HLA-B major histocompatibility complex, class I, B [ ​Homo

sapiens​ (human) ]
LA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer
consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is
anchored in the membrane. Class I molecules play a central role in the immune system by
presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in
nearly all cells. The heavy chain is approximately 45 kDa and its gene​ contains 8 exons.​ Exon
1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both
bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane
region and exons 6 and 7 encode the cytoplasmic tail.
There are 8 exons,out of which 7 are coding.

Gene location 31357179 : 31353875

Interval (exons 5' to 3') Length (bp)

Exon Coding Exon Coding Intron
31357179-31357086 31357158-31357086 94 73 128
31356957-31356688 31356957-31356688 270 270 245
31356442-31356167 31356442-31356167 276 276 574
31355592-31355317 31355592-31355317 276 276 93
31355223-31355107 31355223-31355107 117 117 441
31354665-31354633 31354665-31354633 33 33 106
31354526-31354479 31354526-31354483 48 44 182
31354296-31353875 422

PROMOTER SEQUENCE
-10 TO -35(WRT TSS) SEQUENCE
CCAGTTC​TAAA​GTCCCCACGCACCCA
TAAA:TATA BOX

PEPTIDE SEQUENCE
MAPRTVLLLLSAALALTETWAGSHSMRYFYTSVSRPGRGEPRFISVGYVDDTQFVRFDSD
AASPREEPRAPWIEQEGPEYWDRNTQIYKAQAQTDRESLRNLRGYYNQSEAGSHTLQSMY
GCDVGPDGRLLRGHDQYAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQRRAY
LEGECVEWLRRYLENGKDKLERADPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQR
DGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEPSSQ
STVPIVGIVAGLAVLAVVVIGAVVAAVMCRRKSSGGKGGSYSQAACSDSAQGSDVSLTA
Gn.Ex Type S .Begin ...End .Len Fr Ph I/Ac Do/T CodRg P.... Tscr..

----- ---- - ------ ------ ---- -- -- ---- ---- ----- ----- ------

1.01 Init 31 94 64 0 1 85 117 239 0.513 25.90

1.02 Intr + 223 492 270 2 0 72 117 435 0.996 43.56

1.03 Intr + 738 1013 276 1 0 4 41 588 0.924 44.44

1.04 Intr + 1588 1863 276 2 0 55 74 121 0.972 6.14

1.05 Intr + 1957 2073 117 2 0 110 91 151 0.982 19.21

1.06 Intr + 2515 2547 33 2 0 126 86 -12 0.728 1.72

1.07 Term + 2654 2697 44 0 2 105 48 41 0.757 0.01

1.08 PlyA + 3283 3288 6 1.05

OBSERVATION
● The initiation exon starts from 31-94 position with respect to
transcription start site.
● The terminal exon starts from 2654-2697 position with respect
to transcription start site.
● Poly-A-tail starts from 3283-3288 position with respect to
transcription start site.