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ITT: Intent To Treat Effect - Effect of Treatment ASSIGNMENT On Outcome (For
ITT: Intent To Treat Effect - Effect of Treatment ASSIGNMENT On Outcome (For
The ITT is the most straightforward. If we randomize some individuals into treatment and
some into control, we can certainly recover the causal effect of assignment into treatment.
That's the ITT.
The LATE is a bit more complicated, but the measure most often gleaned via instrumental
variables / two stage least squares, etc. Assuming we're not in a lab setting, even if we assign
some folks to treatment (T = 1) and assign some to control (T = 0), people will do what they
will do! Some will takeup treatment (D = 1) and some will not takeup treatment (D = 0). We
can imagine that some people are just willing to comply with our assignments. We may want
to know what kind of person everybody in our data is -- are they the type of person who will
do what we say, who will rebel, who will always takeup, who will never takeup? To know
this without making any assumptions, we would actually need to know, for each person, what
they would do if assigned to treatment and what they would do if assigned to control. Let's
imagine Fred, for example. In one universe, we assign Fred treatment. He takes it up! In an
alternate universe, we assign Fred control. He doesn't take up treatment! Fred has complied!
Thus:
compliers are those that would takeup treatment only if assigned to treatment, and
would not takeup treatment only if assigned to control. They would comply with our
assignment.
Always takers would takeup treatment whether assigned to it or not.
Never takers would not takeup treatment whether assigned to it or not. And
defiers would do the opposite of what we assign them to do (i.e. would not takeup
treatment if assigned treatment, would takeup treatment if assigned control).
We can't actually glean the type of person each of the folks in our data is, unfortunately. We
live in one universe... but if we make an assumption (monotonicity) we can use folks
ACTUAL behavior to glean their "type." Once we've done that, we can make a few more
assumptions (exclusion restriction, valid randomization, no SUTVA violations on D or Y,
relevancy) to calculate the average effect of treatment FOR COMPLIERS. This is the LATE.
It's called a "local" average treatment effect b/c it doesn't calculate the treatment effect
"globally" (i.e. for all) but instead calculates the effect of treatment "locally" (i.e. for some,
specifically, for compliers). It's also sometimes called the CATE or Complier Average
Treatment Effect for that reason.
Now we get to the mythical ATE! The ATE is the Average Treatment Effect -- the average
effect of treatment for everybody, regardless of the type of person they are. Alas! Our
assumptions will not allow us to recover the ATE! Even with them, we can only recover the
treatment effect for compliers, or the LATE! The most straightforward way to recover the
ATE is to ensure there is no non-compliance. Then your complier average treatment effect IS
the Average Treatment Effect becuase everybody is a complier!
So there you have it!
ITT -- effect of ASSIGNMENT on outcome.
LATE -- effect of treatment on outcome FOR COMPLIERS.
ATE -- effect of treatment on outcome for EVERYBODY.