Multi-compartmental System Modeling

Dr. Shubhajit Roy Chowdhury,

School of Computing and Electrical Engineering,

IIT Mandi, India
Email: src@iitmandi.ac.in

Dr. Shubhajit Roy Chowdhury SCEE, IIT MANDI

Drawbacks of single compartmental model

• Single compartment model does not take into

account finer details of dynamics of solute
transport across various membranes
• Each of the compartments such as cell
volume, interstitial volume, etc can be further
compartmentalized

Dr. Shubhajit Roy Chowdhury SCEE, IIT MANDI

 Generalized N compartmental system model

• Each compartment is characterized by a

conservation of mass differential equation
describing rate of change of solute.
• For N compartments there are N equations of
the general form:
dqi
 input  output
dt

Dr. Shubhajit Roy Chowdhury SCEE, IIT MANDI

An example two compartmental model
Consider a two compartment system for the
distribution of creatinine in the body. Creatinine
is a waste product of metabolism in the muscle
which is cleared from the body through urine.
Assume creatinine production in the muscle is qin
and is given by a step input. Assume that
creatinine is transferred from plasma to muscle at
a rate constant K1 and from muscle to plasma at
a rate constant K2 and removed from plasma
through urine at a rate constant K3. Estimate the
concentration of creatinine in the plasma
compartment as a function of time.

Dr. Shubhajit Roy Chowdhury SCEE, IIT MANDI

Non linearity in compartmental models
• In many systems the transfer rates are
dependent on solute in a compartment.
• Compartmental models can still be applied by
incorporating non linearity in the model.

Dr. Shubhajit Roy Chowdhury SCEE, IIT MANDI

Infectious Disease Model

Dr. Shubhajit Roy Chowdhury SCEE, IIT MANDI

Kermack McKendrick Compartmental Model

Dr. Shubhajit Roy Chowdhury SCEE, IIT MANDI

Kermack McKendrick Compartmental Model

dx
  xy
dt
dy
 xy  y
dt
dz
 y
dt

Dr. Shubhajit Roy Chowdhury SCEE, IIT MANDI

Kermack McKendrick compartmental
model with birth and death rates

Dr. Shubhajit Roy Chowdhury SCEE, IIT MANDI

Kermack McKendrick compartmental
model with birth and death rates

dx
  xy   z  y 
dt
dy
 xy  y  y
dt
dz
 y  z
dt

Dr. Shubhajit Roy Chowdhury SCEE, IIT MANDI

Reed Frost Compartmental Model

avg _ no . _ of _ adequate _ contacts

p
Total _ population
q  1 p

Dr. Shubhajit Roy Chowdhury SCEE, IIT MANDI

Reed Frost Compartmental Model

Ck 1  S k 1  q Ck

S k 1  S k  Ck 1
Rk 1  Rk  Ck

Dr. Shubhajit Roy Chowdhury SCEE, IIT MANDI

 Thank you

Dr. Shubhajit Roy Chowdhury SCEE, IIT MANDI