
10 menit 0,4277 25,6180 mg 5, 1552 %
15 menit 0,3975 23,7015 mg 4, 79722 %
Tablet 3
20 menit 0,4109 24,552 mg 4, 9630 %
25 menit 0,3585 21,2269 mg 4, 2999 %
30 menit 0,3481 22,8514 mg 4, 6174 %

b. waktu hancur tablet

 NO. Tablet Waktu Hancur
1 1 menit 02 detik
2 2 menit 01 detik
3 1 menit 36 detik
4 1 menit 23 detik
5 2 menit 25 detik
6 1 menit 45 detik
∑ = 10 menit 12 detik
∑ = 612 detik

612 detik
Rata-rata waktu hancur = = 102 detik
6