Chem-706 Synthetic Organic Chemistry L-1,

Dec 14, 2016-April 9, 2017

Course Description:
This course will focus on introduction to oxidation,
reduction, C-C bond formations, synthetic
applications of important named reactions, and
organometallic chemistry.

Course In charge: Fatima Basha

Dr. Atta-ur-Rahman Laboratory (TWC)
Lab # 212, Intercom: 237
E-mail: bashafz@gmail.com

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Tentative Schedule of Classes for Course Chem-706
Dec 14, 2016-Apr 14, 2017

4 classes per week (10:15-11:15 AM)

100 marks --4 Separate Exams:

Reductions Abdul Hameed Dec 19th–Jan 10th 25 marks

Oxidations Hina Siddiqui Jan 11th–Jan 31st 20 marks

Organometallics M. Shaiq Ali Feb 01st–Feb 28th 25 marks

C-C bond formations Fatima Basha Mar 20th–Apr 8th 30 marks

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Tentative Schedule of Classes for Course Chem-706
Reductions Abdul Hameed Dec 19th–Jan 10th
25 marks
Oxidations Hina Siddiqui Jan 11th–Jan 31st
20 marks
Organometallics M. Shaiq Ali Feb 01st–Feb 28th
25 marks
C-C bond formations Fatima Basha Mar 20th–Apr 8th
30 marks

4 classes per week

100 marks for Chem-706---4 Separate Exams:

F. Basha E-mail: bashafz@gmail.com

Total 30 marks Home assesment/Take-home Exam April 1, 2017 (15 marks)
Final exam April 6th(Thurs) or 7th(Fri) (15 marks)

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 university's Grade Chart.

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 Recommended Books
1. J. Clayden, N. Greeves, S. Warren and P. Wothers,
―Organic Chemistry.‖ Oxford University Press, Oxford,
England (2001).

2. Francis A. Carey and R.J. Sundberg ―Advanced

Organic Chemistry.‖ Part B: Reactions and Synthesis,
4th Edition, A division of Plenum Publishing Corporation,
New York, USA (2001).

3. Reviews and Current Literature

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 C-C Bond Formation
C-C bond formation----is making C-C bond—construction of
complex molecules from simple building blocks.
Some of these reactions are so important that they are
named after the scientist who developed them (e.g
Girgnard & Claisen condensation).
One of the fundamental way of C-C bond formation is a
reaction between a nucleophilic and an electrophilic carbon.
• C- nucleophiles : Enolates, imine anions, enamines…etc
• C-electrophiles : alkylating and acylation agents…..etc

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Chem 125. Advanced Organic Chemistry.
17. The Carbonyl Group in Carbon-Carbon
Bond Formation
https://www.youtube.com/watch?v=9m4ILdPSJe8

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 C-C Bond Formation
• C-electrophiles : alkylating and acylation agents…..etc

• C- nucleophiles : Enolates, imine anions, enamines…etc

– Aldehydes (alkylation/acylation of aldehyde

enolates is not very common. One reason is that
aldehydes are rapidly converted to aldol addition
products by base).
– Ketones
– Esters (Ester enolates are somewhat less stable
than ketone enolates because of the potential for
elimination of alkoxide).
– Amides
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 – Nitriles
– And their derivatives

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Unwanted Side Reactions

Carbonyl compound must not act as an electrophile

when it is intended to be a nucleophile

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 C-C Bond formation--Carbonyl group as an Electrophile
- 2 examples

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C-C Bond formation--Carbonyl group as an Nucleophile
Nucleophilic substitution can be viewed as C-C bond formation.

Primary groups are the best alkylating agents…

Secondary groups are less reactive…gives lower yields
Tertiary and aryl groups are unreactive.

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