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    Adsdsdwqeqqasdasdafasfzxczxczxczc: Pathophysiology

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    Azria John Demetri
    The document did not contain any text. Pneumonia can spread to the lungs through several pathways and the body has various defense mechanisms to fight it off. However, if pneumonia overwhelms these defenses it can lead to symptoms like fever, rales/crackles, infiltrates on chest x-ray, and ultimately decreased lung compliance.

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    Adsdsdwqeqqasdasdafasfzxczxczxczc: Pathophysiology

    Uploaded by

    Azria John Demetri
    3 views1 page
    The document did not contain any text. Pneumonia can spread to the lungs through several pathways and the body has various defense mechanisms to fight it off. However, if pneumonia overwhelms these defenses it can lead to symptoms like fever, rales/crackles, infiltrates on chest x-ray, and ultimately decreased lung compliance.

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    The document did not contain any text. Pneumonia can spread to the lungs through several pathways and the body has various defense mechanisms to fight it off. However, if pneumonia overwhelms these defenses it can lead to symptoms like fever, rales/crackles, infiltrates on chest x-ray, and ultimately decreased lung compliance.

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    3 views1 page

    Adsdsdwqeqqasdasdafasfzxczxczxczc: Pathophysiology

    Uploaded by

    Azria John Demetri
    The document did not contain any text. Pneumonia can spread to the lungs through several pathways and the body has various defense mechanisms to fight it off. However, if pneumonia overwhelms these defenses it can lead to symptoms like fever, rales/crackles, infiltrates on chest x-ray, and ultimately decreased lung compliance.

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    adsdsdwqeqqasdasdafasfzxczxczxczc

    Microorganism
    PATHOPHYSIOLOGY

    Hematogenous spread Direct inhalation Aspiration from URTI Contiguous extension


    (ex. Tricuspid endocarditis) from an infected
    pleura or mediastinum

    Defense mechanism
    Goblet cells produce
    mucus containing Mucociliary clearance Cough reflex Gag reflex
    lysozome and IgA

    Eliminates via Macrophage


    mucociliary elevators Alveolar macrophage
    kills the bacteria

    Alveolar macrophage +
    Cough
    Complement antibodies +
    surfactand prodtein A and D

    Host inflammatory response

    IL 8 and granulocyte Release of inflammatory


    Fever
    colony-stimulating factor mediators

    Alveolar capillary leak


    Stimulate neutrophil release Rales/Crackles
    (GRAY hepatization)
    Exudate in Alveoli
    Infiltrates on
    Chest X-ray
    Erythrocyte in
    Peripheral leukocytosis and intraalveolar exudates Hemoptysis
    inc. purulent secretions (RED hepatization)

    Dec. lung compliance


    Dyspnea
    VQ mismatch Inc. respiratory drive Tachypnea

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