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modMODULE II-E DRUGS ACTING On NMJ
modMODULE II-E DRUGS ACTING On NMJ
Workload
The amount of work required from students to budget their time to fit pharmacology
course in their entire semester schedule. Five workload components to each module.
1
Core Topics in Pharmacology and Therapeutics
LEARNING PLAN
SY 2020 – 2021
Intended Learning By the end of this course, student should be able to:
Outcomes 1. Identify the fundamental principles of
pharmacokinetics and pharmacodynamics and pply the
pharmacodynamic and pharmacokinetic principles that
describe drug actions in humans. (1D)
2. Convey information, in written and oral formats,
across all types of audiences, venues and media in a
manner that can be easily understood. (2P)
3. Lead and manage health care teams (3P)
4. Engage in research activities (4P)
5. Collaborate within interprofessional teams (5I)
Learning Objectives: By the end of this module, student should be able to:
CASE NO. 4 1.Contrast the mechanism of action of depo;arising and
Given a 25yo man develops and nondepolarizing neuromuscular junction blockers.
muscle rigidity,tachycardia, 2.List the therapeutic uses and advers effects of skeletal ; ;
and high fever during surgery muscle relaxants.
3.Know about malignant hyperthermia(rare) and treatment
Of choice.Know: MOA of DANTROLENE
BASIC PHARMACOLOGY of the following DRUGS:
-MOA of depolarizing and nondepolarizing neuromuscular
junction blocking agents.
-Therapeutic uses and adverse effects of skeletal muscle
Relaxants
-Structure and function of NMJ
(Physiology/Anatomy/Histo Link)
-Drugs acting on NMJ:
a.depolarizing;prototype:succinylcholine
b.nondepolarizing:prototype:d-Tubocurarine
Cisatracurium,Vecuronium,Rocuronium
KNOW THE SIGNS AND SYMPTOMS OF MALIGNANT
HYPERTHERMIA-a rare inherited autosomal dominant
disorder
A healthy 25 yo man is undergoing a brief surgical procedure requiring general
anesthesia.He underwent an unremarkable intubation and induction of anesthesia using IV
succinylcholine and inhaled halothane.During the surgery the patient develops muscle
rigidity and tachycardia and his temperature rapidly rises.
1.What is the mechanism of action of succinylcholine?
2.What reaction is occurring in the patient.?
3.What drug should immediately be given to the patient,and what is its mechanism of
action?