Roll No…………………..

Aug, 2018/20217
(B. Pharmacy 2nd Semester-2018)
PHARMACEUTICAL ORGANIC CHEMISTRY-I
Time: Three hours M. Marks: 75
Note: Do not write anything except roll no. on this question paper

Section-A
Multiple Choice Questions- Attempt all questions
Q.1 (a) The number of structural isomers of alcohol with molecular formula C4H9OH is 20x1=20
(i) 5 (ii) 3
(iii) 4 (iv) 6
(b) Which of the following has the highest boiling point?
(i) Diethyl ether (ii) n-Butyl alcohol
(iii) n-Propyl chloride (iv) n-Butyraldehyde
(c) Lucas reagent is
(i) HCl/NaNO2 (ii) H2/Pd
(iii) H2/Pd/BaSO4 (iv) HCl/Zn
(d) The carbon atom involved in double bond of alkene are
(i) sp hybridised (ii) sp2 hybridised
(iii) sp3 hybridised (iv) none of these
(e) The disappearance of purple colour of KMnO4 in its reaction with alkene is known as
(i) Bayer Test (ii) Wurtz Test (iii) Victor Mayer Test (iv) Grignard Test
(f) Alkyl halides undergo
(i) Electrophilic substitution rteaction (ii) Nucleophilic substitution reaction
(iii) Electrophilic addition reaction (iv) Nucleophilic addition reaction
(g) Rectified Spirit is
(i) 100% Ethanol (ii) 100% Methanol
(iii) 90% Ethanol (iv) 95% Ethanol
(h) in succinic acid, HOOC(CH2)n COOH, n is equal to
(i) 1 (ii) 2
(iii) 4 (iv) 3
(i) Which is strongest acid
(i) CH3COOH (ii) CH3CH2COOH
(iii) ClCH2COOH (iv) FCH2COOH
(j) Which of the following is most basic
(i) Ammonia (ii) Methylamine
(iii) Dimethylamine (iv) Trimethylamine
k) Carbylamines test is given by
(i) Primary amines (ii) Secondary amines
(iii) Tertiary amines (iv) None of these
(l) The hybridisation of Nitrogen in an amine is
(i) sp hybrodization (ii) sp2 hybridisation
(iii) sp3d hybridization (iv) sp3 hybridization
(m) Propene reacts with HBr in the presence of Peroxide to give
(i) n-Propyl bromide (ii) Alkyl bromide
(iii) Vinyl bromide (iv) None of these
(n) In cold countries, ethylene glycol is added to water in car radiators to
(i) reduce viscosity (ii) Make water better lubricant
(iii) Lower the freezing point (iv) Lower the boiling point
 (o) Formalin is
(i) 10% solution of fonrmaldehyde in water (ii) 40% solution of formaldehyde in water
(iii) 20% solution of formaldehyde (iv) 80% solution of formaldehyde in water
(p) Which of the following reaction can be used in prepare alkenes
(i) Wurtz reaction (ii) Wolf-kishner reaction
(iii) Lolbe’s reaction (iv) All of the above
(q) Which of the following statements is false about Tautomers
(i) Tautomer are structural isomers (ii) Tautomer are structural isomers which exist in dynamic equibrium
(iii) Tautomer involves movement of atoms (iv) Tautomer have independent existence
(r) Aliphatic Primary amine react with cold nitrous acid to form
(i) Alcohols (ii) Diazonium salt
(iii) Nitriles (iv) Nitroalkanes
(s) Which of the following compounds have zero dipole moment
(i) cis-1,2-dibromoethylene (ii) 1,1-dibromoethylkene
(iii) trans-,12-dibromoethylene (iv) All of the above
(t) Which of the following reagents will convert acetic aacid into acetyol chloride?
(i) NaCl (ii) HClZnCl2
(iii) SOCl2 (iv) HCl

Section-B
Short answer type questions, Answer any 7 questions
Q.2 Discuss anti-markownikoff’s rule with suitable example 5
Q.3 Discuss stereochemistry of SN2 reaction. 5
Q.4 Give chemical tests to differentiate primary, secondary and tertiary alcohals. 5
Q.5 Discuss briefly basicity of amines taking suitable of examples 5
Q.6 Discuss mechanism of Aldol condensation 5
Q.7 Give steps to synthesize acetone from formaldehyde 5
Q.8 Discuss the effect of substituents on the acidity of carboxylic acids 5
Q.9 How will you differentiate Aldehyde from ketones? 5
Q.10 Conformational analysis of n-Butane 5

Section-C
Long answer type questions. Answer any 2 questions.
Q.11 Discuss the following: 10
(a) Oxidation of alcohols
(b) Halogenation of alkanes
Q.12 Write notes on the followings: 10
(a) Methods of preparation of alkenes
(b) Diel-Alder reaction with mechanism
Q.13 Discuss the chemical properties of alkyl halides. 10